Pharmacokinetics,tissue residues,and ex vivo pharmacodynamics of tylosin against Mycoplasma anatis in ducks     

Sara T. Elazab  Nahla S. Elshater  Yousreya H. Hashem  Seung-Chun Park  Walter H. Hsu 《Journal of veterinary pharmacology and therapeutics》2020,43(1):57-66

The pharmacokinetics of tylosin were investigated in 3 groups of ducks (n = 6). They received a single dose of tylosin (50 mg/kg) by intravenous (IV), intramuscular (IM), and oral administrations, respectively. Plasma samples were collected at various time points to 24 hr post-administration to evaluate tylosin concentration over time. Additionally, tylosin residues in tissues and its withdrawal time were assessed using 30 ducks which received tylosin orally (50 mg/kg) once daily for 5 consecutive days. After IV administration, the volume of distribution, elimination half-life, area under the plasma concentration–time curve, and the total body clearance were 7.07 ± 1.98 L/kg, 2.04 hr, 19.47 µg hr/ml, and 2.82 L hr⁻¹ kg⁻¹, respectively. After IM and oral administrations, the maximum plasma concentrations were 3.70 and 2.75 µg/ml achieved at 1 and 2 hr, and the bioavailability was 93.95% and 75.77%, respectively. The calculated withdrawal periods of tylosin were 13, 8, and 5 days for kidney, liver, and muscle, respectively. For the pharmacodynamic profile, the minimum inhibitory concentration for tylosin against M. anatis strain 1,340 was 1 µg/ml. The calculated optimal oral dose of tylosin against M. anatis in ducks based on the ex vivo pharmacokinetic/pharmacodynamic modeling was 61 mg kg⁻¹ day⁻¹.  相似文献   

瓯柑微芽嫁接脱毒及试管苗的快速培育技术     

姜玲  陈泽雄  徐象华  邓秀新 《华中农业大学学报》2007,26(2):233-236

研究了不同大小的瓯柑茎尖分生组织进行微芽嫁接脱除黄龙病病原的效果。在双目实体显微镜下,分别切取含有生长锥及1、2、3和4个叶原基的茎尖分生组织嫁接到黄化砧木上,以获得茎尖微芽嫁接苗,用PCR进行黄龙病分子检测。试验表明:用含1个和2个叶原基的茎尖嫁接获得的试管苗全部不带病毒;含有3个和4个叶原基的茎尖嫁接获得的试管苗其脱毒率分别为95.7%和73%,感病母株和长春花阳性对照可以扩增出535 bp的特异性片段;尽管在含2个叶原基条件下获得的STG成活率为47.7%,但可以达到理想的脱毒效果。试验还证明,瓯柑二次嫁接与茎尖嫁接直接移栽苗的生长量差异极显著。  相似文献   

四川冶勒红豆杉迁地保护调查与设计研究     

严贤春  周材权  胥晓 《西南大学学报(自然科学版)》2005,27(4):522-525,529

四川冶勒自然保护区有国家一级保护植物红豆杉,因建立水电站,水库淹没区的红豆杉需进行迁地保护.为此,对水库淹没区的红豆杉资源进行了调查研究,并对红豆杉迁移地和原生地的生活及生态环境进行了比较研究,由此做出了红豆杉迁地保护分析论证和风险分析.  相似文献   

柳杉优树子代的遗传变异与再选择   总被引：6，自引：0，他引：6  

刘洪谔  李晓储 《浙江林学院学报》1992,9(1):29-35

根据31个柳杉优树无性系自由授粉子代测验林5龄时树高(H),胸径(D),材积(V),新梢长(N_g),树冠幅(C_d),侧枝数(N_b),结果数(C_n),结果率(C_r)和结果指数(I_c)估算的半同胞家系遗传力分别为0.566,0.509,0.462,0.679,-0.326,0.694,0.091,0.068和0.115.测算的遗传相关表明:H,D,V,N_g,N_b 5个生长性状之间,C_n,C_r,I_c 3个结果性状之间具强度正相关,这5个生长性状对C_r都是强度负相关,D,V对C_n和I_c具强正相关,H,N_g和N_b对C_n和I_c只具弱度相关。以选择强度i=1.4选出最好的6个家系,予测H,D,V,N_g,或N_b单性状选择的遗传增益分别为11.96％,21.25％,44.31％,22.42％和20.81％;按综合上述5个性状的选择指标进行多性状选择,遗传增益提高到28.64％.以全部性状表型值进行主成分分析,按各家系的主成分坐标值,易于直观地选择表型优良的家系,其选择结果近似于综合指标选择。  相似文献   

浙江水青冈的生境与群落初步调查     

李长贵  杨树文 《浙江林学院学报》1992,9(1):106-109

浙江水青冈是我国3级保护珍稀濒危植物台湾水青冈的一个变种,发现仅分布于浙江省永嘉县四海山林场。本文报道浙江水青冈的分布、生境、群落组成结构及天然更新等。  相似文献   

Lime,molybdenum, and cultivar effects on molybdenum deficiency of poinsettia     

Douglas A. Cox 《Journal of plant nutrition》2013,36(5):589-603

Poinsettia (Euphorbia pulcherrima Willd. ex Klotz) cultivars ‘Annette Hegg Brilliant Diamond’ (AH), ‘Gutbier V‐14 Glory’ (GG), and ‘Eckespoint C‐1 Red’ (ER) were grown in a peat‐perlite potting medium to study lime and Mo effects on the occurrence of Mo deficiency. Two rates of dolomitic limestone, 0 and 3 kg/m³of growing medium, and weekly applications of micronutrient solutions containing 0.0 or 1.0 ppm Mo were made in factorial combination. Lime, Mo, or both prevented Mo deficiency symptoms in all cultivars. Without both lime and Mo, Mo deficiency symptoms appeared on AH and GG, but not on ER. Lime and/or Mo reduced NO₃‐N content, increased Mo content and increased nitrate reductase enzyme activity (NRA) in the upper recently matured leaves of all cultivars. Lime and Mo interacted to affect these parameters in all cultivars. Comparing the three cultivars without both lime and Mo, NO‐‐N content was lowest and NRA highest in ER. However, the Mo content of ER leaves was equal to or less than that of AG and GG which showed Mo deficiency symptoms.  相似文献   

羌活挥发油SFE-C02提取工艺研究     

蒋合众 李芬刘春光  罗丽勤马超英 《安徽农业科学》2008,36(5):1740-1740

[目的]为了寻找羌活挥发油的最佳提取工艺。[方法]采用超临界技术提取,通过正交试验,以萃取压力、温度、时间为因素,考察最佳提取工艺。[结果]最佳萃取条件是：压力20MPa,温度40℃,时间4h。在最佳萃取条件下具有较高的提取率,平均为7．76％。[结论]超临界CO2萃取法无有机溶剂残留,无毒,价廉,来源容易,是一种比较理想的研究药用植物有效成分方法。  相似文献   

营养液铵硝比对砂培韭菜生长及硝酸盐含量的影响     

孙世海  彭立新  卢兴霞  李慧  吴琼  张园园 《安徽农业科学》2010,38(14):7223-7226

[目的]研究不同铵硝比营养液对韭菜生长及硝酸盐含量的影响。[方法]2008～2009年,对日光温室内砂培的2年生韭菜,分别浇施总氮量相同、铵硝比为0∶100,15∶85,30∶70,45∶55和60∶40的营养液。[结果]提高营养液铵硝比不仅大幅度降低了韭菜硝酸盐含量,而且显著地提高了春季韭菜的总产量。铵硝混合营养处理的韭菜硝酸盐含量极显著低于纯硝营养,铵硝比60∶40和45∶55处理的韭菜硝酸盐含量最低,均比纯硝营养降低了59.8%;铵硝比45∶55和30∶70处理的韭菜总产量显著高于纯硝营养,分别增产22.4%和14.0%。铵硝比对单茬韭菜产量的影响因收获时期不同而异,增铵对提高第1茬产量的作用最大、对第3茬无明显作用。[结论]45∶55和30∶70是适合韭菜砂培的营养液铵硝比。  相似文献   

广西骨碎补种质资源调查研究     

黄宝优  黄雪彦  彭玉德  韦莹  潘春柳  张占江 《湖北农业科学》2014,53(16):3832-3834,3839

采用走访和实地调查相结合的方法对广西优势药材骨碎补(Davallia mariesii Moore ex Bak.)种质资源种类与分布、生物生态学特性、资源及开发利用状况、有效成分含量等进行调查研究。结果表明,广西骨碎补种质资源丰富,基源植物共3科5属7种。骨碎补原植物喜温暖湿润的气候环境,多附生于林中岩石或树干上,偶生于墙上,土生较少。广西骨碎补药材品质佳,质量好,有较好的利用和开发价值。骨碎补生境受到一定程度破坏,资源逐渐减少,建议加强对骨碎补种质资源收集和原生境保护,开展种苗繁育和人工栽培技术研究,建立较大规模的人工种植与繁育基地,为资源可持续利用提供保障。  相似文献   

我国西藏四种植物染色体数目观察   总被引：10，自引：0，他引：10  

刘玉红  王东江 《草地学报》1994,2(2):55-57

本文对西藏四种植物进行染色体观察，这四种植物的染色体数目均为国内外首次报道。  相似文献