Clinical and in vitro efficacy of amoxicillin against bacteria associated with feline skin wounds and abscesses   总被引：1，自引：0，他引：1  

Roy J  Messier S  Labrecque O  Cox WR 《The Canadian veterinary journal. La revue veterinaire canadienne》2007,48(6):607-611

A clinical trial involving 122 cats with infected skin wounds or abscesses presented to 10 veterinary clinics was conducted to evaluate the efficacy of 2 oral amoxicillin drug products (a paste and a suspension). A 2nd objective of the study was to identify bacteria involved in such infections and verify their in vitro sensitivity to amoxicillin. Samples of wound exudate were harvested at the time of presentation and submitted for aerobic and anaerobic culture. The sensitivity to amoxicillin of isolates thought to be infecting agents was tested, using a standard minimum inhibitory concentration method. Pasteuralla multocida and obligate anaerobes of the genera Prevotella, Fusobacterium, and Porphyromonas were the most frequently isolated pathogens. Overall, their in vitro susceptibility to amoxicillin was very good. Both drug products were clinically efficacious with a global success rate of 95.1% for cats administered oral amoxicillin at 11-22 mg/kg bodyweight (mean 13.8 mg/kg bodyweight) twice daily for 7 to 10 days.  相似文献   

Pathology in the medical curriculum in the United Kingdom     

Reid WA 《Journal of veterinary medical education》2007,34(4):390-395

In the United Kingdom, the medical students of yesteryear undertook a detailed pathology course, often with its own major examinations. This contributed to the increasing overload of factual information that was common in medical curricula. Following General Medical Council reports on medical education, pathology is now more fully integrated into clinical work and into problem-based learning, albeit with greatly reduced contact time with pathologists. Teaching methods have shifted from didactic presentations, such as lectures, to more varied methods, with emphasis on self-access and interactivity. Technological advances have brought well-illustrated textbooks, computer-assisted learning programs, Web resources, and electronic communication. There has been a decline in the role of museum specimens, microscopy, and, partly following a worldwide trend and partly following adverse media publicity, the traditional autopsy. Assessment methods have evolved, with integration of pathology into wider examinations. The greater drive toward increasing funding through the Research Assessment Exercise has had an adverse effect on teaching throughout universities. Despite these setbacks, the importance of pathology as a clinical discipline will ensure its continued role in medical education.  相似文献   

Vesicular stomatitis New Jersey virus (VSNJV) infects keratinocytes and is restricted to lesion sites and local lymph nodes in the bovine, a natural host   总被引：1，自引：0，他引：1  

Scherer CF  O'Donnell V  Golde WT  Gregg D  Estes DM  Rodriguez LL 《Veterinary research》2007,38(3):375-390

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Immediate and delayed movement of resistant and susceptible adults of Tribolium castaneum (Herbst) (Coleoptera: Tenebrionidae) after short exposures to phosphine     

William R Morrison III  Daniel Brabec  Alexander Bruce  Frank H Arthur  Christos G Athanassiou 《Pest management science》2023,79(6):2066-2074

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Inhibitory checkpoint molecule mRNA expression in canine soft tissue sarcoma     

Valentina Beatriz Stevenson  Erwin Kristobal Gudenschwager-Basso  Shawna Klahn  Tanya LeRoith  William R. Huckle 《Veterinary and comparative oncology》2023,21(4):709-716

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Highly recurrent BRAF p.V595E mutation in canine papillary oral squamous cell carcinoma     

Santiago Peralta  Suzin M. Webb  William P. Katt  Jennifer K. Grenier  Gerald E. Duhamel 《Veterinary and comparative oncology》2023,21(1):138-144

Oral squamous cell carcinoma (OSCC) is the most common oral epithelial malignancy in dogs. It exhibits locally aggressive biological behaviour with the potential to metastasize, and a reported 1-year survival rate of 0% when left untreated. Expression studies suggest that aberrant MAPK signalling plays a key role in canine OSCC tumorigenesis, which is consistent with BRAF and HRAS MAPK-activating mutations reported in some tumours. Several morphological subtypes of canine OSCC have been described, with papillary, conventional, and basaloid as the most common patterns. We hypothesized that mutational differences may underlie these phenotypic variations. In this study, targeted Sanger sequencing and restriction fragment length polymorphism assays demonstrate that up to 85.7% of canine papillary OSCC (n = 14) harbour a BRAF p.V595E mutation. Assessment of neoplastic epithelial cell proliferation using Ki67 immunolabelling (n = 10) confirmed a relatively high proliferation activity, consistent with their known aggressive clinical behaviour. These findings underscore a consistent genetic feature of canine papillary OSCC and provide a basis for the development of novel diagnostic and targeted therapeutic approaches that can improve the quality of veterinary care.  相似文献   

Drivers of recent forest cover change in southern South America are linked to climate and CO2     

Ogunkoya  Ayodele  Kaplan  Jed  Whitlock  Cathy  Nanavati  William  Roberts  David W.  Poulter  Benjamin 《Landscape Ecology》2021,36(12):3591-3606

Landscape Ecology - Widespread changes in forest structure and distribution have been documented in northern Patagonia over the past century. We employed LPJ-GUESS, a dynamic global...  相似文献   

Identification of two glycerophosphodiester phosphodiesterase genes in maize leaf phosphorus remobilization     

Jingxin Wang  Wenbo Pan  Alexiy Nikiforov  William King  Wanting Hong  Weiwei Li  Yang Han  Jana Patton-Vogt  Jianbo Shen  Lingyun Cheng 《作物学报(英文版)》2021,(1):95-108

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Agriculture Green Development: a model for China and the world     

Jianbo SHEN  Qichao ZHU  Xiaoqiang JIAO  Hao YING  Hongliang WANG  Xin WEN  Wen XU  Tingyu LI  Wenfeng CONG  Xuejun LIU  Yong HOU  Zhenling CUI  Oene OENEMA  William J. DAVIES  Fusuo ZHANG 《农业科学与工程前沿(英文版)》2020,7(1):5-13

Realizing sustainable development has become a global priority. This holds, in particular, for agriculture. Recently, the United Nations launched the Sustainable Development Goals (SDGs), and the Nineteenth National People’s Congress has delivered a national strategy for sustainable development in China—realizing green development. The overall objective of Agriculture Green Development (AGD) is to coordinate “green” with “development” to realize the transformation of current agriculture with high resource consumption and high environmental costs into a green agriculture and countryside with high productivity, high resource use efficiency and low environmental impact. This is a formidable task, requiring joint efforts of government, farmers, industry, educators and researchers. The innovative concept for AGD will focus on reconstructing the whole crop-animal production and food production-consumption system, with the emphasis on high thresholds for environmental standards and food quality as well as enhanced human well-being. This paper addresses the significance, challenges, framework, pathways and potential solutions for realizing AGD in China, and highlights the potential changes that will lead to a more sustainable agriculture in the future. Proposals include interdisciplinary innovations, whole food chain improvement and regional solutions. The implementation of AGD in China will provide important implications for the countries in developmental transition, and contribute to global sustainable development.  相似文献   

Effect of Pheromone Blend Components,Sex Ratio,and Population Size on the Mating of Cadra cautella (Lepidoptera: Pyralidae)     

Abeysinghe Mudiyanselage Prabodha Sammani  Dissanayaka Mudiyanselage Saman Kumara Dissanayaka  Leanage Kanaka Wolly Wijayaratne  William Robert Morrison  III 《Journal of insect science (Online)》2020,20(6)

The almond moth Cadra cautella (Walker), a key pest of storage facilities, is difficult to manage using synthetic chemicals. Pheromone-based management methods remain a high priority due to advantages over conventional management practices, which typically use insecticides. Cadra cautella females release a blend of pheromone including (Z, E)-9,12-tetradecadienyl acetate (ZETA) and (Z)-9-tetradecadien-1-yl acetate (ZTA). The effect of these components on mating of C. cautella and how response varies with the population density and sex ratio remain unknown. In this study, the mating status of C. cautella was studied inside mating cages under different ratios of ZETA and ZTA diluted in hexane and at different population sizes either with equal or unequal sex ratio. The lowest percentage of mated females (highest mating disruption [MD] effects), corresponding to roughly 12.5%, was produced by a 5:1 and 3.3:1 ratio of ZETA:ZTA. Populations with equal sex ratio showed the lowest percentage of mated females, at 20% and 12.5% under lower and higher density, respectively. The next lowest percentage of mated females was produced when the sex ratio was set to 1: 2 and 2:1 male:female, with just 25% and 22.5% of moths mated, respectively. This study shows that mating status of C. cautella is influenced by ZETA:ZTA ratio, sex ratio, and population size. This current knowledge would have useful implications for mating disruption programs.  相似文献