A portal blood factor as the humoral agent in liver regeneration   总被引：9，自引：0，他引：9  

B Fisher  P Szuch  M Levine  E R Fisher 《Science (New York, N.Y.)》1971,171(971):575-577

It was demonstrated, by use of extracorporeal cross-circulation, that a humoral factor responsible for liver regeneration does not arise from the liver remnant. While intact livers of normal rats incorporated [methyl-(3)H]- thymidine in proportion to the amount of liver removed in the partner, the greatest response occurred after a total hepatectomy. Evidence from portacaval-shunted,partially hepatectomized animals connected to normal members indicates that the factor is in portal blood and that the onset of regeneration is the result of a quantitative imbalance between the available portal blood factor and the number of liver cells present.  相似文献   

WARTIME SCIENTIFIC MANPOWER PRODUCTION     

Nicholas JS 《Science (New York, N.Y.)》1942,96(2484):135-136

  相似文献   

GTF2IRD1 in craniofacial development of humans and mice     

Tassabehji M  Hammond P  Karmiloff-Smith A  Thompson P  Thorgeirsson SS  Durkin ME  Popescu NC  Hutton T  Metcalfe K  Rucka A  Stewart H  Read AP  Maconochie M  Donnai D 《Science (New York, N.Y.)》2005,310(5751):1184-1187

  相似文献   

Species-specific transcription in mice carrying human chromosome 21     

Wilson MD  Barbosa-Morais NL  Schmidt D  Conboy CM  Vanes L  Tybulewicz VL  Fisher EM  Tavaré S  Odom DT 《Science (New York, N.Y.)》2008,322(5900):434-438

  相似文献   

Subnuclear compartmentalization of immunoglobulin loci during lymphocyte development     

Kosak ST  Skok JA  Medina KL  Riblet R  Le Beau MM  Fisher AG  Singh H 《Science (New York, N.Y.)》2002,296(5565):158-162

  相似文献   

Colorectal cancer in mice genetically deficient in the mucin Muc2     

Velcich A  Yang W  Heyer J  Fragale A  Nicholas C  Viani S  Kucherlapati R  Lipkin M  Yang K  Augenlicht L 《Science (New York, N.Y.)》2002,295(5560):1726-1729

The gastrointestinal tract is lined by a layer of mucus comprised of highly glycosylated proteins called mucins. To evaluate the importance of mucin in intestinal carcinogenesis, we constructed mice genetically deficient in Muc2, the most abundant secreted gastrointestinal mucin. Muc2-/- mice displayed aberrant intestinal crypt morphology and altered cell maturation and migration. Most notably, the mice frequently developed adenomas in the small intestine that progressed to invasive adenocarcinoma, as well as rectal tumors. Thus, Muc2 is involved in the suppression of colorectal cancer.  相似文献   

Book reviews     

Roger Paden  Marilyn Holly  Paul B. Thompson  Carl Mitcham  Joel Schor  Nicholas R. Ellig  John Lyon  Carl S. Barfield  Clyde Kiker  Jeffrey Burkhardt  Miguel A. Altieri  Christopher Vecsey 《Agriculture and Human Values》1986,3(3):41-80

  相似文献   

Atlantic meridional overturning circulation during the Last Glacial Maximum     

Lynch-Stieglitz J  Adkins JF  Curry WB  Dokken T  Hall IR  Herguera JC  Hirschi JJ  Ivanova EV  Kissel C  Marchal O  Marchitto TM  McCave IN  McManus JF  Mulitza S  Ninnemann U  Peeters F  Yu EF  Zahn R 《Science (New York, N.Y.)》2007,316(5821):66-69

The circulation of the deep Atlantic Ocean during the height of the last ice age appears to have been quite different from today. We review observations implying that Atlantic meridional overturning circulation during the Last Glacial Maximum was neither extremely sluggish nor an enhanced version of present-day circulation. The distribution of the decay products of uranium in sediments is consistent with a residence time for deep waters in the Atlantic only slightly greater than today. However, evidence from multiple water-mass tracers supports a different distribution of deep-water properties, including density, which is dynamically linked to circulation.  相似文献   

SAVINGS IN LABORATORY EXPENDITURES WITHOUT LOSS OF EFFICIENCY     

Nicholas JS 《Science (New York, N.Y.)》1933,78(2011):38-39

  相似文献   

Detecting genetic diversity in diploid bananas using PCR and primers from a highly repetitive DNA sequence     

Robert L. Jarret  Dirk R. Vuylsteke  Nicholas J. Gawel  Reynold B. Pimentel  Lisa J. Dunbar 《Euphytica》1993,68(1-2):69-76

Summary The polymerase chain reaction (PCR) was used to detect polymorphisms among 29 diploid clones of Musa acuminata Colla. from Papua New Guinea. Primer sequences were derived from a 520 bp highly repetitive DNA sequence isolated from M. acuminata ssp. malaccensis. Primers, used individually, detected a total of 48 polymorphisms that were scored as unit characters and used to generate a Jaccard's similarity index. Principal coordinate analysis (PCO) was used to cluster clones and the unweighted paired-group method of analysis (UPGMA) was used to compute genetic distance among the materials examined. The abundance of diversity within the PNG diploids examined reflects the extreme genetic variability within the M. acuminata gene pool. PCR, utilizing primers from a highly repetitive sequence, is a rapid means of detecting genetic diversity in M. acuminata.  相似文献