Electron microscopic studies on the anterior pituitary cells following castration in fetal and neonatal male rats     

Y Eguchi  S Hanada  Y Morikawa 《Nippon juigaku zasshi. The Japanese journal of veterinary science》1980,42(1):49-59

  相似文献   

Physiological and psychological responses to a heavy floor-impact sound generated by dropping an automobile tire in a wooden house     

Shuzo?SueyoshiEmail author  Yoshifumi?Miyazaki  Takeshi?Morikawa 《Journal of Wood Science》2004,50(6):490-493

We investigated the physiological and psychological responses of ten healthy male volunteers to a single heavy floor-impact sound generated by dropping an automobile tire from heights of 50, 100, and 150cm in a wooden house. Blood pressure and peripheral blood flow were measured simultaneously, and sensory evaluation was conducted using the semantic differential method. The results obtained were as follows: (1) the systolic blood pressure increased and the peripheral blood flow decreased when the subjects heard the heavy floor-impact sound; (2) the heavy floor-impact sound caused the subjects to feel uncomfortable, but there was no significant change in sharp and monotonous feelings; and (3) for the heavy floor-impact sound for 100cm and that for 150cm, the subjects showed no difference in comfortable feeling, but we detected differences in the variations of both the systolic blood pressure and the peripheral blood flow.Part of this research was presented at the 48th Annual Meeting of the Japan Wood Research Society, Shizuoka, April 1998.  相似文献   

Obstructive nephropathy induced with DL-potassium hydrogen tartrate in F344 rats     

Kaoru Inoue  Tomomi Morikawa  Miwa Takahashi  Midori Yoshida  Kumiko Ogawa 《Journal of toxicologic pathology》2015,28(2):89-97

We experienced obstructive nephropathy in F344 rats treated with DL-potassium hydrogen tartrate (PHT) in a 13-week oral repeated dose toxicity study. Six-week-old male and female F344/DuCrj rats were fed a diet containing up to 2.0% PHT for 13 weeks. Microscopical findings including irregular dilation of the distal tubule lumen, foreign body giant cells, inflammatory cell infiltration, and regeneration of renal tubules were observed focally or multifocally in the renal cortex and/or medulla in the 0.5% and higher dosage groups of both sexes. The severity of these lesions increased in a dose-dependent manner. In the urinalysis, an increase in protein and white blood cells or the concentration of tartaric acid was detected in the 0.5% PHT and higher dosage groups of both sexes or males, respectively, though conventional blood biochemical analysis did not indicate failure of renal function. These results indicate that the PHT induces obstructive nephropathy in rats. There were no other treatment-related changes in other organs.  相似文献   

Effects of low protein intake on the development of the remaining kidney in subtotally nephrectomized immature rats: apoptosis and epidermal growth factor     

Mino M  Nakamura J  Nakamuta N  Morioka H  Morikawa Y  Okada T 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2007,69(3):247-252

Effects of low protein intake on the development of the remaining kidney in subtotally (5/6) nephrectomized immature rats were examined. Three week-old weaning rats were kept on a diet containing either 12% (Lp rats) or 18% (Np rats) protein for 4 or 8 weeks after subtotal nephrectomy. Blood urea nitrogen (BUN) concentration was determined at 2, 4, 6, and 8 weeks after 5/6 nephrectomy. At 4 or 8 weeks after the operation, glomerular sclerosis and tubulointerstitial damage were assessed by a standard semiquantitative analysis and were expressed as the glomerular sclerosis index (GSI) and interstitial fibrosis score (IFS), respectively. The localization of DNA fragmented cells in the kidney was examined by the terminal deoxynucleotidyl transferase (TdT) -mediated d-UTP-biotin nick end labeling (TUNEL) method and the localization of the epidermal growth factor (EGF) by immunohistochemical methods. BUN concentration was significantly lower in the Lp rats compared with that in the Np rats. Both 4 and 8 weeks after subtotal nephrectomy, GSI and incidence of TUNEL positive cells in the distal tubules were significantly lower in the Lp rats than in the Np rats. Four weeks after the operation, IFS was significantly lower in the Lp rats than in the Np rats. Four and 8 weeks after the operation, EGF positive cells in the distal tubules were more observed in the Lp rats than in the Np rats. These findings reveal that protein restriction is effective in preventing renal tubular scarring in immature rats and that EGF is involved in the process of this prevention.  相似文献   

Anti type I allergic property of Japanese butterbur extract and its mast cell degranulation inhibitory ingredients     

Shimoda H  Tanaka J  Yamada E  Morikawa T  Kasajima N  Yoshikawa M 《Journal of agricultural and food chemistry》2006,54(8):2915-2920

Pollenosis is a disease that affects 1 in 10 of the Japanese population. During the season of cedar pollen dispersal, many patients suffer from symptoms such as sniffling, sternutation, and itching of the eyes. Japanese butterbur is a popular vegetable and is one of the few domestic vegetables in Japan. The anti type I allergic effects of an aqueous ethanol extract from aerial parts of Japanese butterbur (JBE) were evaluated in rats and RBL-2H3 mast cells. In the passive cutaneous anaphylaxis reaction in rats, a single oral treatment of JBE (1000 mg/kg) was found to suppress the reaction. In IgE-sensitized RBL-2H3 cells, JBE (10-100 microg/mL) inhibited beta-hexosaminidase release, leukotriene C(4)/D(4)/E(4) synthesis, and TNF-alpha production. Moreover, a high concentration of JBE (1000 microg/mL) suppressed smooth muscle constriction induced by histamine (10 microM) and leukotriene D(4) (10 nM) in a guinea pig trachea strip. The search for components in JBE with an inhibitory activity on mast cell degranulation was guided by inhibition of beta-hexsosaminidase release. Two eremophilane-type sesquiterpenes, six polyphenolic compounds, and two triterpene glycosides were isolated. Of these compounds, fukinolic acid, a principal polyphenol constituent, showed potent inhibitory activity (IC(50) value = 2.1 microg/mL). Consequently, On the basis of its inhibition of mast cell activation and direct smooth muscle reaction induced by released mediators, JBE was found to suppress the type I allergic reaction.  相似文献   

Histometry of the developing kidney in fetal rats     

T Okada  Y Morikawa 《Nippon juigaku zasshi. The Japanese journal of veterinary science》1988,50(1):269-272

  相似文献   

Histometric studies on mucus secretion of the sublingual gland of the perinatal rat     

Y Morikawa  S Katsuda  T Okada  Y Hashimoto 《Nippon juigaku zasshi. The Japanese journal of veterinary science》1987,49(5):825-831

  相似文献   

Attachment of Malassezia pachydermatis to the ear dermal cells in canine otitis externa.     

A Masuda  T Sukegawa  H Tani  T Miyamoto  K Sasai  Y Morikawa  E Baba 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2001,63(6):667-669

To investigate the predominance of Malassezia pachydermatis (M. pachydermatis) as a causative agent of canine otitis externa, ear cerumen samples were observed for adhesion of M. pachydermatis to the cornified epithelial cells by light and electron microscopes. The yeasts appeared not to adhere to the cornified epithelial cells directly, but they seemed to exist in the proximity of the epithelial cells with an electron opaque halo-like space around them. Polysaccharide and lipid staining techniques were conducted to identify the substances existing in that space. Lipid substances, not saccharides, were observed around the yeasts and the cornified epithelial cells. These results suggested that in the canine ear canal malassezia yeast attachment to the cornified epithelial cells is mediated by lipids.  相似文献   

Effects of maternal bilateral ureteral ligation on the development of fetal kidney in rats: histometrical study     

T Okada  Y Morikawa 《Nippon juigaku zasshi. The Japanese journal of veterinary science》1988,50(5):985-989

  相似文献   

Stem necrosis of aster and Russell prairie gentian caused by Chrysanthemum stem necrosis virus     

Kazumi Momonoi  Jouji Moriwaki  Toshiyuki Morikawa 《Journal of General Plant Pathology》2011,77(2):142-146

A new disease causing necrotic streaks on stems and necrosis on leaves of aster (Callistephus chinensis) and Russell prairie gentian (Eustoma grandiflorum) was observed in Toyama Prefecture, Japan, in September 2009. On the bases of host reactions, serological reactions, viral particle morphology, and the nucleotide sequence of the nucleocapsid protein gene, the causal pathogen was identified as Chrysanthemum stem necrosis virus (CSNV). This report is the first in the world of natural infection of aster and Russell prairie gentian by CSNV. We propose the name “stem necrosis of aster and Russell prairie gentian” for these new diseases.  相似文献