Effect of omega-3 fatty acids on canine atopic dermatitis     

Mueller RS  Fieseler KV  Fettman MJ  Zabel S  Rosychuk RA  Ogilvie GK  Greenwalt TL 《The Journal of small animal practice》2004,45(6):293-297

Twenty-nine dogs were included in a double-blinded, placebo-controlled, randomised trial and were orally supplemented for 10 weeks with either flax oil (200 mg/kg/day), eicosapentaenoic acid (50 mg/kg/day) and docosahexaenoic acid (35 mg/kg/day) in a commercial preparation, or mineral oil as a placebo. For each dog, clinical scores were determined based on a scoring system developed prior to the trial. Total omega-6 and omega-3 intake and the ratio of omega-6:omega-3 (omega-6:3) were calculated before and after the trial. The dogs' clinical scores improved in those supplemented with flax oil and the commercial preparation, but not in the placebo group. No correlation was identified between total fatty acid intake or omega-6:3 ratio and clinical scores. Based on the results of this study, the total intake of fatty acids or the omega-6:3 ratio do not seem to be the main factors in determining the clinical response.  相似文献   

Immunohistochemical evaluation of mononuclear infiltrates in canine lupoid onychodystrophy     

Mueller RS  West K  Bettenay SV 《Veterinary pathology》2004,41(1):37-43

Claw biopsy samples of 11 dogs with lupoid onychodystrophy were evaluated. They were stained with hematoxylin and eosin and with antibodies against CD 3 as a T-cell marker, BLA 36 and HM 57 (CD 79alpha) as B-cell markers, and lysozyme, Mac 387, and major histocompatibility complex (MHC) class II as a marker for histiocytes using an immunoperoxidase and avidin-biotin technique. Inflammatory cells were counted in five high-power fields. The inflammatory infiltrate comprised predominantly B cells and T cells. Macrophages were typically only present in small numbers. CD 3, BLA 36, lysozyme, and MHC class II preserved significant antigenicity during formalin fixation and short decalcification for 24-48 hours, whereas CD 79alpha and particularly Mac 387 seemed to be more susceptible to denaturation by the decalcification process.  相似文献   

Treatment protocols for demodicosis: an evidence-based review   总被引：4，自引：3，他引：1  

Mueller RS 《Veterinary dermatology》2004,15(2):75-89

Publications discussing the treatment of demodicosis in the dog and cat are reviewed. Based on the evidence in the literature, amitraz rinses at 0.025-0.06% every 7-14 days, and oral daily ivermectin at 300 micro g kg(-1), milbemycin at 2 mg kg(-1) and moxidectin at 400 micro g kg(-1), respectively, can all be recommended for the treatment of generalized canine demodicosis. Ivermectin and moxidectin should be initiated at lower doses and patients monitored for possible adverse effects during therapy. In cats, 2% lime sulfur dips and amitraz rinses at 0.0125-0.025% have been used successfully.  相似文献   

Use of an external ring fixator for correction of an acquired angular limb deformity in a donkey     

Eggleston RB  Mueller PO  Chambers JN  Bentley A 《Journal of the American Veterinary Medical Association》2000,217(8):1186-1190

Numerous techniques for surgical correction of angular limb deformities in horses involving an osteotomy of the affected bone and stabilization with an internal fixation device have been described. However, because the osteotomy typically has to be performed at the level of the physis, leaving little bone between the physis and the nearest joint, stabilizing the osteotomy by use of internal fixation devices may be difficult. In horses with severe chronic angular limb deformities, the amount of soft-tissue contracture may make it impossible to correct the deformity during a single procedure without causing stretch injuries to the adjacent tendons and neurovascular structures. Adjustable external ring fixators incorporating hinged rods on 1 side of the limb and an angular motor assembly on the other may be useful for treatment of severe chronic angular limb deformities in younger equids, because they allow for gradual correction of the deformity.  相似文献   

An undescribed Demodex sp. and demodicosis in a captive koala (Phascolarctos cinereus).     

L J Vogelnest  L Vogelnest  R S Mueller 《Journal of zoo and wildlife medicine》2000,31(1):100-106

A 12-yr-old male koala (Phascolarctos cinereus) in a zoo collection developed bilateral, noninflammatory, periocular alopecia. Deep periocular skin scrapings yielded multiple adult, nymphal, and larval mites of a previously undescribed Demodex species. Skin biopsies from affected areas revealed multiple mites in superficial keratin and within hair follicles, associated with a mild intramural lymphocytic folliculitis. Treatment with daily oral ivermectin was safe and effective. Although Demodex sp. are previously reported from skin scrapings in another koala with periocular alopecia, this is the first confirmed case of koala demodicosis.  相似文献   

Diagnosis of canine claw disease – a prospective study of 24 dogs     

Ralf S. Mueller  Sue Friend  Michael A. Shipstone  & Greg Burton 《Veterinary dermatology》2000,11(2):133-141

The aetiology of claw disease in 24 dogs exhibiting only claw disease was investigated with cytologic examination of claw exudate, complete blood count (CBC), serum biochemistry panel, urinalysis, total thyroxine (tT4) concentration, antinuclear antibody (ANA) titre, bacterial culture and sensitivity testing, fungal culture, histopathology of claw biopsy samples and elimination diet. Abnormalities on the CBC, serum biochemistry panel and urinalysis were minor and nonspecific. Total T4 concentrations were within the normal laboratory reference range. Fungal cultures and ANA titres were negative in all dogs. A bacterial infection was present in approximately half of the dogs. On histological examination of claw tissue, a cell-poor or cell-rich interface onychitis was seen in all but one dog. Evidence for an adverse reaction to food was present in four dogs. One dog responded completely to antibiotic therapy. Interface onychitis seems to be a histological reaction pattern of the claw matrix in the dog with various possible underlying aetiologies. In dogs with claw disease as the only clinical sign, the recommended initial diagnostic evaluation includes cytologic examination, bacterial culture and sensitivity, claw biopsy and an elimination diet.  相似文献   

Seasonal and diurnal variation of downstream fish movement at four small-scale hydropower plants     

Josef Knott  Melanie Mueller  Joachim Pander  Juergen Geist 《Ecology of Freshwater Fish》2020,29(1):74-88

Hydropower structures hinder the movement and migration of fishes, impairing their life cycles. Additionally, downstream moving fish are often at risk of being injured during turbine passage. To improve hydropower production towards more fish-friendly techniques and management, knowledge on timing and extent of natural patterns of fish downstream movement is necessary. So far, migration behaviour of long-distance migrators such as eel or salmon has been well studied, but little is known about seasonal and diurnal movement patterns of nonmigratory species or medium-distance migrators. In this study, movement patterns of 39 fish species captured by stownets while transiting hydropower facilities in four impounded rivers were assessed and compared with the fish community composition directly upstream of the hydropower plants assessed by electrofishing. Strong differences between the fish community composition inhabiting the upstream sides of the dams and the fish detected in downstream passage were evident. In each study river, the downstream moving fish community composition differed significantly between spring and autumn. On average, significantly more fish were caught during the night (2.9 fish/hr) than during the day (1.3 fish/hr). Topmouth gudgeon, European grayling and pike-perch mostly moved downstream during the night, whereas roach, spirlin and bleak were the most frequent downstream moving fish during daytime. Downstream fish movement was positively related with turbidity, water temperature and discharge. The strong differences in seasonal and diurnal fish movement patterns suggest that fish damage can be strongly reduced by adaptive turbine and corridor management, for example by shutting down turbines at peak movements.  相似文献   

Comparison of Tensile Strength and Early Healing of Acute Repeat Celiotomy Through a Ventral Median or a Right Ventral Paramedian Approach     

Lindsey Helms Boone DVM  PhD  Kira Epstein DMV  Diplomate ACVS & ACVECC  Jeanette Cremer Dr. Med. Vet  Diplomate ACVA  Andrew Rogers BS  Tim Foutz PhD  Jane Quandt DVM  Diplomate ACVA & ACVECC  Elizabeth Howerth DVM  PhD  Diplomate ACVP  P.O. Eric Mueller DVM  PhD  Diplomate ACVS 《Veterinary surgery : VS》2014,43(6):741-749

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Pet Obesity Management : Beyond Nutrition     

Deborah Linder  Megan Mueller 《Veterinary Clinics of North America: Small Animal Practice》2014

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Endoscopically Visualized Lesions,Histologic Findings,and Bacterial Invasion in the Gastrointestinal Mucosa of Dogs with Acute Hemorrhagic Diarrhea Syndrome     

S. Unterer  K. Busch  M. Leipig  W. Hermanns  G. Wolf  R.K. Straubinger  R.S. Mueller  K. Hartmann 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2014,28(1):52-58

Background

Etiology of hemorrhagic gastroenteritis (HGE) syndrome in dogs is unknown and histopathologic and microbial investigations have only been performed post mortem.

Objective

To identify characteristic intra vitam endoscopic and histologic mucosal lesions, as well as bacterial species, within the mucosa of dogs with HGE.

Animals

Ten dogs diagnosed with HGE were included. Eleven dogs with gastroduodenoscopy and different intestinal diseases were used as controls for microbial changes. Dogs pretreated with antibiotics or diagnosed with any disease known to cause bloody diarrhea were excluded from the study.

Methods

In this prospective study, gastrointestinal biopsies were collected from 10 dogs with HGE. Endoscopic and histologic changes were assessed according to WSAVA guidelines. Biopsies from the stomach, duodenum, ileum, and colon were investigated by histology and by immunohistochemistry for the presence of Clostridium spp. and parvovirus. The first duodenal biopsy taken with a sterile forceps was submitted for bacterial culture.

Results

Acute mucosal lesions were only found in the intestines, not in the stomach. Clostridium spp., identified as Clostridium perfringens in 6/9 cases, were detected on the small intestinal mucosa in all dogs with HGE, either by culture or immunohistopathology. In the control group, C. perfringens could only be cultured in one of 11 dogs.

Conclusions and Clinical Importance

The results of this study demonstrate an apparent association between C. perfringens and the occurrence of acute hemorrhagic diarrhea. The term “HGE,” which implies the involvement of the stomach, should be renamed as “acute hemorrhagic diarrhea syndrome.”  相似文献