Solid state electrodes for high energy batteries     

Murphy DW  Christian PA 《Science (New York, N.Y.)》1979,205(4407):651-656

A new class of electrode materials for high energy density, rechargeable batteries based on topochemical reactions of lithium and transition metal compounds is evolving. The physical and structural properties relevant to the ability of transition metal oxides with framework structures to topochemically incorporate lithium are discussed. Perovskite-related structures are particularly attractive hosts for lithium.  相似文献   

Pharmacy (Section Np)     

Christian JE 《Science (New York, N.Y.)》1959,129(3347):500-502

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Pharmacy (Section Np)     

Christian JE 《Science (New York, N.Y.)》1958,127(3295):423-425

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FREDERICK CHEEVER SHATTUCK     

Cannon WB  Christian HA  Strong RP 《Science (New York, N.Y.)》1929,69(1782):207-209

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A FACTOR CAUSING THE ASSIMILATION OF CALCIUM     

Hunt CH  Winter AR 《Science (New York, N.Y.)》1923,57(1486):717-718

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Somatovisceral pathway: rapidly conducting fibers in the spinal cord     

H L Fields  D L Winter 《Science (New York, N.Y.)》1970,167(926):1729-1730

Fibers that respond to distension of hollow viscera and to mechanical stimulation of somatic structures were found primarily near the ventromedian fissure of the upper lumbar spinal cord. These fibers could be directly excited by electrical stimulation at C(1). The average conduction velocity for these fibers was 68.6 meters per second.  相似文献   

Biosynthesis of hemoglobin Ann Arbor: evidence for catabolic and feedback regulation   总被引：5，自引：0，他引：5  

J G Adams  W P Winter  D L Rucknagel  H H Spencer 《Science (New York, N.Y.)》1972,176(42):1427-1429

Hemoglobin Ann Arbor, in which arginine replaces leucine in position 80 of the a chain, occurs in aflected individuals in low proportion to hemoglobin A. Biosynthetic studies were perforined on reticulocytes of a patient heterozygous for this hemoglobin. These studies suggested that the low percentage of hemoglobin Ann Arbor is prinlarily due to preferential destruction of the abnormal component. The reduced concentration of alpha Ann Arbor chains was also reflected in a decreased synthesis of normal beta chains.  相似文献   

Comment on "Cerebellar LTD and learning-dependent timing of conditioned eyelid responses"     

Christian KM  Poulos AM  Lavond DG  Thompson RF 《Science (New York, N.Y.)》2004,304(5668):211; author reply 211

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Endogenous MHC class II processing of a viral nuclear antigen after autophagy     

Paludan C  Schmid D  Landthaler M  Vockerodt M  Kube D  Tuschl T  Münz C 《Science (New York, N.Y.)》2005,307(5709):593-596

CD4+ T cells classically recognize antigens that are endocytosed and processed in lysosomes for presentation on major histocompatibility complex (MHC) class II molecules. Here, endogenous Epstein-Barr virus nuclear antigen 1 (EBNA1) was found to gain access to this pathway by autophagy. On inhibition of lysosomal acidification, EBNA1, the dominant CD4+ T cell antigen of latent Epstein-Barr virus infection, slowly accumulated in cytosolic autophagosomes. In addition, inhibition of autophagy decreased recognition by EBNA1-specific CD4+ T cell clones. Thus, lysosomal processing after autophagy may contribute to MHC class II-restricted surveillance of long-lived endogenous antigens including nuclear proteins relevant to disease.  相似文献   

Requirement of JNK2 for scavenger receptor A-mediated foam cell formation in atherogenesis   总被引：1，自引：0，他引：1  

Ricci R  Sumara G  Sumara I  Rozenberg I  Kurrer M  Akhmedov A  Hersberger M  Eriksson U  Eberli FR  Becher B  Borén J  Chen M  Cybulsky MI  Moore KJ  Freeman MW  Wagner EF  Matter CM  Lüscher TF 《Science (New York, N.Y.)》2004,306(5701):1558-1561

In vitro studies suggest a role for c-Jun N-terminal kinases (JNKs) in proatherogenic cellular processes. We show that atherosclerosis-prone ApoE-/- mice simultaneously lacking JNK2 (ApoE-/- JNK2-/- mice), but not ApoE-/- JNK1-/- mice, developed less atherosclerosis than do ApoE-/- mice. Pharmacological inhibition of JNK activity efficiently reduced plaque formation. Macrophages lacking JNK2 displayed suppressed foam cell formation caused by defective uptake and degradation of modified lipoproteins and showed increased amounts of the modified lipoprotein-binding and -internalizing scavenger receptor A (SR-A), whose phosphorylation was markedly decreased. Macrophage-restricted deletion of JNK2 was sufficient to decrease atherogenesis. Thus, JNK2-dependent phosphorylation of SR-A promotes uptake of lipids in macrophages, thereby regulating foam cell formation, a critical step in atherogenesis.  相似文献