Amoxycillin: distribution and clinical efficacy in calves.     

G H Palmer  R J Bywater  M E Francis 《The Veterinary record》1977,100(23):487-491

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DIPHOSPHONATE TREATMENT OF A PRIMARY OSTEOSARCOMA IN A DOG: A CASE REPORT     

Marion D. Francis  Candice L. Slough  Hugh E. Black  Andrew J. Tofe  G. Gilbert Cloyd 《Veterinary radiology & ultrasound》1980,21(4):168-176

The following sequence of treatments was administered to a Saint Bernard dog with a primary distal right radius osteosarcoma: 54 days of daily disodium 1-hydroxyethylidenediphosphonate (HEDP) subcutaneous injections; 53 days of HEDP per os ; one ³²P-HEDP intravenous injection. During the pretreatment period, there was an extensive increase in calcific tumor growth and osteoblastic proliferation. After the subcutaneous HEDP treatment, almost complete tumor necrosis was seen. After the oral HEDP treatment, only the deepest tumor portion contained active osteoblasts, calcific growth of the tumor was completely blocked, and uptake of ^99mTc-Sn-HEDP was reduced to one fourth of the pretreatment uptake. After a single ³²P-HEDP dose, large areas of tumor necrosis were evident histopathologically. However, subsequent resumption of cellular activity occurred in the tumor, and the uptake of ^99mTc-Sn-HEDP increased to pretreatment values. These data suggest that systemically administered HEDP should be studied further for its possible therapeutic potential in the treatment of osteosarcoma and indicate a need for further study of ³²P-HEDP or possibly ³³P-HEDP.  相似文献   

Biochemical evaluation of mitochondrial respiratory chain enzymes in canine skeletal muscle     

Wakshlag JJ  Cooper BJ  Wakshlag RR  Kallfelz FA  Barr SC  Nydam DV  Dimauro S 《American journal of veterinary research》2004,65(4):480-484

OBJECTIVE: To perform respiratory chain enzymatic activity assays on canine skeletal muscle biopsy specimens and establish reference range values of skeletal muscle enzyme activities for dogs. SAMPLE POPULATION: Biopsy specimens from the vastus lateralis muscle were obtained from 24 dogs (8 sexually intact males and 14 sexually intact females) ranging from 15 months to 6 years of age. PROCEDURE: Mean values of citrate synthase, cytochrome-c oxidase, succinate dehydrogenase, succinate dehydrogenase-cytochrome-c reductase, nicotinamide adenine dinucleotide (NADH) dehydrogenase, and NADH dehydrogenase-cytochrome-c reductase activities were established by use of 6 standard spectrophotometric assays for respiratory chain enzyme analysis. RESULTS: Compared with published data for skeletal muscle enzyme activities in humans, skeletal muscle enzyme activities in dogs were 2- to 4-fold higher. Additionally, citrate synthase activity, a marker for mitochondrial volume, was positively correlated with age in dogs, suggesting that mitochondrial volume increases with age, although no apparent change in respiratory chain enzymatic activity with an increase in age was found. CONCLUSIONS AND CLINICAL RELEVANCE: Reference range values for skeletal muscle enzyme activities of dogs are needed to accurately interpret results of respiratory chain enzymatic activity assays. During investigation of metabolic myopathies, if skeletal muscle biopsy specimens are evaluated for respiratory chain enzyme kinetics, they should be performed and evaluated in concert with skeletal muscle biopsy specimens from clinically normal animals of the same species.  相似文献   

Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior     

Chen ZY  Jing D  Bath KG  Ieraci A  Khan T  Siao CJ  Herrera DG  Toth M  Yang C  McEwen BS  Hempstead BL  Lee FS 《Science (New York, N.Y.)》2006,314(5796):140-143

A common single-nucleotide polymorphism in the brain-derived neurotrophic factor (BDNF) gene, a methionine (Met) substitution for valine (Val) at codon 66 (Val66Met), is associated with alterations in brain anatomy and memory, but its relevance to clinical disorders is unclear. We generated a variant BDNF mouse (BDNF(Met/Met)) that reproduces the phenotypic hallmarks in humans with the variant allele. BDNF(Met) was expressed in brain at normal levels, but its secretion from neurons was defective. When placed in stressful settings, BDNF(Met/Met) mice exhibited increased anxiety-related behaviors that were not normalized by the antidepressant, fluoxetine. A variant BDNF may thus play a key role in genetic predispositions to anxiety and depressive disorders.  相似文献   

Time scales of inoculum production and the dynamics of the epidemic     

Ferrandino FJ 《Phytopathology》2012,102(8):728-732

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Identification of quantitative trait loci (QTLs) associated with maintenance of wheat (Triticum aestivum Desf.) quality characteristics under heat stress conditions     

Francis W. Beecher  Esten Mason  Suchismita Mondal  Joseph Awika  Dirk Hays  Amir Ibrahim 《Euphytica》2012,188(3):361-368

The goal of this study was to identify quantitative trait loci (QTLs) associated with the maintenance of wheat grain quality following post-anthesis heat stress in a recombinant inbred line (RIL) population. The response to heat stress was measured using the sodium dodecyl sulfate sedimentation test (SDSS), a significant predictor of bread baking quality. SDSS scores were used to identify QTLs associated with grain quality and QTLs associated with quality stability were identified based on percent change in SDSS score between the heat stress and control treatments. Four QTLs were identified, located one each on linkage groups 1B, 1D, 4A, and 7A. The 1B, 1D, and 4A QTLs were associated with grain quality; the QTL on linkage group 7A was associated with quality stability. To confirm the detected QTLs, eighty advanced lines grown at three Texas nurseries were tested for relationships between allelic polymorphism at QTL linked markers and quality traits. Quality trait stability in the advanced lines was estimated using the coefficient of variability (CV%) of quality traits between nurseries. The analysis supported the relationship of the predicted QTLs on linkage groups 1B, 1D, and 4A with quality traits. The confirmed QTLs may be used in marker assisted selection (MAS) to develop wheat lines possessing superior quality traits. In addition, identification of genetic regions associated with this trait will aid the identification of the underlying genes.  相似文献   

Gasterophilosis: a major cause of rectal prolapse in working donkeys in Ethiopia     

Getachew AM  Innocent G  Trawford AF  Reid SW  Love S 《Tropical animal health and production》2012,44(4):757-762

A retrospective study was conducted to investigate the cause of rectal prolapse in working donkeys in Ethiopia. Analysis of data on rectal prolapse cases obtained from the Donkey Health and Welfare Project clinic at the School of Veterinary Medicine, Addis Ababa University, from 1995 to 2004 revealed that 83.6% (n = 177) of the cases were associated with Gasterophilus nasalis. The rest 10.7% and 5.7% were associated with work-related (overloading) cause and diarrhoea, respectively. The mean and median numbers of G. nasalis recovered from the rectum of infected donkeys were 66 and 64, respectively, with a range of 2–195. Over 100 G. nasalis larvae were recovered from the rectum of 22% of the donkeys. Circular demarcated ulcer-like and deep circumferential pits or ring-like mucosal lesions were found at the larval attachment sites. G. nasalis infection and the associated rectal prolapse were observed year round. However, the intensity of rectal larval infection and incidence of rectal prolapse were significantly higher during the rainy season (P < 0.01). Age and sex of the donkeys had no significant effect on the intensity of rectal larval infection and incidence of rectal prolapse (P > 0.05).  相似文献   

Comparing silvopastoral systems and prospects in eight regions of the world   总被引：1，自引：1，他引：0  

Frederick Cubbage  Gustavo Balmelli  Adriana Bussoni  Elke Noellemeyer  Anibal N. Pachas  Hugo Fassola  Luis Colcombet  Belén Rossner  Gregory Frey  Francis Dube  Marcio Lopes de Silva  Hayley Stevenson  James Hamilton  William Hubbard 《Agroforestry Systems》2012,86(3):303-314

Silvopasture systems combine trees, forage, and livestock in a variety of different species and management regimes, depending on the biophysical, economic, cultural, and market factors in a region. We describe and compare actual farm practices and current research trials of silvopastoral systems in eight regions within seven countries of the world: Misiones and Corrientes provinces, Argentina; La Pampa province, Argentina; northwestern Minas Gerais, Brazil; the Aysén region of Patagonia, Chile; the North Island of New Zealand; the Southeast United States; Paraguay; and Uruguay. Some countries use native trees and existing forests; some use plantations, particularly of exotic species. Natural forest silvopasture systems generally add livestock in extensive systems, to capture the benefits of shade, forage, and income diversification without much added inputs. Plantation forest systems are more purposive and intensive, with more focus on joint production and profits, for small owners, large ranches, and timber companies. Trends suggest that more active management of both natural and planted silvopastoral systems will be required to enhance joint production of timber and livestock, achieve income diversification and reduce financial risk, make more profit, improve environmental benefits, and realize more resilience to adapt to climate change.  相似文献   

Diameter and death of whorl and interwhorl branches in Atlas cedar (<Emphasis Type="Italic">Cedrus atlantica</Emphasis> Manetti): a model accounting for acrotony     

François Courbet  Jean-Christophe Hervé  Etienne K. Klein  Francis Colin 《Annals of Forest Science》2012,69(2):125-138

• Introduction   

Branch size and branch status (dead or alive) are important characteristics closely related to tree growth and wood quality. The aim of this study was to design models for the diameter and status of branches in Atlas cedar (Cedrus atlantica Manetti).  相似文献   

Effects of sample mass and suspension salinity on particle size distribution in predominantly medium to heavy textured soils using the hydrometer method     

Mark N. Wuddivira  De Shorn E. Bramble  Ananda Ramlochan  Gregory A. Gouveia  Ronen C. Francis  Sunshine A. De Caires 《植物养料与土壤学杂志》2023,186(5):580-589

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