Extent of genotypic variation for maize cell wall bioconversion traits across environments and among hybrid combinations     

Andres F. Torres  Cornelie M. M. Noordam-Boot  Oene Dolstra  Louis Vlaswinkel  Richard G. F. Visser  Luisa M. Trindade 《Euphytica》2015,206(2):501-511

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Acrylamide in roasted almonds and hazelnuts     

Amrein TM  Lukac H  Andres L  Perren R  Escher F  Amadò R 《Journal of agricultural and food chemistry》2005,53(20):7819-7825

The influences of composition and roasting conditions on acrylamide formation in almonds and hazelnuts were investigated. Eighteen samples of almonds originating from the U.S. and Europe were analyzed for sugars and free amino acids, and acrylamide formed during roasting was determined. Asparagine was the main free amino acid in raw almonds and correlated with the acrylamide content of dark roasted almonds. Roasting temperature was another key factor and had a very strong influence on acrylamide formation. Almonds of European origin contained significantly less free asparagine and formed significantly less acrylamide during roasting as compared to the almonds from the U.S. Roasted hazelnuts contained very little acrylamide because of the low content of free asparagine in the raw nut. Reducing sugars, although being consumed much faster than free amino acids in both types of nuts, were not decisive for the extent of acrylamide formation during roasting.  相似文献   

"Coulomb Staircase" at Room Temperature in a Self-Assembled Molecular Nanostructure     

RP Andres  T Bein  M Dorogi  S Feng  JI Henderson  CP Kubiak  W Mahoney  RG Osifchin  R Reifenberger 《Science (New York, N.Y.)》1996,272(5266):1323-1325

Double-ended aryl dithiols [alpha,alpha'-xylyldithiol (XYL) and 4,4'-biphenyldithiol] formed self-assembled monolayers (SAMs) on gold(111) substrates and were used to tether nanometer-sized gold clusters deposited from a cluster beam. An ultrahigh-vacuum scanning tunneling microscope was used to image these nanostructures and to measure their current-voltage characteristics as a function of the separation between the probe tip and the metal cluster. At room temperature, when the tip was positioned over a cluster bonded to the XYL SAM, the current-voltage data showed "Coulomb staircase" behavior. These data are in good agreement with semiclassical predictions for correlated single-electron tunneling and permit estimation of the electrical resistance of a single XYL molecule (approximately18 ± 12 megohms).  相似文献   

Epidemiology. Outbreak investigation and response training     

Lescano AG  Salmon-Mulanovich G  Pedroni E  Blazes DL 《Science (New York, N.Y.)》2007,318(5850):574-575

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A look inside the San Andreas Fault at Parkfield through vertical seismic profiling   总被引：1，自引：0，他引：1  

Chavarria JA  Malin P  Catchings RD  Shalev E 《Science (New York, N.Y.)》2003,302(5651):1746-1748

The San Andreas Fault Observatory at Depth pilot hole is located on the southwestern side of the Parkfield San Andreas fault. This observatory includes a vertical seismic profiling (VSP) array. VSP seismograms from nearby microearthquakes contain signals between the P and S waves. These signals may be P and S waves scattered by the local geologic structure. The collected scattering points form planar surfaces that we interpret as the San Andreas fault and four other secondary faults. The scattering process includes conversions between P and S waves, the strengths of which suggest large contrasts in material properties, possibly indicating the presence of cracks or fluids.  相似文献   

A spatially explicit height�Cdiameter model for Scots pine in Estonia     

Matthias Schmidt  Andres Kiviste  Klaus von Gadow 《European Journal of Forest Research》2011,130(2):303-315

This contribution presents an approach to model individual tree height?Cdiameter relationships for Scots pine (Pinus sylvestris) in multi-size and mixed-species stands in Estonia using the Estonian Permanent Forest Research Plot Network. The dataset includes 22,347 trees. The main focus of the study was to use an approach that is spatially explicit allowing for high accuracy prediction from a minimum set of predictor variables that can be easily derived. Consequently, the height?Cdiameter relationship is modeled as a function of only the stand quadratic mean diameter (dg) and the plot geographical coordinates. A specific generalized additive model gam is employed that allows for the integration of a varying coefficient term and 2-dimensional surface estimators representing a spatial trend and a spatially varying coefficient term. The high flexibility of the model is needed due to the very few predictor variables that subsume a variety of potential influential factors. Subsequently, a linear mixed model is used that quantifies the random variation between plots and between measurement occasions within plots, respectively. Hence, our model is based on the theory of structured additive regression models (Fahrmeir et al. 2007) and separates a structured (correlated) spatial effect from an unstructured (uncorrelated) spatial effect. Additionally, the linear mixed model allows for calibration of the model using height measurements as pre-information. Model bias is small, despite the somewhat irregular distribution of experimental areas within the country. The overall model shows some similarity with earlier applications in Finland. However, there are important differences involving the model form, the predictors and the method of parameter estimation.  相似文献   

Dendritic cell stimulation by mycobacterial Hsp70 is mediated through CCR5     

Floto RA  MacAry PA  Boname JM  Mien TS  Kampmann B  Hair JR  Huey OS  Houben EN  Pieters J  Day C  Oehlmann W  Singh M  Smith KG  Lehner PJ 《Science (New York, N.Y.)》2006,314(5798):454-458

An effective host immune response to mycobacterial infection must control pathogen dissemination without inducing immunopathology. Constitutive overexpression of mycobacterial heat shock protein (myHsp70) is associated with impaired bacterial persistence, but the immune-mediated mechanisms are unknown. We found that myHsp70, in addition to enhancing antigen delivery to human dendritic cells, signaled through the CCR5 chemokine receptor, promoting dendritic cell aggregation, immune synapse formation between dendritic cells and T cells, and the generation of effector immune responses. Thus, CCR5 acts as a pattern-recognition receptor for myHsp70, which may have implications for both the pathophysiology of tuberculosis and the use of myHsps in tumor-directed immunotherapy.  相似文献   

Imaginal discs secrete insulin-like peptide 8 to mediate plasticity of growth and maturation   总被引：1，自引：0，他引：1  

Garelli A  Gontijo AM  Miguela V  Caparros E  Dominguez M 《Science (New York, N.Y.)》2012,336(6081):579-582

Developing animals frequently adjust their growth programs and/or their maturation or metamorphosis to compensate for growth disturbances (such as injury or tumor) and ensure normal adult size. Such plasticity entails tissue and organ communication to preserve their proportions and symmetry. Here, we show that imaginal discs autonomously activate DILP8, a Drosophila insulin-like peptide, to communicate abnormal growth and postpone maturation. DILP8 delays metamorphosis by inhibiting ecdysone biosynthesis, slowing growth in the imaginal discs, and generating normal-sized animals. Loss of dilp8 yields asymmetric individuals with an unusually large variation in size and a more varied time of maturation. Thus, DILP8 is a fundamental element of the hitherto ill-defined machinery governing the plasticity that ensures developmental stability and robustness.  相似文献   

The use of megavoltage radiation therapy in the treatment of thymomas in rabbits: 19 cases     

Andres KM  Kent M  Siedlecki CT  Mayer J  Brandão J  Hawkins MG  Morrisey JK  Quesenberry K  Valli VE  Bennett RA 《Veterinary and comparative oncology》2012,10(2):82-94

An overall median survival time (MST) and prognostic factors in rabbits with thymomas treated with megavoltage radiation therapy (RT) were determined in this multi-institutional retrospective case analysis. Medical records for 19 rabbits with suspected or confirmed thymomas treated with RT were evaluated for data including signalment, haematological and serum biochemistry abnormalities, presence of pleural effusion, radiation plan, body weight, total radiation dose and institution administering RT. Statistical significance of these factors related to overall survival was assessed. An overall MST for all 19 rabbits was 313 days; exclusion of 3 rabbits that died acutely during the first 14 days of RT yielded a MST of 727 days. The only factor associated with a significantly decreased survival time was having a body weight lower than mean body weight of 1.57 kg. Radiation treatment-associated complications were infrequent and included radiation-induced myocardial failure, radiation pneumonitis and alopecia.  相似文献   

In vitro and in vivo effect of flutamide on steroid hormone secretion in canine and human inflammatory breast cancer cell lines          下载免费PDF全文

S. Caceres  B. Monsalve  L. Peña  P. J. de Andres  A. Alonso‐Diez  M. J. Illera  W. A. Woodward  J. M. Reuben  G. Silvan  J. C. Illera 《Veterinary and comparative oncology》2018,16(1):148-158

The aim was to study the effects of flutamide on cell proliferation, in vivo tumour growth and steroid production in canine and human IBC cell lines. IPC‐366 and SUM149 cell cultures were exposed to flutamide concentrations for 72 hours. Additionally, IPC‐366 and SUM149 xenotransplanted mice were treated subcutaneously with flutamide 3 times a week for 2 weeks. Steroid hormones determination in culture media, serum and tumour homogenates (pregnenolone, progesterone, androstenedione, testosterone, dihydrotestosterone, 17β‐oestradiol and oestrone sulphate) were assayed by EIA. in vitro cell proliferation percentages showed a decrease in all flutamide dosages in IPC‐366 and SUM149. in vivo flutamide reduced tumour size by 55% to 65%, and metastasis rates decreased. In treated groups, androgen levels in culture media, serum and tumour homogenates were increased as oestrogen levels decreased. These results suggest that flutamide treatment inhibits cell proliferation and promotes tumour reduction by increasing androgen levels and also support future therapy approaches.  相似文献