Dose requirement and cardiopulmonary effects of diluted and undiluted propofol for induction of anaesthesia in dogs     

Hanna Rögels  Fernando Martinez-Taboada 《Veterinary anaesthesia and analgesia》2021,48(2):247-251

ObjectiveTo compare the dose, cardiopulmonary effects and quality of anaesthetic induction in dogs using propofol (10 mg mL^–1) and diluted propofol (5 mg mL^–1).Study designRandomized, blinded, clinical study.AnimalsA total of 28 client-owned dogs (12 males/16 females).MethodsFollowing intramuscular acepromazine (0.02 mg kg^–1) and methadone (0.2 mg kg^–1), propofol (UP, 10 mg mL^–1) or diluted propofol (DP, 5 mg mL^–1) was administered intravenously (0.2 mL kg^–1 minute^–1) by an anaesthetist unaware of the allocated group to achieve tracheal intubation. Sedation, intubation and induction quality were scored from 0 to 3. Pre- and post-induction pulse rate (PR), respiratory rate (f_R) and systolic (SAP), mean (MAP) and diastolic (DAP) arterial blood pressure were compared. Time to first breath and induction dose were recorded. Data were analysed for normality and Mann–Whitney U or Student t tests were performed where appropriate. Significance was set at p < 0.05. Data are presented as mean ± standard deviation or median (range).ResultsThe propofol dose administered to achieve induction was lower in the DP group (2.62 ± 0.48 mg kg^–1) than in the UP group (3.48 ± 1.17 mg kg^–1) (p = 0.021). No difference was observed in pre- and post-induction PR, SAP, MAP, DAP and f_R between groups. The differences between post-induction and pre-induction values of these variables were also similar between groups. Time to first breath did not differ between groups. Sedation scores were similar between groups. Quality of tracheal intubation was marginally better with UP 0 (0–1) than with DP 1 (0–2) (p = 0.036), but overall quality of induction was similar between groups [UP 0 (0–1) and DP 0 (0–1), p = 0.549].Conclusion and clinical relevanceDiluting propofol reduced the dose to induce anaesthesia without significantly altering the cardiopulmonary variables.  相似文献   

Effects of perioperative saphenous and sciatic nerve blocks,lumbosacral epidural or morphine–lidocaine–ketamine infusion on postoperative pain and sedation in dogs undergoing tibial plateau leveling osteotomy     

Alexandra B. Kalamaras  Turi K. Aarnes  Sarah A. Moore  Stephen C. Jones  Carolina Ricco Pereira  Juan Peng  Nina R. Kieves 《Veterinary anaesthesia and analgesia》2021,48(3):415-421

ObjectiveTo compare the quality of postoperative analgesia and sedation after preoperative saphenous and sciatic nerve blockade, preoperative lumbosacral epidural injection and perioperative intravenous (IV) morphine, lidocaine and ketamine infusions in dogs undergoing stifle arthroscopy and tibial plateau leveling osteotomy (TPLO) under general anesthesia.Study designProspective, blinded, randomized, clinical comparison study.AnimalsA total of 45 dogs weighing 33.9 (15.9–56.7) kg and aged 5.2 (1.0–12.0) years, mean (range), undergoing elective unilateral TPLO for spontaneous cranial cruciate ligament rupture.MethodsClient-owned dogs were enrolled. Dogs were randomly assigned to one of three groups: group MLK, perioperative IV morphine, lidocaine and ketamine infusion; group EPID, lumbosacral epidural with ropivacaine and morphine; or group SSNB, saphenous and sciatic nerve blockade with ropivacaine. Routine stifle arthroscopy followed by TPLO surgery was performed. Sedation and pain scores were assessed at 0, 2, 4, 8 and 24 hours following extubation. Rescue analgesia was administered as prescribed by Glasgow composite pain score–short form score >5.ResultsSedation scores for MLK were higher than EPID and SSNB. Pain scores for SSNB were lower than those for EPID and MLK. No significant differences were found in anesthesia duration or surgery duration among groups. No dogs required rescue analgesia.Conclusions and clinical relevanceAlthough analgesia was adequate in all groups, the best combination of analgesia without increased sedation was recorded for SSNB.  相似文献   

Assessment of pulse co-oximetry technology after in vivo adjustment in anaesthetized dogs     

Hamaseh Tayari  Derek Flaherty  Tyfane T. Yamaoka  Adam Auckburally 《Veterinary anaesthesia and analgesia》2021,48(3):297-304

ObjectiveTo compare values of haemoglobin concentration (SpHb), arterial haemoglobin saturation (SpO₂) and calculated arterial oxygen content (SpOC), measured noninvasively with a pulse co-oximeter before and after in vivo adjustment (via calibration of the device using a measured haemoglobin concentration) with those measured invasively using a spectrophotometric-based blood gas analyser in anaesthetized dogs.Study designProspective observational clinical study.AnimalsA group of 39 adult dogs.MethodsIn all dogs after standard instrumentation, the dorsal metatarsal artery was catheterised for blood sampling, and a pulse co-oximeter probe was applied to the tongue for noninvasive measurements. Paired data for SpHb, SpO₂ and SpOC from the pulse co-oximeter and haemoglobin arterial oxygen saturation (SaO₂) and arterial oxygen content (CaO₂) from the blood gas analyser were obtained before and after in vivo adjustment. Bland–Altman analysis for repeated measurements was used to evaluate the bias, precision and agreement between the pulse co-oximeter and the blood gas analyser. Data are presented as mean differences and 95% limits of agreement (LoA).ResultsA total of 39 data pairs were obtained before in vivo adjustment. The mean invasively measured haemoglobin–SpHb difference was –2.7 g dL^?1 with LoA of –4.9 to –0.5 g dL^?1. After in vivo adjustment, 104 data pairs were obtained. The mean invasively measured haemoglobin–SpHb difference was –0.2 g dL^?1 with LoA of –1.1 to 0.6 g dL^?1. The mean SaO₂–SpO₂ difference was 0.86% with LoA of –0.8% to 2.5% and that between CaO₂–SpOC was 0.66 mL dL^–1 with LoA of –2.59 to 3.91 mL dL^–1.ConclusionsBefore in vivo adjustment, pulse co-oximeter derived values overestimated the spectrophotometric-based blood gas analyser haemoglobin and CaO₂ values. After in vivo adjustment, the accuracy, precision and LoA markedly improved. Therefore, in vivo adjustment is recommended when using this device to monitor SpHb in anaesthetised dogs.  相似文献   

Repeatable and objective method for evaluating angiogenesis using real‐time RT‐PCR of endoglin expression in canine tumours     

Mayu Kimura  Masahiro Yamasaki  Hiroshi Satoh  Naohiro Uchida 《Veterinary and comparative oncology》2021,19(1):34-43

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一例比格犬先天性隐睾的组织病理学观察     

胡建廷  邱波  王韶艳  屈卉锦  王凤乾  张鑫  英永 《动物医学进展》2016,(11):133-135

通过研究隐睾症比格(Beagle)犬睾丸、附睾的组织病理学改变,建立适用于GLP的实验动物背景性资料。采用常规组织学方法,对比格犬隐睾及正常侧睾丸、附睾进行光学显微镜观察,确定组织病理学变化特点。与正常组织相比,隐睾胶原纤维组织增生,睾丸曲细精管内仅见少量精原细胞及支持细胞。附睾间质增宽,间质内填充增生的胶原纤维,附睾管内精子缺如。需加强比格犬自发病变的病理监测,为药物安全性评价提供实验动物的背景资料。  相似文献   

IMAGING DIAGNOSIS—MULTIMODALITY FINDINGS IN AN ADULT DOG WITH PRIMARY SARCOMA OF THE PULMONARY ARTERY AND MYOCARDIAL METASTASES          下载免费PDF全文

Susanne M. Stieger‐Vanegas  Bryan Bottorff  David Sisson  Christiane V. Löhr 《Veterinary radiology & ultrasound》2016,57(4):E34-E41

Intravascular pulmonary artery sarcomas in combination with myocardial metastasis are rare in dogs. We describe the radiographic, echocardiographic, and electrocardiographic‐gated (ECG‐gated) computed tomographic angiography (CTA) findings in a dog with pulmonary artery sarcoma. All imaging studies demonstrated severe main pulmonary artery enlargement. Echocardiography and ECG‐gated CTA revealed a mass occluding the lumen of the right pulmonary artery. In addition, CTA revealed focal left ventricular myocardial contrast enhancement and parenchymal lung changes. Postmortem examination confirmed the presence of a large thrombus associated with arteriosclerosis and an intravascular sarcoma in the right pulmonary artery with metastases to the myocardium, lungs and brain.  相似文献   

TRUNCATION ARTIFACT IN MAGNETIC RESONANCE IMAGES OF THE CANINE SPINAL CORD          下载免费PDF全文

Tommaso Gregori  Richard Lam  Simon L. Priestnall  Christopher R. Lamb 《Veterinary radiology & ultrasound》2016,57(6):582-586

The truncation artifact in magnetic resonance (MR) images is a line of abnormal signal intensity that occurs parallel to an interface between tissues of markedly different signal intensity. In order to demonstrate the truncation artifact in sagittal images of the canine spinal cord and the effect of changing spatial resolution, we conducted an experimental in vitro study. A section of fixed canine spinal cord was imaged using a 1.5T magnet. Spatial resolution was increased by increasing the acquisition matrix and reconstruction matrix, producing series of T2‐weighted (T2w) images with the following pixel sizes: A, 1.6 (vertical) × 2.2 mm² (horizontal); B, 1.2 × 1.7 mm²; C, 0.8 × 1.1 mm²; D, 0.4 × 0. 6 mm². Plots of mean pixel value across the cord showed variations in signal intensity compatible with truncation artifact, which appeared as a single, wide central hyperintense zone in low‐resolution images and as multiple narrower zones in high spatial resolution images. Even in images obtained using the highest spatial resolution available for the MR system, the edge of the spinal cord was not accurately defined and the central canal was not visible. The experiment was repeated using an unfixed spinal cord specimen with focal compression applied to mimic a pathologic lesion. Slight hyperintensity was observed within the spinal cord at the site of compression although the cord was normal histologically. Results of this study suggest that caution should be applied when interpreting hyperintensity affecting the spinal cord in T2w sagittal images of clinical patients because of the possibility that the abnormal signal could represent a truncation artifact.  相似文献   

Evaluation of effects of olfactory and auditory stimulation on separation anxiety by salivary cortisol measurement in dogs     

Yoon-Joo Shin  Nam-Shik Shin 《Journal of veterinary science (Suw?n-si, Korea)》2016,17(2):153-158

Separation anxiety (SA) is a serious behavioral problem in dogs. In this study, salivary cortisol was studied to determine if the owner''s odor or voice could reduce SA in dogs. Twenty-eight dogs with SA were divided into three groups: group 1 (control), group 2 (with owner''s clothes during the separation period; SP) and group 3 (a recording of the owner''s voice was played during SP). The dog''s saliva was collected after the owner and their dog were in the experimental room for 5 min (PRE). The dog was then separated from the owner for 20 min and saliva collected four times at intervals of 5 min (SP1–4). Finally, the owner was allowed back into the room to calm the dog for 5 min, after which saliva was collected (POST). Evaluation of salivary cortisol concentrations by ELISA revealed that the ratios of SP1 concentration to PRE or POST concentrations were significantly higher in group 1 than in group 2 or 3. Additionally, the concentrations of SP1–PRE and SP1–POST among groups differed significantly. These findings indicate that the owner''s odor or voice may be helpful to managing stress in dogs with SA.  相似文献   

Intravenous infusion of amino acids in dogs attenuates hypothermia during anaesthesia and stimulates insulin secretion          下载免费PDF全文

Satoshi Takashima  Sanae Shibata  Kazuto Yamada  Mizuho Ogawa  Naohito Nishii  Hitoshi Kitagawa 《Veterinary anaesthesia and analgesia》2016,43(4):379-387

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Adverse reactions following administration of contrast media for diagnostic imaging in anaesthetized dogs and cats: a retrospective study          下载免费PDF全文

Stefania Scarabelli  Peter Cripps  Eva Rioja  Briony Alderson 《Veterinary anaesthesia and analgesia》2016,43(5):502-510

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