The cardiopulmonary effects of dobutamine and norepinephrine in isoflurane-anesthetized foals     

Craig CA  Haskins SC  Hildebrand SV 《Veterinary anaesthesia and analgesia》2007,34(6):377-387

OBJECTIVE: To evaluate the cardiovascular effects of norepinephrine (NE) and dobutamine (DB) in isoflurane-anesthetized foals. STUDY DESIGN: Prospective laboratory study. METHODS: Norepinephrine (0.05, 0.10, 0.20, and 0.40 microg kg(-1) minute(-1)) and dobutamine (2.5, 5.0, and 10 microg kg(-1) minute(-1)) were alternately administered to seven healthy, 1- to 2-week-old isoflurane-anesthetized foals. Arterial and pulmonary arterial blood pressure, right atrial pressure, pulmonary artery occlusion pressure, heart rate, body temperature, cardiac output, arterial and mixed venous blood pH, partial pressure of carbon dioxide, partial pressure of oxygen [arterial partial pressure of oxygen (PaO(2)) and mixed venous partial pressure of oxygen (PvO(2))], and packed cell volume were measured. Standard base excess, bicarbonate concentration, systemic and pulmonary vascular resistance, cardiac index (CI), stroke volume, left and right stroke work indices, oxygen delivery (DO(2)), consumption, and extraction were calculated. Results Norepinephrine infusion resulted in significant increases in arterial and pulmonary arterial pressure, systemic and pulmonary vascular resistance indices, and PaO(2); heart rate was decreased. Dobutamine infusion resulted in significant increases in heart rate, stroke volume index, CI, and arterial and pulmonary arterial blood pressure. Systemic and pulmonary vascular resistance indices were decreased while the ventricular stroke work indices increased. The PaO(2) decreased while DO(2) and oxygen consumption increased. Oxygen extraction decreased and PvO(2) increased. CONCLUSIONS AND CLINICAL RELEVANCE: Norepinephrine primarily augments arterial blood pressure while decreasing CI. Dobutamine primarily augments CI with only modest increases in arterial blood pressure. Both NE and DB could be useful in the hemodynamic management of anesthetized foals.  相似文献   

Effects of intravenous butorphanol on cardiopulmonary function in isoflurane-anesthetized alpacas     

Garcia-Pereira FL  Greene SA  Keegan RD  McEwen MM  Tibary A 《Veterinary anaesthesia and analgesia》2007,34(4):269-274

OBJECTIVE: To determine the effects of intravenous (IV) butorphanol on the cardiopulmonary system and on the bispectral index (BIS) in isoflurane-anesthetized alpacas. STUDY DESIGN: Randomized, blinded cross-over experimental trial. ANIMALS: Eight healthy, young (3 +/- 1 SD years) adult female alpacas weighing 64 +/- 9 SD kg. METHODS: Alpacas were anesthetized with isoflurane by mask followed by tracheal intubation and maintenance of anesthesia with isoflurane in oxygen and intermittent positive pressure ventilation. Animals were assigned to two treatments, butorphanol (0.1 mg kg(-1), IV) and saline (0.01 mL kg(-1), IV) in a randomized manner allowing a 2-week interval between treatments. Cardiovascular variables included systolic, diastolic, and mean arterial blood pressure, heart rate, pulmonary arterial pressure, pulmonary arterial occlusion pressure (PAOP), central venous pressure, cardiac output, and pulmonary temperature (TEMP). Cardiac index, systemic vascular resistance (SVR), and pulmonary vascular resistance (PVR) were calculated. Bispectral index was also measured. Arterial and mixed venous blood samples were collected for blood gas analysis. All variables were recorded at baseline (time 0) and at 5, 10, 15, 30, 45 and 60 minutes following injection and were analyzed by using repeated-measures ANOVA (p < 0.05). PAOP, PVR, and BIS were analyzed by paired t-tests. RESULTS: Butorphanol decreased SVR at all times when compared with the baseline, but no difference was detected between treatments. TEMP decreased with time in both treatments, but they were not different from each other. Other cardiovascular, BIS, and blood gas variables were not different between groups. CONCLUSION AND CLINICAL RELEVANCE: We conclude that butorphanol had minimal effects on the cardiovascular system of the alpacas, causing a mild decrease in SVR.  相似文献   

肉鸡肺动脉高压综合征自然病例肺动脉压的动态变化   总被引：1，自引：0，他引：1  

万春云郭定宗  沈亚菊 《华中农业大学学报》2004,23(3):320-322

将自然发病的肺动脉高压综合征艾维茵商品代肉鸡按日龄分组,右心导管法测定平均肺动脉压(PAPm),根据腹水量确定各组内腹水程度,设无腹水的正常鸡作对照．并进行显著性比较。结果：(1)24、36日龄组发病鸡的PAPm均极显著高于同日龄的正常鸡,30日龄组发病鸡显著高于正常鸡,42日龄组发病鸡高于正常鸡(8．3％)但无显著性差异。(2)发病鸡的PAPm在30日龄时极显著高于24日龄;36日龄时显著高于30日龄;40日龄时低于36日龄(4．3％),但差异不显著。(3)发病鸡的PAPm与腹水量间呈极显著正相关。结果表明,PAPm在本病发生和发展过程中都起着重要作用,并且与本病致死率有一定联系。  相似文献   

Omacor Protects Normotensive and Hypertensive Rats Exposed to Continuous Light from Increased Risk to Malignant Cardiac Arrhythmias     

Tamara Egan Benova  Csilla Viczenczova  Barbara Szeiffova Bacova  Jitka Zurmanova  Vladimir Knezl  Katarina Andelova  Narcis Tribulova 《Marine drugs》2021,19(12)

  相似文献   

梭鱼卵黄蛋白原的化学发光免疫检测法     

吴美琴  和田竜典  罗雯姝  盛田祐加  平松尚志  原彰彦  钟俊生 《水产学报》2010,34(4):572-580

运用建立化学发光免疫(chemiluminescence immunoassay,CLIA)检测法,对梭鱼血清中主要卵黄蛋白原(Vg)类型(B类型;VgB)进行定量测定。梭鱼VgBCLIA法按两步法操作进行,使用纯化的梭鱼VgB制备特异型抗血清(a-VgB)。优化抗体浓度和培育时间等检验条件后,检验范围设定为3.91～500ng/mL。卵黄发生期的梭鱼雌鱼血清和雌激素处理后的梭鱼稚鱼血清稀释曲线与纯化的梭鱼Vg曲线平行,而梭鱼雄鱼稀释血清中几乎不发生相应的免疫学反应。对天津原种场养殖的10尾梭鱼血清VgB水平的定量检测结果表明,在雌鱼(9尾)血清中检测到VgB但个体间差异较大,变化范围为3.0～2700.1μg/mL,并表现出随着卵巢发育而增长的变化趋势。相对而言,成熟梭鱼雄鱼血清VgB水平则极低(2.7μg/mL),表明在其生长环境中不存在雌激素活性。另外,所有个体的组织学观察也未呈现出明显的性腺异常情况。研究为梭鱼主要雌激素诱导生物标志物(VgB)的量化提供了一种新的手段,较以往的检验方法具有更高的灵敏度,有助于建立多元化的水生环境中雌激素活性的检测体系。  相似文献   

水系物质迁移过程示踪及其在环境中的应用   总被引：1，自引：0，他引：1  

李阿梅  袁旭音乔磊 《水土保持学报》2005,19(4):196-200

水是环境中污染物迁移的重要介质,水系污染物也可以直接作用于生物体。本文概述了对水系物质迁移过程示踪的各种方法,包括人工示踪剂方法、生物标志法、微量元素及同位素示踪方法等,指出了它们的环境应用价值。在人工示踪法中叙述了中子活化示踪沙技术和稀土元素-DTPA螯合物示踪法。生物标志物主要叙述了木质素、正构烷烃、脂肪酸的指示意义。微量元素示踪主要涉及到Sr、Ca、Mg和REE的示踪。同位素示踪法着重阐述了较先进的碳、氮、氧和铅同位素的示踪。最后展示了水系物质示踪的应用前景。  相似文献   

Soil microbial communities changed with a continuously monocropped processing tomato system     

Yalong Kang  Feng Jing  Wenqinq Sun  Jianguo Liu 《Acta Agriculturae Scandinavica, Section B - Plant Soil Science》2018,68(2):149-160

To reveal the regulatory mechanisms underlying the productivity of long-term continuous cropping of processing tomato, a multi-year study was carried out to understand the effects of long-term continuous cropping on the community structures of the root zone microbes. Soil samples collected from continuous cropping of processing tomato after 3, 5 and 7 years were used for this study. Results showed that soil microbial biomass C (SMBC), N (SMBN) and microbial quotient (qMB) significantly decreased with longer cropping. After seven years of continuous cropping, the SMBC and SMBN contents, and qMB respectively significantly decreased by 52.3%, 78.8% and 48.2% (p?相似文献   

miR-210-5p对南极独角雪冰鱼心脏发育的作用机制研究     

郭亚南  王丛丛  刘云  武晓会  孙建飞  陈程  许强华 《上海海洋大学学报》2016,25(4):481-487

microRNA为短链非编码RNA,通过与靶基因3'UTR序列互补在转录后水平发挥作用。已有研究表明,microRNA在心脏发育过程中起着重要的调控作用。南极冰鱼因体内缺乏功能性血红细胞,其心脏出现了补偿性增生。前期的研究提示,独角雪冰鱼心脏中特异表达的microRNAs可能与冰鱼心脏的补偿性增生相关。本研究针对南极冰鱼心脏中高表达的miR-210-5p,运用斑马鱼显微注射、靶基因预测等手段研究了miR-210-5p对心脏发育的作用机制。结果表明:斑马鱼胚胎注射miR-210-5p后,出现心包膜水肿,心脏发育畸形等现象。qRT-PCR分析显示,过表达miR-210-5p的斑马鱼胚胎中,心脏发育相关的标志性基因bmp4、smad1、gata6以及tbx2b的表达水平下调。Western blotting分析发现,bmp/smad通路中的BMP2、BMP4、SMAD1、GATA6以及TBX2B的蛋白表达水平也显著下调。通过对tbx20基因3'UTR的靶基因生物信息学预测,以及对其进行GFP荧光表达分析,发现tbx20基因可能是miR-210-5p的一个靶基因。由此推测,miR-210-5p可能通过抑制tbx20基因的表达,并调控bmp/smad通路以抑制冰鱼心脏发育。  相似文献   

埋藏式心脏起搏器术后起搏阈值的动态变化     

陈小卫  吴铿  田丽红  李日健  回皓升  莫振兆 《湛江医学院学报》2004,22(5):448-449,457

目的:观察埋藏式心脏起搏器术后电极成熟期前后起搏阈值的变化规律。方法:对30例接受埋藏式心脏起搏治疗的患者分别于术中、术后1周、2周、1个月、2个月、3个月、6个月测定起搏阈值。结果:16例应用Medtronic CAPSURESP系列(激素洗提)心房电极的患者心房起搏阈值术后升高,本后1周达峰值,后逐渐降低,术后2个月开始趋于稳定,除术后6个月外,其余各时间点与术中比较差异均有非常显著性(P<0.01);24例应用MCSP系列心室电极的患者心室起搏阚值术后均明显高于术中(P<0.01);9例应用BIOTRONIK SYNOX SX系列(高阻抗非激素洗提)电极的患者心房、心室平均起搏阈值具有与MCSP系列起搏电极类似的术后演变趋势.其急性期起搏阈值呈明显峰化现象,且具有较高的慢性期阚值,与40条MCSP系列电极比较,两者急、慢性期起搏阈值差异均有非常显著性(P<0.01)。结论:埋藏式心脏起搏器术后6个月内,起搏阈值明显升高;激素洗提电极能明显降低急性期和慢性期阚值。  相似文献   

Assessment of cardiac troponin I and C-reactive protein concentrations associated with anesthetic protocols using sevoflurane or a combination of fentanyl, midazolam, and sevoflurane in dogs     

Ashley B Saunders DVM  Diplomate ACVIM    rew S Hanzlicek DVM    Elizabeth A Martinez DVM  Diplomate ACVA    Mark J Stickney DVM    Jörg M Steiner Dr.med.vet.  PhD  Diplomate ACVIM  Diplomate ECVIM-CA    Jan S Suchodolski Dr.med.vet.  PhD  & Geoffery T Fosgate† DVM  PhD  Diplomate ACVPM 《Veterinary anaesthesia and analgesia》2009,36(5):449-456

ObjectiveTo report serum cardiac troponin I (cTnI) and C-reactive protein (CRP) concentrations in dogs anesthetized for elective surgery using two anesthetic protocols.Study designProspective, randomized clinical study.AnimalsTwenty client-owned dogs presenting for elective ovariohysterectomy or castration.MethodsThe dogs were randomized into two groups. All dogs were premedicated with glycopyrrolate (0.011 mg kg^?1) and hydromorphone (0.1 mg kg^?1) IM approximately 30 minutes prior to induction of anesthesia. Anesthesia in dogs in group 1 was induced with propofol (6 mg kg^?1) IV to effect and in dogs in group 2 with diazepam (0.2 mg kg^?1) IV followed by etomidate (2 mg kg^?1) IV to effect. For maintenance of anesthesia, group 1 received sevoflurane (adjustable vaporizer setting 0.5–4%) and group 2 received a combination of fentanyl (0.8 μg kg^?1 minute^?1) and midazolam (8.0 μg kg^?1 minute^?1) IV plus sevoflurane (adjustable vaporizer setting 0.5–4%) to maintain anesthesia. Serum cTnI and CRP concentrations were measured at baseline and 6, 18, and 24 hours post-anesthetic induction. Biochemical analysis was performed at baseline. Lactate was obtained at baseline and 6 hours post-anesthetic induction. Heart rate and mean arterial blood pressure were measured intra-operatively.ResultsBaseline serum cTnI and CRP concentrations were comparable between groups. A significant difference in serum cTnI or CRP concentrations was not detected post-operatively between groups at any time point. Serum CRP concentrations were significantly increased post-anesthetic induction in both groups, which was attributed to surgical trauma.Conclusions and clinical relevanceThere was no significant difference in serum cTnI and CRP concentrations between anesthetic protocols. Further investigation in a larger number of dogs is necessary to confirm the current findings.  相似文献