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101.
Rees J 《Science (New York, N.Y.)》2002,296(5568):698-700
Medical research today is dominated by a genocentric point of view. At the same time, clinical discovery and patient-oriented research have become less common. Here, I suggest that these developments are interdependent, each representing the flip side of an inaccurate view of how clinical advance occurs. 相似文献
102.
The mechanosensitive channel of small conductance (MscS) responds both to stretching of the cell membrane and to membrane depolarization. The crystal structure at 3.9 angstroms resolution demonstrates that Escherichia coli MscS folds as a membrane-spanning heptamer with a large cytoplasmic region. Each subunit contains three transmembrane helices (TM1, -2, and -3), with the TM3 helices lining the pore, while TM1 and TM2, with membrane-embedded arginines, are likely candidates for the tension and voltage sensors. The transmembrane pore, apparently captured in an open state, connects to a large chamber, formed within the cytoplasmic region, that connects to the cytoplasm through openings that may function as molecular filters. Although MscS is likely to be structurally distinct from other ion channels, similarities in gating mechanisms suggest common structural elements. 相似文献
103.
People often are unable to report the content of ignored information, but it is unknown whether this reflects a complete failure to perceive it (inattentional blindness) or merely that it is rapidly forgotten (inattentional amnesia). Here functional imaging is used to address this issue by measuring brain activity for unattended words. When attention is fully engaged with other material, the brain no longer differentiates between meaningful words and random letters, even when they are looked at directly. These results demonstrate true inattentional blindness for words and show that visual recognition wholly depends on attention even for highly familiar and meaningful stimuli at the center of gaze. 相似文献
104.
Neptunium and americium are relatively insoluble in ground waters containing high sulfate concentrations, particularly at 90 degrees C. The insoluble neptunium species is Np(IV); hence reducing waters should enhance its formation. Americium can exist only in the trivalent state under these conditions, and its solubility also should be representative of that of curium. 相似文献
105.
Antibodies in gastric juice 总被引：2，自引：0，他引：2
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H.G. Rees D.V.M. M.R.C.V.S. N.D.A. 《New Zealand veterinary journal》2013,61(6):156-158
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