A Review of flavonoids against Cancer and Its Mechanism   总被引：1，自引：0，他引：1  

陈东海  欧阳虹 《中国农学通报》2005,21(4):91-91

类黄酮是植物染料，在流行病学的研究中发现其有抗癌症的作用。类黄酮是许多医用草药的主要功能性成分，表现出生物活性和预防癌症的作用。尽管类黄酮和癌症的流行病学的研究结果仍有限，但富含类黄酮的食物已被提倡。  相似文献   

肺癌术后并发心律失常的相关因素分析     

游永浩  刘荣婷李鸣 王茁齐同谦  黄柒彬邹恭道 李跃 《长江大学学报》2007,4(1):16-17

目的：探讨诱发肺癌术后心律失常的相关因素,为其防治提供依据。方法：对2002年3月～2006年8月期间的肺癌手术患者212例进行回顾性分析,以可能诱发术后心律失常的相关因素分组,比较术后心律失常的发生率。结果：年龄≥60岁、术前肺功能差（FEV1/FVC〈70%）、全肺切除术、术中失血量≥400ml、术后未安装镇痛泵等病例术后心律失常的发生率较高（P〈0.05）。结论：年龄≥60岁、术前肺功能FEV1/FVC〈70%、全肺切除术、术中失血量≥400ml等可能是肺癌术后心律失常的危险因素;术前改善心肺功能,严格掌握手术适应症,术中减少出血、避免损伤自主神经,术后纠正低氧、镇痛等可能会有效减少术后心律失常发生。  相似文献   

Bone metabolic effects of single-dose zoledronate in healthy dogs     

de Lorimier LP  Fan TM 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2005,19(6):924-927

Zoledronate, an aminobisphosphonate with potent antiresorptive activity in bone, has the potential for treatment of malignant osteolysis and hypercalcemia in dogs. The purpose of this study was to evaluate the bone metabolic effects of a single dose of zoledronate in healthy dogs. Four skeletally mature, male, intact dogs received a 15-minute i.v. infusion of zoledronate at a dosage of 0.25 mg/kg. Urine N-telopeptide of type I collagen (NTx) excretion decreased significantly from baseline by 76, 63, 77, and 73% on days 7, 14, 21, and 28, respectively (P < .0125). Serum bone-specific alkaline phosphatase (bALP) decreased significantly from baseline by 36 and 42% on days 21 and 28, respectively (P < .0125). No changes were detected in indices of calcium homeostasis (ionized calcium, intact PTH, or urine calcium excretion). Single-dose i.v. zoledronate at 0.25 mg/kg appears to inhibit homeostatic osteolytic activity in healthy, skeletally mature dogs. Prospective studies should assess repeated-dose safety and activity in healthy and diseased animals of various age groups.  相似文献   

Autologous Peripheral Blood Hematopoietic Cell Transplantation in Dogs with B-cell Lymphoma     

JL Willcox  A Pruitt  SE Suter 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2012,26(5):1155-1163

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鞣花酸的生物学效应     

吴小磊  钟晨  史金铭 《中国林副特产》2019,(1):73-78

天然的植物活性物质对于人体健康状态的维持起着重要作用。类胡萝卜素、生育酚、皂苷化合物等植物活性物质的结构、性质、功能及作用机制相继被研究,它们陆续被开发利用为保健品,药品等产品。广泛存在于各种软果、坚果等植物组织中的活性组分鞣花酸是一种多酚二内酯,是没食子酸的二聚衍生物,具有抗氧化、抗炎、抗增殖、抗病毒等多种生物学效应,在癌症治疗和化学预防方面具有强大潜力。随着相关研究的深入,鞣花酸的作用机制和药用价值不断被挖掘,它将在疾病治疗、美容保健等方面表现出积极作用。对近几年鞣花酸的相关研究进展进行了阐述,以期为鞣花酸的后续研究提供参考。  相似文献   

In vivo and in vitro efficacy of zoledronate for treating oral squamous cell carcinoma in cats     

Wypij JM  Fan TM  Fredrickson RL  Barger AM  de Lorimier LP  Charney SC 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2008,22(1):158-163

BACKGROUND: Feline oral squamous cell carcinoma (OSCC) may cause painful bone destruction. Given the local invasiveness and rapid clinical progression of OSCC, conventional therapies are often palliative. In human cancer patients, zoledronate exerts anticancer effects by inhibiting tumor-induced angiogenesis and malignant osteolysis. HYPOTHESIS: Zoledronate will exert in vitro and in vivo anti-angiogenic and antiresorptive effects in feline OSCC. ANIMALS: Eight cats with OSCC were prospectively treated with zoledronate and conventional treatment modalities. METHODS: In vitro, zoledronate's effects in modulating soluble vascular endothelial growth factor (VEGF) secretion and receptor activator of nuclear factor kappaB (NF-kappaB) ligand (RANKL) expression were investigated in a feline OSCC cell line (SCCF1). In vivo, basal serum C-telopeptide (CTx) concentrations were compared among normal and OSCC-bearing cats, and the biologic effects of zoledronate administration in cats with naturally occurring OSCC were quantified by serially assessing circulating serum VEGF and CTx concentrations. RESULTS: In vitro, zoledronate concentrations greater than 3 microM reduce soluble VEGF secretion in the SCCF1 cell line. The expression of RANKL in the SCCF1 cell line was also modulated by zoledronate, with low concentrations (3 microM) decreasing but higher concentrations (30 microM) increasing RANKL expression in comparison with untreated cells. In vivo, cats with bone-invasive OSCC had greater serum CTx concentrations in comparison with geriatric, healthy controls. Treatment with zoledronate rapidly decreased circulating serum VEGF and CTx concentrations in cats with spontaneously occurring OSCC. CONCLUSIONS AND CLINICAL IMPORTANCE: Zoledronate exerts in vitro and in vivo effects that may favor the slowing of tumor growth and pathologic bone turnover associated with OSCC.  相似文献   

Evaluation of human recombinant tissue factor-activated thromboelastography in 49 dogs with neoplasia   总被引：2，自引：0，他引：2  

Kristensen AT  Wiinberg B  Jessen LR  Andreasen E  Jensen AL 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2008,22(1):140-147

BACKGROUND: Abnormal routine coagulation assay results have been reported to be common in veterinary patients with neoplasia, but the overall hemostatic functional state, including hypercoagulability, has not been described. HYPOTHESIS: The overall hemostatic functional state, including hypercoagulability, can be assessed in dogs with neoplasia by tissue factor (TF)-activated thromboelastography (TEG). ANIMALS: Thirty-six dogs with malignant neoplasia and 13 dogs with benign neoplasia presented to the Small Animal Veterinary Teaching Hospital, The University of Copenhagen, Frederiksberg, Denmark. METHODS: Prospective study evaluating the overall hemostatic functional state in dogs with neoplasia by a newly validated TF-activated TEG assay and routine coagulation parameters activated partial thromboplastin time (aPTT), prothrombin time (PT), platelet count, and D-dimer concentration. RESULTS: Hemostatic dysfunction was observed in 28/49 (57%) dogs with neoplasia. Twenty-four were dogs with malignant neoplasia, the majority of which 18/36 (50%) were hypercoagulable, whereas 6/36 (17%) were hypocoagulable. All hypocoagulable dogs had metastatic disease. The proportion of dogs with altered hemostasis was significantly different between dogs with malignant and benign neoplasia. CONCLUSIONS AND CLINICAL IMPORTANCE: TF-activated TEG detected hypercoagulable and hypocoagulable states in this population of dogs with neoplasia. The most common hemostatic abnormality in dogs with malignant neoplasia was hypercoagulability. These findings suggest that this novel hemostatic function test may be of value as a cage side method for the assessment of overall hemostatic function in dogs with cancer, including the detection of both hyper- and hypocoagulable states as well as mixed disorders.  相似文献   

From viruses to cancer stem cells: dissecting the pathways to malignancy     

Argyle DJ  Blacking T 《Veterinary journal (London, England : 1997)》2008,177(3):311-323

Cancer is a disease of all vertebrate species and has been well documented throughout history with fossil records indicating that dinosaurs of the Jurassic period suffered from the disease. The Greek physician, Galen is accredited with describing human tumours as having the shape of a crab, with leg like tendrils invading deep into surrounding tissues--hence the term cancer. Today cancer can be defined as any malignant growth or tumour caused by abnormal and uncontrolled cell division that is able to invade tissues locally and spread to other parts of the body through the lymphatic system or the blood stream. This is obviously a simplistic attempt at describing a complex disease that can utilize a myriad of biological pathways to sustain growth and proliferation. Dissecting these pathways has been the challenge of cancer researchers for decades in the search for new treatment strategies. This review attempts to condense our understanding of cancer and to offer insights into an alternative theory regarding the existence of true cancer stem cells and how this will inform the development of new therapeutics.  相似文献   

Effects of B7-1 gene expression on the biological characteristics of hepatocarcinoma cells     

TANG Xiao-long  ZHAO Gui-mei  XU Li-fa  ZHOU Xin  CAI Shu-yu 《园艺学报》2008,24(2):225-230

AIM:Modification of tumor cells with B7-1 (CD80) costimulatory adhesion molecules has been proposed as a means to develop therapeutic cancer vaccines for use in human immunotherapy.METHODS:Glycosyl-phosphatidylinositol (GPI)-anchored B7-1 was transfered into QK10341 cell membranes with the plasmid of pcDNA3.1(+)/GPI-B7-1 by lipofectamine transfection. Then the GPI-B7-1 protein was isolated and purified from QK10341 cells. The SKOV3 cells incubated with GPI-B7-1 protein resulted in stable incorporation of B7-1 on SKOV3 cell membranes. Expression of B7-1 in tumors by protein transfer created an immunogenic tumor cell that induced antitumor immunity. The growth curve of T cells, the change of Fas (CD95) expression on cell membranes, and level of cytokines secreted from CTL were determined by MTT, FCM, and ELISA, respectively. The cytotoxicity alteration of the CTL was also studied.RESULTS:Compared with SKOV3 cells, B7-1-SKOV3 cells more effectively induced the proliferation of effector lymphocytes and the generation of specific lytic activity (P<0.01). The level of cytokine secretion also increased.CONCLUSION:The costimulation signal of B7-1 is required for the activation and proliferation of T lymphocytes. The B7-1 expression in SKOV3 tumor cells can increase their immunogenicity and induce more effective T lymphocytes activation.  相似文献   

恶性肿瘤专家咨询系统CIDS的设计与实现     

张丽  杨怀卿 《山西农业大学学报(自然科学版)》1998,18(2):162-164

本文介绍了一个使用ＴＵＲＢＯ－Ｃ开发的用于恶性肿瘤咨询诊疗的专家系统ＣＩＤＳ,该系统具有咨询、诊疗、病案管理、学习和维护等功能。本文主要讨论了ＣＩＤＳ的设计方案,并从维护等方面给出了性能评价。  相似文献