Effects of intravenously administrated omeprazole on gastric juice pH and gastric ulcer scores in adult horses     

Andrews FM  Frank N  Sommardahl CS  Buchanan BR  Elliott SB  Allen VA 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2006,20(5):1202-1206

The study was performed to evaluate the efficacy of omeprazole powder in sterile water, administered intravenously, on gastric juice pH in adult horses with naturally occurring gastric ulcers. Omeprazole (0.5 mg/kg, IV) was administered once daily for 5 days to 6 adult horses with gastric ulcers. Gastric juice was aspirated through the biopsy channel of an endoscope and pH was measured before and 1 hour after administration of omeprazole on day 1, and then before and after administration of omeprazole on day 5. Gastric ulcer scores were recorded on day 1 before administration of omeprazole and on day 5, 23 hours after the 4th daily dose. Gastric juice pH and ulcer scores were compared between the times. When compared with the pre-injection value (2.01 +/- 0.42), mean +/- SD gastric juice pH was significantly higher when measured 1 hour after administration of the initial dose (4.35 +/- 2.31), and before (5.27 +/- 1.74) and 1 hour after (7.00 +/- 0.25) administration of omeprazole on day 5. Nonglandular gastric ulcer number score significantly decreased from a mean +/- SD of 3.2 +/- 0.80 to 2.0 +/- 1.1, but nonglandular gastric ulcer severity score remained the same. Few glandular ulcers were seen in the study, and scores did not change. Because of its potent and long duration of action on gastric juice pH, this intravenous formulation of omeprazole may show promise for treatment of equine gastric ulcer syndrome (EGUS) in horses with dysphagia, gastric reflux, or other conditions that restrict oral intake of omeprazole paste. Aspiration of gastric juice and measurement of pH can be of use to determine whether the desired pH > 4.0 has been reached after omeprazole treatment.  相似文献   

The suppressive effects of IFN-α on human gastric carcinoma cell line BGC-823     

LIU Xin  WANG Yong  PAN Xing-bin  WANG He-ping  ZHANG Yue-ping 《园艺学报》2006,22(9):1756-1761

AIM:To observe the inhibitory effect of interferon-α (IFN-α) on the growth invasiveness and metastasis of human gastric carcinoma cell line BGC-823,and mechanism of its action.METHODS:We detected the influence of IFN-α on the proliferative ability of BGC-823 in cell culture system,the cell vitality with the MTT colorimetric assay,and the cell cycle with flow cytometer (FCM).The regulatory functions of IFN-α to the expression of E-cadherin and matrix metalloproteinase-2 (MMP-2) in tumor cells were estimated by immunohistochemical analysis (S-P).The ultrastructural changes of the junction among the tumor cells were observed under electron microscope.RESULTS:IFN-α can significantly inhibit the growth of human gastric carcinoma cell line BGC-823 in a dose-dependent manner.When the concentration of IFN-α was ≥106 U/L,the cell proliferation can be effectively suppressed，the suppression rate was ≥12.2%,and the blockage appeared at the phase of G1-S of the cell cycle.Under the induction of IFN-α,the expression level of the cell E-cadherin increased while the MMP-2 decreased.The changes on ultrastructure of the cells showed the increased adhesive junctions and the relative compact structure.CONCLUSION:IFN-α can suppress the growth of human gastric carcinoma cell line BGC-823 through its influence on cell cycle.IFN-α can regulate the expression of E-cadherin and MMP-2,make the cell junction closely,so that it has the potential on restricting the invasion and metastasis of gastric carcinoma cells.  相似文献   

梅花鹿皱胃阻塞手术治疗及防制     

田来明  陈景云 《经济动物学报》1999,3(4):28-29

本文对生产实践中运用手术方法治疗梅花鹿皱胃阻塞做了详细的介绍。近年来，我们在生产实践中手术治疗皱胃阻塞１２ 例梅花鹿，治愈率１００ ％ 。  相似文献   

植物源昆虫调控剂研究Ⅰ．茶枯等植物源调控剂的药效测定     

王问学  莫建初  李朔南  张云  周郁  张才学  李益辉 《经济林研究》1996,(4)

测定茶枯水及芫花、苦楝、长叶冻绿、苍耳的乙醇抽提物对卫茅尺蠖和菜青虫药效，结果表明，芫花的效果最好，可使取食量下降７５％，并又进一步降低羽化率，抽提物１０ｇ／Ｌ浓度野外有效期在５天以上；次之为苦楝叶。作用途径主要是拒食和胃毒。茶枯水亦有一定作用，它还是植物抽提物的极好湿润剂，对提高药效起重要作用。  相似文献   

Expression of novel gene SNC66 in gastric cancer tissue and normal gastric mucosa     

WU Han-gui  ZHENG Shu 《园艺学报》2004,20(4):616-619

  相似文献   

Inhibitory effect of ampelopsin combined with mitomycin on proliferation of gastric carcinoma cells     

WU Ming-cai  JIANG Ming  BI Fu-yong 《园艺学报》2011,27(7):1424-1427

AIM: To investigate the synergistic effects of ampelopsin (AMP) and a chemotherapeutic drug mitomycin (MMC) on the proliferation of gastric cancer cell line SGC-7901.METHODS: SGC-7901 cells were cultured in vitro and divided into 4 groups: control group, AMP group, MMC group and AMP+MMC group. Cell proliferation was measured by MTT method. The apoptotic index was examined by flow cytometry. The expression of apoptotic proteins, Bcl-2 and survivin, was detected by Western blotting.RESULTS: AMP at the concentrations ranging from 2.2 mg/L to 14.84 mg/L exerted inhibitory effect on the growth of SGC-7901 cells. Cell proliferation in AMP (14.84 mg/L) group was inhibitory by (60.85±1.13) %, significantly higher than that in control group (P<0.05). The inhibitory rates of cell proliferation varied from (17.40±0.30) % to (72.23±1.36) % when the concentrations of MMC increased from 1×10^-3 g/L to 1×10^-2 g/L. AMP combined with MMC showed a synergistic effect on the growth of SGC-7901 cells. The inhibitory rates of cell proliferation varied from (21.83±2.50) % to (46.70±1.45) % when the concentrations of MMC increased from 1×10^-3g/L to 5×10^-3g/L. The inhibitory effect of AMP plus MMC was higher than that of MMC or AMP alone. The protein levels of Bcl-2 and survivin were inhibited in AMP group, MMC group and AMP+MMC group, and were significantly lower in AMP+MMC group than those in AMP group or MMC group.CONCLUSION: AMP enhances the inhibitory effect of MMC on the growth of SGC-7901 cells. The mechanism is related to the inhibition of apoptotic protein expression.  相似文献   

犊牛开食料的研制及其犊牛瘤胃发育的研究(2)     

嘎尔迪  孟青龙  敖日格乐  金曙光  达胡巴雅尔  高雪峰 《内蒙古农业大学学报(自然科学版)》1991,(3)

本研究将黑白花犊牛分为早期断奶组(试验组)和常规断奶组(对照组),对反刍胃形态,结构生理机能的发育等进行了研究。试验结果表明,在8周龄前第1胃内液 VFA 浓度,试验组均高于对照组,3、4、5、6周龄时,组间差异显著(p<0.05),8周龄以后,对照组则高于试验组。2组牛第1胃液 pH 值的变化与 VFA 浓度的变化规律基本一致。第一胃液 NH 3—浓度2组牛在2周龄时最高,以后均有下降趋势,但试验组低于对照组。43d 龄时各个胃组织重量和容积,试验组均高于对照组,其中第1,2胃容积和第4胃容积均差异显著(p<0.05)。同时第1胃粘膜组织重的比例、粘膜乳头长度和密度以及1、2胃组织重与体重的比例也均优于对照组,组间差异显著(p<0.05)。92d 龄时各个胃组织重量和容积,试验组均高于对照组,其中第1、2胃组织重量和4个胃组织重量均有显著差异(p<0.05)。瘤胃粘膜乳头发育等主要指标均优于对照组,并多数指标已接近成年牛水平。  相似文献   

大麦苗营养及其对白鼠健康的影响   总被引：7，自引：0，他引：7  

张秋英陈剑锋  张绍南 《麦类作物学报》2004,24(2):65-67

为了对大麦苗的开发利用提供必要的理论依据,以闽诱3号为试验材料,对分蘖盛期的大麦苗进行营养分析。结果表明,大麦苗中含有丰富的蛋白质(31.26％)、氨基酸(其中赖氨酸达到了1．1445％)、矿物质(包括Fe、K、Cu、Mg、Ca、P、Mn、Zn等8种元素,以Fe含量最高．达到8580．0μg／m1)、维生素(以维生素C含量最高,达到65．570μg／m1)和SOD酶(0．555μg／m1)等。用大麦苗制品喂养白鼠发现有以下几方面明显作用：①瘦身、抗肥胖;②降低血液中有害物质脂质过氧化物、甘油三脂和胆固醇的含量;③提高血液中有益物质高密度脂蛋白和SOD酶的含量;④减少酒精对胃粘膜的损伤,保护胃粘膜;⑤抗疲劳,增强体力。这些结果表明,大麦苗营养对生命肌体有维护和保健功效。  相似文献   

Effects of marine fungal metabolites 1386A from the South China Sea on proliferation,apoptosis and mitochondrial membrane potential in gastric cancer cell line MCG-803     

CHEN Chuang-qi  FANG Le-kun  LIU Jia-wei  ZHANG Jian-wei  YANG Guang-xin  YANG Wan 《园艺学报》2010,26(10):1908-1912

AIM: To investigate the effects of marine fungal metabolites 1386A from the South China Sea(1386A) on gastric cancer cell line MCG-803.METHODS: The effects of 1386A on cell viability and cell growth were detected by MTT method and colony-forming assay, respectively. The changes of cell cycle, cell apoptosis and mitochondrial membrane potential were determined by flow cytometry.RESULTS: The IC₅₀ of cell viability on MCG-803 cells after treated with 1386A for 24 h, 48 h and 72 h was 29.70 μmol/L, 14.07 μmol/L or 13.47 μmol/L, respectively. The IC₅₀ of the cell growth on MCG-803 cells after treated with 1386A for 48 h was 3.27 μmol/L. After treated with 1386A for 48 h, the MCG-803 cells in S stage was increased from 25.6% to 56.8%. After treated with 1386A for 24 h, the early apoptosis of MCG-803 cells was increased from 3.34% to 8.39%, and the mitochondrial membrane potential of MCG-803 cells was decreased by 56.26%.CONCLUSION: 1386A has an inhibitory effect on the cell growth in MCG-803 cells through the mitochondrial pathway.  相似文献   

Screening of proteins interacting with E2F1 from cDNA library of human gastric mucosa by yeast two-hybrid system     

LIAN Chao  WANG Xiao-tong  XIE Yu-bo  XIAO Qiang 《园艺学报》2012,28(9):1718-1721

  相似文献