Intracranial neoplasia in 61 cats: localisation, tumour types and seizure patterns     

Tomek A  Cizinauskas S  Doherr M  Gandini G  Jaggy A 《Journal of Feline Medicine and Surgery》2006,8(4):243-253

The purpose of this study was to analyse retrospectively a feline population with intracranial neoplastic diseases, to document seizure patterns in these animals and to determine whether partial seizures were more frequently associated with structural brain lesions then generalised seizures. In addition, a comparison was made within the population with intracranial neoplasia between two groups of cats: one with and one without seizures. Special emphasis was given to the evaluation of tumour type, localisation and size of the lesion and its correlation with seizure prevalence. Sixty-one cats with histopathological diagnosis of intracranial tumour were identified. Fourteen cats (23%; group A) had a history of seizure(s). Forty-seven cats (77%; group B) had no history of seizure(s). Generalised tonic-clonic seizures were seen in eight cats (57%) and were the most common seizure pattern in our cats with intracranial neoplasia. Clusters of seizures were observed in six cats. Status epilepticus was observed in one patient. The mean age of the cats was 7.9 years within group A (median 8.5) and 9.3 years (median 10) within group B. The cats with lymphoma within both groups were significantly younger than cats with meningioma. In both groups meningioma and lymphoma were confirmed to be the most frequent tumour type, followed by glial cell tumours. The prevalence of the seizures in patients with glial cell tumours was 26.7%, 26.3% in patients with lymphomas and 15% in cases with meningiomas. In 33 cases (54.1%) the tumours were localised in the forebrain, 15 tumours (24.6%) were in the brainstem, four (6.6%) in the cerebellum and nine tumours (14.7%) had multifocal localisation. Parietal lobe and basal ganglia mostly affected group A. In group B tumours were most frequently located in the parietal and frontal lobes as well as in the diencephalon. A positive association was documented between the localisation of a tumour in the forebrain and seizure occurrence.  相似文献   

Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity   总被引：2，自引：0，他引：2  

Lamming DW  Ye L  Katajisto P  Goncalves MD  Saitoh M  Stevens DM  Davis JG  Salmon AB  Richardson A  Ahima RS  Guertin DA  Sabatini DM  Baur JA 《Science (New York, N.Y.)》2012,335(6076):1638-1643

Rapamycin, an inhibitor of mechanistic target of rapamycin complex 1 (mTORC1), extends the life spans of yeast, flies, and mice. Calorie restriction, which increases life span and insulin sensitivity, is proposed to function by inhibition of mTORC1, yet paradoxically, chronic administration of rapamycin substantially impairs glucose tolerance and insulin action. We demonstrate that rapamycin disrupted a second mTOR complex, mTORC2, in vivo and that mTORC2 was required for the insulin-mediated suppression of hepatic gluconeogenesis. Further, decreased mTORC1 signaling was sufficient to extend life span independently from changes in glucose homeostasis, as female mice heterozygous for both mTOR and mLST8 exhibited decreased mTORC1 activity and extended life span but had normal glucose tolerance and insulin sensitivity. Thus, mTORC2 disruption is an important mediator of the effects of rapamycin in vivo.  相似文献   

What is your diagnosis? Extraskeletal osteosarcoma     

Marcus EC  Marolf A  Thamm DH  Lana SE 《Journal of the American Veterinary Medical Association》2012,240(3):265-266

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Influence of Durotomy on Laser‐Doppler Measurement of Spinal Cord Blood Flow in Chondrodystrophic Dogs with Thoracolumbar Disk Extrusion     

Andrea Blaser DVM  Johann Lang DVM  Diplomate ECVDI  Diana Henke DVM  Marcus G. Doherr DVM  PhD  Diplomate ECVPH  Chiara Adami DVM  PhD  Franck Forterre DVM  Diplomate ECVS 《Veterinary surgery : VS》2012,41(2):221-227

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Comparative spatiotemporal analysis of the intrathecal immune response in natural listeric rhombencephalitis of cattle and small ruminants     

Di Palma S  Brunetti B  Doherr MG  Forster U  Hilbe M  Zurbriggen A  Vandevelde M  Oevermann A 《Comparative immunology, microbiology and infectious diseases》2012,35(5):429-441

This study examined the spatiotemporal immune response in listeric rhombencephalitis of ruminants in situ. Our data support the view that astrocytes facilitate the containment of infectious lesions. Results on the natural disease recapitulate observations in experimental rodent models and suggest that the mounted adaptive lymphocytic response of ruminants is effective in eliminating Listeria monocytogenes (LM). However, our data indicate earlier participation of the adaptive immune response, a stronger B lymphocyte contribution and a more protracted macrophage infiltration in the natural disease than it has been deduced from experimental models. Therefore, such models should be complemented by studies in natural host systems. Various macrophage and microglia subsets are involved in listeric rhombencephalitis and their differential contribution may account for species differences in clinical course and outcome of infection as might species differences in the B-cell response. Future functional ex vivo and in vitro studies are necessary to further investigate the findings obtained in the present study.  相似文献   

Computer-based gait analysis of dogs: Evaluation of kinetic and kinematic parameters after cemented and cementless total hip replacement     

Drüen S  B?ddeker J  Meyer-Lindenberg A  Fehr M  Nolte I  Wefstaedt P 《Veterinary and comparative orthopaedics and traumatology》2012,25(5):375-384

To date it is unclear whether cementless total hip replacement (THR) in dogs is of clinical advantage in comparison to cemented THR with regard to lameness improvement. Thus the aim of this study was to compare objectively the development of the gait pattern after cemented and cementless THR in dogs. For this purpose, 18 adult dogs with hip dysplasia underwent computer-based gait analysis on an instrumented treadmill prior to unilateral THR and then again ten days, four weeks and four months after surgery. Analysed kinetic parameters were symmetry indices (SI) of vertical ground reaction forces (GRF), which included peak vertical forces (PFz), mean vertical forces (MFz), vertical impulse (IFz), and vertical ground reaction forces of the arthroplasty limbs only. Analysed kinematic parameters were range-of-motion and the flexion and extension angles of hip, stifle and hock joints. The symmetry indice for PVF, MFz and IFz decreased to a value less than six in both THR groups four months after surgery, which is defined as not lame. Improvement in lameness of the arthroplasty limbs during the examination period of four months was not significantly different between the cemented and cementless groups. The results suggest that within a short-term observation period of four months after surgery, neither cementless nor cemented THR have a greater advantage with regard to lameness improvement. Additional studies with larger pools of subjects and longer time periods for follow-up examinations are necessary to verify these findings.  相似文献   

Variants of the recently discovered avian gyrovirus 2 are detected in Southern Brazil and The Netherlands     

dos Santos HF  Knak MB  de Castro FL  Slongo J  Ritterbusch GA  Klein TA  Esteves PA  Silva AD  Trevisol IM  Claassen EA  Cornelissen LA  Lovato M  Franco AC  Roehe PM  Rijsewijk FA 《Veterinary microbiology》2012,155(2-4):230-236

A genome of a virus preliminarily named avian gyrovirus 2 (AGV2), a close relative to chicken anemia virus, was recently discovered in a chicken in the state of Rio Grande do Sul, Southern Brazil. To study the occurrence of AGV2 in Rio Grande do Sul and the neighboring state Santa Catarina, a number of adult chickens (n=108 and n=48, respectively) were tested for the presence of AGV2 DNA. An AGV2-specific PCR was developed, optimized and used to analyze DNA extracted from clinical samples. AGV2 DNA was detected in 98/108 (90.7%) of samples collected in the state of Rio Grande do Sul and 29/48 (60.4%) of the samples collected in the state of Santa Catarina. In order to check whether AGV2 DNA would be detected in samples from a geographically distant region, DNA from brain samples of 21 diseased chickens from the Netherlands were tested independently, by the same method. In such specimens, 9/21 (42.9%) brain tissue samples were found to contain AVG2 DNA. Sequence analysis of some of the PCR products demonstrated that the amplified AGV2 sequences could vary up to 15.8% and could preliminarily be divided in three groups. This indicated the occurrence of variants of AGV2, which may reflect differences in geographical origin and/or in biological properties. The data presented here provides evidence that AGV2 seems fairly distributed in chickens in Southern Brazil and that AGV2 also circulates in the Netherlands. Besides, circulating viruses display genetic variants whose significance should be further examined, particularly to determine whether AGV2 would play any role in chicken diseases.  相似文献   

A comparison of the antinociceptive effects of xylazine, detomidine and romifidine on experimental pain in horses     

Moens Y  Lanz F  Doherr MG  Schatzmann U 《Veterinary anaesthesia and analgesia》2003,30(3):183-190

Objective To study the analgesic potency of the α₂‐agonist romifidine in the horse using both an electrical current and a mechanical pressure model for nociceptive threshold testing. In addition, a comparison was made with doses of detomidine and xylazine that produce equivalent degrees of sedation. Study design Randomized, placebo‐controlled, blinded cross‐over study. Animals Six adult Swiss warmblood horses, one mare and five geldings, weighing from 530 to 650 kg and aged 6–15 years. Methods Nociceptive thresholds were measured using an electrical stimulus applied to the coronary band and using a pneumatically operated pin pressing on the cannon bone. Measurements were made immediately before and every 15 minutes for 2 hours after IV injection of the test substances. Lifting of the foot indicated the test end point. Results The three α₂‐agonists caused a temporary increase in nociceptive thresholds with a maximal effect within 15 minutes and a return to baseline levels within 1 hour. Using electrical current testing nociceptive thresholds were significantly different from placebo (mean ± SD) for detomidine at 15 minutes (from control 5.8 ± 0.9 to 23.3 ± 3.9 mA, p = 0.0066) and 30 minutes (from control 6.6 ± 1.1 to 18.8 ± 3.3 mA, p = 0.0091). The difference was significant for romifidine at 15 minutes only (from control 5.8 ± 0.9 to 18.7 ± 3.8 mA, p = 0.0066). With mechanical pressure testing nociceptive thresholds were significantly different from control for detomidine at 15 minutes (from 3.2 ± 0.2 to 6.2 ± 0.5 N, p = 0.00076) and 30 minutes (from 3.2 ± 0.7 to 5.7 ± 0.8 N, p = 0.0167). The difference was significant for xylazine at 15 minutes (from control 3.2 ± 0.2 to 5.6 ± 0.7 N, p = 0.0079). At 15 minutes the order of magnitude of the measured antinociceptive effect was significantly different between the two pain tests for both romifidine and detomidine, but not for xylazine. For romifidine, the increase of mean thresholds compared to placebo was 4.0 ± 1.3 times placebo levels with the electrical current test compared to 1.3 ± 0.3 times for the mechanical pressure test (p = 0.037). For detomidine, the increase of mean thresholds compared to placebo was 5.4 ± 1.7 times control levels with the electrical current test compared to 2.0 ± 0.2 times for the mechanical pressure test (p = 0.040). This represents a 2.7 (romifidine) and 3.4 times (detomidine) greater increase in thresholds using electrical current testing compared to the use of mechanical pressure testing. Conclusion and clinical relevance This study demonstrates the analgesic potential of α₂‐agonists in the horse for somatic pain and that they can have quantitatively different antinociceptive effects according to the antinociceptive test used.  相似文献   

Intramuscular glargine with or without concurrent subcutaneous administration for treatment of feline diabetic ketoacidosis     

Rhett D. Marshall BVSc  MACVSc  Jacquie S. Rand BVSc  DVSc  DACVIM  Marcus N. Gunew BVSc  FACVSc  Victor H. Menrath BVSc  FACVSc 《Journal of Veterinary Emergency and Critical Care》2013,23(3):286-290

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Acoustic and bending properties in Pinus elliottii beams obtained from trees of different ages     

Raquel Gonçalves  Cinthya Bertoldo Pedroso  Marcus Vinicius Massak 《Journal of Wood Science》2013,59(2):127-132

In contrast to wood from native forests, the lumber harvested from planted forests is primarily composed of boards from younger trees. Given the possibility of using wave propagation methods to classify wood for structural purposes, it is important to evaluate if the ultrasonic parameters tend to vary with the age of the tree in a similar manner as static bending parameters. Experiments were conducted using structural beams taken from Pinus elliottii trees that were 8, 9, 13, 15, 22 and 23 years old. The beams were tested by ultrasound in the longitudinal direction and by static bending. The results showed that age of the tree influences the wave propagation velocity, stiffness constant and modulus of elasticity. The results were sorted into two groups based on the variation of these parameters: wood pieces from trees up to 15 years old and wood pieces from trees older than 15 years of age. Statistically, the flexural strength did not change with age due to the significant influence of knots on this parameter, which overcomes the influence of age. The data obtained by ultrasound follow the same trends with age as the elastic modulus in static bending.  相似文献