对一起销售含违禁药品生猪产品案的查处     

李良鉴  肖永鸿 《中国动物检疫》2015,32(7):89-90

目前,我国生猪产品生产与销售等环节的长效监管机制仍处于探索阶段。本案阐述了一起由江西省赣州市畜牧兽医局查处的销售含有违禁药品生猪产品的违法行为,论述了该案的标的检测、调查取证、依法听证、行政处罚等执法过程,并对相关问题进行了思考与探讨。  相似文献   

Disposition,behavioural and physiological effects of escalating doses of intravenously administered fentanyl to young foals          下载免费PDF全文

H. K. Knych  E. P. Steffey  H. C. Casbeer  M. M. Mitchell 《Equine veterinary journal》2015,47(5):592-598

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A Review of the Expected Effects of Antimicrobials in Bovine Respiratory Disease Treatment and Control Using Outcomes from Published Randomized Clinical Trials with Negative Controls     

《Veterinary Clinics of North America: Food Animal Practice》2015,31(1):97-111

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刺山柑果实醇提物正丁醇部位提取物抗炎镇痛效果分析     

张亚涛  包晓玮  曾兰君  魏晨业  何梦梦  金渭荃 《新疆农业科学》2021,58(1):159-167

【目的】 研究刺山柑乙醇提取物正丁醇萃取部位的抗炎镇痛活性。【方法】 以总黄酮提取量为指标采用超声波辅助提取法并结合响应面优化乙醇提取物最佳工艺,将乙醇提取物浸膏通过萃取得到正丁醇部位。采用二甲苯致小鼠耳廓肿胀、小鼠腹腔毛细血管通透性分析正丁醇萃取部位抗炎效果;以热板法和醋酸扭体考察正丁醇萃取部位镇痛效果。【结果】 正丁醇部位高剂量组、中剂量组对二甲苯致小鼠耳廓肿胀有明显抑制作用(P＜0.01);正丁醇部位高剂量组、中剂量组对小鼠毛细血管通透性有明显抑制作用(P＜0.01);正丁醇部位高剂量组、中剂量组可显著提高小鼠热板痛阈值,正丁醇部位高剂量组、中剂量组能明显减少醋酸所致小鼠扭体次数(P＜0.01)。【结论】 刺山柑果实醇提物正丁醇部位提取物具有潜在的抗炎镇痛作用。  相似文献   

Pathology and Neurotoxicity in Dogs after Repeat Dose Exposure to a Serotonin 5-HT1B Inhibitor     

Jane C.F. Chang  Paul Ciaccio  Patricia Schroeder  Lindsay Wright  Russell Westwood  Anna-Lena Berg 《Journal of toxicologic pathology》2014,27(1):31-42

AZD3783, a cationic amphiphilic drug and a potent inhibitor of the 5-hydroxytryptamine (5-HT_1B) receptor, was explored as a potential treatment for depression. To support clinical trials, repeat dose toxicity studies in rats and dogs were conducted. Here we report toxicity findings in dogs after dosing from 1 to 3 months. In the 1-month study, there were minimal neuronal vacuolation in the brain, a marked increase in liver enzymes accompanied by hepatocellular degeneration/necrosis and phospholipidosis (PLD), and PLD/cholecystitis in the gallbladder of animals dosed at 47 mg/kg/day. In the 3-month study, neurotoxicity resulted in euthanasia of one animal dosed at 30 mg/kg/day after 86 days. Extensive pathologic changes were seen in all animals in retina epithelium (inclusion bodies), brain (neuronal vacuolation, degeneration, or necrosis and nerve fiber degeneration), spinal ganglia (vacuolation, degeneration, or necrosis), as well as sciatic and optic nerves (degeneration). Pigment-laden macrophages were observed in the lung, kidney, liver, gallbladder, bone marrow, gastrointestinal tract, and lymphoid tissues. Also seen were vitrel and retinal hemorrhage in the eyes. A brain concentration and pathology study showed that the concentration of AZD3783 in the brain was approximately 4 times higher than in the plasma after 4 weeks of dosing, however, they were similar in all regions examined, and did not correlate with areas with pathologic findings. Our findings with AZD3783 in dogs have not been reported previously with other CNS compounds that effect through serotonergic pharmacology.  相似文献   

UPLC-MS/MS测定4种兽药制剂中非法添加阿托品的方法研究   总被引：1，自引：1，他引：0  

胡兴娟 《中国兽药杂志》2014,48(11):49-52

建立了兽药中非法添加药物阿托品的超高效液相色谱-串联质谱（UPLC-MS/MS）的检测方法。样品经提取稀释,采用BEH C18柱为分离柱,外标法定量。结果表明,阿托品在0.5～10 ng/mL范围内线性关系良好,相关系数大于0.99。在4～6 mg/g(或mg/mL)添加浓度范围内阿托品的平均回收率97.4%～110.9%,批内变异系数均小于10％,检测限为0.2 mg/g(或mg/mL),定量限为0.5 mg/g(或mg/mL)。该方法简便、灵敏度高、重现性好,适用于兽药中非法添加阿托品的含量测定。  相似文献   

对兽药违法案件中货值金额计算的思考     

冯猛 《中国兽药杂志》2014,48(1):52-54

选取货值金额计算有争议的兽药违法典型案例,对货值金额计算的价格及数量确定依据条例条款分析审议,提出货值金额按标价计算等价格确定方法、已售数量争议的界定方法等数值确定方案的建议,以期为兽药规范执法提供参考。  相似文献   

常见降压动物药研究进展     

怀凤武  ;于春华  ;白秀娟 《经济动物学报》2014,(4):233-237

高血压为目前最常见的慢性病,严重威胁人类健康。随着近年来对治疗和控制高血压药物的各方面研究的积极开展,具有降压和控制血压稳定性的动物药越来越引人关注。本文对近年来降压动物药的试验研究,临床应用和其药理作用的研究进展进行了整理,通过对牛黄、地龙等常见动物药在高血压治疗和控制上的研究概况的介绍,综述了降压动物药的研究进展。  相似文献   

Presumptive cocaine toxicosis in 19 dogs: 2004–2012     

Emily K. Thomas BA  VetMB  MRCVS  Kenneth J. Drobatz DVM  MSCE  DACVIM  DACVECC  Deborah C. Mandell VMD  DACVECC 《Journal of Veterinary Emergency and Critical Care》2014,24(2):201-207

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兽用抗生素中非法添加5种解热镇痛类药物的高效液相色谱检测方法研究     

肖学勇  曹莹  徐斐  黄士新  李丹妮 《畜牧与饲料科学》2014,35(11):8-12

建立兽用抗生素注射液与可溶性粉剂中非法添加对乙酰氨基酚、安乃近、安替比林、萘普生、氨基比林5种药物的高效液相色谱—二极管阵列检测分析方法。样品经甲醇超声提取后进行液相色谱分析,采用CAPCELL PAK MG C18(4.6 mm×250 mm,5μm)色谱柱,柱温30℃,流动相为乙腈和磷酸盐缓冲液,梯度洗脱,检测波长229 nm,流速1.0 m L/min。对乙酰氨基酚、安乃近、安替比林、萘普生、氨基比林进样量分别在5.04~100.88、12.04~240.72、5.04~100.72、2.02~40.40、5.02~100.32μg/m L范围内呈良好的线性关系;平均加样回收率(n=5)分别为97.9%~102.8%、91.9%~98.8%、96.2%~101.1%、94.1%~102.3%、96.0%~102.8%,RSD分别为1.0%~3.1%、0.9%~6.4%、1.7%~4.2%、1.4%~3.9%、0.9%~4.8%。该方法快捷、简便,其准确性和灵敏度经方法学验证能很好地满足检测多种抗生素中非法添加解热镇痛类药物的筛查要求。  相似文献