Intensive Intravenous Infusion of Insulin in Diabetic Cats     

M. Hafner  S. Dietiker‐Moretti  K. Kaufmann  C. Mueller  T.A. Lutz  C.E. Reusch  E. Zini 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2014,28(6):1753-1759

Background

Remission occurs in 10–50% of cats with diabetes mellitus (DM). It is assumed that intensive treatment improves β‐cell function and increases remission rates.

Hypothesis

Initial intravenous infusion of insulin that achieves tight glycemic control decreases subsequent insulin requirements and increases remission rate in diabetic cats.

Animals

Thirty cats with newly diagnosed DM.

Methods

Prospective study. Cats were randomly assigned to one of 2 groups. Cats in group 1 (n = 15) received intravenous infusion of insulin with the goal of maintaining blood glucose concentrations at 90–180 mg/dL, for 6 days. Cats in group 2 (n = 15) received subcutaneous injections of insulin glargine (cats ≤4 kg: 0.5–1.0 IU, q12h; >4 kg 1.5–2.0 IU, q12h), for 6 days. Thereafter, all cats were treated with subcutaneous injections of insulin glargine and followed up for 6 months. Cats were considered in remission when euglycemia occurred for ≥4 weeks without the administration of insulin. Nonparametric tests were used for statistical analysis.

Results

In groups 1 and 2, remission was achieved in 10/15 and in 7/14 cats (P = .46), and good metabolic control was achieved in 3/5 and in 1/7 cats (P = .22), respectively. Overall, good metabolic control or remission occurred in 13/15 cats of group 1 and in 8/14 cats of group 2. In group 1, the median insulin dosage given during the 6‐month follow‐up was significantly lower than in group 2 (group 1: 0.32 IU/kg/day, group 2: 0.51 IU/kg/day; P = .013).

Conclusions and Clinical Importance

Initial intravenous infusion of insulin for tight glycemic control in cats with DM decreases insulin requirements during the subsequent 6 months.  相似文献   

Evolutionary history of the symbiosis between fungus-growing ants and their fungi     

Chapela IH  Rehner SA  Schultz TR  Mueller UG 《Science (New York, N.Y.)》1994,266(5191):1691-1694

The evolutionary history of the symbiosis between fungus-growing ants (Attini) and their fungi was elucidated by comparing phylogenies of both symbionts. The fungal phylogeny based on cladistic analyses of nuclear 28S ribosomal DNA indicates that, in contrast with the monophyly of the ants, the attine fungi are polyphyletic. Most cultivated fungi belong to the basidiomycete family Lepiotaceae; however, one ant genus, Apterostigma, has acquired a distantly related basidiomycete lineage. Phylogenetic patterns suggest that some primitive attines may have repeatedly acquired lepiotaceous symbionts. In contrast, the most derived attines have clonally propagated the same fungal lineage for at least 23 million years.  相似文献   

Strange magnetism and the anapole structure of the proton     

Hasty R  Hawthorne-Allen AM  Averett T  Barkhuff D  Beck DH  Beise EJ  Blake A  Breuer H  Carr R  Covrig S  Danagoulian A  Dodson G  Dow K  Farkhondeh M  Filippone BW  Gao J  Herda MC  Ito TM  Jones CE  Korsch W  Kramer K  Kowalski S  Lee P  McKeown RD  Mueller B  Pitt M 《Science (New York, N.Y.)》2000,290(5499):2117-2119

The violation of mirror symmetry in the weak force provides a powerful tool to study the internal structure of the proton. Experimental results have been obtained that address the role of strange quarks in generating nuclear magnetism. The measurement reported here provides an unambiguous constraint on strange quark contributions to the proton's magnetic moment through the electron-proton weak interaction. We also report evidence for the existence of a parity-violating electromagnetic effect known as the anapole moment of the proton. The proton's anapole moment is not yet well understood theoretically, but it could have important implications for precision weak interaction studies in atomic systems such as cesium.  相似文献   

The evolution of agriculture in ants     

UG Mueller  SA Rehner  TR Schultz 《Science (New York, N.Y.)》1998,281(5385):2034-2038

Cultivation of fungi for food by fungus-growing ants (Attini: Formicidae) originated about 50 million years ago. The subsequent evolutionary history of this agricultural symbiosis was inferred from phylogenetic and population-genetic patterns of 553 cultivars isolated from gardens of "primitive" fungus-growing ants. These patterns indicate that fungus-growing ants succeeded at domesticating multiple cultivars, that the ants are capable of switching to novel cultivars, that single ant species farm a diversity of cultivars, and that cultivars are shared occasionally between distantly related ant species, probably by lateral transfer between ant colonies.  相似文献   

Lipoperoxidation of lung lipids in rats exposed to nitrogen dioxide   总被引：8，自引：0，他引：8  

H V Thomas  P K Mueller  R L Lyman 《Science (New York, N.Y.)》1968,159(814):532-534

Absorption spectra characteristic of diene conjugation and typical for peroxidized polyenoic fatty acids can be induced in rat lung lipids after the rats have been exposed to a scant amount of nitrogen dioxide (1 part per million) for 4 hours. The peroxidative changes do not occur immediately but appear to reach a maximum between 24 and 48 hours after exposure. The prooxidant effect of this atmospheric pollutant in rat lung lipids may be partially prevented by prior treatment of the animal with large doses of alpha-tocopherol.  相似文献   

Regulation of NF-kappaB activation in T cells via association of the adapter proteins ADAP and CARMA1     

Medeiros RB  Burbach BJ  Mueller KL  Srivastava R  Moon JJ  Highfill S  Peterson EJ  Shimizu Y 《Science (New York, N.Y.)》2007,316(5825):754-758

  相似文献   

STUDIES ON THE PHYSIOLOGY OF ASCARIS LUMBRICOIDES     

Mueller JF 《Science (New York, N.Y.)》1928,67(1745):590

  相似文献   

Histone synthesis in vitro by cytoplasmic microsomes from HeLa cells   总被引：5，自引：0，他引：5  

D Gallwitz  G C Mueller 《Science (New York, N.Y.)》1969,163(873):1351-1353

HeLa cell microsomes incorporate labeled amino acids in vitro into acid-soluble proteins which have the same electrophoretic mobility as histones isolated from tile purified HeLa cell nuclei. The capacity to Svnthesize histones in vitro is dependent on deoxyribonucleic acid synthesis in the cells from which the microsonal fraction is prepared.  相似文献   

Molecular Responses to Cadmium in Roots of Pisum Sativum L.     

Facundo Rivera-Becerril  Ashraf Metwally  Fabrice Martin-Laurent  Diederik Van Tuinen  Karl-Josef Dietz  Silvio Gianinazzi  Vivienne Gianinazzi-Pearson 《Water, air, and soil pollution》2005,168(1-4):171-186

Molecular responses to Cd were studied in roots of three pea genotypes (cv. Frisson, VIR4788, VIR7128) growing in a polluted substrate. Root and shoot fresh biomass was decreased by Cd pollution in all genotypes. Gene expression profiling after one weeks' exposure to Cd revealed that genes encoding stress-related proteins (heat-shock protein, pI206, chitinase, chalcone isomerase), a metallothionein, γ -glutamylcysteine synthetase and glutathione reductase were up-regulated in the pea genotypes. A glutathione synthetase gene was activated only in VIR4788 but a homoglutathione synthetase gene was unaffected by Cd, and concomitantly glutathione/homoglutathione accumulation in plant roots did not change with Cd stress. However, the overall concentration of thiol groups, which indicate the presence of phytochelatins and/or homophytochelatins, increased more than 2-fold.  相似文献   

Distribution of Al,V, and Mn in lichens across Calcasieu Parish,Louisiana     

C. S. Mueller  R. L. Thompson  G. J. Ramelow  J. N. Beck  M. P. Langley  J. C. Young  D. M. Casserly 《Water, air, and soil pollution》1987,33(1-2):155-164

The lichen Ramalina stenospora was collected from 16 location in Calcasieu Parish and from 2 locations in Cameron Parish in Southwestern Louisiana. The metals V, Mn, and Al were measured in lichen specimens collected during three seasons — fall 1983, winter and spring 1984. The metals were determined using thermal neutron activation analysis. Vanadium was found to range in concentration from 2.1 to 10 mg kg^?1; and Al from 900 to 4500 mg kg^?1. Metal concentration was found to decrease exponentially with distance outward from the industrial corridor. The major industries included were an Al plant, two refineries and five chemical plants mostly related to plastics production.  相似文献