Antioxidant activity of ferulic acid alkyl esters in a heterophasic system: a mechanistic insight     

Anselmi C  Centini M  Granata P  Sega A  Buonocore A  Bernini A  Facino RM 《Journal of agricultural and food chemistry》2004,52(21):6425-6432

The antioxidant activity of some esters of ferulic acid with the linear fatty alcohols C7, C8 (branched and linear), C9, C11, C12, C13, C15, C16, and C18 has been studied in homogeneous and heterogeneous phases. Whereas in homogeneous phase all of the alkyl ferulates possessed similar radical-scavenging abilities, in rat liver microsomes they showed striking differences, the more effective being C12 (7) (IC50 = 11.03 M), linear C8 (3) (IC50 = 12.40 microM), C13 (8) (IC50 = 18.60 microM), and C9 (5) (IC50 = 19.74 microM), followed by C7 (2), C15 (9), C11 (6), branched C8 (4), C16 (10), and C18 (11) (ferulic acid was the less active, IC50 = 243.84 microM). All of the molecules showed similar partition coefficients in an octanol-buffer system. Three-dimensional studies (NMR in solution, modeling in vacuo) indicate that this behavior might be due to a different anchorage of the molecules with the ester side chain to the microsomal phospholipid bilayer and to a consequent different orientation/positioning of the scavenging phenoxy group outside the membrane surface against the flux of oxy radicals.  相似文献   

Determination of carboxylic acids in vinegars and in Aceto Balsamico Tradizionale di Modena by HPLC and GC methods   总被引：1，自引：0，他引：1  

Cocchi M  Lambertini P  Manzini D  Marchetti A  Ulrici A 《Journal of agricultural and food chemistry》2002,50(19):5255-5261

The presence of carboxylic acids in grape products has been investigated for a long time by researchers, from both the qualitative and quantitative points of view. Evaluation of carboxylic acids requires the study and optimization of some operative variables which are strictly related to the matrix. In particular, the determination of organic acids in real matrixes such as Aceto Balsamico Tradizionale of Modena (ABTM; a traditional balsamic vinegar made from cooked grape must) is often difficult because of the presence of numerous interferences that need to be removed by separation techniques. To this aim, in the present work a solid-phase extraction (SPE) method with C18 and NH(2) exchangers was used to clean the ABTM samples prior to analysis or further treatments. Both HPLC and GC techniques were used to determine organic acids. The efficiency of these two different analytical techniques in the study of ABTM acidic composition has been evaluated. Both methods separately were not able to supply all the data related to carboxylic acids. In particular, HPLC allows acetic and lactic acids quantification, but gluconic and succinic acids are better determined by GC. As far as tartaric, citric, and malic acids are concerned, both HPLC and GC methods give statistically equivalent results. The variation of the single acidic species composition along a series of casks furnished interesting information regarding the chemical transformations taking place during the aging process of this product.  相似文献   

Localisation of cannabinoid and cannabinoid-related receptors in the equine dorsal root ganglia     

Roberto Chiocchetti  Riccardo Rinnovati  Claudio Tagliavia  Agnese Stanzani  Giorgia Galiazzo  Fiorella Giancola  Margherita De Silva  Ylenia Capodanno  Alessandro Spadari 《Equine veterinary journal》2021,53(3):549-557

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Physics. Marriage of two device concepts     

Tredicucci A 《Science (New York, N.Y.)》2003,302(5649):1346-1347

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Book review     

Alessandro Bonanno 《Agriculture and Human Values》2007,24(3):413-414

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Agricultural policies and the capitalist State     

Alessandro Bonanno 《Agriculture and Human Values》1987,4(2-3):40-46

The paper examines the social contradictions generated by patterns of reproduction of accumulation of capital, social legitimation and by present agricultural policies fostered by the State. Through a scrutiny of the role of the State in capitalism it is argued that agricultural overproduction, the widening of the gap between small and large farms, the fiscal crisis of the State associated with agricultural programs and waste of resources are the outcomes of an attempt on the part of the State to promote simultaneously accumulation and legitimation. The possibility of enhancing accumulation and maintaining legitimation clashes with the diverse socio-economic demands associated with the present agricultural production system and the general viability of the social structure as a whole.  相似文献   

Human CHN1 mutations hyperactivate alpha2-chimaerin and cause Duane's retraction syndrome     

Miyake N  Chilton J  Psatha M  Cheng L  Andrews C  Chan WM  Law K  Crosier M  Lindsay S  Cheung M  Allen J  Gutowski NJ  Ellard S  Young E  Iannaccone A  Appukuttan B  Stout JT  Christiansen S  Ciccarelli ML  Baldi A  Campioni M  Zenteno JC  Davenport D  Mariani LE  Sahin M  Guthrie S  Engle EC 《Science (New York, N.Y.)》2008,321(5890):839-843

Duane's retraction syndrome (DRS) is a complex congenital eye movement disorder caused by aberrant innervation of the extraocular muscles by axons of brainstem motor neurons. Studying families with a variant form of the disorder (DURS2-DRS), we have identified causative heterozygous missense mutations in CHN1, a gene on chromosome 2q31 that encodes alpha2-chimaerin, a Rac guanosine triphosphatase-activating protein (RacGAP) signaling protein previously implicated in the pathfinding of corticospinal axons in mice. We found that these are gain-of-function mutations that increase alpha2-chimaerin RacGAP activity in vitro. Several of the mutations appeared to enhance alpha2-chimaerin translocation to the cell membrane or enhance its ability to self-associate. Expression of mutant alpha2-chimaerin constructs in chick embryos resulted in failure of oculomotor axons to innervate their target extraocular muscles. We conclude that alpha2-chimaerin has a critical developmental function in ocular motor axon pathfinding.  相似文献   

Distinct ensemble codes in hippocampal areas CA3 and CA1     

Leutgeb S  Leutgeb JK  Treves A  Moser MB  Moser EI 《Science (New York, N.Y.)》2004,305(5688):1295-1298

The hippocampus has differentiated into an extensively connected recurrent stage (CA3) followed by a feed-forward stage (CA1). We examined the function of this structural differentiation by determining how cell ensembles in rat CA3 and CA1 generate representations of rooms with common spatial elements. In CA3, distinct subsets of pyramidal cells were activated in each room, regardless of the similarity of the testing enclosure. In CA1, the activated populations overlapped, and the overlap increased in similar enclosures. After exposure to a novel room, ensemble activity developed slower in CA3 than CA1, suggesting that the representations emerged independently.  相似文献   

Global contested terrain: The case of the tuna-dolphin controversy     

Douglas H. Constance  Alessandro Bonanno  William D. Heffernan 《Agriculture and Human Values》1995,12(3):19-33

Employing the case of the global tuna-fish industry, it is argued that the process of globalization is contested terrain as it opens free spaces to some classes or groups and closes free spaces to others; that the nation-States' regulatory abilities are weakened; and finally, that while some social movements may gain, others are marginalized. Three basic conclusions are reached. (1) The industry's actions were successfully contested by environmental groups supported by the legislative and judicial branches of the US State. (2) Simultaneously, pro-environmental legislation is currently threatened, along with several national and international environmental accords. (3) Workers in the US and, particularly, in Latin America are paying the consequences of the introduction of pro-environmental legislation and the actions of transnational corporations (TNCs).Douglas H. Constance is Research Associate of Rural Sociology at the University of Missouri-Columbia. His research interests include the sociology of agriculture and environmental sociology. He is the author of several journal articles and is coauthor with Alessandro Bonanno of the forthcoming bookCaught in the Net: The Global Tuna Industry, Environmentalists, and the State.  相似文献   

Genetic and environmental factors affecting allergen-related gene expression in apple fruit (Malus domestica L. Borkh)     

Botton A  Lezzer P  Dorigoni A  Barcaccia G  Ruperti B  Ramina A 《Journal of agricultural and food chemistry》2008,56(15):6707-6716

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