Antihypertensive effect of heshiko, a fermented mackerel product, on spontaneously hypertensive rats     

Kouji  ITOU  Yoshiaki  AKAHANE 《Fisheries Science》2004,70(6):1121-1129

ABSTRACT:   During the processing of heshiko , a fermented mackerel product, a rapid increase in peptide content in the extract and a remarkable decrease in the IC₅₀ (the inhibitor concentration to inhibit 50% of enzyme activity) as an index of the angiotensin I-converting enzyme (ACE) inhibitory activity were observed. Systolic blood pressure (SBP) in spontaneously hypertensive rats (SHR) decreased between 2 and 4 h after single oral administration of heshiko extract at a dose of 10 mg/kg as a peptide, and SBP recovered its initial level by 8 h. For single doses of extract at three different levels (5, 10 and 50 mg/kg), SBP similarly decreased after between 2 and 4 h. The decreased SBP at 50 mg/kg was almost equal to that at 10 mg/kg, indicating a low dose dependency for heshiko extract. Through successive administration of heshiko extract or its desalted extract at 10 mg/kg for 10 days, SBP decreased 7 days after the start of administration and it recovered its initial level 5 days after stopping administration. During these periods, the change in ACE activity in blood plasma from SHR administered the extract roughly corresponded to that of SBP, suggesting that ACE inhibition was related to a decrease in SBP. For long-term administration of the extract to 5-week-old SHR for 70 days, SBP decreased 28 days after the start of administration. The decreased SBP remained low for 28 days after stopping administration, whereas the decreased ACE activity recovered its initial level. These results suggest that heshiko extract influences not only ACE inhibition, but also other systems that regulate blood pressure.  相似文献   

苏云金素对棉铃虫幼虫生长发育和取食行为的影响研究   总被引：2，自引：0，他引：2  

左广胜  郭玉杰  王念英  方昌源 《棉花学报》1994,(2)

苏云金素０～１０００μｇ／ｍｌ的含毒饲料喂棉铃虫幼虫，处理后第７天，各处理平均体长和体重与对照差异明显，初孵幼虫体长抑制率为８３％左右，５日龄幼虫体长和体重抑制率分别为４０．１５％～６１．６１％和７８．１０％～９１．４３％。随着测试浓度的增加，含毒饲料上取食的棉铃虫幼虫数量的权重逐渐下降。结果表明，低剂量的含毒饲料对棉铃虫幼虫取食无抑制作用，而高剂量的含毒饲料胁迫幼虫转向提供的对照饲料上取食，但这一现象是由饲养器的大小和供试苏云金素剂量的设置共同决定。  相似文献   

鲜切果蔬酶促褐变物理控制研究进展   总被引：1，自引：0，他引：1  

潘永贵  陈维信 《农产品加工．学刊》2007,(12):7-10

酶促褐变是影响鲜切果蔬品质的重要原因之一。综述了目前采用物理方法(包括温度控制、氧气控制、高压处理和辐照处理)控制鲜切果蔬酶促褐变的研究进展。  相似文献   

我国藤材主导霉菌的分离及其室内抑制试验   总被引：1，自引：0，他引：1  

邢嘉琪 《木材工业》2005,19(5):23-24,27

从分类学的角度描述我国2种常见藤材上分离到的主导霉菌的生物学,报道了4种防霉剂对该主导霉菌的室内抑制试验结果.结果显示:DDAC对4种主导霉菌都具有上佳的抑制效果,当体积分数为2%时,对4种菌的抑制指数在93以上.  相似文献   

Tyrosinase inhibitory activity of proanthocyanidins from woody plants     

Keiji?TakagiEmail author  Tohru?Mitsunaga 《Journal of Wood Science》2003,49(5):461-465

Flavanol values, molecular weight distributions, polyphenolic patterns, and tyrosinase inhibitions of proanthocyanidins (PACs) from karamatsu (Larix sp.) bark, acacia Morishima (Acacia mearnsii) bark, and commercial quebracho (Schinopsis lorentzii) extracts were examined to investigate the relation between the structures of PACs from woody plants and tyrosinase inhibitory activities. Aqueous acetone (70%) extracts of acacia showed high flavanol contents and strong tyrosinase inhibition. On the other hand, the quebracho extracts inhibited tyrosinase activity slightly despite its high flavanol content. Phenyl nucleus analysis by the nucleus exchange reaction provided information that karamatsu, quebracho, and acacia extracts consist of procyanidin, profisetinidin, and prorobinetinidin, respectively. The relation between the phenolic hydroxylation pattern and tyrosinase inhibition suggested that the PACs with a 5,7-dihydroxyphenyl structure in the A-ring and a 3,4,5-trihydroxyphenyl structure in the B-ring have potent tyrosinase inhibitory activity.Part of this paper was presented at the 49th Annual Meeting of the Japan Wood Research Society, Tokyo, April 1999  相似文献   

大蒜、生姜、苦瓜混合提取液对平菇病原真菌的抑制作用及对平菇生长的影响     

段奥其  杨亚苓  汤慧盟  吕祚森  国淑梅  周军  牛贞福 《湖北农业科学》2016,(9):2283-2286

采用抑菌圈法研究了大蒜、生姜、苦瓜混合提取液对平菇(Pleurotus ostreatus)病原真菌的抑制作用,用出菇试验法测定了混合提取液对平菇菌丝体和子实体生长的影响。结果表明,在p H 9时,大蒜、生姜、苦瓜4.5∶4.5∶1.0质量比例的混合提取液抑制平菇病原真菌效果最好,与对照相比增产31.40%,缩短了采菇间隔。大蒜、生姜、苦瓜以4.5∶4.5∶1.0质量比例提取12 h,p H为8、9时混合提取液抑菌效果最好,加入提取12 h混合提取液的菌袋增产35.84%,缩短了采菇间隔,增大了盖柄比,提高了商品性。  相似文献   

几种化合物对土壤脲酶抑制作用动力学   总被引：13，自引：0，他引：13  

邱业先  汪金莲  陈尚钘 《江西农业大学学报》2000,22(3):356-358

茶多酚，硼砂、ＡｇＮＯ３均具有抑制脲酶活性的作用，其抑制效率随浓度增大而提高，茶多酚和硼砂对脲酶的抑制为非竞争性抑制，ＡｇＮＯ３则为反竞争性抑制。  相似文献   

镇跛敏注射液对炎症抑制作用的药效学试验     

鞠玉琳  韩英浩 《中国兽药杂志》2000,34(5):20-24

镇跛敏注射液对各种炎症有无抑制作用进行了药效学的研究。试验采用了巴豆油、琼脂、弗氏完全佐剂致炎及药敏纸片致肉芽肿等试验方法。结果表明，镇跛敏注射液对小白鼠、大白鼠的急性炎症、慢性炎症、免疫性炎症均有显著的抑制作用。试验结果显示，镇跛敏注射液明显优于盐酸普鲁卡因加肾上腺素、盐酸普鲁卡因、盐酸利多卡因注射液对炎症的抑制作用。  相似文献   

色氨酸分解代谢对T细胞分化增殖的影响     

彭全辉  王之盛  周安国 《中国饲料》2007,(18):4-6

色氨酸是动物必需氨基酸之一。体内色氨酸在吲哚胺-2,3-双加氧酶(IDO)等相关酶的作用下进行分解代谢,发挥重要生理作用,包括抑制T细胞分化增殖和影响T细胞功能。本文就色氨酸分解代谢对T淋巴细胞的影响及可能机理作一综述。  相似文献   

负启动机制研究综述          下载免费PDF全文

魏连娣  刘卫春 《安徽农业大学学报》2005,(2):73-75

文对有关负启动机制的理论进行了总结，着重介绍了知觉失匹配说和选择特征失匹配说的有关实验，并为此提出了一些继续研究的设想。  相似文献