Use of a novel one-nostril mask-spacer device to evaluate airway hyperresponsiveness (AHR) in horses after chronic administration of albuterol     

Melissa R. Mazan  Kara Lascola  Susan J. Bruns  Andrew M. Hoffman 《Canadian journal of veterinary research》2014,78(3):214-220

Inflammatory airway disease (IAD) is very common in stabled horses. Short-acting beta agonist (SABA) drugs are often used to relieve clinical signs, although long-term exposure to these drugs may result in rebound bronchoconstriction. The purpose of this study was twofold: i) to describe the deposition of radiolabeled drugs using a novel one-nostril design mask-spacer combination with a breath-activated inhaler (BAI), and ii) to determine whether treatment for 10 d with inhaled albuterol using this device would impair the ability of albuterol to prevent bronchospasm during a histamine challenge test. The percentage of radio-aerosol deposited in the total lung was 12.39% ± 5.05%. All study horses demonstrated airway hyperresponsiveness (AHR) before enrollment in the study [mean provocative concentration eliciting 35% increase in delta flow (PC35) < 6 mg/mL histamine]. There was no significant difference in airway hyperresponsiveness to post-albuterol histamine challenge before or after treatment with albuterol. A 10-d treatment with placebo, however, caused a significant increase in airway hyperresponsiveness in all horses (P < 0.001). The results of this study show that the novel mask-spacer device was effective in delivering radiolabeled aerosolized drug to the lung and that delivery of a SABA for 10 d using this device did not result in increased airway hyperresponsiveness.  相似文献   

Spatiotemporal distributions of reported cases of the avian influenza H5N1 (bird flu) in Southern China in early 2004     

Oyana TJ  Dai D  Scott KE 《Avian diseases》2006,50(4):508-515

This study investigates spatiotemporal distributions of reported cases of the avian influenza H5N1 (bird flu) in Southern China in early 2004. Forty-nine cases of the avian influenza H5N1 covering a 6-week period (January 19, 2004, through March 9, 2004) were compiled from the Chinese Ministry of Agriculture and the World Health Organization. Geographic information systems (GIS) techniques combined with statistical techniques were used to analyze the spatiotemporal variation of reported cases of avian influenza. Using Oden's direction method, we also explored the spatiotemporal interaction of individual-level avian influenza cases during the study duration. The peak period (temporal clustering) for the epidemiological avian influenza outbreak occurred between the third and fourth weeks. Although we observed a major northeast-southwest distribution of the avian influenza H5N1 cases, there was no significant spatiotemporal association in average "direction of advance" of these cases. The directional finding is very consistent with the major migratory bird routes in East Asia, but owing to weak surveillance and reporting systems in the region, the study findings warrant further evaluation.  相似文献   

Theriogenology question of the month. What are the 3 management options for a mare with twin fetuses at this stage of gestation?     

Gray GA  Dascanio JJ  Kolster KA 《Journal of the American Veterinary Medical Association》2006,228(2):207-209

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Economic potential for soil carbon sequestration in the Nioro region of Senegal’s Peanut Basin     

Bocar Diagana  John Antle  Jetse Stoorvogel  Kara Gray 《Agricultural Systems》2007

This paper presents results from an analysis of the economic potential for soil carbon sequestration in the Nioro region of Senegal’s Peanut Basin. This analysis was based on the linkage of site-specific biophysical models and economic simulation models using the Tradeoff Analysis System to simulate farmers’ participation in contracts to sequester soil carbon. Available soils and climate data were used to implement the DSSAT/Century models to estimate crop yields and changes in soil carbon stocks under nine scenarios of increased fertilizer use and increased incorporation of crop residues in a peanut-millet rotation. Data from the 2001 farm survey conducted by the Ecole Nationale d’Economie Appliquée were used to parameterize a spatially explicit econometric-process simulation model for the peanut-millet production system. The economic simulation model was used to simulate a carbon-payment scheme that requires farmers to apply higher fertilizer rates and incorporate some crop residues into the soil. The results show that the combination of increased fertilizer use and crop residue incorporation could result in the supply of marketable quantities of carbon that could be sequestered in the soils of the Nioro region. However, the sensitivity of results to the levels of labor costs of incorporating crop residues, the value of crop residues, and the transaction costs of implementing carbon payment schemes, suggests the need for better data on these variables and for an accurate assessment of the capabilities of local institutions to implement carbon contracts.  相似文献   

Effects of the herbicide Topogard on soil respiration, nitrification, and denitrification in potato-cultivated soils differing in pH     

E. E. Kara  M. Arli  V. Uygur 《Biology and Fertility of Soils》2004,39(6):474-478

We investigated the effects of Topogard 50 WP (3 kg ha^–1) on soil respiration, mineral N content, and number of denitrifying and total bacteria in four coarse-textured volcanic soils for 91 days. Topogard application decreased CO₂ evolution in acid soils (Tepedibi and Karaçakl) whereas soil respiration was initially increased in neutral and alkaline soils (Kaba and Balar). The herbicide application significantly stimulated ammonification in Kaba and Balar soils, while Tepedibi and Karaçakl soils showed significantly lower NH₄⁺-N contents than the control. The treatment inhibited the activity of nitrifying microorganisms and, thus it decreased the NO₃^–-N content in Tepedibi, Karaçakl, and Kaba soils, whereas the NO₃^–-N content was increased in Balar soil. The NO₂^–-N content of soils was not affected by the treatment. The activity of denitrifying bacteria was stimulated by the addition of herbicide in all soils, whereas the total number of bacteria was not influenced. It may be concluded that the effects of Topogard on the microbiological characteristics of coarse-textured soils are likely to be dependent on soil pH.  相似文献   

The effect of plant bioactive compounds on lamb performance,intake, gastrointestinal parasite burdens,and lipid peroxidation in muscle     

Cesar H E C Poli  Kara J Thornton-Kurth  Jerrad F Legako  Carolina Bremm  Viviane S Hampel  Jeffrey Hall  Ignacio R Ipharraguerre  Juan J Villalba 《Journal of animal science》2021,99(1)

Plant extracts have been widely used in animal production systems due to the benefits promoted by their bioactive components, mainly through their antioxidant effects and positive effects on animal growth, health, and meat quality. We determined whether bioactive compounds (BC) from grape (Vitis vinifera), olive (Olea europaea), and pomegranate (Punica granatum) have beneficial effects on lamb growth while controlling gastrointestinal parasitism and reducing skeletal lipid peroxidation in muscle. Fourteen lambs (4 to 5 mo of age) were housed in individual pens and assigned to two treatment groups (seven animals/group), where they received: 1) a basal diet of beet pulp:soybean meal (90:10) (CONTROL) and 2) the same diet, but containing 0.3% of BC extracted from grape, olive, and pomegranate (BNP). After 21 d of consuming their respective rations (period 1), all lambs were dosed with 10,000 L₃ stage larvae of Haemonchus contortus. Intake, production, and physiological parameters were determined before infection (period 1), after oral dosage with L₃ (period 2), and during early (period 3) and later (period 4) developmental stages of infection. Groups of animals did not differ in their ration intake or average daily gain, either before or after the infection, or in their parasitic burdens estimated through fecal egg counts (P > 0.05). Lambs under BNP showed greater feed efficiency before infection (P < 0.001), but the pattern reversed after infection. In addition, the inclusion of plant bioactives to the diet did not have an effect (P > 0.05) on blood or lipid peroxidation in muscle or on hemogram, serum concentration of haptoglobin, and immunoglobulin E. These results could be explained by low dietary doses and constrained absorption or ruminal inactivation of these compounds. Changes in feed efficiencies suggest a negative interaction between BC in the diet and parasitism, which warrants further research.  相似文献   

Effects of air exposure and agitation on quality of stored boar semen samples     

Kayode Babatunde Balogun  Kara Roski Stewart 《Reproduction in domestic animals》2021,56(9):1200-1208

The objective of this study was to investigate the effects of semen volume, air contact inside semen dose tubes, daily agitation of semen doses and extender type on semen quality, thermo-resistance and bacteria growth in extended boar semen doses preserved over 7 days of liquid storage. Ejaculates from 4 proven terminal cross-bred boars were collected using the gloved-hand technique for 4 weeks and used in the 3 × 2 × 2 factorial study. The effects of treatment (CON: 80 ml doses sealed at the top of the tube; 40HIGH: 40 ml doses sealed at top of tube, and 40LOW: 40 ml doses sealed at top of the liquid), agitation (agitated versus not agitated) and extender type (long-term versus short-term) were investigated on semen quality, thermo-resistance and bacteria growth in boar semen doses. The results of the study revealed that motility (p = .031) and viability (p = .041) in 40HIGH were lower than CON. pH (p < .001) was higher in 40HIGH compared with CON and 40LOW. Agitation did not impact motility (p = .581), progressive motility (p = .870), viability (p = .509) or morphology (p = .970), while long-term extender maintained higher motility (p = .002), progressive motility (p = .036), viability (p < .001) and normal acrosome (p < .001) than a short-term extender. VAP (p = .039) of 40HIGH was lower than CON in a thermo-resistance test. Neither treatment (p > .798, .766) nor agitation (p > .396, .476) impacted bacterial growth in this study. In conclusion, air contact negatively impacts boar semen pH and consequently sperm motility. Semen doses prepared with 80 or 40 ml volumes of extended boar semen with minimal air contact in the tubes yield more desirable semen quality and agitating boar semen doses daily does not have negative or positive effects on boar semen quality.  相似文献   

Tensile strength and early healing of self-locking and surgeon's knots     

Kathleen M. Weatherall VMD  Lindsey H. Boone DVM  PhD  DACVS-LA  Fred J. Caldwell DVM  MS  DACVS  DACVSMR  Robert C. Cole DVM  DACVR  Russell C. Cattley VMD  PhD  DACVP  FIATP  Kara M. Lascola DVM  MS  DACVIM-LA  CVA  Stuart C. Clark-Price DVM  MS  DACVIM-LA  DACVAA  CVA  Ramsis Farag PhD  Edmon Perkins PhD  R. Reid Hanson DVM  DACVS  DACVECC 《Veterinary surgery : VS》2020,49(8):1580-1589

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Evaluation of the factors that affect the pregnancy rates during embryo transfer in beef heifers     

Hasan Alkan  Tahir Karaşahin  Şükrü Dursun  Fatma Satılmış  Hüseyin Erdem  Mehmet Güler 《Reproduction in domestic animals》2020,55(4):421-428

The aim of this study was to evaluate the effects of the transfer side, transfer location, cervix transfer score, type and diameter of corpus luteum (CL) during embryo transfer on pregnancy rates in beef heifers. Progesterone-based synchronization and superovulation protocol were applied to Simmental cows used as donors (n = 168). Uterine flushings were performed on day 7 following artificial insemination. Obtained Code I (excellent or good) and II (fair) quality embryos were transferred to recipient beef heifers (n = 561). During embryo transfer, side of transfer (right or left), transfer location (the cranial or middle third of uterine horn), cervix transfer score (easy, moderate or difficult) and type (CLa, CLb and CLc) and diameter of CL were determined. Pregnancy rates following the transfer of Code I and II embryos were 44.66% and 33.07%, respectively (p < .05). The rates of pregnancy after transfers to the right and left uterine horn were 37% and 42.2%, respectively (p > .05). The pregnancy rates were 41.2%, 34.9% and 30.3% for cervix transfer scores as easy, moderate and difficult, respectively (p > .05). Pregnancy rates after transfer to the cranial third and middle third were 41.06% and 29.67%, respectively (p < .05). According to types of CL, pregnancy rates were 31.7%, 40.4% and 45.3% for CLa, CLb and CLc, respectively (p < .05). Moreover, it was found that as the CL diameter increased, the pregnancy rates increased. As a result, it was concluded that there was no effect of side of transfer and cervix transfer score, but embryo quality, transfer location, type and diameter of CL had significant effects on the pregnancy rate during embryo transfer in beef heifers.  相似文献   

Role of subplate neurons in functional maturation of visual cortical columns     

Kanold PO  Kara P  Reid RC  Shatz CJ 《Science (New York, N.Y.)》2003,301(5632):521-525

The subplate forms a transient circuit required for development of connections between the thalamus and the cerebral cortex. When subplate neurons are ablated, ocular dominance columns do not form in the visual cortex despite the robust presence of thalamic axons in layer 4. We show that subplate ablation also prevents formation of orientation columns. Visual responses are weak and poorly tuned to orientation. Furthermore, thalamocortical synaptic transmission fails to strengthen, whereas intracortical synapses are unaffected. Thus, subplate circuits are essential not only for the anatomical segregation of thalamic inputs but also for key steps in synaptic remodeling and maturation needed to establish the functional architecture of visual cortex.  相似文献