Nematicidal activity of grammicin produced by Xylaria grammica KCTC 13121BP against Meloidogyne incognita          下载免费PDF全文

Nan Hee Yu  Won Jae Chi  Chang‐Hwan Bae  Joo Hong Yeo  Ae Ran Park  Jae‐Seon Hur  Hae Woong Park  Ji‐Yeon Park  Jong‐Hwan Park  Sung Ki Lee  Jin‐Cheol Kim 《Pest management science》2018,74(2):384-391

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The intelligent data management system for toxicogenomics     

Lee WS  Lee GJ  Lee GJ  Yeo CD  Kang JS  Kim YH  Kim SJ  Kim JS  Hwang SY  Park JS  Hwang JW  Kang KS  Lee YS  Jeon KS  Um CH  Hong SI  Kim YS 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2004,66(11):1335-1338

Toxicogenomics is now emerging as one of the most important genomic application because the toxicity test based on gene expression profiles is expected to be more precise and efficient than current histopathological approaches in a pre-clinical phase. One of the challenging issues in toxicogenomics is the construction of intelligent database management system which can deal with heterogeneous and complex data from many different experimental and information sources. TEST(Toxicogenomics for Efficient Safety Test) database is especially focused on the connectivity of heterogeneous data and the intelligent query system which enable users to obtain relevant useful information from the complex data sets. The database deals with four kinds of information; compound, histopathology, gene expression, and annotation information. Currently, TEST database maintains toxicogenomics information for 16 compounds, 45 microarrays, 190 animal experiments, and customized 4.8 K rat clone set. Our presented system is expected to be a good information source for studying of toxicology mechanism in the genome-wide level and can also be applied to the designing toxicity test chip.  相似文献   

Effects of aluminum on the reduction of neural stem cells,proliferating cells,and differentiating neuroblasts in the dentate gyrus of D-galactose-treated mice via increasing oxidative stress     

Sung Min Nam  Jong Whi Kim  Dae Young Yoo  Woosuk Kim  Hyo Young Jung  Jung Hoon Choi  In Koo Hwang  Je Kyung Seong  Yeo Sung Yoon 《Journal of veterinary science (Suw?n-si, Korea)》2016,17(2):127-136

Aluminum (Al) accumulation increases with aging, and long-term exposure to Al is regarded as a risk factor for Alzheimer''s disease. In this study, we investigated the effects of Al and/or D-galactose on neural stem cells, proliferating cells, differentiating neuroblasts, and mature neurons in the hippocampal dentate gyrus. AlCl₃ (40 mg/kg/day) was intraperitoneally administered to C57BL/6J mice for 4 weeks. In addition, vehicle (physiological saline) or D-galactose (100 mg/kg) was subcutaneously injected to these mice immediately after AlCl₃ treatment. Neural stem cells, proliferating cells, differentiating neuroblasts, and mature neurons were detected using the relevant marker for each cell type, including nestin, Ki67, doublecortin, and NeuN, respectively, via immunohistochemistry. Subchronic (4 weeks) exposure to Al in mice reduced neural stem cells, proliferating cells, and differentiating neuroblasts without causing any changes to mature neurons. This Al-induced reduction effect was exacerbated in D-galactose-treated mice compared to vehicle-treated adult mice. Moreover, exposure to Al enhanced lipid peroxidation in the hippocampus and expression of antioxidants such as Cu, Zn- and Mn-superoxide dismutase in D-galactose-treated mice. These results suggest that Al accelerates the reduction of neural stem cells, proliferating cells, and differentiating neuroblasts in D-galactose-treated mice via oxidative stress, without inducing loss in mature neurons.  相似文献   

Breaking the speed limits of phase-change memory     

Loke D  Lee TH  Wang WJ  Shi LP  Zhao R  Yeo YC  Chong TC  Elliott SR 《Science (New York, N.Y.)》2012,336(6088):1566-1569

Phase-change random-access memory (PCRAM) is one of the leading candidates for next-generation data-storage devices, but the trade-off between crystallization (writing) speed and amorphous-phase stability (data retention) presents a key challenge. We control the crystallization kinetics of a phase-change material by applying a constant low voltage via prestructural ordering (incubation) effects. A crystallization speed of 500 picoseconds was achieved, as well as high-speed reversible switching using 500-picosecond pulses. Ab initio molecular dynamics simulations reveal the phase-change kinetics in PCRAM devices and the structural origin of the incubation-assisted increase in crystallization speed. This paves the way for achieving a broadly applicable memory device, capable of nonvolatile operations beyond gigahertz data-transfer rates.  相似文献   

Polymelia with two extra forelimbs at the right scapular region in a male Korean native calf.     

C Kim  S Yeo  G Cho  J Lee  M Choi  C Won  J Kim  S Lee 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2001,63(10):1161-1164

In a male Korean native calf 14 days of age, polymelia (notomelia) was observed macroscopically and radiographically. External features included two normal forelimbs, two normal hindlimbs and two undeveloped extra forelimbs. The extra forelimbs were attached to the caudal regions of the right scapula and devoid of muscular tissues. In the extra forelimbs, a scapula-like bone formed a joint with the incompletely duplicated humerus. The humerus fused with the incompletely duplicated radius. The ulna, carpal bones, metacarpal bones and phalanges were completely duplicated. But one set of the duplicated carpal bones consisted of five bones: radial, accessory, fourth carpal, fused second and third carpal, and fused ulnar and intermediate carpal bones. The hoof and the rudimentary hoof of accessory digit were duplicated.  相似文献   

N-acetylserotonin increases cell proliferation and differentiating neuroblasts with tertiary dendrites through upregulation of brain-derived neurotrophic factor in the mouse dentate gyrus     

Yoo DY  Nam SM  Kim W  Lee CH  Won MH  Hwang IK  Yoon YS 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2011,73(11):1411-1416

In this study, we investigated the effects of N-acetylserotonin (NAS) on cell proliferation and neuroblast differentiation in the mouse dentate gyrus using anti-Ki67 and anti-doublecortin (DCX) antibodies. Ki67 is expressed in the nucleus or on the surface of chromosomes during all of the active phases of the cell cycle, and DCX is expressed in neuronal precursor cells as well as in immature neurons. At 17 weeks of age, 20 mg/kg of NAS or the same volume of vehicle was intraperitoneally administered once a day for 3 weeks. The animals were sacrificed 2 hr after the last vehicle or NAS treatment. NAS treatment significantly increased the number of Ki67-positive nuclei and DCX-immunoreactive neuroblasts with well-developed dendrites (tertiary dendrites) compared to the vehicle-treated group. However, the number of DCX-immunoreactive neuroblasts without tertiary dendrites was not changed. The administration of NAS also significantly increased the protein levels of brain-derived neurotrophic factor (BDNF) in the dentate gyrus. This result suggests that NAS significantly promotes cell proliferation and the number of differentiating neuroblasts with tertiary dendrites through an increase in BDNF levels in the mouse dentate gyrus.  相似文献   

Calorimetric measurement of the energy difference between two solid surface phases     

Yeo YY  Wartnaby CE  King DA 《Science (New York, N.Y.)》1995,268(5218):1731-1732

A recently designed single-crystal surface calorimeter has been deployed to measure the energy difference between two solid surface structures. The clean Pt{100} surface is reconstructed to a stable phase in which the surface layer of platinum atoms has a quasi-hexagonal structure. By comparison of the heats of adsorption of CO and of C(2)H(4) on this stable Pt{100}-hex phase with those on a metastable Pt{100}-(1x1) surface, the energy difference between the two clean phases was measured as 20 +/- 3 and 25 +/- 3 kilojoules per mole of surface platinum atoms.  相似文献   

The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase     

Gerken T  Girard CA  Tung YC  Webby CJ  Saudek V  Hewitson KS  Yeo GS  McDonough MA  Cunliffe S  McNeill LA  Galvanovskis J  Rorsman P  Robins P  Prieur X  Coll AP  Ma M  Jovanovic Z  Farooqi IS  Sedgwick B  Barroso I  Lindahl T  Ponting CP  Ashcroft FM  O'Rahilly S  Schofield CJ 《Science (New York, N.Y.)》2007,318(5855):1469-1472

Variants in the FTO (fat mass and obesity associated) gene are associated with increased body mass index in humans. Here, we show by bioinformatics analysis that FTO shares sequence motifs with Fe(II)- and 2-oxoglutarate-dependent oxygenases. We find that recombinant murine Fto catalyzes the Fe(II)- and 2OG-dependent demethylation of 3-methylthymine in single-stranded DNA, with concomitant production of succinate, formaldehyde, and carbon dioxide. Consistent with a potential role in nucleic acid demethylation, Fto localizes to the nucleus in transfected cells. Studies of wild-type mice indicate that Fto messenger RNA (mRNA) is most abundant in the brain, particularly in hypothalamic nuclei governing energy balance, and that Fto mRNA levels in the arcuate nucleus are regulated by feeding and fasting. Studies can now be directed toward determining the physiologically relevant FTO substrate and how nucleic acid methylation status is linked to increased fat mass.  相似文献   

Positive Effects of Astaxanthin on Lipid Profiles and Oxidative Stress in Overweight Subjects     

Choi HD  Youn YK  Shin WG 《Plant foods for human nutrition (Dordrecht, Netherlands)》2011,66(4):363-369

Astaxanthin, a carotenoid, has antioxidant activity as well as many positive effects, such as anticancer and anti-inflammatory effects. We performed a randomized, double-blind, placebo-controlled study to investigate the effects of astaxanthin on lipid profiles and oxidative stress in overweight and obese adults in Korea. In total, 27 subjects with body mass index >25.0 kg/m² were enrolled and randomly assigned into two groups administered astaxanthin or placebo capsules for 12 weeks. Total cholesterol, triglycerides, high density lipoprotein (HDL) cholesterol, low density lipoprotein (LDL) cholesterol, apolipoprotein A1 (ApoA1), and apolipoprotein B (ApoB) were measured before and after intervention. Malondialdehyde (MDA), isoprostane (ISP), superoxide dismutase (SOD), and total antioxidant capacity (TAC), as oxidative stress biomarkers, were measured at baseline and at 4, 8, and 12 weeks after intervention. LDL cholesterol and ApoB were significantly lower after treatment with astaxanthin, compared with the start of administration, whereas none of the lipid profiles was changed in the placebo group. At the baseline, all four biomarkers were not significantly different between the two groups. Compared with the placebo group, MDA and ISP were significantly lower, but TAC was significantly higher in the astaxanthin group at 12 weeks. These results suggest that supplementary astaxanthin has positive effects by improving the LDL cholesterol, ApoB, and oxidative stress biomarkers.  相似文献   

Improvement of hydrophilicity of polylactic acid (PLA) fabrics by means of a proteolytic enzyme from <Emphasis Type="Italic">Bacillus licheniformis</Emphasis>     

So Hee Lee  Sang Young Yeo 《Fibers and Polymers》2016,17(8):1154-1161

Polylactic acid (PLA) has received considerable attention as a biomass material for the textile industry. To use a PLA fabric in the textile industry, suitable postprocessing that can promote hydrophilicity of such fabrics is required. Here, hydrolytic action of a proteolytic enzyme (alcalase from Bacillus licheniformis) on PLA fibers was evaluated. In addition, the effects of an additive on the enzymatic hydrolysis were analyzed. The results revealed that the optimal enzymatic-hydrolysis conditions for this alcalase are pH 9.5, temperature 60 °C, enzyme concentration 50 % on weight of fabric (owf), and Lcysteine concentration of 3 mM. PLA fabrics were hydrolyzed effectively, however; there was no damage to these fabrics judging by tensile strength and surface observations. X-ray diffractometry identified a new peak (at 2θ=18.5 °), implying a morphological change caused by the treatment. Moreover, hydrophilic properties such as moisture regain and dyeing properties were enhanced by this proteolytic enzymatic hydrolysis. Therefore, according to this study, enzymatic hydrolysis is a suitable finishing method for improvement of hydrophilicity of PLA fabrics.  相似文献