The intravenous pharmacokinetics of butorphanol and detomidine dosed in combination compared with individual dose administrations to exercised horses     

Stuart W. Paine  Jane Bright  James P. Scarth  Pamela R. Hincks  Clive M. Pearce  Colette Hannan  Marc Machnik  Lynn Hillyer 《Journal of veterinary pharmacology and therapeutics》2020,43(2):162-170

In equine and racing practice, detomidine and butorphanol are commonly used in combination for their sedative properties. The aim of the study was to produce detection times to better inform European veterinary surgeons, so that both drugs can be used appropriately under regulatory rules. Three independent groups of 7, 8 and 6 horses, respectively, were given either a single intravenous administration of butorphanol (100 µg/kg), a single intravenous administration of detomidine (10 µg/kg) or a combination of both at 25 (butorphanol) and 10 (detomidine) µg/kg. Plasma and urine concentrations of butorphanol, detomidine and 3-hydroxydetomidine at predetermined time points were measured by liquid chromatography–tandem mass spectrometry (LC-MS/MS). The intravenous pharmacokinetics of butorphanol dosed individually compared with co-administration with detomidine had approximately a twofold larger clearance (646 ± 137 vs. 380 ± 86 ml hr⁻¹ kg⁻¹) but similar terminal half-life (5.21 ± 1.56 vs. 5.43 ± 0.44 hr). Pseudo-steady-state urine to plasma butorphanol concentration ratios were 730 and 560, respectively. The intravenous pharmacokinetics of detomidine dosed as a single administration compared with co-administration with butorphanol had similar clearance (3,278 ± 1,412 vs. 2,519 ± 630 ml hr⁻¹ kg⁻¹) but a slightly shorter terminal half-life (0.57 ± 0.06 vs. 0.70 ± 0.11 hr). Pseudo-steady-state urine to plasma detomidine concentration ratios are 4 and 8, respectively. The 3-hydroxy metabolite of detomidine was detected for at least 35 hr in urine from both the single and co-administrations. Detection times of 72 and 48 hr are recommended for the control of butorphanol and detomidine, respectively, in horseracing and equestrian competitions.  相似文献   

Equine digital tendons show breed-specific differences in their mechanical properties that may relate to athletic ability and predisposition to injury     

M. E. Verkade  W. Back  H. L. Birch 《Equine veterinary journal》2020,52(2):320-325

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毛竹PhcircRNA1的鉴定和调控通路分析     

陈玉静  丁一倩  周明兵 《核农学报》2023,37(4):680-689

环状RNA(circRNAs)是一类经过反向剪切后,3′末端和5′末端共价结合形成的闭合环状单链非编码RNA,在环境胁迫下对植物生长发育有着重要调控作用。为探索circRNA在毛竹响应胁迫过程中的调控作用,本研究构建了circRNA-miRNA-mRNA调控通路。在分析毛竹的全转录组测序数据后,选择并鉴定了1个在紫外线胁迫（UV）和高温胁迫（42℃）下均差异表达的circRNA(PhcircRNA1),并利用生物信息学分析其调控的miRNA和靶基因。通过核糖核酸酶R(RNase R)法鉴定其转录的稳定性,并通过实时荧光定量PCR(qRT-PCR)方法分析了PhcircRNA1、靶miRNA(Ph-miR156)和靶mRNA的表达特征。本研究进一步选择GLR3.1(Glutamate Receptor–Like Gene 3.1)靶基因作为研究对象,观察毛竹水培苗根尖生长至1 cm后的circRNA-miRNA-mRNA表达调控趋势。结果表明,在UV胁迫和高温胁迫下,PhcircRNA1和靶mRNA表达量都有明显下降趋势,而miRNA表达量增高。在毛竹根尖细胞中,PhcircRNA1和G...  相似文献   

Annual warm-season grasses vary for forage yield,quality, and competitiveness with weeds     

Andrew W. Lenssen  S. Dennis Cash 《Archives of Agronomy and Soil Science》2013,59(8):839-852

Warm-season annual grasses may be suitable as forage crops in integrated weed management systems with reduced herbicide use. A 2-year field study was conducted to determine whether tillage system and nitrogen (N) fertilizer application method influenced crop and weed biomass, water use, water use efficiency (WUE), and forage quality of three warm-season grasses, and seed production by associated weeds. Tillage systems were zero tillage and conventional tillage with a field cultivator. The N fertilization methods were urea broadcast or banded near seed rows at planting. Warm-season grasses seeded were foxtail (Setaria italica L.) and proso (Panicum mileaceum L.) millets, and sorghum–sudangrass (Sorghum bicolor (L.) Moench × Sorghum sudenense Stapf.). Density of early emerging weeds was similar among treatments, averaging 51 m^?2. Millets exhibited higher weed density and weed biomass than sorghum–sudangrass. At harvest, sorghum–sudangrass produced significantly greater biomass and N accumulation than either millet. Water use (157 mm) and WUE (25.1 kg mm^-1 ha^?1) of total biomass did not vary among treatments or grass entries. Weed seed production by redroot pigweed and green foxtail was respectively 93 and 73% less in sorghum–sudangrass than proso millet. Warm-season grasses offer an excellent fit in semiarid cropping systems.  相似文献   

Comparison of artificial neural networks and prediction models for reference evapotranspiration estimation in a semi-arid region     

Fatemeh Dehbozorgi 《Archives of Agronomy and Soil Science》2013,59(5):477-497

Estimation of reference evapotranspiration (ET_o) is essential for determination of crop water requirements. In this research, Penman–FAO (P-FAO) and Penman–Monteith (PM) equations were calibrated and validated by lysimeter-measured ET_o with six and four weather parameters. Furthermore, two input structures (six and four weather parameters) to artificial neural networks (ANNs) were investigated. Results showed that the accuracy of the PM equation is greater than that of the P-FAO equation. An empirical equation was developed to estimate daily ET_o using mean daily temperature and relative humidity, and sunshine hours. The accuracy of the equation to estimate daily ET_o using smooth weather data is greater than that of an equation using original data. Furthermore, ANNs were able to estimate ET_o properly. The accuracy of ANNs with six inputs is higher than that obtained using the P-FAO equation and is similar to that determined using the PM equation. A decrease in number of inputs to ANNs generally decreased the accuracy of estimation, however, ANNs were able to estimate ET_o properly when wind speed and solar radiation were unavailable. Furthermore, the accuracy of ANNs, with four input parameters is greater than that obtained using the PM equation and is similar to that obtained with P–FAO and the developed empirical equations.  相似文献   

Zinc sorption–desorption by sand,silt and clay fractions in calcareous soils of Iran     

Mahdi Najafi Ghiri  Mahrooz Rezaei  Abdolmajid Sameni 《Archives of Agronomy and Soil Science》2013,59(9):945-957

Zinc sorption–desorption by sand, silt and clay fractions of six representative calcareous soils of Iran were measured. Sand, silt and clay particles were fractionated after dispersion of soils with an ultrasonic probe. Zinc sorption analysis was performed by adding eight rates of Zn from 6 to 120 μmol g^?1. For the desorption experiment, samples retained after the measurement of Zn sorption were resuspended sequentially in 0.01 M NaNO₃ solution and shaken for 24 h. Results indicated that Zn sorption by soil fractions increased in the order clay > silt > sand, and correlated negatively with CaCO₃ content and positively with cation exchange capacity (CEC) and smectite content. Results indicated that for all fractions, the Langmuir equation described the sorption rates fairly well. In contrast to sorption, Zn desorption from soil fractions increased in the order sand > silt > clay, and correlated positively with CaCO₃ content, CEC and smectite content. Results showed that parabolic diffusion and two constant equations adequately described the reaction rates of Zn desorption. In general, for all soils studied, the coarser the particle size, the less Zn sorption and more Zn desorption, and this reflects much higher risk of Zn leaching into groundwater or plant uptake in contaminated soils.  相似文献   

Evaluation of pan coefficient equations for estimating reference crop evapotranspiration in the arid region     

Mohammad Mehdi Heydari  Morteza Heydari 《Archives of Agronomy and Soil Science》2013,59(5):715-731

Reference evapotranspiration (ET₀) can be estimated on basis of pan evaporation data (E_pan), whose measurements have the advantage of low cost, simplicity of the measuring equipment, simple data interpretation and application as well as suitability for locations with limited availability of meteorological data. E_pan values were converted to ET₀ using the pan evaporation coefficient (K_pan). In this study, seven common K_pan equations were evaluated for prediction of ET₀ in the growing season (April to October) in arid region of Iran. The Cuenca approach was best suited compared to the standard FAO Penman–Monteith method (FAO-56 PM).  相似文献   

Calibration of Hargreaves–Samani equation for estimating reference evapotranspiration in semiarid and arid regions     

Mohammad Mehdi Heydari  Morteza Heydari 《Archives of Agronomy and Soil Science》2013,59(5):695-713

The Penman–Monteith (FAO-56 PM) equation is suggested as the standard method for estimating evapotranspiration (ET₀) by the International Irrigation and Drainage Committee and Food and Agriculture Organization (FAO). On the other hand, the Hargreaves–Samani (HS) equation is an alternative method compared with the FAO-56 PM equation. In the present study, the original coefficient C of the HS equation is calibrated based on the FAO-56 PM equation for estimating the reference ET₀ from 15 meteorological stations in central Iran (about 170,000 km²) under semiarid and arid conditions. After calibration, the new values for C are ranged from 0.0018 to 0.0037. The mean bias error (MBE), the root mean square error (RMSE), and the ratio of average estimations of ET₀ (R) values for all stations are ranged from 0.12 to 5.38, ?5.35 to 1.15 mm d^?1 and 0.64 to 1.28 for the HS equation and from 0.12 to 2.48, ?2.2 to 0.60 mm d^?1, and 1.00 to 1.05 for the calibrated Hargreaves–Samani equation (CHS), respectively. Results indicate that the average RMSE and MBE values are decreased by 40% and 66%, respectively. Relationships for calibrating the C coefficient on the basis of annual average of daily temperature range (ΔT) and wind speed (V) are proposed, calibrated, and validated. Hence, the CHS equation can be used for ET₀ estimates with acceptable accuracy instead of the FAO-56 PM method.  相似文献   

Tree biomass,resource use and crop productivity in agri-horti-silvicultural systems in the dry region of Rajasthan,India     

Bilas Singh  Mahipal Bishnoi  Mana Ram Baloch  Genda Singh 《Archives of Agronomy and Soil Science》2013,59(8):1031-1049

A combination of silvicultural species [Prosopis cineraria (L.), Ailanthus excelsa Roxb. and Colophospermum mopane (J. Kirk ex Benth.)] were planted with horticultural species [Ziziphus mauritiana (L.), Cordia myxa (Forster), and Emblica officinalis (Gaertn)] and intercropped with wheat (Triticum aestivum). Z. mauritiana +P. cineraria combination produced greater fruit, fodder and fuel wood and was less competitive to wheat crop. Crop yield reduced by 5% to 23% in the agroforestry systems than the yield in sole crop plot. Lowest yield was in C. mopane + C. myxa combination. Fodder yield was 0.53, 0.20 and 0.07 t ha^?1 from C. mopane (cursive), P. cineraria and A. excelsa, respectively, whereas utilizable biomass was 2.63 t ha^?1 from C. myxa (cursive) + P. cineraria, 2.21 t ha^?1 from C. myxa (cursive) + C. mopane and 2.18 t ha^?1 from Z. mauritiana + P. cineraria combinations. Soil organic carbon and NH₄–N increased (by 7% and 8%, respectively), whereas NO₃–N and PO₄–P decreased in agroforestry compared to the sole tree plots. Primary root attributes of P. cineraria, A. excelsa and C. mopane were higher in agroforestry and mostly concentrated in the top 0–25 cm of the soil layer. Z. mauritiana + P. cineraria were the best combination with minimum yield reduction and were found to be beneficial in enhancing soil fertility.  相似文献   

Grain legume effects on soil nitrogen mineralization potential and wheat productivity in a Mediterranean environment     

Panagiotis Dalias 《Archives of Agronomy and Soil Science》2013,59(4):461-473

The objective of this work was to provide evidence on the effects of faba bean (Vicia faba L.) and chickpea (Cicer arietinum L.) on the dynamics of soil N availability and yield parameters of wheat (Triticum turgidum L. var. durum) in a legume–wheat rotation in comparison with the effects of the more extensively studied common vetch (Vicia sativa L.). Soil samples were taken from field plots just before wheat sowing and incubated in the laboratory to assess N mineralization potential, soil respiration and N immobilization after incorporation of legume residues. Soil after vetch cultivation showed the highest residual N and mineralization potential (120 mg N kg^?1 soil), the greatest CO₂ release and the smallest N immobilization. Smaller mineral N release (80 mg N kg^?1 soil) was shown by soil after faba bean cultivation, which, however, would be capable to support an average wheat production without fertilization. Soil after chickpea and wheat cultivation manifested no differences in residual N and mineralization or immobilization potential. Laboratory results were well correlated with grain yield and N uptake during the second season of rotation in the field. All legumes resulted in significant yield surpluses and provided N credit to the following unfertilized wheat.  相似文献