Cardiovascular biomarkers in dogs with systemic inflammatory response syndrome     

Kris Gommeren  Isabelle Desmas  Alexandra Garcia  Ccile Clercx  Kathleen Mc Entee  Anne‐Christine Merveille  Dominique Peeters 《Journal of Veterinary Emergency and Critical Care》2019,29(3):256-263

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抗菌肽制剂对妊娠母猪蓝耳病抗体水平及生产性能的影响     

陈星星  江康峰  尹会方  郑新添 《福建畜牧兽医》2016,(2)

为了研究抗菌肽制剂对妊娠母猪蓝耳病抗体水平及生产性能的影响,根据品种相同、体重相当的原则,随机选取180头妊娠母猪,试验A组、B组以及对照组各60头,试验A、B组饲料中添加0.3%、0.5%抗菌肽,对照组饲料中添加抗生素。通过ELISA抗体检测方法 ,分别检测试验组和对照组的蓝耳病抗体水平。结果表明:试验A、B组的蓝耳病抗体水平(S/P值)的稳定比例分别为80%和88.3%,显著高于对照组的68.33%(P≤0.05);试验A、B组的死胎率、窝均木乃伊数和死胎数均显著低于对照组(P≤0.05),窝均健仔数显著高于对照组(P≤0.05)。  相似文献   

Oyster-Derived Tyr-Ala (YA) Peptide Prevents Lipopolysaccharide/D-Galactosamine-Induced Acute Liver Failure by Suppressing Inflammatory,Apoptotic, Ferroptotic,and Pyroptotic Signals     

Adrian S. Siregar  Marie Merci Nyiramana  Eun-Jin Kim  Soo Buem Cho  Min Seok Woo  Dong Kun Lee  Seong-Geun Hong  Jaehee Han  Sang Soo Kang  Deok Ryong Kim  Yeung Joon Choi  Dawon Kang 《Marine drugs》2021,19(11)

Models created by the intraperitoneal injection of lipopolysaccharide (LPS) and D-galactosamine (D-GalN) have been widely used to study the pathogenesis of human acute liver failure (ALF) and drug development. Our previous study reported that oyster (Crassostrea gigas) hydrolysate (OH) had a hepatoprotective effect in LPS/D-GalN-injected mice. This study was performed to identify the hepatoprotective effect of the tyrosine-alanine (YA) peptide, the main component of OH, in a LPS/D-GalN-injected ALF mice model. We analyzed the effect of YA on previously known mechanisms of hepatocellular injury in the model. LPS/D-GalN-injected mice showed inflammatory, apoptotic, ferroptotic, and pyroptotic liver injury. The pre-administration of YA (10 mg/kg or 50 mg/kg) significantly reduced the liver damage factors. The hepatoprotective effect of YA was higher in the 50 mg/kg YA pre-administered group than in the 10 mg/kg YA pre-administered group. These results showed that YA had a hepatoprotective effect by reducing inflammation, apoptosis, ferroptosis, and pyroptosis in the LPS/D-GalN-injected ALF mouse model. We suggest that YA can be used as a functional peptide for the prevention of acute liver injury.  相似文献   

植物源杀菌剂对水产养殖常见病原菌的抑菌作用研究     

李殿殿  曾晶晶  林娟 《福建水产》2009,(3):54-57

植物源杀菌剂因其成分复杂、无污染、属性天然等特点,为水产养殖防治病原菌提供了新思路。本文以虎杖、千里光、黄柏、黄岑、苦参等为原材料,研制开发植物源杀菌剂,研究结果表明其对12种水产养殖常见病原菌均有较好的抑菌效果,对大肠杆菌、荧光假单胞菌的的最低抑菌浓度（MIC）为33μL／L,对金黄色葡萄球菌、痢疾志贺氏菌、温和气单胞菌的MIC为25μL／L,对肠炎沙门氏菌、单增李斯特氏菌的MIC为50μL／L,对拟态弧菌的MIC为100μL／L,对溶藻弧菌的MIC为250μL／L,对弗尼斯弧菌、副溶血弧菌的MIC为500μL／L,对创伤弧菌的MIC为1000μL／L。  相似文献   

饲料中添加重组抗菌肽对吉富罗非鱼生长性能及免疫力的影响   总被引：4，自引：0，他引：4  

姜珊  王宝杰  刘梅  蒋克勇  宫魁  王雷 《中国水产科学》2011,18(6):1308-1314

以吉富罗非鱼(genetically improved farmed tilapia,GIFT)幼鱼(体质量10.68 g±0.53 g)为研究对象,在实验饲料中分别添加0、5、10、20、50 mg/kg重组中国明对虾抗菌肽以及100 mg/kg氟苯尼考,并于实验结束时进行注射攻毒(嗜水气单胞菌).通过8周的养殖实验...  相似文献   

Antimicrobial peptide CAP18 and its effect on Yersinia ruckeri infections in rainbow trout Oncorhynchus mykiss (Walbaum): comparing administration by injection and oral routes          下载免费PDF全文

J K Chettri  F Mehrdana  E B Hansen  A Ebbensgaard  M T Overgaard  A H Lauritsen  I Dalsgaard  K Buchmann 《Journal of fish diseases》2017,40(1):97-104

The antimicrobial peptide CAP18 has been demonstrated to have a strong in vitro bactericidal effect on Yersinia ruckeri, but its activity in vivo has not been described. In this work, we investigated whether CAP18 protects rainbow trout Oncorhynchus mykiss (Walbaum) against enteric red mouth disease caused by this pathogen either following i.p. injection or by oral administration (in feed). It was found that injection of CAP18 into juvenile rainbow trout before exposure to Y. ruckeri was associated with lowered mortality compared to non‐medicated fish although it was less effective than the conventional antibiotic oxolinic acid. Oral administration of CAP18 to trout did not prevent infection. The proteolytic effect of secretions on the peptide CAP18 in the fish gastrointestinal tract is suggested to account for the inferior effect of oral administration.  相似文献   

发酵杂粕型饲粮添加小肽对肉牛生长性能、养分表观消化率及血清生化指标的影响     

曾钰  刘垚  张康林  彭忠利  肖伟伟  于星宇  吴华卓 《动物营养学报》2022,34(2):1058-1066

本试验旨在研究发酵杂粕型饲粮中添加小肽对肉牛生长性能、养分表观消化率及血清生化指标的影响,探索发酵杂粕型饲粮中小肽适宜的添加水平.试验选取初重为(481.43±36.36)kg、健康状况良好的肉牛28头,随机分为4组,每组7头牛,分别饲喂小肽添加水平为0(Ⅰ组)、0.5％(Ⅱ组)、1.0％(Ⅲ组)和1.5％(Ⅳ组)的全...  相似文献   

In-vitro and in-vivo nematicidal activities of the cyclic dodecapeptide omphalotin A     

Anke Mayer  Michael Kilian  Birgit Hoster  Olov Sterner  Heidrun Anke 《Pest management science》1999,55(1):27-30

Omphalotin A, a cyclic dodecapeptide produced by submerged cultures of the basidiomycete Omphalotus olearius, exhibited in-vitro and in-vivo nematicidal activity. Meloidogyne incognita was the most sensitive nematode. At 2.0 mg litre⁻¹, 50% of the nematodes were dead after one hour. Heterodera schachtii, Radopholus similis and Pratylenchus penetrans were affected at higher concentrations. Incorporated into agar, the compound prevented infection of cucumber seedlings by M. incognita at concentrations of 1 mg litre⁻¹ and higher. In glasshouse tests, complete protection of cucumbers and lettuce was achieved between 2.5 and 10 mg litre⁻¹. No insecticidal activity was observed when Plutella xylostella, Phaedon cochleariae or Spodoptera frugiperda were fed material containing 4 g kg⁻¹ of omphalotin A. © 1999 Society of Chemical Industry  相似文献   

Antibacterial activity of hydroxyalkenyl salicylic acids from sarcotesta of Ginkgo biloba against vancomycin-resistant Enterococcus     

Choi JG  Jeong SI  Ku CS  Sathishkumar M  Lee JJ  Mun SP  Kim SM 《Fitoterapia》2009,80(1):18-20

A chloroform fraction prepared from the sarcotesta of Ginkgo biloba showed potent inhibitory activity against vancomycin-resistant Enterococcus (VRE). The active compounds were elucidated to be 2-hydroxy-6-(8-pentadecenyl) salicylic acid (1) and 2-hydroxy-6-(10-heptadecenyl) salicylic acid (2) based on their spectral analysis. Compounds 1 and 2 showed significant antibacterial activities against VRE.  相似文献   

核桃产品开发技术进展   总被引：4，自引：0，他引：4  

王丰俊  王建中  周鸿升  郭保香 《河北林果研究》2009,24(3):301-304

核桃可以综合利用,将核桃壳加工成核桃壳超细粉,将核桃仁加工成核桃油、核桃粉和核桃乳、核桃多肽等产品。核桃壳超细粉可用作活性炭、堵漏剂。核桃油的制取方法中,快速液压法可以保持核桃油的天然品质,减少核桃蛋白的变性。采用含有部分油脂的核桃蛋白既可以加工成半脱脂核桃粉和核桃多肽,也可以加工成半脱脂核桃乳。  相似文献