In vitro evaluation of the effect of hypothermia on coagulation in dogs via thromboelastography     

Ryan Taggart DVM  Brenda Austin DVM  MS  DACVS  Eric Hans BS  Daniel Hogan DVM  DACVIM 《Journal of Veterinary Emergency and Critical Care》2012,22(2):219-224

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Arcelins from an Indian wild pulse, Lablab purpureus, and insecticidal activity in storage pests     

Janarthanan S  Suresh P  Radke G  Morgan TD  Oppert B 《Journal of agricultural and food chemistry》2008,56(5):1676-1682

A partially purified protein fraction was isolated from seed flour of the Indian wild bean, Lablab purpureus, by ion exchange and size-exclusion chromatographies. Partially purified L. purpureus proteins had hemagglutination and glycoslyation properties similar to those of lectins or lectin-like proteins from other pulses. Data obtained from two-dimensional gel electrophoresis, MALDI-TOF, and MALDI-TOF/TOF and N-terminal protein sequencing of the isolated polypeptides from L. purpureus demonstrated that the extract contained proteins similar to isoforms of arcelins 3 and 4 and pathogenesis-related protein 1 (PvPR1) of Phaseolus vulgaris. L. purpureus proteins were resistant to degradation by the commercial enzymes trypsin and chymotrypsin and were moderately resistant to pepsin, but were readily hydrolyzed to smaller peptides by papain. Insect feeding bioassays of the extract with the storage pests Rhyzopertha dominica and Oryzaephilus surinamensis, internal and external feeders of grain, respectively, demonstrated that L. purpureus proteins at 2% in the diet resulted in retarded development. However, a 5% dose of the L. purpureus fraction resulted in complete mortality of all larvae in both species. This study has demonstrated that proteins in the partially purified L. purpureus extract have the potential to control storage pests in cereals transformed with L. purpureus defense-related genes, but the need for more studies regarding efficacy and safety is discussed.  相似文献   

What is your diagnosis? Multiple area of lysis of the metaphyses and diaphysis of the left femur     

Austin BR  Henderson RA 《Journal of the American Veterinary Medical Association》2003,223(11):1569-1570

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Requests review of AVMA resolution on gestation crates     

Forsythe BK 《Journal of the American Veterinary Medical Association》2003,223(1):42

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Pharyngeal--laryngeal blastomycosis in a dog     

Salinardi BJ  Marretta SM  McCullough SM  Bischoff MG  Lichtensteiger CA 《Journal of veterinary dentistry》2003,20(3):146-147

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A retrospective study of mortality in Pennsylvania captive white-tailed deer (Odocoileus virginianus): 20000--2003.     

Arthur L Hattel  Daniel P Shaw  Brenda C Love  Donald C Wagner  Thomas R Drake  Jason W Brooks 《Journal of veterinary diagnostic investigation》2004,16(6):515-521

The postmortem records of 160 white-tailed deer (Odocoileus virginianus) submitted for necropsy examination from 59 separate Pennsylvania captive deer farms over a 3.5-year period were reviewed to determine the primary cause of death of each animal. The most common causes of death were bronchopneumonia (39 cases), enterocolitis (30 cases), malnutrition (13 cases), and trauma (11 cases). Other causes of mortality included severe gastrointestinal parasitism (6 cases), cellulitis with septicemia (5 cases), degenerative myopathy (4 cases), ruminal acidosis (4 cases), and nephritis (4 cases). The cause of death was undetermined in 13 of the 160 animals. Arcanobacterium pyogenes (19 cases), Fusobacterium necrophorum (10 cases), Escherichia coli (7 cases), and Mannheimia haemolytica (4 cases) were the most commonly isolated bacteria from the pneumonic lungs. Bacterial agents associated with enterocolitis included Clostridium perfringens (15 cases), E. coli (12 cases), and Mycobacterium avium subsp. paratuberculosis (2 cases). The majority (52.2%) of the death loss in white-tailed deer of known ages occurred in animals 1 year of age or less, with 46.2% of the bronchopneumonia cases and 50.0% of the enterocolitis cases occurring during this time period. Cases of degenerative myopathy, myocardial degeneration, hepatic necrosis, meningoencephalitis, peritonitis, and urolithiasis considered severe enough to be the primary cause of death appeared early in life, affecting deer 6 months of age or less in all cases. In conclusion, bronchopneumonia, enterocolitis, malnutrition, and trauma were considered the most common causes of death in confined white-tailed deer in this study.  相似文献   

Mortality in Pennsylvania captive elk (Cervus elaphus): 1998-2006.     

Arthur L Hattel  Daniel P Shaw  Jenny S Fisher  Jason W Brooks  Brenda C Love  Thomas R Drake  Donald C Wagner 《Journal of veterinary diagnostic investigation》2007,19(3):334-337

The necropsy records of 65 elk ranging from 1 day to 13(1/2) years of age were reviewed to determine the primary cause of death of each animal. The animal carcasses were submitted from 22 separate Pennsylvania elk farms over an approximately 8-year period. The most common causes of mortality in animals in which the cause of death was determined were gastrointestinal parasitism (21 cases), pneumonia (7 cases), enterocolitis (5 cases), malnutrition (5 cases), and rumenitis/acidosis (5 cases). The cause of death was undetermined in 4 of the 65 elk. Nematode organisms (20 cases) were the primary parasites identified in cases of mortality owing to gastrointestinal parasitism. Arcanobacterium pyogenes (3 cases), Escherichia coli (3 cases), and Streptococcus sp. (2 cases) were the most commonly isolated bacteria from the lung in the cases of pneumonia. Fungal organisms, consistent with Aspergillus sp. were present histologically within the pulmonary lesions in 5 cases. Bacterial agents associated with enterocolitis included Clostridium perfringens (2 cases), E. coli (1 case), Salmonella Newport (1 case) and Salmonella Thompson (1 case). The majority (56.3%) of the death loss in elk of known ages occurred in animals 1 year of age or less, with 71.4% of the gastrointestinal parasitism, 60.0% of the malnutrition, 60.0% of the enterocolitis, and 57.1% of the pneumonia cases occurring in animals within this age range. In conclusion, gastrointestinal parasitism, pneumonia, malnutrition, enterocolitis and rumenitis/acidosis were considered the most common causes of death in captive elk in this study.  相似文献   

Cancer detection in clinical practice and using blood-based liquid biopsy: A retrospective audit of over 350 dogs     

Andi Flory  Lisa McLennan  Betsy Peet  Marissa Kroll  Deirdre Stuart  Devon Brown  Kathy Stuebner  Brenda Phillips  Brenda L. Coomber  J. Paul Woods  Mairin Miller  Chelsea D. Tripp  Amber Wolf-Ringwall  Kristina M. Kruglyak  Angela L. McCleary-Wheeler  Ashley Phelps-Dunn  Lilian K. Wong  Chelsea D. Warren  Gina Brandstetter  Michelle C. Rosentel  Lauren R. DiMarzio  Allison L. O'Kell  Todd A. Cohen  Daniel S. Grosu  Jason Chibuk  Dana W. Y. Tsui  Ilya Chorny  Jill M. Rafalko 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2023,37(1):258-267

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Alternating rabacfosadine and doxorubicin for treatment of naïve canine lymphoma     

Corey F. Saba  Timothy M. Fan  Brenda S. Phillips  Zachary M. Wright  Douglas H. Thamm 《Veterinary and comparative oncology》2024,22(2):278-283

The current standard of care treatment for canine lymphoma is a multi-agent, CHOP-based chemotherapy protocol. Single agent doxorubicin (DOX) is less burdensome; however, multi-agent chemotherapy protocols are often superior. The recently approved drug rabacfosadine (RAB, Tanovea) provides an attractive option for combination therapy with DOX, as both drugs demonstrate efficacy against lymphoma and possess different mechanisms of action. A previous study evaluating alternating RAB/DOX reported an overall response rate (ORR) of 84%, with a median progression-free survival time (PFS) of 194 days. The aim of this prospective trial was to evaluate the same protocol in an additional population of dogs. Fifty-nine dogs with treatment naïve lymphoma were enrolled. RAB (1.0 mg/kg IV) was alternated with DOX (30 mg/m² IV) every 21 days for up to six total treatments (3 cycles). Response assessment and adverse event (AE) evaluation were performed every 21 days using VCOG criteria. The ORR was 93% (79% CR, 14% PR). The median time to maximal response was 21.5 days; median PFS was 199 days. T cell immunophenotype and lack of treatment response were predictive of inferior outcomes. AEs were mostly gastrointestinal. Six dogs developed presumed or confirmed pulmonary fibrosis; four were grade 5. One dog experienced grade 3 extravasation injury with RAB that resolved with supportive treatment. These data mirror those of the previously reported RAB/DOX study, and support the finding that alternating RAB/DOX is a reasonable treatment option for canine lymphoma.  相似文献   

Prediction of Cooked Rice Texture Quality Using Near-Infrared Reflectance Analysis of Whole-Grain Milled Samples     

William R. Windham  Brenda G. Lyon  Elaine T. Champagne  Franklin E. Barton  Bill D. Webb  Anna M. McClung  Karen A. Moldenhauer  Steve Linscombe  Kent S. McKenzie 《Cereal Chemistry》1997,74(5):626-632

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