Tetradecylthioacetic acid modulates cardiac transcription in Atlantic salmon, Salmo salar L., suffering heart and skeletal muscle inflammation     

Grammes F  Rørvik KA  Takle H 《Journal of fish diseases》2012,35(2):109-117

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多不饱和脂肪酸代谢及其对炎症的调节     

弓剑  晓敏 《动物营养学报》2017,29(1)

炎症是一种机体对感染或组织损伤的保护性反应。适度的或可控的炎症对于入侵病原微生物的清除以及受损组织的修复是必需的,然而过度的或不可控的炎症往往会导致病理性炎症反应发生,大大提高了各种感染性和代谢性疾病的发病风险。多不饱脂肪酸代谢生成的脂质调控介质对炎症的启动、发展以及消退均具有重要的调节作用,了解多不和脂肪酸的代谢及其代谢产物对炎症反应的调节机制,对于通过饲粮营养途径控制疾病发生以及改善人和动物健康具有重要的理论和现实意义。鉴此,本文综述了多不饱和脂肪酸的代谢途径,并就其代谢产物对炎症反应的调节进行了详细论述。  相似文献   

Cytokine,catabolic enzyme and structural matrix gene expression in synovial fluid following intra‐articular administration of triamcinolone acetonide in exercised horses          下载免费PDF全文

H. K. Knych  M. A. Vidal  N. Chouicha  M. Mitchell  P. H. Kass 《Equine veterinary journal》2017,49(1):107-115

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Chronic Gingivostomatitis with Esophagitis in Cats          下载免费PDF全文

M.I. Kouki  S.A. Papadimitriou  D. Psalla  A. Kolokotronis  T.S. Rallis 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2017,31(6):1673-1679

Background

Chronic gingivostomatitis in cats (FCG) is a debilitating disease with potentially deleterious effects on overall health.

Hypothesis/Objectives

Little is known about the pathophysiology and overall impact of FCG. The aims of our study were to investigate whether gingivostomatitis occurs concurrently with esophagitis, if FCG treatment contributes to esophagitis and if esophagitis exacerbates signs of FCG.

Animals

Fifty‐eight cats with clinical signs of FCG and 12 healthy control cats exhibiting no signs of oral disease, all client‐owned.

Methods

Prospective study. Physical, oral and endoscopic examinations were performed on all cats. Measurements of salivary and esophageal lumen pH were obtained from both groups. Biopsies were acquired from sites of esophageal inflammation in cats with FCG and from normal‐appearing esophageal mucosa in control cats.

Results

The majority of cats with clinical signs of FCG exhibited some degree of esophagitis especially in the proximal (44/58) and distal (53/58) parts (P < 0.001) with or without columnar metaplasia, compared to controls. All cats lacked signs related to gastrointestinal disease. Salivary and esophageal lumen pH were not statistically different compared to controls.

Conclusions and Clinical Importance

Feline chronic gingivostomatitis seems to occur concurrently with esophagitis. Esophagitis also should be managed in cats with chronic gingivostomatitis because it may aggravate the existing condition.  相似文献   

Whip-like heterophil projections in consecutive blood films from an injured gopher tortoise (Gopherus polyphemus) with systemic inflammation     

N. I. Stacy  D. V. Fredholm  C. Rodriguez  L. Castro  J. W. Harvey 《The Veterinary quarterly》2017,37(1):162-165

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Anti-inflammatory effects of a Houttuynia cordata supercritical extract     

Sunhee Shin  Seong Soo Joo  Jeong Hee Jeon  Dongsun Park  Min-Jung Jang  Tae-Ook Kim  Hyun-Kyu Kim  Bang Yeon Hwang  Ki-Yon Kim  Yun-Bae Kim 《Journal of veterinary science (Suw?n-si, Korea)》2010,11(3):273-275

Anti-inflammatory effects of Houttuynia cordata supercritical extract (HSE) were investigated in a carrageenan-air pouch model. HSE (200 mg/kg, oral) suppressed exudation and albumin leakage, as well as inflammatory cell infiltration. Dexamethasone (2 mg/kg, i.p.) only decreased exudation and cell infiltration, while indomethacin (2 mg/kg, i.p.) reduced exudate volume and albumin content. HSE lowered tumor-necrosis factor (TNF)-α and nitric oxide (NO), as well as prostaglandin E₂ (PGE₂). Dexamethasone only reduced TNF-α and NO, while indomethacin decreased TNF-α and PGE₂. The suppressive activity of HSE on NO and PGE₂ production was confirmed in RAW 264.7. These results demonstrate that HSE exerts anti-inflammatory effects by inhibiting both TNF-α-NO and cyclooxygenase II-PGE₂ pathways.  相似文献   

Age‐associated changes to pathogen‐associated molecular pattern‐induced inflammatory mediator production in dogs     

Sarah J. Deitschel DVM  Marie E. Kerl DVM  DACVIM  DACVECC  Chee‐Hoon Chang DVM  Amy E. DeClue DVM  MS  DACVIM 《Journal of Veterinary Emergency and Critical Care》2010,20(5):494-502

Objective – To determine whether older dogs will have a more pronounced pro‐inflammatory response and blunted anti‐inflammatory response to pathogen‐associated molecular patterns (PAMPs) compared with younger dogs. Design – Prospective. Setting – University teaching hospital. Animals – Thirty‐eight privately owned sexually altered dogs of various ages. Interventions – Blood was collected for HCT, WBC count, plasma biochemical analysis, and whole blood culture. Whole blood was stimulated with lipopolysaccharide (LPS) or, lipoteichoic acid or, peptidoglycan or, addition of phosphate‐buffered saline. Tumor necrosis factor (TNF), interleukin (IL)‐6, and IL‐10 production from whole blood were compared among young, middle aged, and geriatric dogs. Measurements and Main Results – LPS, lipoteichoic acid, and peptidoglycan stimulated significant TNF, IL‐6, and IL‐10 production from canine whole blood compared with phosphate‐buffered saline. Whole blood from geriatric dogs had a blunted IL‐10 response to LPS stimulation and middle‐aged dogs had increased LPS‐induced TNF production compared with the other groups. Conclusion – PAMPs from gram‐positive and gram‐negative bacteria stimulate TNF, IL‐6, and IL‐10 production from canine whole blood. The inflammatory mediator response to PAMPs from gram‐negative bacteria alters with age and may be one factor contributing to mortality in geriatric dogs with sepsis.  相似文献   

白细胞介素-8及其在动物疾病发生中的作用   总被引：2，自引：2，他引：0  

王宇  郑世民 《中国畜牧兽医》2010,37(3):198-200

白细胞介素-8(interleukin-8,IL-8)作为细胞因子,其在炎症和肿瘤性疾病的发生发展中发挥着重要作用。对其生物学功能和作用机制进行深入系统研究将为抗炎药物研发提供科学依据,为肿瘤治疗开辟新途径。作者就IL-8及其在动物疾病发生中的作用作一简要概述。  相似文献   

Neutrophilic myeloperoxidase index and mean light absorbance in neonatal septic and nonseptic foals     

Piviani M  Segura D  Monreal L  Bach-Raich E  Mesalles M  Pastor J 《Veterinary clinical pathology / American Society for Veterinary Clinical Pathology》2011,40(3):340-344

Background: Two neutrophilic indices reported by the ADVIA 120 Hematology Analyzer, neutrophilic myeloperoxidase index (MPXI), and mean light absorbance (neutrophil X mean [NXM]) have been proposed as indicators of systemic inflammatory disease in horses and of neutrophil activation in coronary ischemic syndromes in people. Objective: The aim of this study was to evaluate NXM and MPXI in healthy, sick nonseptic, and sick septic foals to determine whether conditions likely associated with neutrophil activation result in decreases in these variables. Methods: In this retrospective study, CBC data from 61 neonatal foals presented to the Equine Teaching Hospital of Barcelona were evaluated for correlations between MPXI, NXM, percentage of large unstained cells, neutrophil count, and percentage of band neutrophils. Results obtained in septic (n=32), sick nonseptic (n=22), and healthy foals (n=7) were compared. In addition, results recorded in septic/neutropenic (n=12), septic/non‐neutropenic (n=20), nonseptic/neutropenic (n=8), nonseptic/non‐neutropenic (n=14), and healthy foals (n=7) were also compared. Results: A weak negative correlation was found between MPXI and neutrophil count and between NXM and percentage of band neutrophils. Septic/neutropenic foals had significantly higher MPXI values (median 17.9, minimum–maximum 4.7–42.5) than did septic/non‐neutropenic (1.5, ?24.4 to 22.3), nonseptic/neutropenic (6.6, 0.6–17.9), and nonseptic/non‐neutropenic foals (8.8, ?10.1 to 16.8) but did not differ significantly from controls (12.8, ?8.5 to 20.4). Conclusions: Significant differences in NXM or MPXI were not found when disease groups were compared with controls; however, septic/neutropenic foals had significantly higher median MPXI than other groups of sick foals. Further prospective studies are needed to clarify if this finding is related to decreased neutrophil function or activation in septic/neutropenic foals.  相似文献   

Evaluation of a point-of-care test for canine C-reactive protein     

Plickert HD  Einspanier R  Arndt G  Brunnberg L  Kohn B 《Veterinary clinical pathology / American Society for Veterinary Clinical Pathology》2011,40(3):384-388

Background: In veterinary medicine, there is increasing interest in measuring C‐reactive protein (CRP) as a tool for diagnosis and monitoring of inflammatory diseases. Reported CRP concentrations for healthy dogs have ranged from 0 to 8.9 mg/L. Objectives: The aims of this study were to evaluate a canine‐specific point‐of‐care (POC) lateral flow immunoassay for qualitative CRP measurement in healthy and diseased dogs and to compare results with those obtained by a quantitative ELISA. Methods: Blood samples from 73 client‐owned dogs were available for testing: 16 healthy dogs and 57 dogs with a variety of infectious, inflammatory, or neoplastic diseases. CRP was measured in heparinized whole blood samples and serum with the TECOmedical Dog CRP‐visual POC test. A red line develops in the POC device if CRP is ≥5 mg/L, and results are scored as negative or positive. An ELISA validated previously for canine serum was used as the reference method. Results: For all dogs, serum CRP concentrations measured by the ELISA ranged from 0.1 to ≥350 mg/L (median=38 mg/L). Percentages of the CRP POC test results that agreed with the ELISA results were 98.6% for whole blood and 97.3% for serum samples. For serum samples, sensitivity of the POC test was 96.4% and specificity was 81.3%. For whole blood, sensitivity was 94.7% and specificity was 93.8%. Conclusions: The POC test had very good agreement with the ELISA test and had high sensitivity and specificity; therefore, it can be used as a qualitative test to screen for increases in CRP concentrations.  相似文献