禽网状内皮组织增生病病毒和马立克氏病病毒共感染对鸡的致肿瘤作用   总被引：6，自引：3，他引：6  

张志  庄国庆  孙淑红  崔治中 《畜牧兽医学报》2005,36(1):62-65

用禽网状内皮组织增生病病毒(REV)和马立克氏病病毒(MDV)共感染肉鸡，研究这2种病毒对鸡的致瘤作用，结果表明肉鸡共感染MDV和REV后13d即可发生死亡．接种后100d死亡率达84％。死亡鸡的肝脏、脾脏、肾脏和心脏等可以形成2种外观明显不同的散在的大肿瘤结节和弥漫性的小肿瘤结节。取发病鸡的肝脏、脾脏、肾脏、心脏和腺胃等组织样品做连续石蜡切片，HE染色后发现这些脏器均存在2种不同类型的肿瘤细胞增生。对这些连续切片分别用MDV和REV的单克隆抗体进行间接荧光试验，则同1份样品存在可以与REV和MDV分别呈现阳性反应的肿瘤细胞团，结果表明REV和MDV可以在感染鸡的体内分别诱发形成肿瘤。在接种后14、21、28和42d随机采集3只鸡的全血分离MDV和REV，均可以同时分离到MDV和REV。表明REV和MDV的共感染延长了病毒血症的时间。  相似文献   

Comparison of aloe vera and omeprazole in the treatment of equine gastric ulcer syndrome          下载免费PDF全文

J. Bush  R. van den Boom  S. Franklin 《Equine veterinary journal》2018,50(1):34-40

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Canine GM2‐Gangliosidosis Sandhoff Disease Associated with a 3‐Base Pair Deletion in the HEXB Gene          下载免费PDF全文

P. Wang  P.S. Henthorn  E. Galban  G. Lin  T. Takedai  M. Casal 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2018,32(1):340-347

Background

GM2‐gangliosidosis is a fatal neurodegenerative lysosomal storage disease (LSD) caused by deficiency of either β‐hexosaminidase A (Hex‐A) and β‐hexosaminidase B (Hex‐B) together, or the GM2 activator protein. Clinical signs can be variable and are not pathognomonic for the specific, causal deficiency.

Objectives

To characterize the phenotype and genotype of GM2‐gangliosidosis disease in an affected dog.

Animals

One affected Shiba Inu and a clinically healthy dog.

Methods

Clinical and neurologic evaluation, brain magnetic resonance imaging (MRI), assays of lysosomal enzyme activities, and sequencing of all coding regions of HEXA, HEXB, and GM2A genes.

Results

A 14‐month‐old, female Shiba Inu presented with clinical signs resembling GM2‐gangliosidosis in humans and GM1‐gangliosidosis in the Shiba Inu. Magnetic resonance imaging (MRI) of the dog's brain indicated neurodegenerative disease, and evaluation of cerebrospinal fluid (CSF) identified storage granules in leukocytes. Lysosomal enzyme assays of plasma and leukocytes showed deficiencies of Hex‐A and Hex‐B activities in both tissues. Genetic analysis identified a homozygous, 3‐base pair deletion in the HEXB gene (c.618‐620delCCT).

Conclusions and Clinical Importance

Clinical, biochemical, and molecular features are characterized in a Shiba Inu with GM2‐gangliosidosis. The deletion of 3 adjacent base pairs in HEXB predicts the loss of a leucine residue at amino acid position 207 (p.Leu207del) supporting the hypothesis that GM2‐gangliosidosis seen in this dog is the Sandhoff type. Because GM1‐gangliosidosis also exists in this breed with almost identical clinical signs, genetic testing for both GM1‐ and GM2‐gangliosidosis should be considered to make a definitive diagnosis.  相似文献   

Sonographic Evaluation of Liver Hemodynamic Indices in Overweight and Obese Dogs          下载免费PDF全文

A.F. Belotta  C.R. Teixeira  C.R. Padovani  S.C. Rahal  M.N. Mayer  M.J. Mamprim 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2018,32(1):181-187

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Management and Rehabilitation of Joint Disease in Sport Horses     

《Veterinary Clinics of North America: Equine Practice》2018,34(2):345-358

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Comparative,multidimensional imaging of patent ductus arteriosus and a proposed update to the morphology classification system for dogs          下载免费PDF全文

Kelley R. Doocy  Ashley B. Saunders  Sonya G. Gordon  Nicholas Jeffery 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2018,32(2):648-657

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UV‐light and dietary vitamin D and their effects on ionized calcium and 25‐OH‐D plasma concentrations in captive gentoo penguins (Pygoscelis papua)          下载免费PDF全文

Ursina Tröndle  Hanspeter W. Steinmetz  Simon R. Rüegg  Anja Müller  Annette Liesegang 《Journal of animal physiology and animal nutrition》2018,102(5):1419-1428

In this study, the effect of ultraviolet (UV) light and dietary vitamin D on calcium metabolism in permanently indoor‐housed gentoo penguins (Pygoscelis papua ) was investigated. The study consisted of three periods, each completed with blood samples to analyse plasma concentrations of 25‐OH‐D, 1,25‐(OH)₂‐D, ionized (iCa) and total calcium (tCa). During the first study period (D), animals were housed under routine conditions without UV‐light and fed a diet of different fish species, supplemented with 1,000 IU vitamin D per animal and day. The following study period (Baseline) of 28‐day duration consisted of the same diet without any vitamin D supplementation and without UV‐light. During the study period (UVB) artificial UV‐light was added for 3 weeks. The vitamin D content of fish was measured by high‐performance liquid chromatography. It varied between fish species and between facilities, ranging from no measurable content in capelin (Mallotus villosus ) to 7,340 IU vitamin D/kg original matter (OM) in herring (Clupea spp). The average dietary vitamin D content was 311 IU/kg OM at facility 1 and 6,325 IU/kg OM at facility 2, resulting in a vitamin D intake per animal and day without supplementation of 130 IU (25.5 IU/kg body weight BW) and 2,454 IU (438.2 IU/kg BW) respectively. The supplementation of vitamin D elevated significantly the plasma concentrations of 25‐OH‐D by an intraindividual difference of 15 (range ?2 to 59) nmol/L and tCa by 0.1 (0.0–0.3) mmol/L only at facility 2. The exposure to UV‐light raised the blood concentrations of tCa at facility 2 by 0.15 (0.1–0.2) mmol/L, and of iCa and tCa for females at facility 1 by 0.23 (0.13–0.41) mmol/L and 1.8 (1.1–2.5) mmol/L respectively. No significant influence of the study periods (D) and (UVB) was found for the concentrations of 1,25‐(OH)₂‐D at both facilities.  相似文献   

Anatomy and Disorders of the Oral Cavity of Chinchillas and Degus     

《Veterinary Clinics of North America: Exotic Animal Practice》2016,19(3):843-869

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浙西南山区巨峰葡萄平棚避雨栽培病害发生及防治     

毛金华 《福建农业科技》2015,(3)

总结浙西南山区巨峰葡萄平棚避雨栽培主要病害的发生规律,并提出防治措施。  相似文献   

我国热区疫霉种的分布、疫病及其防治研究进展     

唐庆华  宋薇薇  朱辉  牛晓庆  余凤玉  韩超文  吴多扬  覃伟权 《江西农业学报》2011,23(8):100-103

综述了我国热带地区疫霉种类及其引起的植物病害,并总结了疫病的防治措施,最后对疫病防治的新策略进行了展望。  相似文献