Volvulus of the colon in a Cat     

Kenneth J. Drobatz DVM  Dez Hughes BVSc  Chris Hill VMD  Lynn Walker VMD 《Journal of Veterinary Emergency and Critical Care》1996,6(2):99-102

We report the first case of colonic volvulus in a cat. A 12-year old spayed, female domestic shorthair cat with chronic bowel disease presentated with one-day history of lethargy and anorexia. Physical examination abnormalities included cachexia, poor perfusion, and poor skin turgor. A large, non painful, gas-filled, tubular structure, occupying the majority of the abdominal cavity was noted by palpation. Abdominal radiographs revealed a gas-filled displaced colon. Exploratory laparotomy confirmed a volvulus at the root of the colonic mysetery, along with a partial torsion of the distal colon. The majority of the colon was determined to be necrotic and was surgically resected. Due to persistent hypotension and perceived poor prognosis, the cat was euthanized.  相似文献   

Surgical lesions of the small colon and post operative survival in a UK hospital population     

M. P. de Bont  C. J. Proudman  D. C. Archer 《Equine veterinary journal》2013,45(4):460-464

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Survival of horses following strangulating large colon volvulus     

J. M. SUTHERS  G. L. PINCHBECK  C. J. PROUDMAN  D. C. ARCHER 《Equine veterinary journal》2013,45(2):219-223

Reasons for performing study: The pattern of long‐term survival and specific factors associated with long‐term survival have not previously been evaluated in horses with a strangulating large colon volvulus (LCV). Objectives: To provide data on the long‐term survival of horses with LCV and to identify pre‐, intra‐ and post operative variables associated with survival. Methods: Clinical data and long‐term follow‐up information were obtained from 116 horses with a strangulating LCV (≥360°) undergoing general anaesthesia. Two multivariable Cox proportional hazards models for post operative survival time were developed: Model 1 included all horses and evaluated preoperative variables and Model 2 included horses that survived anaesthesia and evaluated pre‐, intra‐ and post operative variables. Results: The study population comprised 116 horses. Eighty‐nine (76.7%) survived general anaesthesia. Of these, the percentage that survived until discharge, to one year and to 2 years was 70.7%, 48.3% and 33.7%, respectively. Median survival time for horses that survived general anaesthesia was 365 days. In Model 1 increased preoperative packed cell volume (PCV) was significantly associated with reduced post operative survival (hazard ratio [HR] 1.08, 95% confidence interval [CI] 1.05–1.11). However, this effect changed over time. In Model 2 abnormal serosal colour intraoperatively (HR 3.61, 95% CI 1.55–8.44), increased heart rate at 48 h post surgery (HR 1.04, 95% CI 1.02–1.06), and colic during post operative hospitalisation (HR 2.63, 95% CI 1.00–6.95), were all significantly associated with reduced post operative survival. Conclusions: Survival time in horses with a LCV was associated with preoperative PCV, serosal colour, heart rate at 48 h post operatively and colic during post operative hospitalisation. Potential relevance: This study provides evidence‐based information on the long‐term survival of horses with LCV and identifies parameters that may assist decision‐making by clinicians and owners.  相似文献   

Colon Preneoplastic Lesions in Animal Models     

Masumi Suzui  Takamitsu Morioka  Naoki Yoshimi 《Journal of toxicologic pathology》2013,26(4):335-341

The animal model is a powerful and fundamental tool in the field of biochemical research including toxicology, carcinogenesis, cancer therapeutics and prevention. In the carcinogenesis animal model system, numerous examples of preneoplastic lesions have been isolated and investigated from various perspectives. This may indicate that several options of endpoints to evaluate carcinogenesis effect or therapeutic outcome are presently available; however, classification of preneoplastic lesions has become complicated. For instance, these lesions include aberrant crypt foci (ACF), dysplastic ACF, flat ACF, β-catenin accumulated crypts, and mucin-depleted foci. These lesions have been induced by commonly used chemical carcinogens such as azoxymethane (AOM), 1,2-dimethylhydrazine (DMH), methylnitrosourea (MUN), or 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Investigators can choose any procedures or methods to examine colonic preneoplastic lesions according to their interests and the objectives of their experiments. Based on topographical, histopathological, and biological features of colon cancer preneoplastic lesions in the animal model, we summarize and discuss the character and implications of these lesions.  相似文献   

结肠癌细胞系LHX6基因启动子甲基化检测与分析     

刘海洋  李彦杰  吴宗辉  胡昌华 《西南大学学报》2013,35(5)

为探讨结肠癌细胞SW480和HT-29中LHX6基因启动子区CpG岛的甲基化状态,分析去甲基化与结肠癌细胞增殖的关系,用甲基化特异性PCR对SW480和HT-29细胞的LHX6基因启动子区域CpG岛进行检测,对比经5-氮杂-2-脱氧胞苷(5-aza-2-deoxycytidine,5-Aza-CdR)处理后两株细胞该区域甲基化水平之间的差异,用(3-(4,5-二甲基噻唑-2)-2,5-二苯基四氮唑溴盐,噻唑蓝)(MTT)法检测5-Aza-CdR对其增殖的影响,观察5-Aza-CdR对细胞形态的影响.结果表明,SW480与HT-29细胞的LHX6基因启动子区域CpG岛均存在甲基化,分别为41.9％和28.6％;经5-Aza-CdR处理后,SW480甲基化率由41.4％降低到39.7％,HT-29甲基化率由27.4％降低至18.5％(p＜0.05);两株细胞的增殖明显被抑制.结肠癌细胞系SW480和HT-29的LHX6基因均存在不同程度的甲基化,研究结果为LHX6可能作为结肠癌肿瘤检测的新分子靶标奠定基础.  相似文献   

Surgical Removal of a Descending (Small) Colon Foreign Body through a Secondary Paramedian Approach     

Antonio Cezar de Oliveira Dearo  Roberta Garbelini GomesRafael Goulart Araújo  DVM  Peter ReichmannMariana Cosenza  DVM  Mariana Marcantonio Coneglian  DVM 《Journal of Equine Veterinary Science》2009

Intestinal obstruction due to foreign body ingestion is one cause of colic in horses. Although it occurs more frequently in juveniles, adult horses also may be affected. The small colon is a common location in which foreign bodies can be found. Depending on the location of the obstruction in the small colon, different techniques to dislodge the foreign body toward areas where it can be safely exteriorized and removed can be attempted. Alternatively, different approaches to the abdomen can be performed to facilitate exteriorization of the obstructed segment and removal of the foreign body. This paper describes a case of large and small colon obstruction in an adult horse caused by two distinct foreign bodies. The large colon obstruction was removed through a pelvic flexure enterotomy using the ventral midline approach, and the small colon obstruction was removed through a small colon enterotomy using a paramedian approach. Information regarding signalment, history, clinical signs, surgical treatment, and follow-up status of the horse are described.  相似文献   

Nonsteroidal anti‐inflammatory drug associated right dorsal colitis in the horse          下载免费PDF全文

J. L. Davis 《Equine Veterinary Education》2017,29(2):104-113

Right dorsal colitis in horses is a disease characterised by mucosal ulceration and oedema that is localised to the right dorsal colon. It is considered one of the more severe adverse effects associated with the use of nonsteroidal anti‐inflammatory drugs (NSAIDs), particularly phenylbutazone. Diagnosis is typically made based on a history of NSAID administration, the presence of hypoproteinaemia and hypoalbuminaemia, as well as ultrasound evidence of thickening and oedema of the right dorsal colon wall. Definitive diagnosis is made at surgery or necropsy. Treatment involves discontinuation of NSAID therapy, dietary management, and mucosal protectants such as misoprostol and sucralfate. Prognosis is dependent upon early recognition and appropriate treatment. Horses on prolonged courses of NSAIDs should have frequent monitoring of serum total protein and albumin concentrations, as this is one of the earliest and most consistent clinicopathological findings.  相似文献   

芪楂口服液药渣发酵前后对断奶仔猪结肠微生物、代谢产物及细胞因子表达的影响     

苏家宜  耿梅梅  陈闻  印遇龙  王占彬  孔祥峰 《动物营养学报》2017,29(9)

为了探讨中药渣用于断奶仔猪养殖的可行性,比较研究了芪楂口服液药渣发酵前后对断奶仔猪结肠微生态和健康的影响。试验选用21日龄断奶仔猪120头,随机分为空白对照组、芪楂口服液药渣组(添加5kg/t芪楂口服液药渣)、发酵芪楂口服液药渣组(添加5kg/t发酵芪楂口服液药渣)和阳性对照组(添加0.04kg/t维吉尼亚霉素+0.2kg/t硫酸黏杆菌素+3 000mg/kg氧化锌),每组5个重复,每个重复6头。于试验第28天,分别取结肠内容物及其组织,测定微生物数量、代谢产物含量以及细胞因子mRNA表达量。结果表明:芪楂口服液药渣组和发酵芪楂口服液药渣组的7种细菌及总细菌数量与空白对照组相比均无显著差异(P0.05),白细胞介素(IL)-12mRNA表达量显著低于2个对照组(P0.05),吲哚含量显著低于阳性对照组(P0.05);发酵芪楂口服液药渣组乙酸、丁酸、戊酸、异丁酸、直链脂肪酸和总短链脂肪酸含量以及结肠组织IL-4mRNA表达量显著低于芪楂口服液药渣组(P0.05);阳性对照组粒细胞巨噬细胞集落刺激因子mRNA表达量显著高于、梭菌ⅩⅣa和双歧杆菌数量显著低于空白对照组(P0.05)。综上所述,芪楂口服液药渣可增加断奶仔猪结肠短链脂肪酸含量,调节结肠细胞因子表达;芪楂口服液药渣发酵前后均不影响肠道菌群稳态,但抗生素和氧化锌会影响仔猪肠道菌群的稳态;微生物发酵未增强芪渣口服液药渣对肠道微生物代谢的改善作用。  相似文献   

中西医结合治疗晚期结肠癌的临床疗效          下载免费PDF全文

张静  刘畅 《勤云标准版测试》2017,37(5):548-551

目的 探讨中西医结合治疗晚期结肠癌的临床疗效及生活质量研究。方法 选取在本院住院治疗的经病理检查确诊的晚期结肠癌患者73例,根据治疗方案随机分为中西医结合组（n=38）接受扶正消积汤联合XELOX方案（卡培他滨+奥沙利铂）治疗和西医组（n=35）单纯接受XELOX方案治疗,比较两组患者治疗后近期疗效、治疗前后中医症状积分、肿瘤标志物、免疫细胞水平以及生活质量的差异。结果 中西医结合组总的中医症状积分高于西医组（P<0.05）;中西医结合组治疗后的癌胚抗原（CEA）低于西医组和治疗前（P<0.05）;中西医结合组治疗后的CD4⁺、CD8⁺高于西医组（P<0.05）,与治疗前比无差异（P>0.05）。结论 中西医结合治疗晚期结肠癌的近期疗效,降低中医症状积分,提高生活质量方面均好于单独西医治疗,且对免疫系统的影响较小。  相似文献   

Protein biomarker of cell proliferation determines survival to discharge in cases of equine large colon volvulus          下载免费PDF全文

C. R. Kucera  L. W. Stranahan  F. Hughes  A. T. Blikslager  L. M. Gonzalez 《Equine veterinary journal》2018,50(4):452-456

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