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本文报道了喹乙醇多剂量给药时对AA鸡的生化毒性和病理学研究。42只AA鸡随机分成7组,按喹乙醇500mg/kg饲料连续饲喂7d,测定生化指标并作病理学检查。结果表明,血浆醛固酮显著下降、血清Na+下降而血清K+显著上升、Na+/K+比显著下降、肝微粒体蛋白含量呈起伏变化、细胞色素P-450含量减少、血浆肌酐和血清尿酸均显著上升(P<0.05或P<0.01),肝、肾和肾上腺组织结构均受损害。本研究证实,中毒剂量的喹乙醇对鸡的肾上腺皮质功能、肝微粒体酶系统及肾功能均产生抑制性损害。病理学变化与生化指标的变化相一致。 相似文献
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AIM: To study the effect of olaquindox on phospholipase A2 (PLA2) activity and phospholipid metabolism in biomembrane.METHODS: 150 healthy avin chicks were divided into normal control group and olquindox group.The two groups were fed with same feedstuff without olaquindox.The animals in olquindox group were fed with olquindox at dose of 15mg/kg body weight everyday.The experimental period lasted six weeks.Every week 6 vein blood samples were collected randomly from every group for preparing erythrocyte membrane (ECM) and hepatic mitochondria membrane (MiM).RESULTS: PLA2 activities of ECM and MiM in olquindox group were significant higher than those in control group from 3 to 6 weeks of experiment (P<0.05,P<0.01).The level of major membrane phospholipids in olquindox group was lower than that in control group (P<0.05,P<0.01).CONCLUSION: Olaquindox affects PLA2 activity and major phospholipid concentration in ECM and MiM,indicating that olaquindox may induce biomembrane injury. 相似文献
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喹乙醇人工抗原的合成与鉴定 总被引:1,自引:1,他引:0
采用琥珀酸酐法合成喹乙醇半琥珀酸酯(OLA-HS),以质谱法对其进行鉴定;活化酯法合成全抗原OLA-BSA、OLA-OVA,以紫外(UV)和凝胶电泳(SDS-PAGE)鉴定之;用OLA-BSA免疫BALB/c小鼠,间接ELISA测定多抗血清效价,阻断ELISA鉴定其敏感性、特异性。紫外扫描测得OLA-BSA、OLA-OVA中OLA-HS和BSA、OVA的分子结合比分别为17.1∶1和12.4∶1;3号小鼠抗血清的效价最高,对OLA的IC50为58.923 ng/mL,与卡巴氧的交叉反应率为1.841%,与其他药物无交叉反应。通过系列ELISA鉴定,获得高价、敏感、特异的多克隆抗体(pAb),为OLA残留免疫学检测方法的建立奠定基础。 相似文献
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为了评价喹乙醇对家禽的致突变性,试验将鸡分为试验组(150 mg.kg-1.diet喹乙醇)、阴性对照组(灭菌生理盐水)、阳性对照组(环磷酰胺),连续染毒15 d,间隔5 d采样一次,检测骨髓细胞染色体畸变率和微核率。结果表明,试验组骨髓细胞染色体畸变率和微核率与阴性对照组比较差异显著(P0.01),且呈时间-效应关系。表明喹乙醇是鸡骨髓细胞突变的诱变剂。 相似文献
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喹乙醇在鲫体内消除规律的研究 总被引:1,自引:0,他引:1
报道了鲫单剂量口灌50mg/kg喹乙醇在血浆、肌肉和肝胰脏中消除规律的研究。用乙腈-乙酸乙酯(1/1:V/V)提取组织中的喹乙醇,血浆中喹乙醇用3%的三氯乙酸沉淀蛋白,乙酸乙酯和磷酸盐缓冲液提取喹乙醇代谢物3-甲基喹嗯啉-2-羧酸,超高效液相色谱串联质谱法测定血浆及组织中喹乙醇及其代谢物的浓度。鲫单剂量口灌喹乙醇50mg/kg后,在血浆、肌肉和肝胰脏中的喹乙醇随着时间的延长呈现不同浓度的降解趋势。喹乙醇在血浆中的消除需要4d,在肌肉和肝胰脏中需要7d;喹乙醇的代谢物3-甲基喹嗯啉-2-羧酸在鲫体内消除比较缓慢,肌肉中需要15d,肝胰脏中需要20d。 相似文献