Space science. Scientists fear collateral damage from NASA's revised vision     

Lawler A 《Science (New York, N.Y.)》2004,303(5666):1952-1953

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Remaking NASA. NASA hopes bigger is better for planned mission to Jupiter     

Lawler A 《Science (New York, N.Y.)》2004,303(5658):614-615

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Planetary science. Los Alamos's woes spread to Pluto mission     

Lawler A 《Science (New York, N.Y.)》2004,305(5686):930

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Space science. NASA climate satellite wins reprieve     

Lawler A 《Science (New York, N.Y.)》2004,305(5686):927

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Academic leaders. Neuroscientist named MIT president     

Lawler A 《Science (New York, N.Y.)》2004,305(5689):1389

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Diabetes research. Broad-Novartis venture promises a no-strings, public gene database     

Lawler A 《Science (New York, N.Y.)》2004,306(5697):795

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Space science. Rising cost of shuttle and Hubble could break NASA budget     

Lawler A 《Science (New York, N.Y.)》2004,305(5692):1882-1883

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Serum and mucosal antibody responses and protection in pigs vaccinated against Mycoplasma hyopneumoniae with vaccines containing a denatured membrane antigen pool and adjuvant     

SP DJORDJEVIC  GJ EAMENS  LF ROMALIS  PJ NICHOLLS  V TAYLOR  J CHIN 《Australian veterinary journal》1997,75(7):504-511

Objective To investigate the protective efficacy of a pool of denatured membrane protein antigens of Mycoplasma hyopneumoniae (J strain) in the molecular size range 70 to 85 kDa (F3 antigen) in combination with adjuvants for pigs challenged with M hyopneumoniae .
Design A vaccine efficacy experiment with assessment of serum and respiratory tract antibody responses.
Procedure F3 antigens were emulsified with five different adjuvants. To groups of three pigs per vaccine, four vaccines were given by intramuscular injection, and two vaccines, including one of those given intramuscularly, were given by intraperitoneal injection.
Results Compared to six unvaccinated pigs, animals vaccinated with F3 antigen displayed significantly reduced pneumonia (54% reduction in mean lung score) following experimental challenge. Analysis of post-vaccination, pre-challenge IgG and IgA ELISA antibody absorbances in serum and respiratory tract washings revealed no correlation with lung score. Six weeks after challenge, pigs previously vaccinated intramuscularly mostly demonstrated greater IgG and IgA responses in respiratory tract washings, and greater IgG serum antibody responses, than those vaccinated by intraperitoneal injection.
Conclusion Pigs vaccinated with M hyopneumoniae antigens in the molecular size range of 70 to 85 kDa showed a significant reduction in lung lesions compared with unvaccinated control animals after experimental challenge. IgG and IgA antibody concentrations in serum and respiratory tract washings after vaccination do not provide a useful prognostic indicator of protection from enzootic pneumonia.  相似文献   

Reclaiming Afghanistan's past. Fate of Tilya Tepe remains a mystery     

Lawler A 《Science (New York, N.Y.)》2002,298(5596):1199

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Resuscitating Asia's damaged heart     

Lawler A 《Science (New York, N.Y.)》2002,298(5596):1196-1200

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