Recognition by human V gamma 9/V delta 2 T cells of a GroEL homolog on Daudi Burkitt's lymphoma cells   总被引：26，自引：0，他引：26  

P Fisch  M Malkovsky  S Kovats  E Sturm  E Braakman  B S Klein  S D Voss  L W Morrissey  R DeMars  W J Welch 《Science (New York, N.Y.)》1990,250(4985):1269-1273

All human gamma delta T cells coexpressing the products of the variable (V) region T cell receptor (TCR) gene segments V gamma 9 and V delta 2 recognize antigens from mycobacterial extracts and Daudi cells. Exogenous and endogenous ligands on the cell surface, homologous to the groEL heat shock family, induced reactivities that resembled superantigen responses in this major subset of human peripheral blood gamma delta T cells. Stimulation of human V gamma 9/V delta 2 T cells is not restricted by human leukocyte antigens (HLA), including nonpolymorphic beta 2-microglobulin (beta 2M)-associated class Ib molecules. These data may be important for understanding the role of gamma delta T cells in autoimmunity and in responses to microorganisms and tumors.  相似文献   

A Scientist's Campaign     

Welch BL 《Science (New York, N.Y.)》1974,186(4164):586

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Ecologists     

Welch BL 《Science (New York, N.Y.)》1972,177(4044):115

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PRESENTATION OF THE KOBER MEDAL TO DR. WILLIAM H. WELCH     

Kober GM  Welch WH 《Science (New York, N.Y.)》1927,66(1697):21-25

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Ice flow direction change in interior West Antarctica     

Siegert MJ  Welch B  Morse D  Vieli A  Blankenship DD  Joughin I  King EC  Vieli GJ  Payne AJ  Jacobel R 《Science (New York, N.Y.)》2004,305(5692):1948-1951

Upstream of Byrd Station (West Antarctica), ice-penetrating radar data reveal a distinctive fold structure within the ice, in which isochronous layers are unusually deep. The fold has an axis more than 50 kilometers long, which is aligned up to 45 degrees to the ice flow direction. Although explanations for the fold's formation under the present flow are problematic, it can be explained if flow was parallel to the fold axis approximately 1500 years ago. This flow change may be associated with ice stream alterations nearer the margin. If this is true, central West Antarctica may respond to future alterations more than previously thought.  相似文献   

Concentration of chromium, nickel, and vanadium in plant materials.     

R M Welch  E E Cary 《Journal of agricultural and food chemistry》1975,23(3):479-482

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Effect of colostrum intake on plasma glucose, non-esterified fatty acid and glucoregulatory hormone patterns in the neonatal pig   总被引：1，自引：0，他引：1  

A J Lepine  R D Boyd  J Welch 《Domestic animal endocrinology》1989,6(3):231-241

The effect of colostrum on endocrine and metabolic factors affecting glucose homeostasis was evaluated in 60 neonatal pigs that were fasted, fed (nursed ad libitum) or limit-fed colostrum (25% ad libitum, 4-hr interval feeding). Plasma acquired at birth (t0), and after 10, 20 and 30 hr (t10, t20 and t30, respectively) was analyzed for glucose, non-esterified fatty acids (NEFA), and the glucoregulatory hormones--insulin, glucagon, cortisol, growth hormone and catecholamines. The concentration of glucose and NEFA was similar among treatment groups at birth and increased in proportion to the quantity of colostrum consumed. Pigs fed ad libitum achieved and maintained a higher (greater than or equal to 40%; P less than .01) glucose concentration when compared to fasted neonates. Limit-fed counterparts also achieved and maintained higher levels, with glucose concentration being approximately 20% higher throughout (P less than .05). Fed pigs maintained NEFA concentrations which were approximately 2.5-fold to 4-fold greater than that of fasted pigs (P less than .05). Likewise, limit-fed pigs tended (P = .19) to have elevated NEFA concentrations and a lower (P less than .05) insulin:glucagon molar ratio. An inverse relationship was observed between colostrum intake and plasma concentrations of cortisol and growth hormone. Concentrations of epinephrine and norepinephrine tended (P greater than .10) to be elevated in fed pigs, relative to those of fasted counterparts. Provision of even limited quantities of colostrum is therefore beneficial to the glucoregulatory response in newborn pigs.  相似文献   

The in vitro cytotoxicity of native and modified trichloroacetic acid-extracted antigens from Fusobacterium necrophorum for mouse peritoneal macrophages     

Richard D Garman  Michael F Lyons  Kelton P Hepper  George W Teresa 《Comparative immunology, microbiology and infectious diseases》1979,2(4):531-543

A Boivin lipopolysaccharide-protein complex (LPS-P), Westphal LPS (W-LPS), Boivin LPS (B-LPS), and a lipid A-associated protein (LAP) were extracted from Fusobacterium necrophorum bov 5 strain and chemically analyzed for protein, total nitrogen, hydrolyzed hexosamine, and nucleic acid content. Dose and time effects on the in vitro cytotoxicity of these preparations for mouse peritoneal macrophages were determined. Macrophage monolayers were exposed to 2.0 ml of 10, 100, 250, 500, or 1000 μg/ml solutions of the individual preparations for 1, 2, 4, or 6 hr at 37°C, and relative toxicities were determined; B-LPS> LPS-P> LAP, W-LPS. The effects of heat, NaOH, and trypsin and pronase on the native antigens were determined. Heat treatment had no effect on the cytotoxicity of B-LPS, but increased the toxicity of LPS-P and LAP for macrophages. Alkaline treatment decreased the cytotoxicity of B-LPS and increased the toxicity of LPS-P and LAP for macrophages. Enzyme treatment had no effect on LPS-P toxicity. The relationship of lipid A and protein content to toxicity for macrophages is discussed. Lipid A appears to be important in the cytotoxicity of B-LPS, and the protein components of LPS-P and LAP may contribute to their toxic activity. The ability of these bacterial cellular antigens to destroy phagocytic cells may facilitate the establishment of necrotic abscesses in susceptible hosts.  相似文献   

Epistaxis in two horses with dacryohemorrhea.     

J Schumacher  P Dean  B Welch 《Journal of the American Veterinary Medical Association》1992,200(3):366-367

Unilateral epistaxis in 2 horses was caused by inflammation of the distal portion of the lacrimal system. The origin of epistaxis was identified during physical examination by observing hemorrhage emanating from the nasal opening of the nasolacrimal duct. Dacryohemorrhea caused by bacterial infection was successfully treated with antibacterial drugs administered systemically and instilled into the lacrimal system.  相似文献   

Response in mice to erythropoiesis regulatory factors     

J P Lewis  C S Wright  R R Moores  W A Neal  E T Welch  L L Smith  E Gardner  W G Lewis 《American journal of veterinary research》1973,34(10):1367-1368

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