Changes of biomechanical characteristics of the bone in experimental tibial osteotomy model in the dog     

Hara Y  Nakamura T  Fukuda H  Harada Y  Nezu Y  Tagawa M 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2003,65(1):103-107

Experimental osteotomy model of canine tibia was prepared to investigate the changes in biomechanical characteristics during the healing process. After 16 weeks, although radiographs revealed that fracture healing proceeded, the recovery rates of the mechanical parameters ranged from 12.3 to 47.3%, compared to the intact side. After 32 weeks, those recovered to 68.9-93.2%. These results suggested that the biomechanical characteristics of the healing bone could not be recovered sufficiently even after the passage of the healing period which has been empirically proposed from clinical findings. It was also considered that evaluation of the mechanical parameters using this osteotomy model would be suitable for investigating the effect of osteoinductive growth factors on fracture healing.  相似文献   

Efficacy of bovine viral diarrhea vaccine used in Japan against bovine viral diarrhea virus type 2 strain 890     

Shimazaki T  Nakamura S  Taguchi K  Inoue Y 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2003,65(2):263-266

Bovine viral diarrhea virus (BVDV) has been segregated into two genotypes, type 1 and type 2. To determine the efficacy of the commercially available bovine viral diarrhea type 1 vaccine used in Japan against BVDV type 2, calves were infected with BVDV type 2 strain 890 4 weeks after administration of the vaccine. The vaccinated calves did not develop any clinical signs and hematological changes such as observed in unvaccinated calves after the challenge. Furthermore, the challenge virus was not recovered from the vaccinated calves throughout the duration of the experiment, whereas it was recovered from all unvaccinated calves. The bovine viral diarrhea vaccine used in Japan is efficacious against infection with BVDV type 2 strain 890.  相似文献   

Adjuvant effect of chicken interferon-gamma for inactivated Salmonella Enteritidis antigen   总被引：3，自引：0，他引：3  

Takehara K  Kobayashi K  Ruttanapumma R  Kamikawa M  Nagata T  Yokomizo Y  Nakamura M 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2003,65(12):1337-1341

The adjuvant effect of chicken interferon-gamma (ChIFN-gamma) was examined for protecting chickens against intestinal colonization of Salmonella Enteritidis (SE) following oral exposure. Ten 7-week-old chickens per group were immunized with inactivated SE twice with or without co-administration of ChIFN-gamma intramuscularly, and all chickens were challenged with SE. Sera collected from immunized groups with or without ChIFN-gamma, and from unimmunized group were measured for SE antibody by agglutination test. The levels of antibodies were raised by 1 week post-immunization and did not show any difference between groups with and without ChIFN-gamma. No antibodies were detected in unimmunized group before challenge. Fecal samples from each group were cultured at 1, 4, 7, and 13 days post-challenge to determine the incidence of intestinal colonization and the numbers of SE shed into the environment. Co-administration of ChIFN-gamma, significantly reduced the incidence of intestinal colonization (P<0.05). At 13 days post-challenge, the bacterial counts of SE in organs were also reduced in ChIFN-gamma administered group. These data suggest co-administration of ChIFN-gamma with SE antigen enhances protection against SE challenge without acceleration of antibody production.  相似文献   

The influence of early weaning on aggressive behavior in mice     

Nakamura K  Kikusui T  Takeuchi Y  Mori Y 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2003,65(12):1347-1349

Early postnatal experiences have been shown to have a tremendous influence on behavior development. In this study, we focused on weaning time and investigated the effects of early weaning on adulthood aggressive behavior in mice with the resident-intruder test. Early weaning resulted in decreased sideways threat and tail rattle. In addition, the frequency of attack bites was more variable in the early weaned group, although the mean frequency did not differ from the normally weaned group. The results of the present study suggest that aggressive behavior is also affected by early weaning manipulation.  相似文献   

Pathology of listerial encephalitis in chickens in Japan     

Kurazono M  Nakamura K  Yamada M  Yonemaru T  Sakoda T 《Avian diseases》2003,47(4):1496-1502

Neural signs (torticollis, drowsiness) and mortality were observed in five chickens of a native chicken flock (reared for meat) that included 450 male birds on a farm that had 2300 native chickens and 1120 layers. Histologic lesions were observed in the medulla oblongata, optic lobe, cerebellum, and spinal cord of the affected birds. The lesions, which were most severe in the medulla oblongata, were massive abscesses with rarefaction (demyelination and malacia) of the parenchyma with gram-positive bacteria. The degenerative and necrotic areas were characterized by fibrin thrombosis, hemorrhages, and congestion in the blood vessels. Immunohistochemically, the bacteria positive for L. monocytogenes antigen were observed in the medulla oblongata, cerebellum, and spinal cord. Ultrastructurally, the small rod-shaped and thin-cell-walled bacteria were observed in the parenchyma of the medulla oblongata. Listeria monocytogenes (serotype 4b) was isolated from the medulla oblongata and spinal cord. The pathogenesis of listerial encephalitis in chickens was discussed.  相似文献   

Changes in Activities of Enzymes Related to Energy Metabolism in Testicular Tissues of Dogs with Seminoma     

Arai T  Ogawa T  Hosoya M  Nakamura M  Kawakami E 《Veterinary research communications》2002,26(5):347-352

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Pancreatic necrosis and ventricular erosion in adenovirus-associated hydropericardium syndrome of broilers     

Nakamura K  Tanaka H  Mase M  Imada T  Yamada M 《Veterinary pathology》2002,39(3):403-406

Seven 19-day-old broiler chickens affected with hydropericardium syndrome (HPS) with pancreatic necrosis and gizzard erosions were investigated pathologically and virologically. Mortality increased after 13 days of age in a flock on a broiler farm. The mortality rate of the flock reached 10% by 19 days of age. Macroscopically, the chickens had hydropericardium (the characteristic gross change of HPS), pinpoint white foci in the pancreas, and ventricular erosions. Histologically, the chickens had multifocal hepatic necrosis with intranuclear inclusions in hepatocytes, a marked increase of macrophages in the spleen and lung, mild epicardial edema, multifocal necrosis of pancreatic acinar cells with intranuclear inclusions, focal necrosis of the ventricular koilin layer, and degeneration of the ventricular glandular epithelium with intranuclear inclusions. Immunohistochemically, intranuclear inclusions in the liver, pancreas, and ventriculi were stained positively against group I avian adenovirus (GIAAV) antigens. Ultrastructurally, 67-nm diameter viral particles were present in intranuclear inclusions. Virologically, serotype 4 of GIAAV was isolated from the liver, heart, and kidney of affected chickens. The pathologic changes of the present cases differ from previous cases of HPS; therefore, the present strain of GIAAV may have different pathogenicity for chickens than the previous virus strain of HPS.  相似文献   

Thymoma and multiple thymic cysts in a dog with acquired myasthenia gravis     

Uchida K  Awamura Y  Nakamura T  Yamaguchi R  Tateyama S 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2002,64(7):637-640

An anterior mediastinal cystic lesion in an 11-year-old mongrel dog was examined. The dog showed dysbasia and vomiting due to megaoesophagus, and anterior mediastinal round mass lesion, approximately 35 mm in diameter, was found by X ray. Based on clinical examinations, the dog was diagnosed as acquired myasthenia gravis and was successfully controlled by anticholinesterase treatment for approximately 4 months. The dog died of thermic stroke and was necropsied. Grossly, fatty tissues with cysts containing yellowish fluid and white nodules were found in the anterior mediastinal area. Histopathologically, multiple cysts, neoplastic tissues, and atrophic thymus were found within the examined tissues. The cysts were lined by thin wall consisting of ciliated long cuboidal and non-ciliated round cells and were filled with eosinophilic colloidal fluid. Some extended cysts contained neoplastic foci within their lumen and walls. The neoplastic tissues consisted of mixed population of large epithelial cells with abundant clear cytoplasm and large oval nuclei, and lymphocytes. Immunohistochemically, proliferating epithelial cells were intensely positive for keratin and cytokeratin, and more than half number of infiltrating lymphocytes were intensely positive for CD3 suggesting T cells. All these findings indicate the neoplastic lesion is thymoma and multiple cysts are considered as thymic or brachial cleft cysts.  相似文献   

Penetration of drug resistance in Escherichia coli isolated from laboratory animals     

Shimoda K  Kimura J  Oguri S  Nakamura N  Urano T  Maejima K 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2002,64(12):1133-1135

A total of 713 strains of fecal Escherichia coli (E. coli) isolated from laboratory animals in the colonies of 4 research laboratories and 4 commercial breeders in Japan in 1994 were examined in regard to resistance to 8 antibacterial agents. The incidence of resistance to sulfadimethoxine (Su), streptomycin (Sm), ampicillin, cephaloridine, tetracycline, chloramphenicol, kanamycin, and gentamicin was 99.9%, 32.5%, 6.7%, 0.7%, 7.0%, 2.6%, 6.6% and 0.7%, respectively. These results indicated that Su and Sm resistance are penetrating into normal E. coli strains isolated from laboratory animals.  相似文献   

Inflammatory cytokine profiles of calves and lambs with strongyloidosis     

Nakamura Y 《The Veterinary record》2000,146(12):349-350

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