中草药复方注射剂治疗仔猪腹泻的试验研究     

贺泂杰  郭慧琳 《安徽农业科学》2014,(22):7435-7436

[目的]探讨中草药复方注射剂对仔猪腹泻的治疗效果。[方法]提取中草药有效成分,制备中草药复方注射剂。用不同剂量(0.25、0.50和1.00 ml/kg)的中草药复方注射剂对人工感染的仔猪腹泻进行治疗试验。[结果]经过3 d治疗后,3个剂量组均有明显的治疗效果,治愈率可达60%~95%,极显著高于感染对照组,剂量以0.5 ml/kg为佳。将制备的复方注射剂和临床用的硫酸庆大霉素、诺氟沙星、头孢噻呋混悬、硫酸黄连素和博落回注射剂对人工感染的仔猪腹泻进行疗效对比试验,结果表明复方注射剂的治疗效果最好,治愈率达98.0%,明显优于其他注射剂。[结论]该中草药复方注射剂是临床上治疗仔猪腹泻的有效药物。  相似文献   

苦参注射液治疗乙型肝炎性肝硬化疗效及其作用机制研究     

暴秀兰  尹桂华 《吉林林学院学报》2014,(6):780-782

目的：观察苦参注射液对慢性乙型肝炎性肝硬化的临床效果及其作用机制.方法将58例慢性乙型肝炎性肝硬化患者随机分为观察组和对照组,在一般支持治疗的基础上,观察组加用苦参注射液,治疗8周后,比较两组肝功能、肝纤维化指标.结果观察组肝功能改善显著,肝纤维化减轻,与对照组比较差异均有统计学意义（P〈0.05）.结论在正常治疗基础上加用苦参注射液,有助于肝炎性肝硬化患者的肝功能恢复,有较好的临床效果.其作用机制可能是通过影响外周单核细胞IL-10表达、调节机体促炎抗炎平衡而实现的.  相似文献   

土霉素固体脂质纳米粒在家兔体内的药代动力学研究     

申芸  符华林  周凤 《西北农林科技大学学报(自然科学版)》2014,42(8):27-33

【目的】研究土霉素固体脂质纳米粒在家兔体内的药代动力学特征,以评价其应用效果。【方法】将10只家兔随机分为2组,分别按土霉素剂量20mg/kg腹腔注射土霉素固体脂质纳米粒和土霉素注射液,于设定的时间点采血,用HPLC法测定血浆药物质量浓度,并用DAS3.1.0药动学程序计算药代动力学参数。【结果】土霉素注射液与固体脂质纳米粒的达峰质量浓度(Cmax)分别为(3.676±0.376)和(3.699±0.562)mg/L;吸收平衰期(T1/2Ka)分别为(18.570±0.851)和(27.871±1.767)h;0-∞时段药时曲线下的面积(AUC(0-∞))分别为(83.955±3.720)和(170.150±10.403)mg/(L·h);0-∞时段的平均滞留时间(MRT(0-∞))分别为(36.848±0.268)和(44.672±0.392)h。【结论】土霉素制备成固体脂质纳米粒后,具有明显的缓释作用,血药质量浓度达峰值的时间推迟,同时药物在兔体内平均滞留时间明显长于土霉素注射液,生物利用度得以显著提高。  相似文献   

褐点石斑鱼的核型研究   总被引：8，自引：2，他引：8  

廖经球  尹绍武  陈国华  黄海  雷从改  娄甜甜 《水产科学》2006,25(11):567-569

采用胸腔活体注射PHA和秋水仙素溶液,取头肾细胞,低渗处理,空气干燥法制片,对染色体进行G iem sa染色来研究褐点石斑鱼的核型。试验结果表明,禢点石斑鱼的核型为2n=48,2 sm 46 t,NF=50;其核型特点符合典型的高位类群鱼类核型特征。  相似文献   

井窖式烟草移栽机设计与试验     

王德权  杜传印  荐世春  徐高伟  何腾飞 《农业装备与车辆工程》2022,60(1):15-19

针对井窖式烟草移栽人工栽植劳动强度较大、现有机械化装备作业效率和可靠性不高等问题,结合"井窖式烟草移栽技术"提出的农艺要求,设计一种用于井窖式烟草移栽的专用移栽机.在确定整机的结构和工作原理的基础上,对成穴移栽注水机构和栽植器进行设计,建立成穴移栽注水机构的运动学模型,以此建立其人机交互辅助界面,通过人机交互的方式获取...  相似文献   

Content Determination of Ivermectin in the Ivermectin Microemulsion Injection     

WANG Si-han  ZHANG Ji-yu  XING Shou-ye  LI Bing  ZHOU Xu-zheng 《中国畜牧兽医》2017,44(6):1861-1868

In order to establish the determination method of ivermectin (IVM) in the ivermectin microemulsion injection by high performance liquid chromatography (HPLC), Hypersil ODS2 colunm (5 μm,4.6 mm×250 mm) was used in this study. The mobile phase composed of methanol, acetonitrile and water (35:60:5,V/V/V) at a flow rate of 1 mL/min. The detection wave length was set at 244 nm and the column temperature was 30 ℃. The results showed that the HPLC system suitability of IVM was good. A good linear correlation of IVM was observed within the concentration range 80 to 320 μg/mL, and the average recovery rate was 101.90%±2.94% with RSD was 2.88%, the regression equation was Y=22 700X+2 510 (R²=0.9998). The RSD of IVM content in ivermectin microemulsion injection was 1.86%. The method was accurate and reliable,reproducible,easy to operate, which could be used in new type of ivermectin microemulsion injection. The method could be used as the basis of quality control and establishing a quality standard, and to provide basis for quality evaluation, also can provide reliable reference for safe veterinary clinical application in the future.  相似文献   

Clinical Therapeutic Effect of Praziquantel Injection on Buffalo Schistosomiasis     

YANG Hai-feng  LI Yong-jun  LU Guang-fu  TAO Jian-ping 《中国畜牧兽医》2017,44(5):1552-1556

To observe the clinical therapeutic effect of 30% praziquantel injection on buffalo schistosomiasis, the sick buffalos naturally infected with Schistosoma japonicum were selected by miracidium hatching method. In experimental clinical trials, sick buffalos were randomly divided into five groups, high-dose (20 mg/kg), middle-dose (10 mg/kg) and low-dose (5 mg/kg) praziquantel injection groups, praziquantel tablet group (30 mg/kg) and positive control group. After the treatment of 30 d, the negative conversion rate of miracidium were 100.0%, 100.0%, 77.8% and 85.7%, respectively, in praziquantel injection groups with the high, middle and low dose and oral medication group. In expanded clinical trials, the sick buffalos were randomly divided into two groups, praziquantel injection group (10 mg/kg, i.m.) and praziquantel tablet group (30 mg/kg). The results showed that, the negative conversion rate of miracidium were all 100% in the former 52 patients and the latter 6 patients after 30 d. The research confirmed that praziquantel injection was significantly effective in the treatment of buffalo schistosomiasis and convenient for administration. It was concluded that 30% praziquantel injection could replace the traditional oral praziquantel tablet for the treatment of buffalo schistosomiasis, and the recommended dose was 10 mg/kg.  相似文献   

柴油发动机喷油泵喷油量自动检测装置实用化     

毕翠丽 《湖南农机》2008,(3):12-14

原始的实验箱采用长方体结构,对燃气混合是不利的,因此首先考虑设计成型喷雾室,底部有突起,以规范气流的运动。实验台和喷油泵采用了安装定位工具将其固定。基于实际情况考虑选用了实用化设置图像采集卡,可以考虑其他几中系列产品。摄像机可以采用多种型号的CCD摄像头,像素要求35万。  相似文献   

凌源市猪附红细胞体病诊断与防治研究     

邓广庆  范世彤  周金章  贾骥  杨玉萍  薛红波  高玉枝  吕海兵  王孝云  王春艳  季秉琦  王守金 《中国兽医寄生虫病》2003,11(1):12-14

凌源市2002年3月首次发生以高热、贫血、黄疸、消瘦、流产为主要特征的猪附红细胞体病。血浆中、红细胞表面附有0.2-1.5μm多形态的生物体，姬姆萨染色呈淡紫红色。人工接种该生物体可使猪、兔发病，并能检出相同病原体。病猪是主要传染源，吸血昆虫、受污染的饲料、胎盘也传播。三氮咪为首选治疗药，配合性性血素疗效更好。  相似文献   

二甲硝咪唑注射液的稳定性研究   总被引：2，自引：1，他引：1  

刘永琼  刘家龙  邓素珍 《中国兽药杂志》2002,36(3):27-30

从合成得到的水溶性二甲硝咪唑盐配方制备二甲硝咪唑注射液 ,对其进行光加速和热加速稳定性研究。证实本品对光不稳定、对热稳定 ,预测室温 (2 5℃ )避光保存有效期为 3.4 6年  相似文献