Clinical comparison of dexmedetomidine and medetomidine for isoflurane balanced anaesthesia in horses     

Muriel Sacks  Simone K. Ringer  Andrea S. Bischofberger  Sabrina M. Berchtold  Regula Bettschart-Wolfensberger 《Veterinary anaesthesia and analgesia》2017,44(5):1128-1138

Objective

To compare the effects of two balanced anaesthetic protocols (isoflurane–dexmedetomidine versus medetomidine) on sedation, cardiopulmonary function and recovery in horses.

Study design

Prospective, blinded, randomized clinical study.

Animals

Sixty healthy adult warm blood horses undergoing elective surgery.

Methods

Thirty horses each were sedated with dexmedetomidine 3.5 μg kg^?1 (group DEX) or medetomidine 7 μg kg^?1 (group MED) intravenously. After assessing and supplementing sedation if necessary, anaesthesia was induced with ketamine/diazepam and maintained with isoflurane in oxygen/air and dexmedetomidine 1.75 μg kg^?1 hour^?1 or medetomidine 3.5 μg kg^?1 hour^?1. Ringer's lactate (7–10 mL kg^?1 hour^?1) and dobutamine were administered to maintain normotension. Controlled mechanical ventilation maintained end-tidal expired carbon dioxide pressures at 40–50 mmHg (5.3–6.7 kPa). Heart rate, invasive arterial blood pressure, inspired and expired gas composition and arterial blood gases were measured. Dexmedetomidine 1 μg kg^?1 or medetomidine 2 μg kg^?1 was administered for timed and scored recovery phase. Data were analysed using two-way repeated-measures analysis of variance and chi-square test. Significance was considered when p ≤ 0.05.

Results

In group DEX, significantly more horses (n = 18) did not fulfil the sedation criteria prior to induction and received one or more supplemental doses, whereas in group MED only two horses needed one additional bolus. Median (range) total sedation doses were dexmedetomidine 4 (4–9) μg kg^?1 or medetomidine 7 (7–9) μg kg^?1. During general anaesthesia, cardiopulmonary parameters did not differ significantly between groups. Recovery scores in group DEX were significantly better than in group MED.

Conclusions and clinical relevance

Horses administered dexmedetomidine required more than 50% of the medetomidine dose to reach equivalent sedation. During isoflurane anaesthesia, cardiopulmonary function was comparable between the two groups. Recovery scores following dexmedetomidine were better compared to medetomidine.  相似文献   

Retrospective evaluation of and risk factor analysis for presumed fluid overload in cats with urethral obstruction: 11 cases (2002–2012)          下载免费PDF全文

Cassandra J. Ostroski DVM  DACVECC  Kenneth J. Drobatz DVM  MSCE  DACVIM  DACVECC  Erica L. Reineke VMD  DACVECC 《Journal of Veterinary Emergency and Critical Care》2017,27(5):561-568

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VBNC状态乳酸杆菌的复苏     

魏忠彬  李影  钱爱东  段锐 《中国饲料》2006,(18):27-28

将活的非可培养状态(VBNC)的乳酸杆菌的菌悬液中加入6%的吐温20,并在37℃恒温振荡培养箱中振荡培养(200r/min,48h),可使非可培养状态的乳酸杆菌恢复到可培养状态。在复苏过程中加入吐温20可增加益生菌的数量。  相似文献   

低浓度冰醋酸诱导的鸡源大肠杆菌"活的非可培养状态"   总被引：1，自引：0，他引：1  

李影  魏忠彬  钱爱东 《中国兽医学报》2007,27(5):645-648

利用LIVE/DEAD试剂盒染色法,流式细胞仪检测法,以及RT-PCR方法检测了经低浓度冰醋酸作用的鸡源大肠杆菌活细胞,并对其进行了复苏。结果表明,当可培养菌数降为零时,LIVE/DEAD试剂盒染色法及流式细胞仪检测法均能检测出较高数量的活菌数;RT-PCR法也能检测到活细胞信号分子-mRNA,并扩增出“活的非可培养状态”（VBNC）细菌的cDNA片段。这些均显示细菌已进入VBNC,且在吐温80作用下又恢复为可培养状态,从而证实大肠杆菌具有“VBNC”状态。  相似文献   

Evaluation of automated external defibrillator designed for people in dogs     

Meriel C. LeSueur BS  Elizabeth A. Rozanski DVM  DACVECC  DACVIM  Emily T. Karlin DVM  DACVIM  Joey LaMastro VMD  John E. Rush DVM  MS  DACVIM  DACVECC 《Journal of Veterinary Emergency and Critical Care》2023,33(2):173-179

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Evaluation of compressor fatigue at 150 compressions per minute during cardiopulmonary resuscitation using a large dog manikin     

María Reyes-Martínez GdaVet  Vicente J. Herrería-Bustillo LV MVetMed  DACVECC  DECVECC 《Journal of Veterinary Emergency and Critical Care》2023,33(5):495-500

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Describing acid-base balance using three different methods of analysis in a feline acute haemorrhage-resuscitation model     

《Veterinary anaesthesia and analgesia》2022,49(1):65-75

ObjectiveTo describe acid-base status using the Henderson-Hasselbalch, Stewart and semi-quantitative methods of analysis in a feline haemorrhage-resuscitation model.Study designRandomized crossover study.AnimalsA total of six domestic cats (mean age, 21 months; weight, 4.9 kg).MethodsVenous blood samples were taken before haemorrhage, after haemorrhage at 30 minute intervals during fluid resuscitation and at 24 hours. The cats were anaesthetized and underwent following treatments: no purposeful haemorrhage and resuscitation (NoPHR), purposeful haemorrhage followed by either lactated Ringer’s solution (LRS) or 6% tetrastarch 130/0.4 (Voluven) for resuscitation. LRS and Voluven were administered at 60 and 20 mL kg^–1 hour^–1, respectively, for 120 minutes. Variables used for the analysis methods were measured or calculated from the blood samples and then compared among treatments over time using a general linear mixed model (p < 0.05; data reported as mean and standard deviation).ResultsThe total blood loss at 120 minutes was 10.2 ± 2.3, 29.3 ± 9.0 and 29.1 ± 6.3 mL kg^–1 for NoPHR, LRS and Voluven, respectively. Total volumes of LRS and Voluven administered were 120 and 40 mL kg^–1, respectively. All cats became acidaemic during anaesthesia regardless of treatment. The Henderson-Hasselbalch method indicated that anaesthetized cats undergoing severe haemorrhage and resuscitation manifest a mixed acidosis. The Stewart method indicated two counter metabolic processes that contributed to the overall pH—decrease in apparent strong ion difference (acidosis) and decrease in total weak acids (alkalosis). The semi-quantitative method identified the free water and chloride effects as variables causing acidosis and the albumin effect causing alkalosis.Conclusions and clinical relevanceIn an experimental haemorrhage and resuscitation model in cats, blood pH was similar among treatments over time regardless of severe haemorrhage and resuscitation with LRS or Voluven or mild haemorrhage and no resuscitation.  相似文献   

Cardiopulmonary effects of thoracoscopy in anesthetized normal dogs   总被引：1，自引：0，他引：1  

Kudnig ST  Monnet E  Riquelme M  Gaynor JS  Corliss D  Salman MD 《Veterinary anaesthesia and analgesia》2004,31(2):121-128

Objective To evaluate the effect of an open‐chest condition on oxygen delivery in anesthetized dogs. Study design Prospective, controlled experimental study. Animals Eight clinically normal adult Walker Hound dogs weighing 25.6–29.2 kg. Methods Eight anesthetized dogs underwent an open‐chest operation after the insertion of thoracoscopy cannulae in the lateral chest walls . A Swan Ganz catheter was used to both measure hemodynamic parameters and obtain mixed venous blood samples for blood gas analysis. A dorsal pedal catheter was placed to both measure arterial blood pressure and obtain blood samples for blood gas analysis. Oxygen delivery index and oxygen extraction ratio were calculated. A randomized block anova for repeated measures was used to evaluate the effect of the treatment on hemodynamic and pulmonary parameters. Results Creation of an open chest did not significantly affect oxygen delivery index (DO₂I; p = 0.545). It induced a significant decrease in arterial oxygen partial pressure (PaO₂; p = 0.018) and arterial oxygen content (CaO₂; p = 0.025). It induced a significant increase in shunt fraction (p = 0.023), physiologic dead space (p = 0.015), and alveolar‐arterial oxygen difference (p = 0.019). Arterial partial pressure of carbon dioxide (PaCO₂; p = 0.766) and arterial hemoglobin oxygen saturation (SaO₂; p = 0.178) were not significantly affected. Diastolic (DPAP; p = 0.050) and mean (MPAP; p = 0.033) pulmonary arterial pressures were significantly increased by opening the chest. Other hemodynamic parameters were not significantly affected. Conclusions Opening the thoracic cavity is not detrimental to hemodynamic function and oxygen delivery in normal dogs, although impaired gas exchange does occur. Clinical relevance Close monitoring of patients is recommended during open‐chest thoracoscopy as adverse effects on gas exchange can contribute to hypoxemia.  相似文献   

A pilot study evaluating the use of cervical ultrasound to confirm endotracheal intubation in dogs          下载免费PDF全文

Vicente J. Herreria‐Bustillo LV  MRCVS  Kendon W. Kuo DVM  MS  DACVECC  Pierre J. Burke DVM  Robert Cole DVM  DACVR  Lenore M. Bacek DVM  MS  DACVECC 《Journal of Veterinary Emergency and Critical Care》2016,26(5):654-658

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Evaluation of end‐tidal carbon dioxide as a predictor of return of spontaneous circulation in dogs and cats undergoing cardiopulmonary resuscitation          下载免费PDF全文

Talli Hogen DVM  DACVECC  Steven G. Cole DVM  DACVECC  DACVIM ;  Kenneth J. Drobatz DVM  MSCE  DACVIM  DACVECC 《Journal of Veterinary Emergency and Critical Care》2018,28(5):398-407

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