The mast cell in wound healing   总被引：6，自引：0，他引：6  

Noli C  Miolo A 《Veterinary dermatology》2001,12(6):303-313

This review describes the role of the mast cell in the pathobiology of skin healing. After illustrating its main morphofunctional characteristics, with special reference to the dog and cat, we consider the involvement of the mast cell in the various phases of skin repair. With the aid of a wide array of newly formed or preformed mediators released by degranulation, the activated mast cell controls the key events of the healing phases: triggering and modulation of the inflammatory stage, proliferation of connective cellular elements and final remodelling of the newly formed connective tissue matrix. The importance of the mast cell in regulating healing processes is also demonstrated by the fact that a surplus or deficit of degranulated biological mediators causes impaired repair, with the formation of exuberant granulation tissue (e.g. keloids and hypertrophic scars), delayed closure (dehiscence) and chronicity of the inflammatory stage.  相似文献   

Effects of dietary flax seed and sunflower seed supplementation on normal canine serum polyunsaturated fatty acids and skin and hair coat condition scores     

Rees CA  Bauer JE  Burkholder WJ  Kennis RA  Dunbar BL  Bigley KE 《Veterinary dermatology》2001,12(2):111-117

This prospective study involved supplementing 18 normal dogs with flax seed (FLX) and sunflower seed (SUN) and evaluating their effects on skin and hair coat condition scores and serum polyunsaturated fatty acids (PUFA) concentrations. Skin and hair coat were evaluated in a double-blinded fashion using a numeric scoring system and serum PUFA concentrations were determined. Our hypothesis was that changes in serum PUFA concentrations are associated with improvements in skin and hair coat and that serum PUFA would provide an objective method for making dietary fatty acid supplement recommendations. Although a numerical improvement was found in hair coat quality in both groups, this improvement was not sustained beyond 28 days. The relative per cent of 18:3n-3 concentrations in serum phospholipids increased in the FLX treated dogs but these concentrations remained unchanged in the SUN treated dogs. Also, elevations in relative per cent of 18:2n-6 concentrations in serum phospholipids were seen in the FLX group. The ratio of serum polyunsaturated to saturated fatty acids also showed a transient increase. These increases preceded the peak skin condition score peak value by approximately 14 days. It was concluded that a 1-month supplementation with either flax seed or sunflower seed in dogs provides temporary improvement in skin and hair coat. These changes appeared to be associated with increased serum 18 carbon PUFA.  相似文献   

Clinical and histological evaluation of an analogue of palmitoylethanolamide, PLR 120 (comicronized Palmidrol INN) in cats with eosinophilic granuloma and eosinophilic plaque: a pilot study   总被引：2，自引：0，他引：2  

Scarampella F  Abramo F  Noli C 《Veterinary dermatology》2001,12(1):29-39

Fifteen cats with eosinophilic granuloma or eosinophilic plaque were given PLR 120 at the dosage of 10 mg kg⁻¹ twice daily for one month. PLR-120 down-modulates mast cell degranulation via a receptor-mediated mechanism. No other drugs were permitted and cats were kept free of parasites throughout the study. A clinical evaluation and skin biopsies were performed before and after the treatment. Clinical improvement was assessed at 15 and 30 days. Mast cell numbers were counted and their granular content was assessed by densitometric analysis on toluidine blue-stained sections before and after the treatment. Ten of 15 (67%) cats showed clinical improvement of signs and lesions. There was no significant difference between mast cell numbers in skin biopsies taken before and after the trial, whereas the number of granules was significantly increased ( P < 0.009). This pilot study suggests that PLR-120 might be a useful drug for the treatment of eosinophilic granuloma and eosinophilic plaque.  相似文献   

Congenital hypotrichosis in a Percheron draught horse     

Valentine BA  Hedstrom OR  Miller WH  Scott DW  Mathies S 《Veterinary dermatology》2001,12(4):215-217

A blue roan Percheron foal was born with poorly circumscribed patchy alopecia of the trunk and legs. Teeth and hoof development were normal. Alopecia was progressive, becoming almost complete by 1 year of age. Histopathological findings in a skin biopsy obtained at 7 months of age were consistent with severe follicular hypoplasia. Sebaceous glands, epitrichial sweat glands and arrector pilae muscles were normal. The horse is alive and otherwise well at 6 years of age, although adult stature is considered small for this breed. The clinical history and histopathological findings are most consistent with a form of congenital hypotrichosis.  相似文献   

Intracorneal vacuoles in skin diseases with parakeratotic hyperkeratosis in the dog: a retrospective light-microscopy study of 111 cases (1973-2000)     

Senter DA  Scott DW  Miller WH  Erb HN 《Veterinary dermatology》2002,13(1):45-49

Two recent case reports described a congenital keratinization defect (congenital follicular parakeratosis; CFP) in Rottweiler and Siberian Husky dogs. Skin biopsy specimens revealed marked parakeratosis targeting the hair follicle and numerous intracorneal vacuoles. A retrospective histopathological study was conducted on skin biopsy specimens from 111 dogs with diseases associated with parakeratotic hyperkeratosis to determine whether intracorneal vacuoles were present. Additional criteria evaluated were the size and location of the vacuoles and the degree of parakeratosis. Cases examined included dogs with primary idiopathic seborrhoea, necrolytic migratory erythema (NME), Malassezia dermatitis, zinc-responsive dermatosis, hereditary nasal hyperkeratosis of Labrador Retriever dogs, thallotoxicosis and CFP. Thirty-seven cases (37/111, 33%) had intracorneal vacuoles, including nine cases of primary idiopathic seborrhoea (9/29, 31%), 10 cases of NME (10/18, 56%), five cases of Malassezia dermatitis (5/19, 26%), five cases of zinc-responsive dermatosis (5/36, 14%), five cases of hereditary nasal hyperkeratosis (5/5, 100%) and three cases of CFP (3/3, 100%). If present, intracorneal vacuoles were found throughout all layers of the parakeratin. The sizes of intracorneal vacuoles varied among diseases, but large (> 5 microm) vacuoles only were present in CFP. Biopsies with a larger degree of parakeratosis were significantly more likely to have intracorneal vacuoles (P = < 0.001). Based on this study, intracorneal vacuoles are a common finding in many parakeratotic skin diseases of the dog, but large (> 5 microm) vacuoles are found only in CFP.  相似文献   

Cutaneous lesions in dogs with Dirofilaria (Nochtiella) repens infestation and concurrent tick-borne transmitted diseases     

Tarello W 《Veterinary dermatology》2002,13(5):267-274

A pruritic dermatitis characterized by the presence of erythema, papules, focal or multifocal alopecia, crusting and nodules was seen in 28 dogs with Dirofilaria repens microfilariae infestation in an endemic area in north-west Italy. Previous unsuccessful nonspecific antipruritic treatments, flea control and restricted diet were recorded in 53.6% of the patients. Both the Knott and the antigen tests were negative for Dirofilaria immitis and Acanthocheilonema reconditum. Concurrent babesiosis and/or canine granulocytic ehrlichiosis was also diagnosed in many affected dogs. Preliminary treatment of the concurrent diseases was followed by specific filaricide treatment. The cutaneous lesions, although slightly improved with the initial treatment, resolved completely with macro- and microfilaricide treatment. Although D. repens may be an opportunistic pathogen, this parasite should not be considered as harmless as previously thought and its potential pathogenic role in causing cutaneous lesions in dogs should be considered. Furthermore, it has a zoonotic importance as human cases have been reported worldwide.  相似文献   

Dermal arteritis of the nasal philtrum in a Giant Schnauzer and three Saint Bernard dogs     

Torres SM  Brien TO  Scott DW 《Veterinary dermatology》2002,13(5):275-281

Arteritis of the nasal philtrum is described in four dogs. Two of the Saint Bernards were related. The lesions were solitary, well-circumscribed, linear ulcers that were neither pruritic nor painful. The age of the dogs at the time the owners first noticed the lesion ranged from 3 to 6 years. The ulcers had been present for 0.5-5 years before diagnosis was pursued. Three of the dogs experienced repeated, mild episodes of arterial bleeding from the ulcers. Two dogs also experienced a severe episode of bleeding that required surgical intervention. Histopathological findings included a V-shaped ulcer, neutrophilic dermal inflammation subjacent to the ulcer and lymphoplasmacytic dermatitis bordering the ulcer. The most remarkable pathological findings were present in the deep dermal arteries and arterioles subjacent to the ulcer. The changes were characterized by subendothelial spindle cell proliferation with marked extracellular matrix deposition that stained blue with Alcian Blue (mucin) and Masson's trichrome (collagen) and resulted in intimal thickening, and stenosis of dermal arteries and arterioles. Immunohistochemical studies suggested that the proliferating spindle cells were of either myofibroblast or smooth muscle origin (actin and vimentin positive). Anti-inflammatory therapy (glucocorticoids; tetracycline and niacinamide; fish oil) may be beneficial for long-term control of this condition, however, long-term maintenance treatment appears to be necessary.  相似文献   

Putative drug-related pemphigus foliaceus in four dogs     

White SD  Carlotti DN  Pin D  Bonenberger T  Ihrke PJ  Monet E  Nishifuji K  Iwasaki T  Papich MG 《Veterinary dermatology》2002,13(4):195-202

Four dogs developed cutaneous lesions following the administration of various antibiotics. Histopathology of the lesions was compatible with pemphigus foliaceus, although apoptotic cells suggestive of erythema multiforme were seen in two cases. In two dogs the lesions resolved after 7.5-8.5 months of immune-suppressive treatment. No recurrence was seen during the follow-up period (3 and 4.5 years). The lesions in the other two dogs resolved within 3 weeks to 3 months following discontinuation of the antibiotic. No recurrence of clinical signs occurred during the follow-up period (1 and 4 years, respectively).  相似文献   

Lupoid Dermatosis in Five German Short-haired Pointers     

MARGREET W. VROOM †  MANDy J. THEAKER‡  JOAN R. REST§  STEPHEN D. WHITE¶ 《Veterinary dermatology》1995,6(2):93-98

Résumé— La dermatose lupoïde du Braque Allemand doit être considéré comme une génodermatose bien que le nombre de cas décrit soit faible. Cette maladie concerne de jeunes chiens. Aucune prédisposition sexuelle n'est notée. Pour l'instant, cette maladie n'a été observée que chez le Pointer. Le diagnostic repose sur l'examen clinique et l'examen histopathologique des biopsies cutanées. Le pronostic est généralement réservé, mais l'utilisation des acides gras et un traitement symptomatique peuvent être préconisés. [Vroom, M.W., Theaker, M.J., Rest, J.R., White, S.D. Lupoid dermatosis in five German short-haired pointers (Dermatose lupoïde chez cinq Braques Allemands). Resumen— La dermatosis lupoide del Pointer Alemán de pelo corto podria ser un genodermatosis, aunque el número de casos descritos es bajo. Esta enfermedad se presenta en perros jóvenes. No hay predisposición por sexo. Hasta el momento sólo se ha descrito como tal en el Pointer Alemán de pelo corto. El diagnóstico se realiza mediante examen clinico e histopatológico de biopsias cutáneas. El pronóstico es grave, pero se recomienda un tratamiento sintomático y con ácidos grasos. [Vroom, M.W., Theaker, M.J., Rest, J.R., White, S.D. Lupoid dermatosis in five German short-haired pointers (Dermatosis lupoide en cinco perros Pointer alemán de pelo corto). Abstract— Lupoid dermatosis of the German short-haired pointer may be a genodermatosis, although the number of cases reported is low. The disease occurs in young dogs. There is no sex predisposition. Until now the disease has only been consistently described in the German short-haired pointer. Diagnosis can be made by clinical examination together with histopathological examination of skin biopsies. The prognosis is usually poor, but fatty acid and symptomatic treatment should be attempted.  相似文献   

幼猪皮肤红斑疹病的研究     

张恒轩  万福江 《黑龙江畜牧兽医》1994,(7):3-4,17

１９９０年以来在宁安市发生一种猪的慢性皮肤病，发病年龄主要是１０月龄以内的幼猪，感染率为２０％－３０％，临床使用抗生素类和治癞灵等治疗无效，残废率低，但严重影响生长，饲料报酬低，经研究，查到病原是猪穿孔螨引起的慢性皮肤病型或过敏型皮炎。  相似文献