关于我国新兽药研究开发的战略思考     

胡海燕 《中国兽药杂志》2006,40(8):45-48

以提高自主创新能力为主题，分析了我国兽药研究开发现状，提出了今后我国兽药行业及生产企业进行新兽药研究开发的战略目标设想、内容和建议。  相似文献   

液相色谱-质谱联用技术在检测食品中兽药残留的应用   总被引：1，自引：0，他引：1  

严凤  黄士新  余琛  徐梅倩  何国声 《中国兽医寄生虫病》2007,15(2):34-40

动物性食品安全问题现已成为一个全球性的议题。动物性食品药残超标、安全性差的问题十分突出。建立一种准确、灵敏、可靠的分析动物性食品中兽药残留的方法刻不容缓。介绍了液相色谱-质谱联用技术(LC-MS)应用于动物性食品中几种常见兽药残留的检测方法。  相似文献   

液相色谱-离子阱质谱联用技术定性检测渔药中喹诺酮类抗菌素   总被引：2，自引：0，他引：2  

邹红梅 《福建水产》2007,(2):24-27

建立了高效液相色谱-质谱联用技术定性检测渔药中喹诺酮类抗菌素的方法.利用喹诺酮类化合物的质荷比(m/z)和其荧光光谱特性对渔药中恩诺沙星、环丙沙星、诺氟沙星、氧氟沙星四种喹诺酮类化合物进行定性分析,结果表明该方法快速可行,方法检出限分别为1.29 ng、1.23 ng、1.08 ng、1.00 ng,可用于渔药中喹诺酮类抗菌素的监控.  相似文献   

Epidemiological Cut-off Values (ECOFFs) of Salmonella from Chicken Intestinal Tract for Three Animal-specific Antibiotics     

WU Sili  FU Jiali  ZHU Jiahang  ZHANG Yan  DING Xiaomin  JIANG Hongxia 《中国畜牧兽医》2007,47(9):2917-2925

In order to establish epidemiological cut-off values (ECOFFs) of Salmonella for three animal-specific antibiotics (florfenicol,apramycin and danofloxacin) in Guangdong province.A total of 166 strains of Salmonella isolates from chicken intestinal tract from veterinary clinics and farms in Guangdong province in 2017 were recruited in this study,the minimum inhibitory concentrations (MIC) of florfenicol,apramycin and danofloxacin were determined in triplicate for each bacterial strain using the agar dilution method on Mueller-Hinton agar plates according to the CLSI reference method (CLSI-M100-S26).ECOFFs were calculated for the MIC data sets by application of nonlinear regression analysis,NRI(normalized resistance interpretation) and ECOFFinder software.MIC distribution of florfenicol,apramycin and danofloxacin against Salmonella from 2 to >512,4 to >512 and 0.015 to 64 μg/mL,respectively.MIC₅₀ and MIC₉₀ for apramycin,florfenicol and danofloxacin were 256 and >512,16 and >512,0.5 and 16 μg/mL,respectively.MIC distribution of apramycin and florfenicol presented obvious unimodal shape,while that of danofloxacin was a discontinuous multi-peak.The ECOFFs of florfenicol,apramycin and danofloxacin were recommended to be 16,16 and 0.125 μg/mL,respectively.In present study,the ECOFFs of Salmonella from chicken intestinal tract for apramycin,florfenicol and danofloxacin were determined,which provided scientific basis for resistance surveillance.  相似文献   

我国兽药行业科技成果转化及思考     

张广川  刘业兵 《中国兽药杂志》2022,56(2):77-81

基于我国2016-2020年批准的兽药产品数据,从新兽药种类、新兽药研发及转化主体、新兽药成果转化方式等方面进行分析。结合国家当前科技成果转化政策及兽药行业政策,本文分析了我国兽药科技成果转化过程中存在的问题,提出进一步促进我国兽药行业科技成果转化对策建议,以期为兽药行业科研发展、科技成果转化提供参考。  相似文献   

几种药剂浸种处理对西瓜幼苗生长的影响   总被引：2，自引：0，他引：2  

陆晓民  赵冰  丁祖文  陈光华  吴智勇 《中国林副特产》2007,(1):13-15

采用黄腐酸盐、绿风95、稀土、爱多收、油菜素内酯等几种药剂对西瓜进行浸种处理,测定其对西瓜幼苗某些生长、生理指标的影响。结果表明:采用几种药剂处理后,与相应的对照相比,均可提高叶绿素含量、增加根系活力、促进幼苗生长,从而有利于西瓜的壮苗培育。从几种药剂处理对西瓜的营养生长及生理指标的影响进行综合判断可知,以爱多收处理为最好。  相似文献   

兽药广告宣传中的中西方文化差异分析     

李鹏飞 《中国兽药杂志》2015,49(12):61-64

介绍了中西方兽药广告宣传的各种表现形式,分析了中西方文化差异对兽药广告宣传的影响,提出了我国兽药广告宣传在融合中西方文化的同时,要多学习西方优秀作品的创意,使之相互融合、相互渗透的发展建议,从而推动我国优秀的兽药企业及兽药产品走向世界。  相似文献   

对一起销售含违禁药品生猪产品案的查处     

李良鉴  肖永鸿 《中国动物检疫》2015,32(7):89-90

目前,我国生猪产品生产与销售等环节的长效监管机制仍处于探索阶段。本案阐述了一起由江西省赣州市畜牧兽医局查处的销售含有违禁药品生猪产品的违法行为,论述了该案的标的检测、调查取证、依法听证、行政处罚等执法过程,并对相关问题进行了思考与探讨。  相似文献   

A Review of the Expected Effects of Antimicrobials in Bovine Respiratory Disease Treatment and Control Using Outcomes from Published Randomized Clinical Trials with Negative Controls     

《Veterinary Clinics of North America: Food Animal Practice》2015,31(1):97-111

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Pathology and Neurotoxicity in Dogs after Repeat Dose Exposure to a Serotonin 5-HT1B Inhibitor     

Jane C.F. Chang  Paul Ciaccio  Patricia Schroeder  Lindsay Wright  Russell Westwood  Anna-Lena Berg 《Journal of toxicologic pathology》2014,27(1):31-42

AZD3783, a cationic amphiphilic drug and a potent inhibitor of the 5-hydroxytryptamine (5-HT_1B) receptor, was explored as a potential treatment for depression. To support clinical trials, repeat dose toxicity studies in rats and dogs were conducted. Here we report toxicity findings in dogs after dosing from 1 to 3 months. In the 1-month study, there were minimal neuronal vacuolation in the brain, a marked increase in liver enzymes accompanied by hepatocellular degeneration/necrosis and phospholipidosis (PLD), and PLD/cholecystitis in the gallbladder of animals dosed at 47 mg/kg/day. In the 3-month study, neurotoxicity resulted in euthanasia of one animal dosed at 30 mg/kg/day after 86 days. Extensive pathologic changes were seen in all animals in retina epithelium (inclusion bodies), brain (neuronal vacuolation, degeneration, or necrosis and nerve fiber degeneration), spinal ganglia (vacuolation, degeneration, or necrosis), as well as sciatic and optic nerves (degeneration). Pigment-laden macrophages were observed in the lung, kidney, liver, gallbladder, bone marrow, gastrointestinal tract, and lymphoid tissues. Also seen were vitrel and retinal hemorrhage in the eyes. A brain concentration and pathology study showed that the concentration of AZD3783 in the brain was approximately 4 times higher than in the plasma after 4 weeks of dosing, however, they were similar in all regions examined, and did not correlate with areas with pathologic findings. Our findings with AZD3783 in dogs have not been reported previously with other CNS compounds that effect through serotonergic pharmacology.  相似文献