Effects of working-memory training on striatal dopamine release     

Bäckman L  Nyberg L  Soveri A  Johansson J  Andersson M  Dahlin E  Neely AS  Virta J  Laine M  Rinne JO 《Science (New York, N.Y.)》2011,333(6043):718

Updating of working memory has been associated with striato-frontal brain regions and phasic dopaminergic neurotransmission. We assessed raclopride binding to striatal dopamine (DA) D2 receptors during a letter-updating task and a control condition before and after 5 weeks of updating training. Results showed that updating affected DA activity before training and that training further increased striatal DA release during updating. These findings highlight the pivotal role of transient neural processes associated with D2 receptor activity in working memory.  相似文献   

Airborne laser scanning-based decision support for wood procurement planning     

Jari Vauhkonen  Petteri Packalen  Jukka Malinen  Juho Pitkänen  Matti Maltamo 《Scandinavian Journal of Forest Research》2014,29(7):132-143

We present a decision support tool for guiding the selection of marked stands based on airborne laser scanning (ALS) data. We describe three stages, namely (1) wall-to-wall mapping of the stands matured for cutting using low-density ALS data; (2) tree-level inventory of these stands using high-density ALS data and (3) theoretical bucking of the imputed tree stems to produce detailed information on their characteristics. We tested them in a Scots pine dominated boreal forest area in Eastern Finland, where 79 sample plots were measured in the field. The detection of the stands matured for cutting had a success rate of 95% and our results demonstrated a further potential to limit the result towards stands dominated by certain species by means of intensity values derived from the low-density ALS data. The applied single-tree detection and estimation chain produced detailed tree-level information and realistic diameter distributions, yet the detection was highly emphasised on the dominant tree layer. The error levels in the estimates were generally less than standard deviations of the field attributes. Finally, plot-level accumulations of saw-log volumes were found rather similar, whether the input was based on the imputed tree data or trees measured in the field. The results are considered useful for ranking the stands based on their properties, whether the aim in the wood procurement is to focus on certain species or to select stands suitable for production needs.  相似文献   

Cyanobacteria from Terrestrial and Marine Sources Contain Apoptogens Able to Overcome Chemoresistance in Acute Myeloid Leukemia Cells     

Liwei Liu  Lars Herfindal  Jouni Jokela  Tania Keiko Shishido  Matti Wahlsten  Stein Ove D?skeland  Kaarina Sivonen 《Marine drugs》2014,12(4):2036-2053

In this study, we investigated forty cyanobacterial isolates from biofilms, gastropods, brackish water and symbiotic lichen habitats. Their aqueous and organic extracts were used to screen for apoptosis-inducing activity against acute myeloid leukemia cells. A total of 28 extracts showed cytotoxicity against rat acute myeloid leukemia (IPC-81) cells. The design of the screen made it possible to eliminate known toxins, such as microcystins and nodularin, or known metabolites with anti-leukemic activity, such as adenosine and its analogs. A cytotoxicity test on human embryonic kidney (HEK293T) fibroblasts indicated that 21 of the 28 extracts containing anti-acute myeloid leukemia (AML) activity showed selectivity in favor of leukemia cells. Extracts L26-O and L30-O were able to partly overcome the chemotherapy resistance induced by the oncogenic protein Bcl-2, whereas extract L1-O overcame protection from the deletion of the tumor suppressor protein p53. In conclusion, cyanobacteria are a prolific resource for anti-leukemia compounds that have potential for pharmaceutical applications. Based on the variety of cellular responses, we also conclude that the different anti-leukemic compounds in the cyanobacterial extracts target different elements of the death machinery of mammalian cells.  相似文献   

Tetrodotoxin sensitivity of the vertebrate cardiac Na+ current     

Vornanen M  Hassinen M  Haverinen J 《Marine drugs》2011,9(11):2409-2422

Evolutionary origin and physiological significance of the tetrodotoxin (TTX) resistance of the vertebrate cardiac Na(+) current (I(Na)) is still unresolved. To this end, TTX sensitivity of the cardiac I(Na) was examined in cardiac myocytes of a cyclostome (lamprey), three teleost fishes (crucian carp, burbot and rainbow trout), a clawed frog, a snake (viper) and a bird (quail). In lamprey, teleost fishes, frog and bird the cardiac I(Na) was highly TTX-sensitive with EC(50)-values between 1.4 and 6.6 nmol·L(-1). In the snake heart, about 80% of the I(Na) was TTX-resistant with EC(50) value of 0.65 μmol·L(-1), the rest being TTX-sensitive (EC(50) = 0.5 nmol·L(-1)). Although TTX-resistance of the cardiac I(Na) appears to be limited to mammals and reptiles, the presence of TTX-resistant isoform of Na(+) channel in the lamprey heart suggest an early evolutionary origin of the TTX-resistance, perhaps in the common ancestor of all vertebrates.  相似文献   

FOREWORD     

Károly Pintér  Matti Sipponen 《Fisheries Management and Ecology》2001,8(4-5):iii-iv

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Inventory of aspen trees in spruce dominated stands in conserva-tion area     

Matti Maltamo  Annukka Pesonen  Lauri Korhonen  Jari Kouki  Mikko Vehmas  Kalle Eerik?inen 《中国林学(英文版)》2015,(2):143-154

Background: The occurrence of aspen trees increases the conservation value of mature conifer dominated forests.Aspens typically occur as scattered individuals among major tree species, and therefore the inventory of aspens is challenging.Methods: We characterized aspen populations in a boreal nature reserve using diameter distribution, spatial pattern, and forest attributes: volume, number of aspens, number of large aspen stems and basal area median diameter. The data were collected from three separate forest stands in Koli National Park, eastern Finland. At each site, we measured breast height diameter and coordinates of each aspen. The comparison of inventory methods of aspens within the three stands was based on simulations with mapped field data. We mimicked stand level inventory by locating varying numbers of fixed area circular plots both systematically and randomly within the stands. Additionally, we also tested if the use of airborne laser scanning(ALS) data as auxiliary information would improve the accuracy of the stand level inventory by applying the probability proportional to size sampling to assist the selection of field plot locations.Results: The results showed that aspens were always clustered, and the diameter distributions indicated different stand structures in the three investigated forest stands. The reliability of the volume and number of large aspen trees varied from relative root mean square error figures above 50% with fewer sample plots(5–10) to values of25%–50% with 10 or more sample plots. Stand level inventory estimates were also able to detect spatial pattern and the shape of the diameter distribution. In addition, ALS-based auxiliary information could be useful in guiding the inventories, but caution should be used when applying the ALS-supported inventory technique.Conclusions: This study characterized European aspen populations for the purposes of monitoring and management of boreal conservation areas. Our results suggest that if the number of sample plots is adequate,i.e. 10 or more stand level inventory will provide accurate enough forest attributes estimates in conservation areas(minimum accuracy requirement of RMSE% is 20%–50%). Even for the more ecologically valuable attributes, such as diameter distribution, spatial pattern and large aspens, the estimates are acceptable for conservation purposes.  相似文献   

Predicting and calibrating diameter distributions of Eucalyptus grandis (Hill) Maiden plantations in Zimbabwe     

Mabvurira  Danaza  Maltamo  Matti  Kangas  Annika 《New Forests》2002,23(3):207-223

Diameter distribution models for even-aged Eucalyptus grandis plantations in Zimbabwe were developed using the two-parameter Weibull function. The analysis was based on data from Correlated Curve Trend (CCT) experiments replicated on four different sites. Parameters of the Weibull distribution were predicted using stand characteristics as regressors. Two sets of parameter models were estimated: a set with and one without stand basal area as a predictor. Stand variables such as dominant height, age, site index and number of stems were used in both sets. The models were further calibrated to result in a given number of stems and stand basal area simultaneously. The usability of constructed models was tested both in prediction of yield in a stand inventory situation and in simulation of growth in connection with different growth models. The results indicated that models not including stand basal area produce considerably less precise stand volume estimates compared to models including also stand basal area. Calibration improved the accuracy of diameter distribution models. In growth simulation diameter distribution models can be connected both to single tree growth models and to stand projection models. The usability of calibration in growth simulation depends on the accuracy of the prediction of stand characteristics.  相似文献   

Modelling crop growth and biomass partitioning to shoots and roots in relation to nitrogen and water availability, using a maximization principle. II. Simulation of crop nitrogen balance     

Jouko Kleemola  Matti Teittinen  Tuomo Karvonen 《European Journal of Agronomy》1998,8(3-4):191-204

This study analysed of the ability of a crop model to simulate crop nitrogen (N) balance. The model was originally developed to serve as a foundation to develop a decision-making tool to analyse the impact of water management and nitrogen fertilization on crop yield. The model included a dynamic parameter for allocation of dry matter between root and shoot allowing root to shoot ratio to vary according to differing environmental conditions. The new allocation parameter was introduced in order to make the model more applicable under water and nitrogen limited growing conditions. Two wheat (Triticum aestivum L.) data sets were used to test the model simulations. Generally, the model simulations agreed well with the recorded data on crop N uptake. The relationship between the actual and simulated amount of N taken up by the crop was close in the calibration treatments of a greenhouse experiment. The coefficient of determination (r²) of the regression line (simulated value = independent variable, measured value = dependent variable) was 0.90. The r² was 0.83 for the validation data. In the field experiments, the r² values were 0.91 for the calibration data and 0.82 for the validation data. In field data, the model underestimated in some cases the crop N uptake during the period when actual shoot dry weight increased exponentially in spring. Therefore, methods used in computation of nitrogen uptake have to be analysed further. Plant organ N content was simulated satisfactorily for both greenhouse and field data. However, the range over which the simulated values varied was larger than in the actual data.

The results from the study indicate that our model is capable of simulating the crop N balance and we suggest that the model could be used when developing an N application decision tool for field crops. However, the availability of N and soil water were provided as inputs in the present study. Thus, the model should be integrated with models simulating below ground processes in the future. Moreover, the model should be further validated with actual field data.  相似文献   

Autosomal trisomy in a heifer     

Auli Mkinen  Ilkka Alitalo  Matti Alanko 《Acta veterinaria Scandinavica》1987,28(1):1-8

A malformed Ayrshire heifer had one additional autosome in all the lymphocyte metaphases studied. Chromosome banding techniques showed the karyotype of the calf to be 2n = 61, XX, +24.Slight prognathia of the lower jaw and peculiar abbrevations in the structure of the genitals were the most apparent anomalies, in addition to heart abnormalities, a poorly-closed urachus and slow growth rate.  相似文献   

Comparing nearest neighbor configurations in the prediction of species-specific diameter distributions     

Janne Räty  Petteri Packalen  Matti Maltamo 《Annals of Forest Science》2018,75(1):26

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