WESTERN EQUINE AND ST. LOUIS ENCEPHALITIS ANTIBODIES IN THE SERA OF MAMMALS AND BIRDS FROM AN ENDEMIC AREA     

Hammon WM  Gray JA  Evans FC  Izumi EM  Lundy HW 《Science (New York, N.Y.)》1941,94(2439):305-307

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Total synthesis of norzoanthamine     

Miyashita M  Sasaki M  Hattori I  Sakai M  Tanino K 《Science (New York, N.Y.)》2004,305(5683):495-499

Norzoanthamine, an alkaloid isolated from Zoanthus sp., can suppress the loss of bone weight and strength in ovariectomized mice. Norzoanthamine derivatives can also strongly inhibit the growth of P-388 murine leukemia cell lines and human platelet aggregation. However, norzoanthamine's densely functionalized complex stereostructure and scarce availability from natural sources have proved a synthetic challenge. We report the stereoselective total synthesis of norzoanthamine in 41 steps, with an overall yield of 3.5% (an average of 92% yield each step).  相似文献   

Databases for technical aspects of immunohistochemistry: 2021 update     

Takayasu Moroki  Saori Matsuo  Hirofumi Hatakeyama  Seigo Hayashi  Izumi Matsumoto  Satoshi Suzuki  Takashi Kotera  Kazuyoshi Kumagai  Kiyokazu Ozaki 《Journal of toxicologic pathology》2021,34(2):161

With the aim of sharing information about the technical aspects of immunohistochemistry (IHC) and facilitating the selection of suitable antibodies for histopathological examination, this technical report describes the results of a questionnaire distributed during the period of 2018 to 2019 among members of the Conference on Experimental Animal Histopathology. Additionally, it describes the immunological properties and supplier details (clone, supplier, catalog number, species reactivity, etc.) as well as the IHC staining conditions (fixing solution, fixing time, embedding, antigen retrieval method, antibody dilution, incubation time, incubation temperature, positive control tissue, blocking condition, secondary antibody information, etc.) for a total of 509 primary antibodies (comprising 220 different types). These survey results were an update on the contents reported by CEAH in 2017.  相似文献   

Fine Particle Dry Deposition onto a Cropland — a Trial to Estimate Deposition Velocity     

M. Utiyama  T. Fukuyama  K. Izumi  K. Sakamoto  K. Sekiguchi  W. Kim  A. Koyama  M. Aoki  H. Hara 《Water, air, and soil pollution》2001,130(1-4):547-552

The dry deposition velocity of fine particles is usually on the order of several tenths of cm s^?1, and accordingly, the concentration gradient of particles above the surface is very small. This makes the application of the gradient method to the determination of the particle deposition velocity very difficult. This study is a trial to find a way around this difficulty. The idea is to evaluate the thickness of the molecular diffusion layer, zb by simultaneously measuring the concentration gradient of gaseous species such as SO₂ ; zb is obtained by combining the turbulent and molecular transport equations for the gas. Then the particle deposition velocity is estimated on the basis of zb and the Brownian diffusion coefficient with an assumption that zb is equal to the thickness of the Brownian diffusion layer. By applying this method to the data collected in a field observation, the velocity of deposition onto a cropland was estimated for submicron particles.  相似文献   

Rate of Sulfur Dioxide Removal Artificial Cloud Experiments Utilizing a Long Vertical Shaft     

Utiyama  M.  Fukuyama  T.  Yamagata  S.  Ohta  S.  Izumi  K.  Harimaya  T.  Fujiyoshi  Y.  Yamada  T.  Inage  M. 《Water, air, and soil pollution》2001,130(1-4):325-330

Water, Air, &; Soil Pollution - Removal of sulfur dioxide through the absorption into cloud droplets is the initial stage of acid rain formation. We studied this process by forming an artificial...  相似文献   

Pyrolysis of lignin in the presence of tetramethylammonium hydroxide: a convenient method for S/G ratio determination     

Kuroda K  Nishimura N  Izumi A  Dimmel DR 《Journal of agricultural and food chemistry》2002,50(5):1022-1027

Pyrolysis-gas chromatography in the presence of tetramethylammonium hydroxide (TMAH) was applied to the determination of the ratio of the abundances of the syringyl beta-aryl ether subunits to those of the guaiacyl equivalents (S/G) in lignin. Diazomethane-methylated kenafs (Hibiscus cannabinus and Hibiscus sabdariffa) and beech (Fagus crenata) in situ lignins were employed. Relative abundances of pyrolysis products derived from the guaiacyl and syringyl beta-aryl ether subunits were determined. The S/G ratios for in situ lignins were obtained with average 3.1% relative standard deviation for a minimum of six repeated runs. The S/G ratios determined by pyrolysis in the presence of TMAH agreed well with those determined by thioacidolysis, with a significant linear regression (R(2) = 0.9867). The results showed that pyrolysis with TMAH is an effective tool for obtaining information on the S/G ratio for in situ lignins.  相似文献   

Histological observation of the pituitary-thyroid axis of a neotenic fish (the ice fish, <Emphasis Type="Italic">Salangichthys microdon</Emphasis>)     

Yasuko?HaradaEmail author  Katsushi?Kuwamura  Izumi?Kinoshita  Masaru?Tanaka  Masatomo?Tagawa 《Fisheries Science》2005,71(1):115-121

ABSTRACT:   In order to study the physiological characteristics of neoteny in teleosts, the development of the thyroid axis and digestive tract of the ice fish, Salangichthys microdon (Salmonoidei), were examined using wild caught samples in the Yura River and its estuary. In all developmental stages examined in this study, the digestive tract was straight, and no gastric gland was observed, even in adults. Since these features are only observed in larval stages of a related species, ayu, Plecoglossus altivelis (Salmonoidei), it is suggested that the ice fish retains larval features, not only in appearance but also in internal organs. Additionally, the thyroid axis exhibited a unique characteristic. Until the end of the juvenile stage, thyroid glands remained inactive, and no thyroid stimulating hormone (TSH) cells were observed. Activation of the thyroid gland and the first appearance of TSH cells occurred in adults. Since activation of the thyroid axis was generally known to occur by the time larval have transformed to juveniles in several teleosts, a delayed functioning of the thyroid axis was suggested as a specific characteristic, and probably a major factor contributing to neotenic development of the ice fish.  相似文献   

Potential impacts of non‐native channel catfish on commercially important species in a Japanese lake,as inferred from long‐term monitoring data     

Shin‐Ichiro S. Matsuzaki  Noriko Takamura  Kazunori Arayama  Atsushi Tominaga  Jun Iwasaki  Izumi Washitani 《水产资源保护:海洋与淡水生态系统》2011,21(4):348-357

Response of plasma bone markers to a single intramuscular administration of calcitriol in dairy cows     

Danil Kim  Norio Yamagishi  Izumi Abe  Bhuminand Devkota  Norimoto Okura  Shuichi Ohashi 《Research in veterinary science》2011,90(1):124-126

To elucidate the effects of an exogenous calcitriol (1,25-dihydroxyvitamin D₃) on plasma bone markers, the formation item osteocalcin (OC), undercarboxylated OC (ucOC) and bone-specific alkaline phosphatase (BALP), and the resorption parameter tartrate-resistant acid phosphatase isoform 5b (TRAP5b) and hydroxyproline (HYP) were measured in conjunction with plasma calcitriol and calcium (Ca) concentrations in dairy cows receiving calcitriol or its vehicle according to a 2 × 2 crossover design. Calcitriol (0.5 μg/kg, i.m.) increased significantly its plasma level during 6 h to day 2 and plasma Ca concentration during 12 h to day 7 compared to the vehicle. Also, plasma OC and ucOC started to rise from day 3 and 1, respectively, and remained elevated until day 7. No change in plasma BALP, TRAP5b or HYP associated with calcitriol treatment was noted. These results demonstrate that exogenous calcitriol stimulates osteoblasts to biosynthesise OC, a determinant of the bone formation in cows.  相似文献   

High susceptibility to zymbal gland and intestinal carcinogenesis in diabetic Otsuka long-evans Tokushima Fatty rats     

Hafez E  Takahashi T  Ogawa H  Sato M  Nakai T  Takasu C  Uehara H  Izumi K 《Journal of toxicologic pathology》2011,24(4):187-193

Diabetes mellitus (DM) and obesity are believed to be risk factors for colorectal cancer in humans. In experiment 1, male nondiabetic Long-Evans Tokushima Otsuka (LETO) rats and Otsuka Long-Evans Tokushima Fatty (OLETF) rats, a model animal of type 2 DM, were whole-body X-irradiated (4 Gy) at 6 and 8 weeks of age and euthanized at 78 weeks of age (n=15, respectively). The incidences of small intestine adenocarcinoma in LETO and OLETF rats were 0% and 30%, respectively. In experiment 2, male LETO and OLETF rats (n=24, respectively) were given s.c. injections of 15 mg/kg azoxymethane (AOM) once weekly for 3 weeks and euthanized at 36 weeks of age. The incidences of Zymbal gland tumors in LETO and OLETF rats were 0% and 67%, respectively (P<0.001), whereas those of small intestine adenocarcinoma were 0% and 43% (P<0.001) and those of cecum/colon adenocarcinoma were 46% and 79% (P<0.05), respectively. Fatty change of hepatocytes was common in OLETF rats (63%) but not in LETO rats. Serum triglyceride and free fatty acid levels in OLETF rats were significantly higher than in LETO rats at sacrifice, whereas serum insulin levels in OLETF rats were very diverse. These data suggest that hyperlipidemia plays a significant role in high susceptibility to lower intestinal tract carcinogenesis in OLETF rats; this strain is susceptible to AOM-induced Zymbal gland carcinogenesis.  相似文献