Evaluation of leukocyte counts and neutrophil‐to‐lymphocyte ratio as predictors of local recurrence of feline injection site sarcoma after curative intent surgery     

L. E. Chiti  M. Martano  R. Ferrari  P. Boracchi  A. Giordano  V. Grieco  P. Buracco  S. Iussich  C. Giudice  B. Miniscalco  D. D. Zani  D. Proverbio  E. Morello  D. Stefanello 《Veterinary and comparative oncology》2020,18(1):105-116

Local recurrence (LR) is the major concern in the treatment of feline injection‐site sarcoma (FISS). Pretreatment leukocyte counts and ratios have been reported as diagnostic and/or prognostic markers in human and canine oncology. The aim of this retrospective study was to explore the prognostic impact on LR and overall survival time (OST) of pretreatment neutrophil‐to‐lymphocyte ratio (NLR), white blood cell count (WBCC), neutrophil count (NC) and lymphocyte count (LC) in cats with surgically excised FISS. Eighty‐two cats with histologically confirmed FISS at first presentation, without distant metastases, and with available pretreatment haematological analyses were retrospectively enrolled. The correlation of NLR, WBCC, NC, LC with tumour variables and patient variables was explored. NLR was correlated with tumour size (P = .004), histological pattern of tumour growth (P = .024) and histotype (P = .029), while WBCC and NC were associated with ulceration (P = .007, P = .011) and pattern of growth (P = .028, P = .004). No significant relationships emerged between LC and any of the considered variables. The impact of NLR, WBCC, NC, LC on LR and OST was then estimated in univariate and multivariate analysis. In univariate analysis, NLR, WBCC and NC were significant prognostic factors for both LR and OST. NLR, WBCC and NC remained prognostic in multivariate analysis for LR but not for OST. When NLR, WBCC and NC were jointly analysed, WBCC was the marker with the greater impact on LR. Preoperative NLR, WBCC and NC may aid in identifying cats at higher risk of LR.  相似文献   

A cocoon of freshly accelerated cosmic rays detected by Fermi in the Cygnus superbubble     

Ackermann M  Ajello M  Allafort A  Baldini L  Ballet J  Barbiellini G  Bastieri D  Belfiore A  Bellazzini R  Berenji B  Blandford RD  Bloom ED  Bonamente E  Borgland AW  Bottacini E  Brigida M  Bruel P  Buehler R  Buson S  Caliandro GA  Cameron RA  Caraveo PA  Casandjian JM  Cecchi C  Chekhtman A  Cheung CC  Chiang J  Ciprini S  Claus R  Cohen-Tanugi J  de Angelis A  de Palma F  Dermer CD  do Couto E Silva E  Drell PS  Dumora D  Favuzzi C  Fegan SJ  Focke WB  Fortin P  Fukazawa Y  Fusco P  Gargano F  Germani S  Giglietto N  Giordano F 《Science (New York, N.Y.)》2011,334(6059):1103-1107

The origin of Galactic cosmic rays is a century-long puzzle. Indirect evidence points to their acceleration by supernova shockwaves, but we know little of their escape from the shock and their evolution through the turbulent medium surrounding massive stars. Gamma rays can probe their spreading through the ambient gas and radiation fields. The Fermi Large Area Telescope (LAT) has observed the star-forming region of Cygnus X. The 1- to 100-gigaelectronvolt images reveal a 50-parsec-wide cocoon of freshly accelerated cosmic rays that flood the cavities carved by the stellar winds and ionization fronts from young stellar clusters. It provides an example to study the youth of cosmic rays in a superbubble environment before they merge into the older Galactic population.  相似文献   

Effect of plot size on measured soil loss for two Italian experimental sites     

V. Bagarello  V. Ferro  G. Giordano  F. Mannocchi  V. Pampalone  F. Todisco  L. Vergni 《Biosystems Engineering》2011,108(1):18-27

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A Metataxonomic Approach Reveals Diversified Bacterial Communities in Antarctic Sponges     

Nadia Ruocco  Roberta Esposito  Marco Bertolino  Gianluca Zazo  Michele Sonnessa  Federico Andreani  Daniela Coppola  Daniela Giordano  Genoveffa Nuzzo  Chiara Lauritano  Angelo Fontana  Adrianna Ianora  Cinzia Verde  Maria Costantini 《Marine drugs》2021,19(3)

Marine sponges commonly host a repertoire of bacterial-associated organisms, which significantly contribute to their health and survival by producing several anti-predatory molecules. Many of these compounds are produced by sponge-associated bacteria and represent an incredible source of novel bioactive metabolites with biotechnological relevance. Although most investigations are focused on tropical and temperate species, to date, few studies have described the composition of microbiota hosted by Antarctic sponges and the secondary metabolites that they produce. The investigation was conducted on four sponges collected from two different sites in the framework of the XXXIV Italian National Antarctic Research Program (PNRA) in November–December 2018. Collected species were characterized as Mycale (Oxymycale) acerata, Haliclona (Rhizoniera) dancoi, Hemigellius pilosus and Microxina sarai by morphological analysis of spicules and amplification of four molecular markers. Metataxonomic analysis of these four Antarctic sponges revealed a considerable abundance of Amplicon Sequence Variants (ASVs) belonging to the phyla Proteobacteria, Bacteroidetes, Actinobacteria and Verrucomicrobia. In particular, M. (Oxymycale) acerata, displayed several genera of great interest, such as Endozoicomonas, Rubritalea, Ulvibacter, Fulvivirga and Colwellia. On the other hand, the sponges H. pilosus and H. (Rhizoniera) dancoi hosted bacteria belonging to the genera Pseudhongella, Roseobacter and Bdellovibrio, whereas M. sarai was the sole species showing some strains affiliated to the genus Polaribacter. Considering that most of the bacteria identified in the present study are known to produce valuable secondary metabolites, the four Antarctic sponges could be proposed as potential tools for the discovery of novel pharmacologically active compounds.  相似文献   

Crude glycerol in diets for Nile tilapia sex reversal (Oreochromis niloticus,Linnaeus 1758)          下载免费PDF全文

Fábio Meurer  Aldo Tovo Neto  Lilian Carolina Rosa da Silva  Luana Cagol  Marise Taise Theisen  Lilian Dena dos Santos 《Aquaculture Research》2016,47(8):2682-2685

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Serum creatine kinase isoenzymes and macroenzymes in dogs with different neurologic diseases          下载免费PDF全文

Saverio Paltrinieri  Laura Pintore  Federica Balducci  Alessia Giordano  Annaluce Costabile  Marco Bernardini 《Veterinary clinical pathology / American Society for Veterinary Clinical Pathology》2017,46(1):91-99

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Temporal horizontal H‐figure sliding skin flap for central eyelid reconstructive surgery in dogs: a retrospective study          下载免费PDF全文

C. Giordano  A. Vercelli  G. Barsotti 《The Journal of small animal practice》2017,58(12):709-713

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Spineless cactus associated with Tifton hay or sugarcane bagasse may replace corn silage in sheep diets     

Julimar do Sacramento Ribeiro  Luana Lira Santos  Dorgival Morais de Lima Júnior  Tobyas Maia de Albuquerque Mariz  Márcio Machado Ladeira  Paulo Sérgio de Azevedo  Carolyny Batista Lima  Maria Josilaine Matos dos Santos Silva 《Tropical animal health and production》2017,49(5):995-1000

The effect of the replacement of corn silage with spineless cactus associated with Tifton 85 hay or sugarcane bagasse was evaluated on the performance, body weight components and sheep meat quality. Twenty-one Santa Inês male sheep with initial body weight of 22.9 ± 2.9 kg were used. They were confined in individual stalls for 74 days receiving the following diets: corn silage + concentrate (CS); spineless cactus + Tifton 85 hay + concentrate (TH); spineless cactus + sugarcane bagasse + concentrate (SB). After the feedlot period, the animals were slaughtered and their body components were weighed and sampled. Data were submitted to Tukey’s test at 5% probability. The average daily gain (0.25 vs 0.14 kg), cold carcass weight (13.3 vs 13.7 kg), loin muscularity (0.6 vs 0.4 kg) and liver weight (0.7 vs. 0.5 kg) were higher (P < 0.05) for the TH diet when compared to that for the CS. The physical-chemical parameters of meat were not influenced (P > 0.05) by the treatments and presented about 20.1% of crude protein, 6.1% of crude fat and shear force of 2.0 kgf/cm². In complete diets for sheep, Tifton 85 hay associated with spineless cactus provides greater weight gain, cold carcass muscularity and organ weight when compared to those for animals fed with corn silage as exclusive roughage. Sugarcane bagasse associated with spineless cactus may replace corn silage in complete diets for sheep.  相似文献   

Resistance to classical scrapie in experimentally challenged goats carrying mutation K222 of the prion protein gene     

Acutis PL  Martucci F  D'Angelo A  Peletto S  Colussi S  Maurella C  Porcario C  Iulini B  Mazza M  Dell'atti L  Zuccon F  Corona C  Martinelli N  Casalone C  Caramelli M  Lombardi G 《Veterinary research》2012,43(1):8

ABSTRACT: Susceptibility of sheep to scrapie, a transmissible spongiform encephalopathy of small ruminants, is strongly influenced by polymorphisms of the prion protein gene (PRNP). Breeding programs have been implemented to increase scrapie resistance in sheep populations; though desirable, a similar approach has not yet been applied in goats. European studies have now suggested that several polymorphisms can modulate scrapie susceptibility in goats: in particular, PRNP variant K222 has been associated with resistance in case-control studies in Italy, France and Greece. In this study we investigated the resistance conferred by this variant using a natural Italian goat scrapie isolate to intracerebrally challenge five goats carrying genotype Q/Q 222 (wild type) and five goats carrying genotype Q/K 222. By the end of the study, all five Q/Q 222 goats had died of scrapie after a mean incubation period of 19 months; one of the five Q/K 222 goats died after 24 months, while the other four were alive and apparently healthy up to the end of the study at 4.5 years post-challenge. All five of these animals were found to be scrapie negative. Statistical analysis showed that the probability of survival of the Q/K 222 goats versus the Q/Q 222 goats was significantly higher (p = 0.002). Our study shows that PRNP gene mutation K222 is strongly associated with resistance to classical scrapie also in experimental conditions, making it a potentially positive target for selection in the frame of breeding programs for resistance to classical scrapie in goats.  相似文献   

Does orchiectomy enhance the immune-stimulatory effects of melatonin during experimental Chagas’ disease?     

Santello FH  Caetano LC  Filipin Mdel V  Brazão V  Caetano LN  Toldo MP  do Prado JC 《Research in veterinary science》2012,93(2):819-825

Melatonin has been reported to play a fundamental role in T-cell immunoregulation. Control of Trypanosoma cruzi parasitism during the acute phase of infection is considered to be critically dependent on direct macrophage activation by cytokines. The aim of this work was to evaluate the influence of exogenous melatonin treatment and the influences exerted by sexual hormones during the acute phase of the experimental Chagas' disease in rats. With melatonin treatment, orchiectomized animals (CMOR and IMOR) displayed the highest concentrations of IFN-γ and TNF-α. On the 7th day post-infection, untreated and treated orchiectomized animals (IOR and IMOR) showed an enhanced number of peritoneal macrophages. Nitric oxide levels were also increased in untreated and treated orchiectomized (IOR and IMOR) when compared to the other groups, with or without LPS. Our data suggest that melatonin therapy associated with orchiectomy induced a stimulating effect on the immune response to the parasite.  相似文献