硝苯地平控释片治疗无痛性心肌缺血对左心功能的影响     

钟珍  莫振兆 《湛江医学院学报》1994,12(3):206-208

硝苯地平（２０ｍｇ，ｑ１２ｈ×３ｗｋ）治疗无痛性心肌缺血２３例（男１５例，女８例，年龄５５±９．４ａ），对左心功能和ＲＡＡ检测结果显示：治疗后ＨＲ、ＳＢＰ、ＤＢＰ和ＭＡＰ均降低，以ＤＢＰ和ＭＡＰ降低显著（Ｐ＜０．０５）；缺血型ＳＴ段明显改善（Ｐ＜０．０１）；核素心功能ＬＶＥＦ、ＳＶ、ＥＲ和ＲＣＯ均升高（Ｐ＜０．０５～０．０１）；血浆ＰＲＡ和ＡｎｇⅡ降低明显（Ｐ＜０．０５）。表明该药有良好的降压和改善左心功能效应。  相似文献   

Heart structure and coronary blood supply of the Giant anteater (Myrmecophaga tridactyla)     

Nathany Ribeiro Lima dos Santos  Edson José Benetti  Kleber Mirallia de Oliveira  Max Vinicius Malmann Medeiros  Karina Simões 《Anatomia, histologia, embryologia》2021,50(1):15-22

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Combined effects of dexmedetomidine and vatinoxan infusions on minimum alveolar concentration and cardiopulmonary function in sevoflurane-anesthetized dogs     

Rachel C. Hector  Marlis L. Rezende  Khursheed R. Mama  Eugene P. Steffey  Marja R. Raekallio  Outi M. Vainio 《Veterinary anaesthesia and analgesia》2021,48(3):314-323

ObjectiveTo evaluate the effects of combined infusions of vatinoxan and dexmedetomidine on inhalant anesthetic requirement and cardiopulmonary function in dogs.Study designProspective experimental study.MethodsA total of six Beagle dogs were anesthetized to determine sevoflurane minimum alveolar concentration (MAC) prior to and after an intravenous (IV) dose (loading, then continuous infusion) of dexmedetomidine (4.5 μg kg^–1 hour^–1) and after two IV doses of vatinoxan in sequence (90 and 180 μg kg^–1 hour^–1). Blood was collected for plasma dexmedetomidine and vatinoxan concentrations. During a separate anesthesia, cardiac output (CO) was measured under equivalent MAC conditions of sevoflurane and dexmedetomidine, and then with each added dose of vatinoxan. For each treatment, cardiovascular variables were measured with spontaneous and controlled ventilation. Repeated measures analyses were performed for each response variable; for all analyses, p < 0.05 was considered significant.ResultsDexmedetomidine reduced sevoflurane MAC by 67% (0.64 ± 0.1%), mean ± standard deviation in dogs. The addition of vatinoxan attenuated this to 57% (0.81 ± 0.1%) and 43% (1.1 ± 0.1%) with low and high doses, respectively, and caused a reduction in plasma dexmedetomidine concentrations. Heart rate and CO decreased while systemic vascular resistance increased with dexmedetomidine regardless of ventilation mode. The co-administration of vatinoxan dose-dependently modified these effects such that cardiovascular variables approached baseline.Conclusions and clinical relevanceIV infusions of 90 and 180 μg kg^–1 hour^–1 of vatinoxan combined with 4.5 μg kg^–1 hour^–1 dexmedetomidine provide a meaningful reduction in sevoflurane requirement in dogs. Although sevoflurane MAC-sparing properties of dexmedetomidine in dogs are attenuated by vatinoxan, the cardiovascular function is improved. Doses of vatinoxan >180 μg kg^–1 hour^–1 might improve cardiovascular function further in combination with this dose of dexmedetomidine, but beneficial effects on anesthesia plane and recovery quality may be lost.  相似文献   

Cardiovascular effects of dose escalating of norepinephrine in healthy dogs anesthetized with isoflurane     

《Veterinary anaesthesia and analgesia》2021,48(5):654-662

ObjectiveTo evaluate the systemic cardiovascular effects of dose escalating administration of norepinephrine in healthy dogs anesthetized with isoflurane.Study designExperimental study.AnimalsA total of six adult laboratory Beagle dogs, 10.5 (9.2–12.0) kg [median (range)].MethodsEach dog was anesthetized with isoflurane at an end-tidal concentration of 1.7%, mechanically ventilated and administered a continuous rate infusion of rocuronium (0.5 mg kg^–1 hour^–1). Each dog was administered incremental dose rates of norepinephrine (0.05, 0.125, 0.25, 0.5, 1.0 and 2.0 μg kg^–1 minute^–1), and each dose was infused for 15 minutes. Cardiovascular variables were recorded before administration and at the end of each infusion period.ResultsNorepinephrine infusion increased mean arterial pressure (MAP), cardiac output (CO) and oxygen delivery in a dose-dependent manner. Systemic vascular resistance did not significantly change during the experiment. Stroke volume increased at the lower dose rates and heart rate increased at the higher dose rates. Oxygen consumption and lactate concentrations did not significantly change during infusions.ConclusionsIn dogs anesthetized with isoflurane, norepinephrine increased MAP by increasing the CO. CO increased with a change in stroke volume at lower dose rates of norepinephrine. At higher dosage, heart rate also contributed to an increase in CO. Norepinephrine did not cause excessive vasoconstriction that interfered with the CO during this study.Clinical relevanceNorepinephrine can be useful for treating hypotension in dogs anesthetized with isoflurane.  相似文献   

Prevalence and risk factors for atrial fibrillation in dogs with myxomatous mitral valve disease     

Carlo Guglielmini  Marlos Goncalves Sousa  Marco Baron Toaldo  Carlotta Valente  Vinicius Bentivoglio  Chiara Mazzoldi  Ilaria Bergamin  Michele Drigo  Helen Poser 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2020,34(6):2223-2231

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夹竹桃（Nerium indicum）皂甙对鲫鱼（Carassius auratus）幼鱼的影响     

王芳  戴灵鹏  郑祥河  席启斐  王倩 《农业环境保护》2011,(8):1526-1530

为了评价夹竹桃皂甙对非靶标生物的潜在危害,采用半静态法研究了不同浓度（0、5.89、20.12mg·L-1和80.76mg·L-1）的夹竹桃皂甙对鲫鱼幼苗的死亡情况、特定生长率、糖原、蛋白质含量、SOD酶活性和微核率的影响。结果表明,当夹竹桃皂甙处理浓度≤20.12mg·L-1时,处理组的鲫鱼在试验期间无死亡;而在80.76mg·L-1皂甙的处理下,鲫鱼5d后全部死亡。当皂甙染毒浓度达20.12mg·L-1时,随处理时间的增加,特定生长率、糖原和蛋白质含量逐渐下降,而SOD活性先上升后下降;在清水中恢复饲养7d后,鲫鱼幼苗特定生长率和SOD活性受到的抑制作用逐渐减弱,糖原和蛋白含量恢复至与对照组相比无显著差异。此外,微核试验表明夹竹桃皂甙对鲫鱼幼苗的微核率无影响。研究结果表明,夹竹桃皂甙对鲫鱼的毒性属低等毒性且未发现遗传毒性,但高浓度的皂甙能影响鲫鱼幼鱼的正常生理代谢,导致生长受到抑制,严重时可致其死亡。  相似文献   

Diagnostic challenges and treatment options of a suspected pericardial metallic projectile foreign body in a dog     

Joshua M. Elliott MA  DVM  DACVIM  Philipp D. Mayhew BVM&S  DACVS  MRCVS 《Journal of Veterinary Emergency and Critical Care》2011,21(6):684-691

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门电路心血池显象在病毒性心肌炎诊断中的意义     

龙冠洲  欧阳智  李昭骥 《湛江医学院学报》1995,13(1):8-10

应用门电路心血池显象的勾边轮廓法及相位分析中的振幅图和心室相角程标准差观察３８例病毒性心肌炎患者（急性期２０例、后遗症期１８例）和１０例正常人。结果：勾边轮廓法显示左舒缩功能紊乱占９２．１％，其中７３．７％同时显示局部收缩下降；振幅图显示灰阶不均匀、局部灰度下降占７６．３％；左室相角程标准差增宽占６０．５％，其参数为１０．２３±２．９３，与正常对照组比较有极显著差异（Ｐ＜０．０１）。对本文结果分析，认为上述门电路心血池显象三种检查，在病毒性心肌炎（包括急性期和后遗症期）诊断中，能较好地反映心肌损害的程度和心功能状态。  相似文献   

18 例心肺脑复苏成功的体会     

黄鹤龄  唐飞宇 《湛江医学院学报》2002,20(2):103-104

目的：探讨心肺脑复苏的成功经验6方法：回顾性分析18例心肺脑复苏成功的患者（其中急性心肌梗死4例，有机磷农药中毒5例)，银环蛇咬伤2例，安定中毒2例，溺水2例，电击伤2例，气管异物1例)，抢救方法除了胸外按压，人工呼吸，肾上腺素，电击除颤，利多卡因、碳酸氢钠、脱水等常规措施外，对4例心跳骤停时间超过5min者加用了硫喷妥钠静滴，对3例中枢性高热者加用4-8℃生理盐水（冰盐水)静摘。结果：肾上腺素所需的剂量为1mg者12例，3mg 5例，5mg 1例，4例加用硫喷妥钠和3例加用冰盐水静滴的患者均取得满意疗效。结论：在心肺脑复苏的救治中，尽快恢复心跳，及时静脉摘注硫喷妥钠和冰盐水可能是保护脑功能的有效措施。  相似文献   

血液稀释复合光量子综合疗法治疗冠心病心绞痛合并高粘血症患者的疗效观察     

罗发强  尹梅祥  陈启华  叶国鸿  杜志恒  沈均南 《湛江医学院学报》2001,19(5):329-330

目的 :观察血液稀释复合光量子综合疗法对冠心病心绞痛合并高粘滞血症患者的疗效及安全性。方法 :88例随机分为 2组 ,治疗组 :48例在常规临床治疗基础上采用少量多次高容性血液稀释、紫外光及低强度 He- Ne激光体外照射与充氧血液磁化等处理后自血回输 ;对照组 :40例用低分子右旋糖酐加复方丹参液静滴。治疗后观察两组的临床症状、心电图缺血性 ST- T段、血脂、血液流变学及心肌耗氧指数等变化及不良反应 ,并作比较。结果 :治疗组的临床症状 ,心电图缺血性 ST- T改变 ,血脂、血液流变学及心肌耗氧指数均较对照组差异有显著性 ( P<0 .0 5 ) ,而且不良反应少。结论 :血液稀释复合光量子综合疗法对冠心病心绞痛合并高粘滞血症的患者有较好的近期临床疗效 ,安全性好 ,简便易行。  相似文献