Pharmacokinetics of articaine hydrochloride and its metabolite articainic acid after subcutaneous administration in red deer (Cervus elaphus)     

D Venkatachalam  JP Chambers  K Kongara  P Singh 《New Zealand veterinary journal》2018,66(1):16-20

AIM: To develop and validate a simple and sensitive method using liquid chromatography-mass spectrometry (LC-MS) for quantification of articaine, and its major metabolite articainic acid, in plasma of red deer (Cervus elaphus), and to investigate the pharmacokinetics of articaine hydrochloride and articainic acid in red deer following S/C administration of articaine hydrochloride as a complete ring block around the antler pedicle.

METHODS: The LC-MS method was validated by determining linearity, sensitivity, recovery, carry-over and repeatability. Articaine hydrochloride (40?mg/mL) was administered S/C to six healthy male red deer, at a dose of 1?mL/cm of pedicle circumference, as a complete ring block around the base of each antler. Blood samples were collected at various times over the following 12 hours. Concentrations in plasma of articaine and articainic acid were quantified using the validated LC-MS method. Pharmacokinetic parameters of articaine and articainic acid were estimated using non-compartmental analysis.

RESULTS: Calibration curves were linear for both articaine and articainic acid. The limits of quantifications for articaine and articainic acid were 5 and 10?ng/mL, respectively. Extraction recoveries were >72% for articaine and >68% for articainic acid. After S/C administration as a ring block around the base of each antler, mean maximum concentrations in plasma (C_max) of articaine were 1,013.9 (SD 510.1) ng/mL, detected at 0.17 (SD 0.00) hours, and the C_max for articainic acid was 762.6 (SD 95.4) ng/mL at 0.50 (SD 0.00) hours. The elimination half-lives of articaine hydrochloride and articainic acid were 1.12 (SD 0.17) and 0.90 (SD 0.07) hours, respectively.

CONCLUSIONS AND CLINICAL RELEVANCE: The LC-MS method used for the quantification of articaine and its metabolite articainic acid in the plasma of red deer was simple, accurate and sensitive. Articaine hydrochloride was rapidly absorbed, hydrolysed to its inactive metabolite articainic acid, and eliminated following S/C administration as a ring block in red deer. These favourable pharmacokinetic properties suggest that articaine hydrochloride should be tested for efficacy as a local anaesthetic in red deer for removal of velvet antlers. Further studies to evaluate the safety and residues of articaine hydrochloride and articainic acid are required before articaine can be recommended for use as a local anaesthetic for this purpose.  相似文献   

Gas and short‐chain fatty acid production from feeds commonly fed to red deer (Cervus elaphus L.) and incubated with rumen inoculum from red deer and sheep          下载免费PDF全文

Andrej Lavrenčič  Darko Veternik 《Journal of animal physiology and animal nutrition》2018,102(5):1146-1153

Efficient red deer supplementary feeding depends on estimations of the nutritive value of offered feeds, frequently estimated with the use of equations derived from domestic ruminants. The aim of this study was to compare the 24‐hour in vitro true dry matter degradability (ivTD₂₄), in vitro gas production (GP) kinetic parameters, GP in 24 hr of incubation (GAS₂₄) and short‐chain fatty acid (SCFA) and microbial biomass (MBS) produced after 24‐hour incubation of feeds in inoculum prepared from sheep and red deer rumen fluid. Eleven feeds, frequently consumed by red deer in Slovenia, which occur either naturally (two fresh grasses, chestnut fruits and common and sessile oak acorns) or are fed as winter supplemental feeds (two grass hays, two grass silages, apple pomace, fresh sugar beetroot), were investigated. The in vitro GP kinetic parameters, GAS₂₄ and ivTD₂₄, did not differ between animal species. Amounts of SCFAs were greater (p < 0.05) when feeds were incubated in sheep inoculum, while molar proportions of acetic and propionic acids did not differ. Molar proportions of butyric acid produced during incubation of high fibre feeds did not differ between animal species, but were higher (p < 0.05) when feeds high in starch or sugar were incubated in red deer inoculum. Greater production of SCFA by sheep rumen microbes suggests better coverage of host animal with energy precursors, while greater production of MBS by red deer rumen microbes suggests better coverage of host animal with protein. Results also suggest that rumens of sheep and red deer are inhabited by different microbial communities, which did not affect the extent of in vitro GP and degradation of feeds used in the present experiment. However, the possibility exists that the divergent nutrient use could be a consequence of different priming by different feeds of the donor animal diets.  相似文献   

新时期红色文化在江西高校的传承与发展     

刘利娟  李霜 《现代农业研究》2020,(2):56-58

红色文化在我国当代文化体系建设中占据着重要的地位，积极地传承和发展红色文化，丰富 其内涵，对建立民族文化自信有重要的价值。当代大学生作为祖国的希望，是实现中国梦的主力军， 而红色文化教育是进一步提升我国文化软实力、建设文化强国的重要途径。本文从传播发展红色文 化的必要性和重要性入手，就新时期红色文化在江西高校中的传承和发展现状、存在问题、发展对策 做分析，总结出高校红色文化教育可以将本土红色文化旅游基地作为教育实践基地，利用社会实践让 学生走进具有浓郁乡村特色的红色文化基地，亲身其感受、体验红色文化。旨在  相似文献   

渤海湾外来浮游植物物种及其入侵途径分析     

蒲阿敏  张贝贝  贾鹏  王庆改 《农业环境科学学报》2020,37(4):477-483

为了预防外来浮游植物入侵引发的渤海湾赤潮灾害，基于近20年建设项目环境影响评价报告书和相关文献资料的研究成果，收集整理了渤海湾海域已发现的外来浮游植物物种及具体物种信息，分析了物种入侵的主要途径及可能产生的赤潮灾害影响。结果表明：渤海湾海域共发现17种外来浮游植物，其中，甲藻门最多，有10种；硅藻门次之，有5种；金藻门和黄藻门最少，各有1种。研究表明：渤海湾外来浮游植物中，除中华盒形藻外，其余16种均属于赤潮生物，这些物种主要通过压载水引入、传播的方式进入渤海湾海域，应加强港口监控和管理，以防赤潮灾害。  相似文献   

红叶甜菜-花生和油葵-花生轮作修复土壤Cd的能力   总被引：1，自引：0，他引：1  

涂鹏飞  谭可夫  陈璘涵  杨洋  袁婧  陈奕暄  杨耀东  曾清如 《农业环境科学学报》2020,37(4):609-614

利用生物量高的经济作物进行轮作，可在加快修复土壤Cd污染进程的同时获得一定的经济效益。本研究在长沙市望城区群力村Cd轻度污染的土壤进行冬季种植红叶甜菜、夏季复种植花生和春末种植油葵、夏季复种植花生的轮作模式试验，探究重金属修复潜力。结果表明：花生、油葵、红叶甜菜各部位Cd富集系数除花生果实外均大于1，对Cd均有较强的富集能力。油葵-花生、红叶甜菜-花生轮作模式种植一季可提取土壤Cd总量分别为40.80 g·hm^-2和53.34 g·hm^-2。红叶甜菜-花生轮作将土壤Cd含量由0.316 mg·kg^-1降至0.286 mg·kg^-1，油葵-花生轮作一季将土壤Cd含量由0.316 mg·kg^-1降至0.283 mg·kg^-1。研究表明，红叶甜菜-花生、油葵-花生轮作模式均对土壤重金属Cd有较好的修复潜力。  相似文献   

黄麻土工布覆盖对花岗岩红壤表土坡面侵蚀特性的影响     

董博文  孙耀清  梁祥鹏  胡强 《水土保持通报》2020,40(4):17-24,31

[目的]探究黄麻土工布覆盖条件下花岗岩红壤表土坡面侵蚀特性,为花岗岩红壤区坡面土壤侵蚀防治提供科学依据。[方法]通过室内模拟降雨试验,在2个坡度(5°和15°坡度)、3种密度(无覆盖,6 cm×6 cm及3 cm×3 cm网格)的黄麻土工布覆盖条件下,研究极端降雨条件下(90 mm/h)花岗岩红壤表土的坡面侵蚀特性,并观测径流系数、土壤侵蚀速率、泥沙颗粒变化规律及富集率等指标。[结果]坡面径流随降雨历时增加而增加,土壤侵蚀速率则相反,表明侵蚀过程是一个分离受限的过程。和对照组相比,黄麻土工布覆盖在不同试验条件下都具有明显的减流减沙作用。另外,由侵蚀泥沙的粒径分选规律可知,坡面土壤中的黏粒和粉粒大小的颗粒倾向于被优先选择性搬运,其结果致使坡面石英粗颗粒富集,在缓坡(5°)与高密度黄麻土工布覆盖条件下(3 cm×3 cm网格)尤为突出。坡面石英粗颗粒随降雨历时增加不断富集进一步增加了原位坡面的侵蚀抗性,产生了土壤侵蚀速率随降雨历时不断降低的现象。[结论]高密度黄麻土工布的覆盖能够有效地减流减沙,增加原位坡面抗蚀性,是一种有效的水土保持措施,在今后的土壤侵蚀防治和劣地恢复工作中应该被重视。  相似文献   

基于LabVIEW的红枣干燥机控制系统的设计     

刘立果  张学军  刘超山  鄢金山  史增录  辛倩倩 《农机化研究》2017,(5):264-268

为了解决现有红枣干燥机自动化程度低、劳动强度高和不能很好地满足红枣干燥工艺需要的问题,通过对国内外自动化控制系统的研究和借鉴,设计了基于LabVIEW的红枣干燥机的控制系统。同时,设计了LabVIEW控制系统的前面板和程序框图,完成了外部硬件电路的设计。试验表明:该LabVIEW控制系统可以实现鼓风机和物料提升机的启动和停止,3路温度的采集、分析、显示和对加热管的控制,3路湿度的采集、分析、显示和对排湿阀门的控制,2路风速的采集和显示,以及6个进/出风通道按照设定的时间间隔实现5种工作模式的切换。  相似文献   

Differences between wheat genotypes in damage from freezing temperatures during reproductive growth     

《European Journal of Agronomy》2016

Cereal crops in the reproductive stage of growth are considerably more susceptible to injury from freezing temperatures than during their vegetative growth stage in the fall. While damage resulting from spring-freeze events has been documented, information on genotypic differences in tolerance to spring-freezes is scarce. Ninety wheat genotypes were subjected to a simulated spring-freeze at the mid-boot growth stage under controlled conditions. Spring-freeze tolerance was evaluated as the number of seeds per head at maturity after plants were frozen at −6 °C. Plants that froze, as confirmed by infrared (IR) thermography, died shortly after thawing and consequently the heads did not mature. Only in plants that had no visible freezing (super-cooled) were heads able to reach maturity and produce seeds. In plants that super-cooled four genotypes had significantly higher seed counts after being exposed to freezing than three with the lowest. In addition, significant differences between genotypes were found in whole plant survival among those that had frozen. Genotypes with high whole-plant freezing survival were not necessarily the same as the super-cooled plants with the highest seed counts. Spring-freeze tolerance was not correlated with maturity suggesting that improvement in freezing tolerance could be selected for without affecting heading date. Spring-freeze tolerance was not correlated with freezing tolerance of genotypes of plants in a vegetative state, either under non-acclimated or cold-acclimated conditions indicating that vegetative freezing tolerance is not a good predictor of spring-freeze tolerance.  相似文献   

早熟鲜食枣新品种‘串枣’     

王翠香  赵德田  孙超  刘珍  韩传明  亓玉昆  高嘉  张万锋 《园艺学报》2017,44(Z2):2655-2656

 ‘串枣’是从山东省济南市南部山区枣树实生群体中选出的早熟鲜食新品种。果实椭圆形，平均单果质量14.47 g，最大23.16 g；成熟果实红色，果面光滑，果肉浅绿色，肉质细腻，风味甜，品质佳。果核0.4 g，含仁率40%。鲜果可溶性固形物31.5%，可滴定酸4.11 g · kg^-1，可食率96.7%，维生素C 3.039 mg · g^-1。在济南市南部山区8月下旬果实成熟，果实发育期80 ~ 85 d。早熟，丰产，稳产，耐瘠薄，耐干旱，适应性强，适合在枣产区栽植。  相似文献   

丘陵红黄壤区施用399对“一种两收”再生稻根系和产量的影响     

蔡克桐  沈其文  黄志谋  施仕胜  耿协议 《安徽农业科学》2015,(26):51-52

[目的]研究399对"一种两收"再生稻的影响。[方法]以适宜丘陵红黄壤种植的丰两优香1号、准两优527、宜优673再生稻品种为材料,分别设置喷施399和不喷施399(CK)2种处理,研究各处理对再生稻根系和产量的影响。[结果]结果表明:施用399使水稻在生育期上延缓成熟,且施后再生稻的总根系数量、白根数量、根鲜重、根干重、根体积大幅度增加,同时在两季总产量上准两优527、丰两优香1号和宜优673品种分别比对照增产6.39%、4.86%、5.94%。[结论]施用399有利于准两优527、丰两优香1号和宜优673再生稻品种再生根的发生。  相似文献