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121.
AIM: To explore the role of poly-(ADP-ribose)polymerase (PARP) in the cultured endothelial cell apoptosis induced by angiotensin Ⅱ.METHODS: The cultured endothelial cells were treated with angiotensin Ⅱ at concentration of 1 μmol/L.The apoptosis of endothelial cells was assessed by TUNEL.Meanwhile,the activity of PARP and the content of nitric oxide (NO) were also measured.RESULTS: Angiotensin Ⅱ induced apoptosis in endothelial cells in a time-dependent manner.The content of NO begun to increase at 6 h (P<0.05),and peaked at 24 h.The activity of PARP also increased at 6 h (P<0.05),peaked at 12 h,and was lower than that in the control at 48 h (P<0.05).CONCLUSION: The cytotoxicity of NO has a relevant role in apoptosis of endothelial cells induced by angiotensin Ⅱ,and can increases the activity of PARP. 相似文献
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Two isochinoline alkaloids, glaucine and oxoglaucine were investigated for their suggested anti-inflammatory influence concerning nitric oxide and cytokine production. Mouse peritoneal macrophages were stimulated with different Toll-like receptor (TLR) ligands such as LPS for TLR4, zymosan for TLR2 and CpG for TLR9. The alkaloids inhibited TNF-α and IL-6 production induced by these ligands. In regard to IL-12 suppressive effect was registered in the case of CpG stimulation. Glaucine succeeded to enhance LPS and zymosan-induced IL-10 production. The reduction of pro-inflammatory cytokines and increase of anti-inflammatory IL-10 are indicative for their use in different acute and chronic inflammatory diseases. 相似文献
126.
Abstract. Field margins are a valuable resource in the farmed landscape, providing numerous environmental benefits. We present a preliminary analysis of the carbon mitigation potential of different field margin management options for Great Britain, calculated using data from long-term experiments and literature estimates. The carbon sequestration potential of the individual options investigated here varies from 0.1 to 2.4% of 1990 UK CO2 -C emissions, or 0.7–20% of the Quantified Emission Limitation Reduction Commitment (QELRC). The scenarios investigated covered three possible margin widths and options for the management of margins at each width (viz. grass strips, hedgerows and tree strips). Scenarios involving margin widths of 2, 6 or 20 m would require approximately 2.3, 6.7 or 21.3% of the total arable area of Great Britain, respectively. Scenarios including tree strips offered the greatest potential for carbon sequestration, since large amounts would be accumulated in above-ground biomass in addition to that in soil. We also accounted for the possible impacts of changed land management on trace gas fluxes, which indicated that any scenario involving a change from arable to grass strip, hedgerow or tree strip would significantly reduce N2 O emissions, and thus further increase carbon mitigation potential. There would also be considerable potential for including the scenarios investigated here with other strategies for the alternative management of UK arable land to identify optimal combinations. We assumed that it would take 50–100 years for soil carbon to reach a new equilibrium following a land use change. More detailed analyses need to be conducted to include environmental benefits, socioeconomic factors and the full system carbon balance. 相似文献
127.
氧化石墨烯(Graphene Oxide,GO)拥有较大的比表面积和较高的稳定性,可用来吸附水体中的多种污染物,其潜在功能稳定性具有规模化应用前景。考虑到GO在高级氧化体系中结构和形貌会发生改变,探究了经UV/H2O2和UV/过硫酸盐(Persulfate, PS)产生强氧化性自由基的体系处理后所得GOs对亚甲基蓝(Methylene Blue, MB)的吸附性能。氧化性自由基体系光源为300 W中压汞灯,30 mL GO储备液(1 mg/mL)在2种氧化体系下反应1、2、4 h后制得GOs。实验考察了不同反应条件对GOs吸附动力学的影响,傅里叶变换红外光谱(FTIR)研究了GOs氧化前后表面官能团的变化。结果显示,经UV/H2O2, UV/PS氧化1 h后,GOs表面的含氧官能团数量开始明显减少;吸附动力学过程更符合准二级动力学模型(R2>0.999);吸附热力学过程更符合Langmuir模型,MB饱和吸附量(经UV/H2O2和UV/PS氧化1、2、4 h后分别记G1-1, G1-2, G1-3, G2-1, G2-2, G2-3)依次为580.26, 591.80, 598.63, 521.77, 554.91, 568.00 mg/g。研究表明,GO可以快速吸附较大浓度范围内的MB,且对低浓度染料表现出更好的去除效果;GO对MB的吸附量随着pH值的增加逐渐增大,且在碱性条件下的增加得更明显;经氧化处理后,GOs的吸附性能随着氧化时间的增长,性能减弱,尤其在UV/PS体系中更为显著。 相似文献
128.
通过金属钼粉与H2O2反应制得过氧钼酸溶胶液后,减压蒸馏除去过氧钼酸溶液中的溶剂水和过量的H2O2,再加入无水乙醇作为溶剂,采用浸泽一提拉法成功地在玻璃表面制备了平整均匀的无定形MoO3薄膜.并通过热分析和X射线衍射分析等对MoO3薄膜的制备机理进行了探讨. 相似文献
129.
Paul Joseph Dimitri Bakirtzis Audrey Vieille 《Wood material science & engineering》2015,10(1):130-144
AbstractSaving lives and properties are of primary importance in fire disasters. Unfortunately, current fire detectors are not fast enough to allow the detection of many fires, especially, at the smouldering stages. Some preliminary studies on laevoglucosan (LG), as an important product from cellulose degradation, have shown interesting properties and could be detected by devices classified as “electronic noses” (e-noses). In the present work, the mechanisms of pyrolysis of some ligno-cellulosic materials were investigated using thermo-gravimetric analysis, differential scanning calorimetry, Fourier transform infrared spectroscopy and by a tube furnace with a view to determining the major degradation products from wood, white paper and cardboard samples. Additionally, an odour sensor, made of tin oxide semiconductor thin film, was employed to evaluate its sensitivity in detecting LG. It was found that LG can be readily found among the thermal degradation products of cellulosic materials in question, and that the metal oxide sensor employed was sufficiently sensitive in detecting its presence. Therefore, the work opens up the potential of using such a sensor as an “e-nose” for the early detection of fires stemming from forest product fire loads in storage places and in other enclosures. 相似文献
130.
《Veterinary immunology and immunopathology》2015,163(1-2):1-7
Cytauxzoonosis is a hemoprotozoal disease of cats and wild felids in the South and Southeastern United States caused by Cytauxzoon felis. Although the causative agent has been recognized since the seventies, no study has examined the local immune response in affected organs, such as the lung, and compared them to the lungs of uninfected domestic cats. Previous studies have suggested that the histopathologic findings in the lungs of C. felis-infected cats are caused by the release of pro-inflammatory mediators, such as cytokines and increased production of inducible nitric oxide synthase (iNOS), by the infected macrophages. Our laboratory had previously found an upregulation of the adhesion molecule CD18, which can stimulate the release of these pro-inflammatory mediators. The objective of this study was to characterize local pulmonary immune responses in cats naturally infected with C. felis. Immunohistochemistry was performed to detect tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-6, iNOS, and major histocompatibility complex (MHC) II in 19 lungs from affected cats that died between 2005 and 2013. Results showed increased expression of all of these molecules when compared to lungs from uninfected, healthy cats. Furthermore, MHC II is expressed in the endothelium of C. felis naturally infected cats. These results support that there is a marked, local, pro-inflammatory immune response that can contribute to the pathogenesis of cytauxzoonosis in the lungs. 相似文献