Cerebral haemorrhage in a pregnant Standardbred mare with Evan's syndrome     

L. Väänänen  H.‐K. Sihvo  M. Hewetson 《Equine Veterinary Education》2013,25(7):353-358

A 3‐year‐old pregnant Standardbred mare was treated at the University of Helsinki Equine Teaching Hospital for severe idiopathic immune‐mediated thrombocytopenia and haemolytic anaemia (Evan's syndrome). Despite initial improvement with supportive care and immunosuppressive doses of corticosteroids and azathioprine, the mare died from a fatal cerebral haemorrhage on Day 21 of treatment.  相似文献   

Molecular basis of Iron Biofortification in crop plants; A step towards sustainability     

Attiq ur Rehman  Sara Masood  Naqib Ullah Khan  Muhammad Ejaz Abbasi  Zawar Hussain  Ihtisham Ali 《Plant Breeding》2021,140(1):12-22

Iron is one of the most important micronutrients for crop plants due to its use in important physiological processes such as photosynthesis, mitochondrial respiration, metal homeostasis, and chlorophyll synthesis. Crop plants have adapted different strategies for uptake, transport, accumulation, and storage of iron in tissues and organs which later can be consumed by humans. Estimates indicate that about 2 billion people (33% of human population) are at risk of iron deficiency in which infants, children, and pregnant women are potentially compromised. Biofortification refers to the increase in concentration of micronutrients in edible parts of plants and understanding the pathways for iron accumulation in plants is necessary for breeding iron‐enriched crops. Iron‐biofortified crops are also one of the key factors in achieving multiple United Nations Sustainable Development goals. This review article covers different strategies of iron acquisition and transport in plants, its bioavailability, coping with the iron deficiency as a global perspective, the current status of iron biofortification, and how breeding future biofortified crops could be helpful in combating the said issue in a sustainable manner.  相似文献   

“血多泉”与“Pigdex-100”对仔猪抗贫血效果的比较研究     

金升藻  程太平 《湖北农学院学报》1992,(1)

本文对国产抗贫血制剂“血多泉”与美国同类制剂“Pigdex-100”对仔猪抗贫血效果进行了比较研究。结果表明,对照组仔猪贫血症状明显,血红蛋白(Hb)值显著低于处理组(P<0.01),50日龄平均增重也较补铁组低1.3kg。但“血多泉”组与“Pigdex-100”组之间在相同剂量(200mgFe/仔猪)下,Hb值和增重均无显著差异,但使用“血多泉”经济成本低于进口产品。  相似文献   

Thermal stress altered growth performance and metabolism and induced anaemia and liver disorder in Labeo rohita     

Prasun Roychowdhury  Mohammad Aftabuddin  Manoj Kumar Pati 《Aquaculture Research》2020,51(4):1406-1414

Sudden fish deaths occurred during summer peaks in India and expected to be more in future. This study was conducted to explain the biochemical responses of Labeo rohita under extreme thermal condition (treated: 37–38°C against controlled: 28–30°C). Exposure of 14 days resulted in 30% of fish mortality. Glucose concentration was maintained in serum for both treated and controlled groups. However, triglycerides, protein, globulin, calcium, cholesterol and haemoglobin were declined and enzymes (glutamate‐pyruvate transaminase, GPT and glutamate‐oxalate transaminase, GOT) were elevated in serum in the treated group. Indicators of overall metabolism (biomolecules: glucose, triglycerides, protein, cholesterol; enzymes: GPT, GOT; and RNA: DNA) were diminished in liver, whereas these were less affected in muscle. Higher GPT, GOT and lower albumin in serum confirmed disturbance in hepatic panel. Simultaneously compromised growth (lower SGR, DNA content in liver) was observed in treated fish due to impaired metabolism. Extreme thermal stress induced by such catastrophic warmer water exposure caused liver problems and anaemia which ultimately caused fish death.  相似文献   

Molecular cloning of MDA5, phylogenetic analysis of RIG‐I‐like receptors (RLRs) and differential gene expression of RLRs,interferons and proinflammatory cytokines after in vitro challenge with IPNV,ISAV and SAV in the salmonid cell line TO          下载免费PDF全文

I‐K G Nerbøvik  M A Solheim  H Ø Eggestøl  A Rønneseth  R A Jakobsen  H I Wergeland  G T Haugland 《Journal of fish diseases》2017,40(11):1529-1544

The RIG‐I receptors RIG‐I, MDA5 and LGP2 are involved in viral recognition, and they have different ligand specificity and recognize different viruses. Activation of RIG‐I‐like receptors (RLRs) leads to production of cytokines essential for antiviral immunity. In fish, most research has focused on interferons, and less is known about the production of proinflammatory cytokines during viral infections. In this study, we have cloned the full‐length MDA5 sequence in Atlantic salmon, and compared it with RIG‐I and LGP2. Further, the salmonid cell line TO was infected with three fish pathogenic viruses, infectious pancreatic necrosis virus (IPNV), infectious salmon anaemia virus (ISAV) and salmonid alphavirus (SAV), and differential gene expression (DEG) analyses of RLRs, interferons (IFNa‐d) and proinflammatory cytokines (TNF‐α1, TNF‐α2, IL‐1β, IL‐6, IL‐12 p40s) were performed. The DEG analyses showed that the responses of proinflammatory cytokines in TO cells infected with IPNV and ISAV were profoundly different from SAV‐infected cells. In the two aforementioned, TNF‐α1 and TNF‐α2 were highly upregulated, while in SAV‐infected cells these cytokines were downregulated. Knowledge of virus recognition by the host and the immune responses during infection may help elucidate why and how some viruses can escape the immune system. Such knowledge is useful for the development of immune prophylactic measures.  相似文献