犬心肺复苏中浅低温闭胸心肺转流对脑的保护作用     

何湛  陈捷  程可洛  吴平  姚月华  陈莫异 《湛江医学院学报》2009,27(1):11-12

目的观察闭胸浅低温心肺转流（CPB）对犬心肺复苏中脑损伤的保护作用。方法制作犬心搏骤停模型,停搏15min后行浅低温（32-34℃）（A组,n=6）和正常体温非开胸CPB复苏（B组,n=6）。于停搏前、停搏后15min,CPB开始后l、3h抽血,于3h取大脑皮层,测定血清和脑组织S100β蛋白浓度。结果停搏15min和CPB开始后1、3h,A、B两组犬血浆S100β含量均明显高于停搏前（P〈0．01）;A组于CPB1、3h时的S100β含量明显低于B组,差异有统计学意义（P〈0．01）,CPB后3h,A组大脑皮层中S100β含量为（2．051±0．923）pg／（mg·prot）,明显低于B组（4．068±1．462）pg／（mg·prot）（P〈0．05）。结论犬心脏停搏15min后行浅低温闭胸CPB复苏对大脑皮层的损伤较轻,有一定保护作用。  相似文献   

Update on Cardiopulmonary Resuscitation in Small Animals     

《Veterinary Clinics of North America: Small Animal Practice》2020,50(6):1183-1202

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Flow rates of large animal fluid delivery systems used for high‐volume crystalloid resuscitation     

Rose D. Nolen‐Walston DVM  DACVIM 《Journal of Veterinary Emergency and Critical Care》2012,22(6):661-665

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Severe burn injury,burn shock,and smoke inhalation injury in small animals. Part 1: Burn classification and pathophysiology     

Lindsay Vaughn DVM  Nicole Beckel DVM  DACVECC 《Journal of Veterinary Emergency and Critical Care》2012,22(2):179-186

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Liquid resuscitation combined with hydrogen inhalation reduce acute kidney injury during septic shock in rats     

LIU Wei  SHAN Li-ping  LIU Qian-qian  LIU Zhi 《园艺学报》2017,33(9):1703

AIM: To investigate the therapeutic effects of a novel fluid resuscitation protocol (early fluid resuscitation plus 2% hydrogen inhalation) on acute kidney injury during septic shock induced by lipopolysaccharide (LPS) in rats.METHODS: Male Wistar rats were randomly divided into 4 groups (15 rats per group):control group, septic shock group, septic shock with early fluid resuscitation group (fluid group) and septic shock with early fluid resuscitation plus 2% hydrogen inhalation group (fluid+H₂ group). The rats were ventilated, and a 2% hydrogen mixture was used in fluid+H₂ group. LPS (10 mg/kg) was administered to establish the septic shock model in rats and fluid resuscitation was performed in fluid group and fluid+H₂ group.RESULTS: Fluid resuscitation with 2% hydrogen inhalation decreased the le-vels of serum creatinine, blood urea nitrogen and neutrophil gelatinase-associated lipocalin. It also reduced oxidative stress injury and decreased renal tumor necrosis factor-α and interleukin-6 levels compared with fluid resuscitation alone.CONCLUSION: Early fluid resuscitation plus 2% hydrogen inhalation provided more protection against acute kidney injury du-ring septic shock.  相似文献   

Effect of synthetic colloid administration on hemodynamic and laboratory variables in healthy dogs and dogs with systemic inflammation     

Vincent Gauthier DVM  DVSc  DACVECC  Marie K. Holowaychuk DVM  DACVECC  Carolyn L. Kerr DVM  DVSc  PhD  DACVAA  Alexa M.E. Bersenas DVM  MSc  DACVECC  R. Darren Wood DVM  DVSc  DACVP 《Journal of Veterinary Emergency and Critical Care》2014,24(3):251-258

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Effect of modified ultrafiltration on cytokines and hemoconcentration in dogs undergoing cardiopulmonary bypass     

Haruhiko SUZUKI  Naoko OSHIMA  Toshihiro WATARI 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2020,82(11):1589

Cardiac surgery using cardiopulmonary bypass (CPB) generates severe inflammatory reactions secondary to hemodilution and surgical stress. This study was conducted to evaluate whether modified ultrafiltration (MUF) could be performed safely and to clarify its effects during mitral valve repair in dogs in terms of hemodilution and the status of inflammatory cytokines. We retrospectively studied 38 dogs with mitral valve disease who underwent MUF immediately after mitral valve repair under CPB. To determine the effect of MUF, we measured the pre- and post-MUF blood dilution and blood cytokine levels. The levels of red blood cells, hematocrit (HCT), and albumin were significantly increased after MUF, whereas interleukin (IL)-6 levels were significantly increased from 24.3 (range 9.6–54.6) to 32.3 (15.9–65.1) pg/ml. The levels of IL-8 and IL-10 declined significantly after MUF, from 368.2 (246.1–669.4) and 45.4 (28.6–76.1) to 272.2 (174.1–414.4) and 28.8 (18.8–44.5) pg/ml, respectively. Our results demonstrated that MUF can be applied in dogs undergoing CPB and is effective in achieving hemoconcentration. Moreover, MUF may be useful for the removal of cytokines. Further studies are needed to validate these findings and clarify the effects of inflammatory cytokines after CPB.  相似文献   

犬低温体外循环下冷温血停搏液灌注的动态心电监测     

祁克宗  王林安 《安徽农业大学学报》1998,25(3):260-265

２８只低温体外循环犬,按停搏液灌注方式随机分为４组：Ａ组为冷晶组（Ｎ＝７）,Ｂ组为冷血组（Ｎ＝７）,Ｃ组为温血组（Ｎ＝７）,Ｄ组为冷温血组（Ｎ＝７）。借助现代医学监测设备ＸＪ－２型心电监护除颤仪,首次在我国兽医临床系统开展了动态电主（ＥＣＧ）监测研究。通过心脏复跳后心电图的心律变化是ＳＴ的高低分析。结果表明：冷温血停搏液联合应用对改善心脏功能机械活动具的良好的作用。研究提示：密切观察心律的变化。是  相似文献   

Therapeutic hypothermia applicable to cardiac surgery          下载免费PDF全文

Klaus A Otto 《Veterinary anaesthesia and analgesia》2015,42(6):559-569

ObjectiveTo review the beneficial and adverse effects of therapeutic hypothermia (TH) applicable to cardiac surgery with cardiopulmonary bypass (CPB) in the contexts of various temperature levels and techniques for achieving TH.Databases usedMultiple electronic literature searches were performed using PubMed and Google for articles published from June 2012 to December 2014. Relevant terms (e.g. ‘hypothermia’, ‘cardiopulmonary bypass’, ‘cardiac surgery’, ‘neuroprotection’) were used to search for original articles, letters and reviews without species limitation. Reviews were included despite potential publication bias. References from the studies identified were also searched to find other potentially relevant citations. Abstracts, case reports, conference presentations, editorials and expert opinions were excluded.ConclusionsTherapeutic hypothermia is an essential measure of neuroprotection during cardiac surgery that may be achieved most effectively by intravascular cooling using hypothermic CPB. For most cardiac surgical procedures, mild to modest (32–36 °C) TH will be sufficient to assure neuroprotection and will avoid most of the adverse effects of hypothermia that occur at lower body core temperatures.  相似文献   

Investigation of biomarkers for impending fluid overload in a feline acute haemorrhage-resuscitation model     

《Veterinary anaesthesia and analgesia》2021,48(6):871-881

ObjectiveTo determine biomarkers for impending fluid overload during intravenous fluid administration in a feline haemorrhage-resuscitation model.Study designRandomized crossover study.AnimalsA group of six domestic cats (mean age and weight: 21 months; 4.9 kg, respectively).MethodsThe cats underwent three treatments, 2 months apart. They were anaesthetized and instrumented to measure a range of physiological, blood gas, haematological and biochemical variables over time. Samples were taken during a health check, before haemorrhage, after haemorrhage and then at 30 minute intervals during fluid resuscitation and 24 hours later. The three treatments were: 1) control, sham haemorrhage and resuscitation; 2) lactated Ringer’s solution (LRS); and 3) 6% tetrastarch 130/0.4 (Vol) where the cats underwent a controlled haemorrhage then resuscitation by administering LRS and Vol at 60 and 20 mL kg^–1 hour^–1, respectively, for 120 minutes. Fluid overload was identified by nasal discharge and radiographic evidence. Biomarkers were variables that exceeded the reference interval for cats during treatment. Potential biomarkers were analysed using receiver operating characteristic curves (p < 0.05).ResultsMean ± standard deviation total blood loss was 10.2 ± 2.3, 29.3 ± 9.0 and 29.1 ± 6.3 mL kg^–1 for control, LRS and Vol, respectively. The total volume of LRS and Vol administered was 120 and 40 mL kg^–1, respectively. Haematocrit, albumin, magnesium, chloride-to-sodium ratio and sodium-chloride difference were identified as potential biomarkers. These variables exceeded the reference intervals from 30 minutes of resuscitation onwards. A chloride-to-sodium ratio > 0.84 was the most sensitive (90%) and specific (75%) of all potential biomarkers.Conclusions and clinical relevanceChanges in physiological variables, haematocrit and albumin were poor biomarkers of impending fluid overload compared with electrolytes. Finding the ideal biomarker to identify impending fluid overload of commonly used intravenous fluids should improve the safety of their administration in cats.  相似文献