Use of posaconazole in the management of invasive orbital aspergillosis in a cat     

McLellan GJ  Aquino SM  Mason DR  Kinyon JM  Myers RK 《Journal of the American Animal Hospital Association》2006,42(4):302-307

Orbital infection with Aspergillus fumigatus was diagnosed in a Persian cat that was presented with chronic third eyelid protrusion and exophthalmos. Evidence of nasal, sinus, or disseminated aspergillosis was not detected in this cat. Complete surgical excision of diseased tissues was not possible during orbital exenteration, and infection subsequently extended into the tissues of the oral cavity. Oral therapy with itraconazole and parenteral therapy with amphotericin B were ineffective in resolving the infection. Oral therapy with a novel triazole, posaconazole, was curative.  相似文献   

OCCIPITAL DYSPLASIA AND ASSOCIATED CRANIAL SPINAL CORD ABNORMALITIES IN TWO DOGS     

Rodney S.  Bagley  DVM  Michael L.  Harrington  DVM  Russell L.  Tucker  DVM  Ronald D.  Sande  DVM  PhD  Charles R.  Root  DVM  MS  Robert W.  Kramer  DVM 《Veterinary radiology & ultrasound》1996,37(5):359-362

Occipital dysplasia was found in association with cervical spinal cord abnormalities in two dogs. One dog presented for tetraparesis and cervical hyperesthesia, the other for historical cervical hyperesthesia and mild paraparesis. In dog 1, a midline cervical spinal cord defect consistent with a communicating syrinx was found. In the other dog, a presumptive syringo/hydromyelia of the cervical spinal cord was found on magnetic resonance imaging. While occipital dysplasia alone is not thought to cause any clinical abnormalities, the dogs of this report suggest that intramedullary central nervous system abnormalities may be present concurrently with occipital dysplasia and should be considered as a possible cause of the clinical signs. The relationship between occipital dysplasia and syringo/hydromyelia in these dogs remains unclear, however, similar associated abnormalities are occasionally found in humans with Chiari malformation.  相似文献   

Interaction of captan and folpet with mammalian DNA and histones     

Ronald C. Couch  Malcolm R. Siegel 《Pesticide biochemistry and physiology》1977,7(6):531-546

The reactions of captan, folpet, and thiophosgene with calf thymus histones and total rat liver histones were investigated. The binding of radioactivity from [³⁵S]captan or [¹⁴C]folpet and changes in polyacrylamide gel patterns of captan-treated calf thymus histones were pH dependent. At pH 7.5, gel patterns of captan-treated histones were not different from those of non-treated histones; whereas, at pH 9.0 the Amido Schwartz-staining bands of captan- and thiophosgene-treated histones in polyacrylamide gels were characterized by band diffusion, loss of staining definition, band migration, and aggregate formation. Nearly equal amounts of radio-activity from [¹⁴C]folpet and [³⁵S]captan were bound to lysine-rich histones at pH 9.0, while at pH 7.5 there was little binding of radioactivity to the proteins. Approximately equal amounts of radioactivity were removed from histones in the presence of the low-molecular-weight thiol, dithiothreitol. Reconstitution experiments using captan-treated lysine-rich histones and non-treated calf thymus DNA yielded less stable complexes, as well as smaller nucleohistone-nucleohistone complexes. These data suggest that the intact molecule binds to deprotonated sites on the lysine-rich histones. This binding causes changes in the configuration of the protein molecule which alters the ability of nuclear histones to stabilize DNA structure.  相似文献   

ACCURACY OF POSITIONING THE CERVICAL SPINE FOR RADIATION THERAPY AND THE RELATIONSHIP TO GTV, CTV AND PTV     

Hege  Kippenes  DVM  PhD  Patrick R.  Gavin  DVM  PhD  Ronald D.  Sande  DVM  MS  PhD  Dennis  Rogers  RT  Vaughn  Sweet  MS 《Veterinary radiology & ultrasound》2003,44(6):714-719

The purpose of the study was to evaluate the accuracy and precision of a rigid positioning device for repositioning the cervical spine accurately and precisely during conformal radiation therapy of dogs. Fifteen purpose bred research dogs in a radiation therapy study were included. The dogs were positioned using a head holder and a deflatable pillow attached to the treatment table. Port films were reviewed retrospectively, and repositioning precision was recorded by measurements in three orthogonal planes of the head, 2nd cervical vertebra and 1st thoracic spinous process. Mean treatment position was compared to the planning position for a measurement of systematic set-up error. Mean interfraction position variation of the 2nd cervical vertebra was 0.2, 0.1 and 0.2 cm for the ventrodorsal, caudocranial and laterolateral directions respectively, and the average systematic set up error was 0.2, 0.1 and 0.2 cm for the ventrodorsal, caudocranial and laterolateral directions respectively. Knowledge of the magnitude of reposition errors should be included when determining the margins around the tumor.  相似文献   

Swine production.     

Ronald L Plain  John D Lawrence 《Veterinary Clinics of North America: Food Animal Practice》2003,19(2):319-337

The US swine industry is large and growing. The quantity of pork desired by consumers of US pork is growing at the rate of 1.5%/y. New production systems and new technology have enabled production per sow to grow at a rate of 4% annually in recent years. Consequently, the number of sows in the United States is declining. Because productivity growth is outpacing demand growth, the deflated price of hogs and pork is declining. Hog production and prices continue to exhibit strong seasonal and cyclic patterns. Pork production is usually lowest in the summer and highest in the fall. Production and prices tend to follow 4-year patterns. The US swine industry continues to evolve toward fewer and larger producers who rely on contracts for both hog production and marketing. In 2000, over half of the hogs marketed were from approximately 156 firms marketing more than 50,000 head annually. These producers finished 60% of their production in contract facilities. Over 90% of their marketings were under contract or were owned by a packer. These producers expressed a high level of satisfaction with hog production. Both they and their contract growers were satisfied with production contracts. These large producers were satisfied with their marketing contracts and planned to continue them in the future. The hog industry has changed a great deal in the last decade. There is little reason to believe this rapid rate of change will not continue. This swine industry is highly competitive and profit driven. Profit margins are too small to allow producers the luxury of ignoring new technology and innovative production systems. Consequently, hog production will continue its rapid evolution from traditional agriculture to typical industry.  相似文献   

FAMILIAL CEREBELLAR ATAXIA WITH HYDROCEPHALUS IN BULL MASTIFFS     

Ronald P.  Johnson  DVM  T. Mark  Neer  DVM  Beth P.  Partington  DVM  MS  Doo-Youn  Cho  DVM  PhD  Curtis R.  Partington  MD  PhD 《Veterinary radiology & ultrasound》2001,42(3):246-249

Familial cerebellar ataxia with concurrent hydrocephalus has previously been described in a family of bull mastiff pups, and recently has been identified in a litter from Louisiana. The 4 affected pups had ataxia, hypermetria, conscious proprioceptive deficits, behavioral abnormalities, and a visual deficit. In magnetic resonance imaging of the brain of two of the pups, there were symmetric hydrocephalus and two focal areas of increased signal intensity within the central nuclei of the cerebellum. Histopathologically there was vacuolization and mild astrogliosis within the deep cerebellar nuclei (dentate, interpositus, fastigial), caudal colliculi, and lateral vestibular nuclei. Although the postmortem results were not exactly the same as in the previously published report, the clinical features and histopathologic findings strongly support the diagnosis. This disorder is most likely inherited in an autosomal recessive manner.  相似文献   

Adrenal Cortex of the Dog (Canis familiaris): I. Histomorphologic Changes during Growth,Maturity, and Aging1     

Ronald L. Hullinger 《Anatomia, histologia, embryologia》1978,7(1):1-27

The adrenal glands of 56 dogs ranging in age from birth to 13.6 years were examined for a determination of normal zonal and cellular morphology patterns throughout development, maturity and aging. Routine light microscopic techniques as well as lipid and cholesterol staining were used. The zona arcuata is described as developing between the fibrous and cellular layers of the capsule forming the cortical blastema layer, a zona biproliferativa. It is proposed that both centrifugal and centripetal migration of cortical parenchyma can result. The formation of accessory nodules is described as compensatory hyperplasia. Histomorphometric analysis revealed growth in the zona fasciculata to be by hyperplasia and the zonal volume percentages to be arcuata, 27%; fasciculata, 50%; reticularis, 23%.  相似文献   

Evaluation in Donkeys of an Inactivated Venezuelan Equine Encephalitis Vaccine     

Darío Parra Villasmil  Julieta de Siger  Mario Prez Barrientos  Manfred Mussgay  Ronald B. Mackenzie 《Zoonoses and public health》1975,22(2):162-168

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Gastroduodenal Ulceration in Dogs   总被引：2，自引：0，他引：2  

Marylynn E. Stanton DVM  Ronald M. Bright DVM  MS 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》1989,3(4):238-244

Forty three dogs with non-neoplastic canine gastric and/or duodenal ulcers were diagnosed at the University of Tennessee Veterinary Teaching Hospital (UTVTH) and reviewed in conjunction with dogs reported in the literature. No age, sex, or breed predilection was found. Most of the 43 UTVTH dogs presented with clinical signs referable to gastrointestinal disease, but evidence of hemorrhage was not always present. Nonregenerative anemia was a common (33/43 dogs) finding. Diagnosis of ulcer disease was made by contrast radiography, with clinical evidence of gastrointestinal hemorrhage, or surgery, endoscopy, or necropsy. Treatment with nonsteroidal, anti-inflammatory drugs (NSAIDs) and hepatic disease were the two most common predisposing factors for ulcer disease. Dogs with liver disease tended to have duodenal ulcers, dogs receiving NSAID treatment tended to have pyloroantral ulcers, and dogs with mastocytosis had ulcers in multiple locations. Three dogs with duodenal ulcers receiving NSAID treatment had an additional predisposing factor. Surgical treatment (with or without medical treatment) had a good outcome when the predisposing factors could be controlled or eliminated. Only 3 of 27 dogs in both the surgical and medically treated groups died from ulcer disease, whereas 6 of 16 dogs in the untreated group died from ulcer disease.  相似文献   

Establishing Medical Protocols to Facilitate and Improve Delivery of Emergency Veterinary Care     

Ronald W. Stone DVM  Ken L. Ward DVM 《Journal of Veterinary Emergency and Critical Care》1992,2(2):85-88

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