New Deoxyisoaustamide Derivatives from the Coral-Derived Fungus Penicillium dimorphosporum KMM 4689     

Olesya I. Zhuravleva  Alexandr S. Antonov  Vo Thi Dieu Trang  Mikhail V. Pivkin  Yuliya V. Khudyakova  Vladimir A. Denisenko  Roman S. Popov  Natalya Y. Kim  Ekaterina A. Yurchenko  Andrey V. Gerasimenko  Anatoly A. Udovenko  Gunhild von Amsberg  Sergey A. Dyshlovoy  Shamil S. Afiyatullov 《Marine drugs》2021,19(1)

Seven new deoxyisoaustamide derivatives (1–7) together with known compounds (8–10) were isolated from the coral-derived fungus Penicillium dimorphosporum KMM 4689. Their structures were established using spectroscopic methods, X-ray diffraction analysis and by comparison with related known compounds. The absolute configurations of some alkaloids were determined based on CD and NOESY data as well as biogenetic considerations. The cytotoxic and neuroprotective activities of some of the isolated compounds were examined and structure-activity relationships were pointed out. New deoxyisoaustamides 4–6 at concentration of 1 µM revealed a statistical increase of PQ(paraquat)-treated Neuro-2a cell viability by 30–39%.  相似文献   

Changes in net ecosystem production associated with forest fire in taiga ecosystems,near Yakutsk,Russia     

Takuji Sawamoto  Ryusuke Hatano  Masato Shibuya  Kunihide Takahashi  Alexander P. Isaev  Roman V. Desyatkin 《Soil Science and Plant Nutrition》2013,59(4):493-501

Abstract

The effect of sucrose on the growth of rice plants under gnotobiotic conditions was studied at test tube scale in vinyl isolators under weak or strong light. Under weak light (500 lux) the growth of rice plants on agar medium containing only inorganic nutrients during the 20 days after transplanting stopped at 3rd leaf stage, whereas plants on agar medium containing inorganic nutrient plus 2% sucrose grew to 5th or 6th leaf stage. Under strong light (1.5 × 10⁴ lux) the stage of tillering was promoted by supplying sucrose. The growth of rice plants in pot-hydroculture under weak light had the same tendency as that obtained in test tube culture under weak light.

Considering the concentration of inorganic elements in rice shoots, it seems most likely that the uptake of inorganic elements. especially phosphorus and potassium, was enhanced by the supplements of 2% sucrose under weak light. An increase of calcium and manganese uptake was observed in plants grown in medium containing 2% sucrose compared with that of plants grown in inorganic medium alone under strong light. The uptake of inorganic elements from medium containing inorganic nutrients plus 2% sucrose depended chiefly on light energy under strong light in the phytotron used.  相似文献   

Effects of Poly (ADP-ribose) Polymerase Inhibition on DNA Integrity and Gene Expression in Ovarian Follicular Cells in Mice with Endotoxemia     

Olena Kondratska  Nataliya Grushka  Svitlana Pavlovych  Nataliya Krasutska  Serhii Tsyhankov  Roman Yanchii 《Iranian Biomedical Journal》2022,26(1):44

  相似文献   

Neuroprotective Metabolites from Vietnamese Marine Derived Fungi of Aspergillus and Penicillium Genera     

Elena V. Girich  Anton N. Yurchenko  Olga F. Smetanina  Phan Thi Hoai Trinh  Ngo Thi Duy Ngoc  Mikhail V. Pivkin  Roman S. Popov  Evgeny A. Pislyagin  Ekaterina S. Menchinskaya  Ekaterina A. Chingizova  Shamil S. Afiyatullov  Ekaterina A. Yurchenko 《Marine drugs》2020,18(12)

Low molecular weight secondary metabolites of marine fungi Aspergillus flocculosus, Aspergillus terreus and Penicillium sp. from Van Phong and Nha Trang Bays (Vietnam) were studied and a number of polyketides, bis-indole quinones and terpenoids were isolated. The structures of the isolated compounds were determined by 1D and 2D NMR and HR-ESI-MS techniques. Stereochemistry of some compounds was established based on ECD data. A chemical structure of asterriquinone F (6) was thoroughly described for the first time. Anthraquinone (13) was firstly obtained from a natural source. Neuroprotective influences of the isolated compounds against 6-OHDA, paraquat and rotenone toxicity were investigated. 4-Hydroxyscytalone (1), 4-hydroxy-6-dehydroxyscytalone (2) and demethylcitreoviranol (3) have shown significant increasing of paraquat- and rotenone-treated Neuro-2a cell viability and anti-ROS activity.  相似文献   

Kurilosides A1, A2, C1, D,E and F—Triterpene Glycosides from the Far Eastern Sea Cucumber Thyonidium (= Duasmodactyla) kurilensis (Levin): Structures with Unusual Non-Holostane Aglycones and Cytotoxicities     

Alexandra S. Silchenko  Anatoly I. Kalinovsky  Sergey A. Avilov  Pelageya V. Andrijaschenko  Roman S. Popov  Pavel S. Dmitrenok  Ekaterina A. Chingizova  Vladimir I. Kalinin 《Marine drugs》2020,18(11)

Six new monosulfated triterpene tetra-, penta- and hexaosides, namely, the kurilosides A₁ (1), A₂ (2), C₁ (3), D (4), E (5) and F (6), as well as the known earlier kuriloside A (7), having unusual non-holostane aglycones without lactone, have been isolated from the sea cucumber Thyonidium (= Duasmodactyla) kurilensis (Levin) (Cucumariidae, Dendrochirotida), collected in the Sea of Okhotsk near Onekotan Island from a depth of 100 m. Structures of the glycosides were established by 2D NMR spectroscopy and HR-ESI mass spectrometry. Kurilosides of the groups A and E contain carbohydrate moieties with a rare architecture (a pentasaccharide branched by C(4) Xyl1), differing from each other in the second monosaccharide residue (quinovose or glucose, correspondingly); kurilosides of the group C are characterized by a unique tetrasaccharide branched by a C(4) Xyl1 sugar chain; and kurilosides of the groups D and F are hexaosides differing from each other in the presence of an O-methyl group in the fourth (terminal) sugar unit. All these glycosides contain a sulfate group at C-6 of the glucose residue attached to C-4 Xyl1 and the non-holostane aglycones have a 9(11) double bond and lack γ-lactone. The cytotoxic activities of compounds 1–7 against mouse neuroblastoma Neuro 2a, normal epithelial JB-6 cells and erythrocytes were studied. Kuriloside A₁ (1) was the most active compound in the series, demonstrating strong cytotoxicity against the erythrocytes and JB-6 cells and a moderate effect against Neuro 2a cells.  相似文献   

Reproduction of chub, Leuciscus cephalus L., under controlled conditions     

S&#;awomir Krejszeff  Dariusz Kucharczyk  Krzysztof Kupren  Katarzyna Targo&#;ska  rzej Mamcarz  Roman Kujawa  Zbigniew Kaczkowski  & Sebastian Ratajski 《Aquaculture Research》2008,39(9):907-912

Research into artificial reproduction of chub was studied during three subsequent reproductive seasons. Chub reproduction was conducted in two different variations. In the first experiment different hormonal agents were given to fish, such as CPE, hCG, or an analogue of GnRH with dopamine antagonist (ovopel). In the second one, the optimum moment of applying of artificial reproduction was sought and the fish were only obtained an analogue of GnRH in different periods. The results obtained in two first seasons indicated that ovopel is the most effective agent for the artificial reproduction of chub. Consequently, it was decided that the fish would obtain only this agent in the final year of research. In last year (experiment II), chub spawners were taken to the hatchery under controlled conditions every few weeks from February to the beginning of June. Periodically, the maturity of oocytes was checked. As soon as the oocytes had achieved stage 2–3 of maturity, fish were obtained ovopel. It was noted that there was no problem with collecting semen. Obtaining oocytes was much more difficult. Most frequently, they were not obtained at all or obtained in very small amounts. It was also observed that the administration of hormones caused a very quick maturation of gonads and their over-maturation.  相似文献   

Phosphonic analogues of morphactins. Part IV: 9-aminofluoren-9-ylphosphine oxides     

Roman Gancarz  Witold Wielkopolski  Elbieta Jaskuska  Pawel Kafarski  Barbara Lejczak  Przemyslaw Mastalerz  Jan Sylwester Wieczorek 《Pest management science》1985,16(3):234-238

9-Aminofluoren-9-ylphosphine oxides and the corresponding 9-hydroxy analogues were synthesised and evaluated for herbicidal activity using Spirodela oligorrhiza (Kurz.) Hegelm. All the test compounds were highly active at concentrations of about 10 μM and were comparable with the corresponding phosphonic esters.  相似文献   

Phosphonic analogues of morphactins. Part III: Peptides containing p-terminal 9-aminofluoren-9-ylphosphonic acid     

Barbara Lejczak  Pawel Kafarski  Roman Gancarz  Elzbieta Jaskulska  Przemyslaw Mastalerz  Jan Sylwester Wieczorek  Marta Krl 《Pest management science》1985,16(3):227-233

Peptides of 9-aminofluoren-9-ylphosphonic or 1-aminocyclohexylphosphonic acids were synthesised and found to have typical morphactin activity when tested on Lepidium sativum and Triticum vulgare. The observed effects included root elongation with simultaneous stem shortening. The results obtained indicate that these phosphonic acid derivatives of cyclohexylamine and fluoren-9-ylamine may have a similar mechanism of action.  相似文献   

Herbicidal activity of derivatives of 9-aminofluoren-9-ylphosphonic acid     

Hubert Wojtasek  Piotr Wieczorek  Barbara Lejczak  Bogdan Boduszek  Roman Gancarz  Pawel Kafarski 《Pest management science》1991,32(2):245-252

A series of derivatives of 9-aminofluoren-9-ylphosphonic acid (phosphonic analogues of morphactins) were synthesized and screened for herbicidal activity against Lepidium sativum, Cucumis sativus and Lycopersicon esculentum. Ethyl 9-(N-alkylamino)fluoren-9-yl(phenyl)phosphinates appeared to be equipotent with glyphosate and thus may be recognized as new lead compounds for further structural modifications.  相似文献   

Seroprevalence of retrovirus in North American captive macropodidae     

Timothy A Georoff  Priscilla H Joyner  John P Hoover  Mark E Payton  Roman M Pogranichniy 《Journal of zoo and wildlife medicine》2008,39(3):335-341

Laboratory records of serology results from captive macropodidae sampled between 1997 and 2005 were reviewed to assess the seroprevalence of retrovirus exposure. Serum samples from 269 individuals (136 males, 133 females) representing 10 species of macropods housed in 31 North American captive collections were analyzed for retrovirus antibody using an indirect immunofluorescent assay. The prevalence of positive antibody titers comparing male versus female, between species, between age groups, and among animals with identified parentage was examined by nonparametric statistical analyses. Median age of animals at time of sample collection was 36 mo (range 2-201 mo). Total percentage seropositive was 20.4%. Serum antibody was detected in 31 of 47 (66.0%) tammar wallaby (Macropus eugenii), nine of 24 (37.5%) yellow-footed rock wallaby (Petrogale xanthopus), four of 11 (36.4%) swamp wallaby (Wallabia bicolor), 10 of 80 (12.5%) red-necked wallaby (Macropus rufogriseus), and one of 54 (1.9%) parma wallaby (Macropus parma). No individuals of western gray kangaroo (n=3) (Macropus fuliginosus), eastern gray kangaroo (n=19) (Macropus giganteus), common wallaroo (n=6) (Macropus robustus), red kangaroo (n=11) (Macropus rufus), or Matschie's tree kangaroo (n=14) (Dendrolagus matschiei) were positive for retrovirus antibody. These results demonstrate that five species of captive macropods have a history of exposure to retrovirus, with the highest percentage seropositive and highest statistical correlation in M. eugenii (pair-wise Fisher's exact test, alpha = 0.05). Additionally, one wild-caught M. eugenii was confirmed seropositive during quarantine period, indicating that retrovirus exposure may exist in wild populations.  相似文献