Quantitative structure-activity study of herbicidal N-aryl-3,4,5,6-tetrahydrophthalimides and related cyclic imides     

Hiroki Ohta  Tetsuo Jikihara  Ko Wakabayashi  Toshio Fujita 《Pesticide biochemistry and physiology》1980,14(2):153-160

The quantitative relationship between structure and inhibitory activity against the root growth of sawa millet of 30 N-aryl-3,4,5,6-tetrahydrophthalimides and 88 related N-aryl cyclic imide compounds (3-aryl-1,5-tetramethylenehydantoins, 4-aryl-1,2-tetramethylenetriazolidine-3,5-diones, and their thiocarbonyl analogs) was analyzed by means of physicochemical parameters of the aryl substituents and regression analysis. The results showed that, in each series of these classes of compounds, the position-specific steric effects of aromatic substituents, as represented by Verloop's STERIMOL values, are highly important in determining the inhibitory potency of the compound.  相似文献   

Fluorescein sodium‐guided resection of intracranial lesions in 22 dogs          下载免费PDF全文

Yukiko Nakano BVSc  Kohei Nakata BVSc  Sanae Shibata BVSc  PhD  Yasuhiro Heishima BVSc  Hidetaka Nishida BVSc  PhD  Hiroki Sakai BVSc  PhD  Hirohito Yano MD  PhD  Hiroaki Kamishina BVSc  MS  PhD 《Veterinary surgery : VS》2018,47(2):302-309

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Bacteriological evaluation of composted manure solids prepared from anaerobic digested slurry for hygienic recycled bedding materials for dairy cows          下载免费PDF全文

Eiryu Okamoto  Hiroki Miyanishi  Akinobu Nakamura  Tomoyuki Kobayashi  Norihiko Kobayashi  Yoshinori Terawaki  Hajime Nagahata 《Animal Science Journal》2018,89(4):727-732

Changes in mastitis‐causing pathogens, pH and water content in composted manure solids (CMS) prepared from digested slurry were evaluated during turning at 2‐day intervals for 8 days (C1–C4). The numbers of streptococci, coagulase‐negative staphylococci and coliforms were 2.6 × 10¹, 1.7 × 10² and 1.0 × 10¹ colony‐forming units (cfu)/g in CMS (C4) (summer), and these counts were markedly lower (P < 0.05) than those in CMS (C0 and C1). The bacterial counts ranged from 10¹ to 1.7 × 10² cfu/g in CMS (C4) (summer) and were within approved levels, <1 × 10⁶ cfu/g, indicating a minimal mastitis risk. The temperatures in CMS (C1–C4) increased to 63°C–74°C in summer and 67°C–70°C in winter. The mean pH values in CMS (C0–C4) were 9.2 in summer and 8.7 in winter, and water contents ranged from 61.7% to 69.6% in summer and 73.2% to 66.2% in winter. The significant decrease of pathogenic bacteria in CMS appears to be closely related to temperature >63°C for 8 days, pH 8.7–9.2, and water content 62% to 73%. This study demonstrates that prepared CMS has value as a recycled material with the potential to alleviate udder health issues in dairy cows.  相似文献   

Evaluation of pulse pressure variation and pleth variability index to predict fluid responsiveness in mechanically ventilated isoflurane‐anesthetized dogs          下载免费PDF全文

Hiroki Sano BVSc  Joonbum Seo BVSc  Paul Wightman BVSc  Nick J. Cave BVSc  PhD  DACVN  Mike A. Gieseg BVSc  PhD  Craig B. Johnson BVSc  PhD  Paul Chambers BVSc  PhD 《Journal of Veterinary Emergency and Critical Care》2018,28(4):301-309

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Comparative anatomy of the hepatobiliary systems in quail and pigeon,with a perspective for the gallbladder-loss     

Hiroki HIGASHIYAMA  Yoshiakira KANAI 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2021,83(5):855

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Effect of feeding non-fibrous carbohydrate before grazing on intake and nitrogen utilization in dairy cows throughout the grazing season     

Tomohiro MITANI  Koichiro UEDA  Tetsushiro ENDO  Makoto TAKAHASHI  Hiroki NAKATSUJI  Seiji KONDO 《Animal Science Journal》2012,83(2):121-127

Ten lactating cows were used to determine the effect of feeding non-fibrous carbohydrate (NFC) supplement before grazing on feed intake and nitrogen (N) utilization throughout a grazing season. The experiment was conducted from June to September. Cows grazed twice a day (2.5 h × 2) under a set stocking system and were fed NFC supplement (1 kg/4 kg of milk yield) 2 h before grazing (PRE) or immediately after grazing (POST). Cows were also fed a grass and corn silage mixture ad libitum. Herbage dry matter intake (DMI) was greater for PRE than for POST throughout the experiment and decreased from June to September. Conversely, silage DMI was less for PRE than for POST throughout the experiment and increased over the grazing season. Consequently, total DMI for PRE did not differ from that for POST. Milk urea-N concentration and urinary urea-N excretion in June did not differ between the treatments, whereas that after July was higher for PRE than for POST. Proportion of urinary N excretion to absorbed N intake in June was lower for PRE than for POST, but that after July was higher for PRE than for POST. Feeding NFC supplement before grazing would improve N utilization when cows eat large amounts of herbage high in N.  相似文献   

Comparison of quantity and structures of hydroxyproline-containing peptides in human blood after oral ingestion of gelatin hydrolysates from different sources     

Ohara H  Matsumoto H  Ito K  Iwai K  Sato K 《Journal of agricultural and food chemistry》2007,55(4):1532-1535

We compared quantity and structures of food-derived gelatin hydrolysates in human blood from three sources of type I collagen in a single blind crossover study. Five healthy male volunteers ingested type I gelatin hydrolysates from fish scale, fish skin, or porcine skin after 12 h of fasting. Amounts of free form Hyp and Hyp-containing peptide were measured over a 24-h period. Hyp-containing peptides comprised approximately 30% of all detected Hyp. The total area under the concentration-time curve of the fish scale group was significantly higher than that of the porcine skin group. Pro-Hyp was a major constituent of Hyp-containing peptides. Ala-Hyp, Leu-Hyp, Ile-Hyp, Phe-Hyp, and Pro-Hyp-Gly were detected only with fish scale or fish skin gelatin hydrolysates. Ala-Hyp-Gly and Ser-Hyp-Gly were detected only with fish scale gelatin hydrolysate. The quantity and structure of Hyp-containing peptides in human blood after oral administration of gelatin hydrolysate depends on the gelatin source.  相似文献   

Identification of marker genes for intestinal immunomodulating effect of a fructooligosaccharide by DNA microarray analysis     

Fukasawa T  Murashima K  Matsumoto I  Hosono A  Ohara H  Nojiri C  Koga J  Kubota H  Kanegae M  Kaminogawa S  Abe K  Kono T 《Journal of agricultural and food chemistry》2007,55(8):3174-3179

Prebiotic fructooligosaccharides are noted for their intestinal immunodulating effects, and the identification of markers for the effects is a matter of great concern. This study aimed to identify marker genes for physiological effects of a particular fructooligosaccharide (FOS) on a host animal and also to define the target of its function in the small intestine. DNA microarray technology was used to screen candidate marker genes, and comprehensive changes in gene expressions in the ileum of mice fed with FOS were investigated. One of the major physiological effects of FOS was intestinal immunomodulation. Marker genes were then identified for major histocompatibility complex classes I and II, interferon, and phosphatidylinositol metabolites. Also, the ileum was segmented into Peyer's patch (PP) and the other ileal organ (DeltaPP), and these were analyzed by quantitative RT-PCR method, with the result that the site for recognizing the FOS function was the DeltaPP rather than the PP. This is the first paper showing the markers for the physiological effects of FOS in the small intestine at gene expression level. Applying these marker genes would make it possible to clarify the mechanisms of how the administration of dietary FOS and associated changes in the intestinal environment are recognized by host organisms as well as how its immunomodulating effects are expressed in the body.  相似文献   

Effects of age, egg-laying activity, and Salmonella-inoculation on the expressions of gallinacin mRNA in the vagina of the hen oviduct   总被引：1，自引：0，他引：1  

Yoshimura Y  Ohashi H  Subedi K  Nishibori M  Isobe N 《The Journal of reproduction and development》2006,52(2):211-218

Gallinacins (Gal) are antimicrobial peptides that play significant roles in innate immunity in chickens. The aim of this study was to examine whether age of birds and egg-laying activity (laying and non-laying caused by feed-regulation) affect the mRNA expression of Gal-1, -2, and -3 in the vagina of hens, and whether their expressions are changed in response to the stimulation with Salmonella enteritidis (SE) and lipopolysaccharide (LPS). White Leghorn hens were divided into groups of young and old laying hens, and groups of laying and non-laying hens after feed-regulation. Vaginal cells were cultured and stimulated with SE or LPS. Expressions of Gal-1, -2, and -3 mRNA in their vaginal mucosa and cultured cells were examined by quantitative real-time RT-PCR. The expressions of Gal-1, -2, and -3 of the vaginal mucosa were significantly greater in old birds than in young birds. Expression of these Gals in the vagina were decreased in the regressed oviduct of non-laying birds compared with laying birds. The expressions of Gal-1, -2, and -3 in the cultured vaginal cells were increased by stimulation with SE or LPS within 24 h. These results suggest that the mRNA expressions of Gal-1, -2 and -3 in the vagina of laying hens increased with age, whereas they decreased in the regressed oviduct during the non-laying phase. Also, synthesis of these antimicrobial peptides in the vagina may increase in response to SE and LPS to eliminate SE bacteria.  相似文献   

Characterization of monoclonal antibodies directed against the canine distemper virus nucleocapsid protein     

Masuda M  Sato H  Kamata H  Katsuo T  Takenaka A  Miura R  Yoneda M  Tsukiyama-Kohara K  Mizumoto K  Kai C 《Comparative immunology, microbiology and infectious diseases》2006,29(2-3):157-165

We have established four monoclonal antibodies (MAbs) against the nucleocapsid protein (NP) of canine distemper virus (CDV). A competitive binding assay has revealed that the MAbs are directed against two antigenic domains. An immunofluorescence assay using a series of deletion clones of the NP and an immunoprecipitation assay using the NP have revealed that two of the MAbs recognize the C-terminal region of the NP while the other two recognize the tertiary structure of the N-terminal domain. These MAbs reacted with all eight strains of CDV used in this study, but showed different reactivities against measles virus and rinderpest virus.  相似文献