Oncogenesis of the lens in transgenic mice   总被引：37，自引：0，他引：37  

K A Mahon  A B Chepelinsky  J S Khillan  P A Overbeek  J Piatigorsky  H Westphal 《Science (New York, N.Y.)》1987,235(4796):1622-1628

Neoplastic tumors of the ocular lens of vertebrates do not naturally occur. Transgenic mice carrying a hybrid gene comprising the murine alpha A-crystallin promoter (-366 to +46) fused to the coding sequence of the SV40 T antigens developed lens tumors, which obliterated the eye cavity and even invaded neighboring tissue, thus establishing that the lens is not refractive to oncogenesis. Large-T antigen was detected early in lens development; it elicited morphological changes and specifically interfered with differentiation of lens fiber cells. Both alpha- and beta-crystallins persisted in many of the lens tumor cells, while gamma-crystallin was selectively reduced. Accessibility, characteristic morphology, and defined protein markers make this transparent epithelial eye tissue a potentially useful system for testing tumorigenicity of oncogenes and for studying malignant transformation from its inception until death of the animal.  相似文献   

Mineralogy and petrology of comet 81P/Wild 2 nucleus samples     

Zolensky ME  Zega TJ  Yano H  Wirick S  Westphal AJ  Weisberg MK  Weber I  Warren JL  Velbel MA  Tsuchiyama A  Tsou P  Toppani A  Tomioka N  Tomeoka K  Teslich N  Taheri M  Susini J  Stroud R  Stephan T  Stadermann FJ  Snead CJ  Simon SB  Simionovici A  See TH  Robert F  Rietmeijer FJ  Rao W  Perronnet MC  Papanastassiou DA  Okudaira K  Ohsumi K  Ohnishi I  Nakamura-Messenger K  Nakamura T  Mostefaoui S  Mikouchi T  Meibom A  Matrajt G  Marcus MA  Leroux H  Lemelle L  Le L  Lanzirotti A  Langenhorst F  Krot AN  Keller LP  Kearsley AT 《Science (New York, N.Y.)》2006,314(5806):1735-1739

The bulk of the comet 81P/Wild 2 (hereafter Wild 2) samples returned to Earth by the Stardust spacecraft appear to be weakly constructed mixtures of nanometer-scale grains, with occasional much larger (over 1 micrometer) ferromagnesian silicates, Fe-Ni sulfides, Fe-Ni metal, and accessory phases. The very wide range of olivine and low-Ca pyroxene compositions in comet Wild 2 requires a wide range of formation conditions, probably reflecting very different formation locations in the protoplanetary disk. The restricted compositional ranges of Fe-Ni sulfides, the wide range for silicates, and the absence of hydrous phases indicate that comet Wild 2 experienced little or no aqueous alteration. Less abundant Wild 2 materials include a refractory particle, whose presence appears to require radial transport in the early protoplanetary disk.  相似文献   

Erratum to: Woody habitats promote pollinators and complexity of plant–pollinator interactions in homegardens located in rice terraces of the Philippine Cordilleras     

Schrader  Julian  Franzén  Markus  Sattler  Cornelia  Ferderer  Paul  Westphal  Catrin 《Paddy and Water Environment》2018,16(1):207-207

Paddy and Water Environment -  相似文献   

Effects of iodized salt on the histopathology of the gills and liver in Rhamdia quelen and Metynnis maculatus          下载免费PDF全文

Thayzi de Oliveira Zeni  André Luiz Vicente  Gisela Geraldine Castilho‐Westphal  Aline Horodesky  Roberto Montanhini Neto  Antonio Ostrensky 《Aquaculture Research》2017,48(5):2198-2208

Table salt has been used as a reference substance in toxicological studies on fish and as an antiparasitic agent in aquaculture. The objectives of this work were to evaluate the sensitivity of Rhamdia quelen and Metynnis maculatus to iodized salt and to assess the possible changes in the gills and liver resulting from subchronic exposure of fish to this compound. The iodized salt toxicity levels after 96 h of exposure were 11.4 and 10.8 g L^?1 for R. quelen and M. maculatus. None of the observed changes in the livers of the studied fish could be unequivocally correlated with salt exposure. In turn, it could not be entirely ruled out that the changes found in the gills, including epithelial lifting, oedema formation and vascular congestion, were caused by exposure of fish to salt.  相似文献