Seizure‐precipitating factors in dogs with idiopathic epilepsy     

Johanna A. Forsgrd  Liisa Metshonkala  Anna‐Mariam Kiviranta  Sigitas Cizinauskas  Jouni J.T. Junnila  Outi Laitinen‐Vapaavuori  Tarja S. Jokinen 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2019,33(2):701-707

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LGI Proteins and Epilepsy in Human and Animals          下载免费PDF全文

A. Pakozdy  M. Patzl  L. Zimmermann  T.S. Jokinen  U. Glantschnigg  A. Kelemen  D. Hasegawa 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2015,29(4):997-1005

Leucine‐rich glioma‐inactivated (LGI) protein was first thought to have a suppressor effect in the formation of some cancers. Developments in physiology and medicine made it possible to characterize the function of the LGI protein family and its crucial role in different conditions more precisely. These proteins play an important role in synaptic transmission, and dysfunction may cause hyperexcitability. Genetic mutation of LGI1was confirmed to be the cause of autosomal dominant lateral temporal lobe epilepsy in humans. The LGI2 mutation was identified in benign familial juvenile epilepsy in Lagotto Romagnolo (LR) dogs. Cats with familial spontaneous temporal lobe epilepsy have been reported, and the etiology might be associated with LGI protein family dysfunction. In addition, an autoimmune reaction against LGI1 was detected in humans and cats with limbic encephalitis. These advances prompted a review of LGI protein function and its role in different seizure disorders.  相似文献   

地肤农用生物活性研究   总被引：1，自引：0，他引：1  

魏艳  张晓华  刘正东  郝双红 《西北林学院学报》2009,24(6):129-132

研究了地肤各器官及其提取物的除草及抑菌活性.结果表明:地肤各器官对供试植物种子胚根及胚轴的生长均有抑制作用,其中,种子抑制效果最强,在0.01 g·mL-1 (干粉)时,对供试4种植物种子胚根生长的抑制率均大于80;地肤种子乙醇提取物3种溶剂萃取物中,正丁醇萃取物的除草活性最强,对黄瓜胚轴及反枝苋胚根生长的EC50为0.05 mg·mL-1.抑菌活性测定结果表明:地肤种子提取物的抑菌作用最强,在0.05 g·mL-1 (相当于干样)时,对苹果腐烂病菌及葡萄黑痘病菌菌丝生长的抑制率分别为90.7及71.5;地肤种子乙醇提取物3种溶剂萃取物中,正丁醇萃取物的抑菌作用最强,对苹果腐烂病菌和葡萄黑痘病菌菌丝生长的EC50分别为0.10 mg·mL-1和0.24 mg·mL-1.  相似文献   

Computerized and subjective assessments of post-thaw motility of semen from Finnish Ayrshire AI bulls in relation to non-return rates.     

M. Andersson  T. Hellman  B.-G. Holmstrm  L. Jokinen 《Acta veterinaria Scandinavica》1992,33(1):89-93

A semen analyser (Lazymot), was used to evaluate post-thaw motilities in 296 batches of semen from 74 Ayrshire bulls used for artificial insemination (AI). Motility was also assessed subjectively. A significant correlation was observed between assessments of motility using the Lazymot analyser and the subjective assessments. There was no correlation between post-thaw motility assessments and non-return rates in relation to the batches examined, which met Finnish criteria for use in AI. This suggests that criteria for post-thaw semen motility should not be increased beyond the present requirement for 40% motile spermatozoa.  相似文献   

Benign familial juvenile epilepsy in Lagotto Romagnolo dogs     

Jokinen TS  Metsähonkala L  Bergamasco L  Viitmaa R  Syrjä P  Lohi H  Snellman M  Jeserevics J  Cizinauskas S 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2007,21(3):464-471

BACKGROUND: Idiopathic childhood epilepsies with benign outcomes are well recognized in human medicine, but are not reported in veterinary literature. We recognized such a neurologic syndrome in Lagotto Romagnolo dogs. ANIMALS: Twenty-five Lagotto Romagnolo puppies from 9 different litters examined because of simple or complex focal seizures and 3 adult Lagotto Romagnolo dogs exhibiting similar clinical signs were used. METHODS: Clinical and diagnostic evaluations of affected dogs were conducted, including electromyography, electroencephalography, and other testing. RESULTS: Seizures in puppies began at 5 to 9 weeks of age and usually resolved spontaneously by 8 to 13 weeks. Those with the most severe seizures also had signs of neurologic disease between these seizures, including generalized ataxia and hypermetria. There were no abnormalities in routine laboratory screenings of blood, urine, and cerebrospinal fluid. Electromyography, brainstem auditory-evoked potentials, and magnetic resonance imaging revealed no specific and consistent abnormalities. Fourteen of 16 (87.5%) affected puppies and 2 of 3 (67%) adult dogs revealed epileptiform activity in the electroencephalogram. Histopathologic examination in 1 puppy and 1 adult dog revealed lesions of Purkinje cell inclusions and vacuolation of their axons restricted to the cerebellum. Pedigree analysis suggests an autosomal recessive mode of inheritance. CONCLUSIONS AND CLINICAL IMPORTANCE: This disorder, with simple or complex focal seizures and cerebellar lesions, represents a newly recognized epileptic syndrome in dogs.  相似文献