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41.
为了解促炎、抗炎细胞因子在小鼠LPS致炎模型中的动态变化,探讨中药方剂清温消热饮的抗炎治疗作用,采用酶联免疫法测定112例用LPS致小鼠急性炎症模型治疗过程中血清中促炎因子(TNF-α、IL-1β、PGE2)、抗炎因子(IL-10)含量。与LPS致小鼠急性炎症模型组比较:清温消热饮组在18、24 h血清中IL-1β含量明显降低,差异显著(P0.05);清温消热饮组在6、12、18 h血清中TNF-α含量明显降低,6、18 h差异显著(P0.05),12 h差异极显著(P0.01);清温消热饮组血清中的PGE2含量均低于模型组,在6、18、24、36 h时血清中的PGE2含量明显降低,差异极显著(P0.01);清温消热饮组在18、48 h血清中IL-10含量明显升高,差异极显著(P0.01)。同时,清温消热饮组与地塞米松组在各时间段血清中TNF-α、IL-1β、IL-10、PGE2含量无显著差异(P0.05)。结果表明,清温消热饮在急性炎症模型中能有效降低血清促炎因子TNF-α、IL-1β、PGE2含量水平,提升抗炎因子(IL-10)含量水平以表现出明显的抗炎作用。 相似文献
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STEPHEN D. WHITE ROD A. W. ROSYCHUK KATHRYN V. SCOTT ANN M. HARGIS AMY TRETTIEN 《Veterinary dermatology》1992,3(3):107-113
Abstract— A skin disease resembling inflammatory linear verrucous epidermal nevus is reported in four dogs. Three of the dogs were related cocker spaniels. Linear, pigmented verrucous lesions were noted most commonly on the lateral trunk, foot pads and ears. Histologic findings included focal areas of marked epidermal thickening by ortho-and parakeratotic hyperkeratosis and acanthosis, both in epidermis and follicular infundibular epithelium. This was associated with follicular distention and papillomatosis. Both hyper-and hypogranulosis were noted in association with parakeratosis. Improvement was noted in the three dogs administered isotretinoin and/or etretinate. Résumé— Une maladie cutanée ressemblant à un névus épidermique verruqueux linéaire inflammatoire est décrite chez quatre chiens. Trois de ces animaux sont des Cocker Spaniels. Les lesions verruqueuses, linéaires sont localisées le plus souvent sur les faces latérales du tronc, aux coussinets plantaires et aux oreilles. Les observations histologiques mettent en évidence des zones focales d'épaississement épidermique provoqué par une acanthose et une hyperkérathose ortho et parakératosique. Ceci est associéà une papillomatose et une distension folliculaire. On note à le fois une hyper et une hypogranulose associées à la parakératose. L'administration d'isotrétinoïne et/ou d'étritinate a entrainé une amélioration chez trois chiens. Zusammenfassung— Es wird über eine Hauterkrankung bei vier Hunden berichtet, die dem entzündlichen linearen vérrukösen epidermalen Naevus ähnelt. Drei der Hunde waren miteinander verwandte Cock-erspaniel. Lineare pigmentierte verruköse Hautveränderungen wurden am häufigsten lateral am Rumpf, an den Pfotenballen und an den Ohren festgestellt. Die histologischen Befunde beinhalten herdförmige Bezirke mit deutlicher Epidermisverdickung durch ortho-und parakeratotische Hyperkeratose und Akanthose, beides in der Epidermis und im Epithel des Haarbalginfundibulum. Letztere waren mit einer Ausweitung und Papillomatose der Haarbälge vergesellschaftet. In Verbindung mit der Parakératose wurden sowohl Hyperals auch Hypogranulose festgestellt. Nach Verabreichung von Isotretinoin und/oder Etretinate konnte bei den drei Hunden eine Verbesserung erzielt werden. Resumen El presente artículo trata de un caso dermatológico que asemeja a un nevus epidérmico infalmatorio linear verrucoso, reportado en cuatro perros. Tres de los perros eran cocker spaniels que estaban emparentados. En la región lateral del tronco, almohadillas plantares y orejas, se advirtieron lesiones verrucosas pigmentadas, de formal linear. Exámenes histológicos demostraron la presencia de foco de epidermis engrosada, asi como hiperqueratosis orto y paraqueratótica y acantosis, tanto en la epidermis, como en el infundíbulo folicular de la misma. Este hallazgo se asoció con distension folicular y papilomatosis. Tambien se encontró hiper e hipogranulosis en asociación con paraqueratosis. En los tres perros a los que se les administró isotretinoina/o etretinato, se advirtió una mejora considerable. 相似文献
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AIM: To observe the effects of ginsenoside Rh1 on the levels of inflammatory factors in serum and bronchoalveolar lavage fluid (BALF), and the pathological changes of the lung tissues in an experimentally induced mouse asthma model. METHODS: Male BALB/c mice (n=40) were divided into 4 groups:normal control group, asthma mo-del group, and low-dose (40 mg·kg-1·d-1) and high-dose (80 mg·kg-1·d-1) ginsenoside Rh1 groups. The bronchial asthma mouse model was established by the method of ovalbumin induction and excitation, and during the excitation period, the mice were daily treated with ginsenoside Rh1 for 2 weeks. At 24 h after the final dose of ginsenoside Rh1, the mice were sacrificed. The number of eosinophils (EOS) and the concentrations of interleukin (IL)-4, IL-5 and interferon (IFN)-γ in BALF were determined. The levels of IgG and IgE in serum were measured, and the expression of transforming growth factor (TGF)-β1 and the pathological changes in lung tissues were evaluated. RESULTS: Ginsenoside Rh1 inhibited the increases in the number of EOS and the concentrations of IL-4, IL-5, IFN-γ and IgE, reversed the increased expression of TGF-β1, and improved the pathological changes of the lung tissues in asthmatic mice. CONCLUSION: Ginsenoside Rh1 improves the immuno-inflammatory profile and pathological changes in the experimentally induced mouse asthma model, implying its potential therapeutic effect on asthma. 相似文献
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Safety of Intraperitoneal Injection of Adipose Tissue‐Derived Autologous Mesenchymal Stem Cells in Cats 
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AIM: To investigate the effect of growth hormone receptor (GHR) knockdown on nuclear factor-κB (NF-κB) activity and inflammatory cytokine production stimulated by growth hormone (GH) in 3T3-L1 adipocytes. METHODS: The specific siRNA for GHR was transfected into 3T3-L1 adipocytes to silence GHR expressions. The effects of GH on NF-κB activation and inflammatory cytokine production in 3T3-L1 adipocytes transfected with siRNA-GHR or siRNA-control were measured by dual-luciferase system analysis, real-time RT-PCR and ELISA. RESULTS: The protein expression of GHR was diminished after transfection with GHR specific siRNA. Dual-luciferase reporter system analysis revealed that GHR knockdown resulted in attenuation of GH-stimulated NF-κB activation in the 3T3-L1 adipocytes. GHR knockdown ameliorated the GH-induced production of inflammatory cytokines TNF-α, IL-1β, IL-6, MCP-1 and MIP-1α in the 3T3-L1 adipocytes. CONCLUSION: Knockdown of GHR might be efficacious to prevent GH-induced inflammatory responses in the 3T3-L1 adipocytes. 相似文献
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AIM: To investigate the difference between immune-related pain induced by antigen-special complex and inflammatory pain induced by formalin, and to observe the differential expression of p38 mitogen-activated protein kinase in spinal cord. METHODS: Thirty adult health SD rats were randomly divided into control group, formalin group and immune complex group (10 rats in each group). After the baseline tests were finished, 5 rats in each group underwent intrathecal administration of p38 MAPK inhibitor SB203580. The right hindpaw of the rats were injected with PBS, formalin or rat IgG immune complex. The thickness of hindpaw and pain behaviors were observed at time points of 0 min, 30 min, 1 h, 2 h, 4 h, 8 h and 12 h after injection. The expression levels of total and activated p38 MAPK in spinal cord were determined by Western blotting analysis. RESULTS: The rats in formalin group showed significant nociceptive behaviors immediately, such as licking foot, and limping with highly swollen foot which could touch the ground. The pain threshold was decreased rapidly 30 min after injection and alleviated after then. The pain threshold of the rats in immune complex group obviously decreased 4 h after injection without red swollen hindpaw. The expression of activated p-p38 MAPK in spinal cord in formalin group was significantly higher than that in immune complex group and control group (P<0.01). No statistic difference of p-p38 expression between immune complex group and control group, also no significant effects of SB203580 on pain behaviors in immune complex group were observed. CONCLUSION: Activated p38 MAPK contributes to the pathogenesis of inflammatory pain, but not to the pathogenesis of immune-related pain. The mechanism of immune-related pain is different from inflammatory pain induced by formalin. 相似文献
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