Hypoxia inducible factor 1α expression and effects of its inhibitors in canine lymphoma     

Satoshi KAMBAYASHI  Masaya IGASE  Kosuke KOBAYASHI  Ayana KIMURA  Takako SHIMOKAWA MIYAMA  Kenji BABA  Shunsuke NOGUCHI  Takuya MIZUNO  Masaru OKUDA 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2015,77(11):1405-1412

Hypoxic conditions in various cancers are believed to relate with their malignancy, and hypoxia inducible factor-1α (HIF-1α) has been shown to be a major regulator of the response to low oxygen. In this study, we examined HIF-1α expression in canine lymphoma using cell lines and clinical samples and found that these cells expressed HIF-1α. Moreover, the HIF-1α inhibitors, echinomycin, YC-1 and 2-methoxyestradiol, suppressed the proliferation of canine lymphoma cell lines. In a xenograft model using NOD/scid mice, echinomycin treatment resulted in a dose-dependent regression of the tumor. Our results suggest that HIF-1α contributes to the proliferation and/or survival of canine lymphoma cells. Therefore, HIF-1α inhibitors may be potential agents to treat canine lymphoma.  相似文献   

Follicular Thyroid Carcinoma Characterized by Abundant Stromal Components with Chondroid and Osseous Metaplasia in a Dog     

Ryosuke KOBAYASHI  Naoaki YAMADA  Takashi KITAMORI  Fumiyo KITAMORI  Kazunari SATO  Takuya DOI  Yumi WAKO  Junko SATO  Minoru TSUCHITANI 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2014,76(8):1161-1164

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Carbon source and trophic position of pelagic fish in coastal waters of south-eastern Izu Peninsula,Japan, identified by stable isotope analysis     

Noriyuki Takai  Noriyuki Hirose  Takuya Osawa  Kazuyuki Hagiwara  Takahito Kojima  Yuji Okazaki  Tomohiro Kuwae  Toru Taniuchi  Kiyoshi Yoshihara 《Fisheries Science》2007,73(3):593-608

ABSTRACT:   It is important to clarify trophic dynamics in marine ecosystems for management of the fishing ground. Organic carbon sources and trophic position of pelagic fishes in the coastal waters of the south-eastern Izu Peninsula, Japan, were examined on the basis of carbon and nitrogen stable isotope distributions. The δ¹³C of the fishes was mostly distributed from −19 to −16‰ for nektonic fishes (13 species of adults and immatures) and planktonic fishes (10 species of larvae and juveniles), close to the δ¹³C values of particulate organic matter and planktonic decapods. These δ¹³C signatures for the inhabitants of the water column were in contrast with the high δ¹³C values (mainly −16 to −13‰) for demersal fishes of Scorpaeniformes and benthic polychaetes collected in the surf zone. These results indicate that nektonic and planktonic fishes depend on phytoplankton for carbon supply. The δ¹⁵N signatures suggest that the trophic position ranged 3.1–4.5 for the nektonic fishes and 2.9–3.7 for the planktonic fishes, premised on trophic level 3 for larval Japanese anchovy Engraulis japonicus . Thus, planktivorous fishes should be mainly assigned to trophic levels 3 and 4 in this area.  相似文献   

The Silicon Concentration in Cat Urine and Its Relationship with Other Elements     

Fumihito TAKAHASHI  Mariko MOCHIZUKI  Takuya YOGO  Katsumi ISHIOKA  Norio YUMOTO  Toshinori SAKO  Fukiko UEDA  Masahiro TAGAWA  Hiroyuki TAZAKI 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2014,76(4):569-572

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Anti-inflammatory and Intestinal Barrier–protective Activities of Commensal Lactobacilli and Bifidobacteria in Thoroughbreds: Role of Probiotics in Diarrhea Prevention in Neonatal Thoroughbreds     

Soichi TANABE  Takuya SUZUKI  Yuichiro WASANO  Fumihiko NAKAJIMA  Hiroshi KAWASAKI  Tomonori TSUDA  Natsuko NAGAMINE  Takashi TSURUMACHI  Kiyoshi SUGAYA  Hiroaki AKITA  Misako TAKAGI  Kuniaki TAKAGI  Yoshinobu INOUE  Yo ASAI  Hidetoshi MORITA 《Journal of Equine Science》2014,25(2):37-43

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Movement of the fluvial form of masu salmon, <Emphasis Type="Italic">Oncorhynchus masou masou</Emphasis>, in a mountain stream in Kyushu,Japan     

Kazuhiro?SakataEmail author  Takuya?Kondou  Naohiko?Takeshita  Akinobu?Nakazono  Seir??Kimura 《Fisheries Science》2005,71(2):333-341

Using mark-recapture methods, the movements of the fluvial form of masu salmon (Oncorhynchus masou masou) in a mountain stream on the island of Kyushu, Japan, were studied. Most (78%) of the masu salmon were recaptured in the pool in which they had been originally caught and tagged. Of those that moved between pools, the proportion of individuals that moved during the breeding period was not significantly higher than the proportion that moved during the non-breeding period. However, during the breeding period, a higher proportion of larger salmon moved than did smaller fish. The proportion of mobile large males during breeding period was higher than that for small males. Also, it was found that a few individuals showed long-range movement in the autumn. As a long-term movement, 78 individual fish (65%) that were recaptured more than three times showed high sedentary tendencies. Sixteen individual mobile fish (13%) moved and returned to the original pool. Fluvial form of masu salmon in Kyushu show a high sedentary nature; however, large mature males seem to actively move in search of female during breeding period.  相似文献   

Altitudinal differences in bark stripping by sika deer in the subalpine coniferous forest of Mt. Fuji     

Toru Takeuchi  Takuya KobayashiMakoto Nashimoto 《Forest Ecology and Management》2011,261(11):2089-2095

Deer expansion is a growing concern for forest ecosystem management. In Japan, upward expansion to subalpine and alpine areas has reached alarming proportions in recent years. We examined bark stripping by sika deer along an altitudinal gradient in the subalpine coniferous forest at three altitude ranges (1800-2000 m, 2000-2200 m, and 2200-2400 m) on the southern slope of Mt. Fuji. We tested differences in densities and diameter at breast height (DBH) of trees and those with bark-stripped stems of all tree species among the three altitude ranges. Then, we compared the relative densities of deer, based on pellet counts, to determine the impact of deer in relation to deer use and forest stand patterns across the altitudinal range studied. The results of the study show that differences in bark stripping by sika deer depended largely on the elevation and the species. Larger stems were sparsely distributed in the lowest elevation zone between 1800 and 2000 m. The relative density of deer was highest in the areas exhibiting high bark-stripping intensity on small regenerating trees of the dominant coniferous species, Abies veitchii, and on broadleaf species. In the highest elevation zone between 2200 and 2400 m, smaller stems were densely distributed, and the relative deer density was lowest where the bark-stripping intensity on small stems was lower for all three species studied. The damage to subalpine tree stems corresponded to the availability of palatable tree species with a small diameter, as reflected by the successional stage along the elevational gradient of subalpine forest on Mt. Fuji. These results suggest that the continuous impact of bark stripping on the dominant tree species might cause severe changes in forest succession.  相似文献   

Fog and Precipitation Chemistry at Mt. Rokko in Kobe, April 1997-March 1998     

Masahide Aikawa  Takatoshi Hiraki  Mitsuru Shoga  Motonori Tamaki 《Water, air, and soil pollution》2001,130(1-4):1517-1522

Fog water and precipitation were collected and analyzed to study fog and precipitation chemistry. The research was carried out through one year from April 1997 to March 1998 at Mt. Rokko in Kobe. Higher fog occurrence and larger volume of fog water were observed in summer, corresponding to the trend of seasonal variation in precipitation amount. The annual mean pH value of fog water (3.80) was lower by ca. one pH unit than that of precipitation (4.74). The concentration of chemical species in fog water was ca. 7 times that in precipitation. The highest anion and cation concentrations were SO₄ ^2? and NH₄ ⁺ in fog water and Cl^? and Na⁺ in precipitation, although the Cl^?/Na⁺ equivalent ratio in both fog water and precipitation was almost the same value as that in sea water. It is considered that in the longest fog event, NH₄ ⁺ and nss-SO₄ ^2? in fog water mainly scavenged as (NH₄)₂SO₄, mainly derived from (NH₄)₂SO₄ (aerosol) in the atmosphere, NH₃ was scavenged at the growing stage, and SO₂ was also scavenged after the mature stage. NO₃ ^? in this fog event was mainly absorbed as HNO₃.  相似文献   

Control mechanism of the circadian clock for timing of cell division in vivo     

Matsuo T  Yamaguchi S  Mitsui S  Emi A  Shimoda F  Okamura H 《Science (New York, N.Y.)》2003,302(5643):255-259

Cell division in many mammalian tissues is associated with specific times of day, but just how the circadian clock controls this timing has not been clear. Here, we show in the regenerating liver (of mice) that the circadian clock controls the expression of cell cycle-related genes that in turn modulate the expression of active Cyclin B1-Cdc2 kinase, a key regulator of mitosis. Among these genes, expression of wee1 was directly regulated by the molecular components of the circadian clockwork. In contrast, the circadian clockwork oscillated independently of the cell cycle in single cells. Thus, the intracellular circadian clockwork can control the cell-division cycle directly and unidirectionally in proliferating cells.  相似文献   

Promotion of host plant growth and infection of roots with arbuscular mycorrhizal fungus Gigaspora margarita by the application of peat     

Nan MA  Kazuhira YOKOYAMA  Takuya MARUMOTO 《Soil Science and Plant Nutrition》2006,52(2):162-167

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