霉菌毒素免疫抑制作用的研究进展   总被引：1，自引：1，他引：0  

戈娜  袁慧 《中国畜牧兽医》2008,35(3):126-128

霉菌毒素是霉菌的有毒代谢产物,对动物机体最重要的危害作用就是能够抑制动物机体的免疫机能,引起动物生长缓慢,生产性能下降,对疾病的抵抗能力降低,造成长远的经济失。同时霉菌毒素之间还有对免疫系统的协同抑制作用。作者针对饲料中几种主要的霉菌毒素对动物机体免疫抑制作用作一综述。  相似文献   

Ochratoxin A cytotoxicity on Madin–Darby canine kidney cells in the presence of alpha‐tocopherol: Effects on cell viability and tight junctions          下载免费PDF全文

E. Fusi  C. Giromini  R. Rebucci  L. Pinotti  V. Caprarulo  F. Cheli  F. Vitari  C. Domeneghini  A. Baldi 《Journal of animal physiology and animal nutrition》2018,102(1):350-355

Ochratoxin A (OTA) is a potent nephrotoxic fungi metabolite that affects animal and human health. At the cellular level, OTA is able to alter functions and viability by several mechanisms of action. Several strategies to counteract its toxicity have been studied. We investigated the role of α‐tocopherol in counteracting OTA oxidative damage in Madin–Darby canine kidney (MDCK) cells by pre‐incubating the cells for 3 hr with the antioxidant (1 nm , 10 μm ) and then adding OTA (0–1.2 μg/ml) for the following 24 hr. Cell viability, lactate dehydrogenase (LDH) release, TUNEL staining and occludin and Zo1 localization by immunofluorescence were determined. Here, 1 nm α‐tocopherol was shown to significantly reduce (p < .05) the cytotoxicity, LDH release and apoptotic rate induced by OTA. The presence of the antioxidant at the same concentration maintained the localization of occludin and Zo1 in the rim of the MDCK cells after the 24‐hr OTA exposure. These results indicate that a low concentration of α‐tocopherol could block OTA toxicity, supporting its defensive role in the cellular membrane.  相似文献   

Identification of hypoglycin A binding adsorbents as potential preventive measures in co‐grazers of atypical myopathy affected horses          下载免费PDF全文

T. Krägeloh  J. M. V. Cavalleri  J. Ziegler  J. Sander  M. Terhardt  G. Breves  A. Cehak 《Equine veterinary journal》2018,50(2):220-227

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Deactivation of T-2 toxin in broiler ducks by biotransformation     

《The Journal of Applied Poultry Research》2012,21(1):13-20

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Mycoflora and Mycotoxicological Quality of Four Freshly Harvested Paddy Rice Cultivars and Relation with Harvest to Industry Reception Timing     

Menithen BEBER-RODRIGUES  Vildes Maria SCUSSEL 《水稻科学》2013,20(4):303-308

Grain quality and safety of four freshly harvested paddy rice (Oryza sativa L.) cultivars (Epagri 109,SCS 114 Andosan,Tio Taka 113 and Epagri 115 CL) grown under irrigation system in the north of Santa Catarina State,Brazil were studied.The quality parameters evaluated were mycoflora,mycotoxins (aflatoxins,ochratoxin A and zearalenone),water distribution (moisture content and water activity) apart from environmental conditions (relative humidity and temperature) and the relation between harvest and the industry reception timing.All cultivars presented an average waiting time of 8.6 h (ranged from 0.3 to 24.9 h),a total fungi load of 8.6×104 cfu/mL (ranged from 1.8×103 to 9.4×105 cfu/mL) with a rather high humidity condition of 19.0% moisture content (varied from 14.9% to 24.5%) and 0.92 water activity (varied from 0.78 to 0.99) under the average environmental conditions of 87.3% relative humidity (varied from 80.0% to 96.8%) and 25.4 ℃ (varied from 22.5 to 27.5 ℃),respectively.The conditions to which the samples were submitted allowed fungal growth,but no mycotoxins were detected.Regarding the rice cultivars fungal genera isolated,Aspergillus and Penicillium were the most often isolated among all the cultivars and variation on fungi distribution among them was not observed.Moreover,it was not found a correlation of the grain loading & unloading time with the humidity conditions and the total fungi load.Furthermore,all results and the importance of monitoring the rice mycotoxicological quality and safety were discussed.  相似文献   

玉米赤霉烯酮的危害及物理吸附剂脱毒研究进展     

冯雪莲 《现代农业科技》2021,21(21)

玉米赤霉烯酮（Zearalenone, ZEN）主要是由镰刀真菌所产生的一种非甾体类真菌毒素。大量分布于玉米、大麦、小麦、高粱等作物中，对动物和人体健康造成严重危害。本文综述了ZEN的理化性质、毒性危害、检测方法及物理吸附剂对ZEN吸附脱毒的研究进展。  相似文献   

国内外饲料真菌毒素限量规定及评析     

陈茹 《中国饲料》2013,(17):38-42

真菌毒素污染饲料可对人类和动物健康造成严重危害。本文对我国及美国、欧盟、加拿大等主要贸易国家和地区发布的饲料真菌毒素法规或卫生标准进行整理和比较分析,针对如何进一步完善我国饲料卫生标准和法规体系以及加强进出口把关进行探讨并提出建议。  相似文献   

Virulence and mycotoxic effects of Metarhizium anisopliae on Mahogany shoot borer, Hypsipyla robusta (Lepidoptera: Pyralidae)   总被引：2，自引：0，他引：2  

M.Balachander  O.K.Remadevi  T.O Sasidharan  N.Sapna Bai 《林业研究》2012,23(4):651-659

Developing appropriate control measures for the Mahogany shoot borer,Hypsipyla robusta Moore has become increasingly important due to the severe damaging effect of the pest on the establishment of the saplings of Swietenia mahagoni Jacq(Sapindales:Meliaceae).Existing management methods are largely limited to silvicultural practices and spraying of chemical insecticides.To identify a potential fungal biocontrol agent,we compared the virulence of six native and two standard ARSEF isolates of Metarhizium anisopliae Metsch.against this pest.The average survival time and conidial yield of IWST-Ma7 was higher(6.2 to 7.3 days and 4.9 to 4.7 × 10 5 conidia/ml) than the standards.Significant difference in sporulation on the cadavers between isolates,doses and incubation periods were substantiated for the selection of potential strain.The mycotoxic effects of crude soluble protein extract when incorporated in the artificial diet,the ARSEF 2596 and ARSEF 3603 showed LD 50 value of 3.7% and 5.6%.However,IWST-Ma7 was highly lethal with significant lowest LD 50 value of 2.6%.The enzyme activity of IWST-Ma7 was highest for chitinase,CDA,protease and lipase viz.,1.90 U/mg,1.80 U/mg,0.98 U/mg and 0.80 U/mg respectively.However the enzyme activity of chitinase and Chitin deacetylase assay for all the isolates was significantly higher than protease and lipase activity.The ITS regions(5.8S rDNA and 28S rDNA) of seven isolates of M.anisopliae were amplified using the ITS1 and ITS4 primers which was a unique fragment of approximately 550 bp.Based on ITS regions,phylogenetic tree have been constructed and the isolates have been grouped in to 5 clades.The virulence and mycotoxic effects of different isolates could rationally be used to employ them for the management of the mahogany borer.  相似文献   

奶牛专用霉菌毒素吸附剂对泌乳奶牛生产性能的影响     

袁耀明  徐元年  刘仕军  梁建光  王治国  丰强 《乳业科学与技术》2009,32(3)

奶牛饲料原料中霉菌毒素广泛存在,并严重威胁着奶牛健康,影响奶牛生产性能的发挥.选择年龄、胎次、产奶量、泌乳天数接近的荷斯坦奶牛90头,随机分成两组,考察奶牛专用霉菌毒素吸附剂对乳牛生产性能的影响.在饲喂等量的基础日粮上,对照组额外添加20 g/d·头精料补充料,试验组添加霉菌毒素吸附剂--普乐菲特20g/d头·其他饲养管理方式不变.该试验预饲期7 d,试验期77 d.结果表明,霉菌毒素吸附剂的添加不影响乳脂、乳蛋白,但对提高产奶量及降低原料奶中体细胞数(P<0.05)有明显效果.研究表明,日粮添加霉菌毒素吸附剂可有效提高原料奶质量,提高牧场整体经济效益.  相似文献   

Oxidation capability of modified fly ash based adsorbent for mercury in coal-fired flue gas     

XU Zhipeng  LIU Qingcai  YAO Chunling  YANG Jian  WEI Min 《保鲜与加工》2012,(11):81-85

Fly ash based adsorbent is dipping modified by NaCl or NaBr solution and the purpose is to improve their oxidation capability. Adsorption experiments of vapor-phase elemental mercury are performed in a laboratory-scale fixed-bed reactor. Physical properties of the adsorbent before and after modification are measured and the influences of the solution concentration and flue gas temperature on mercury oxidation rate are studied. The results show that when NaBr solution concentration is 5%, the mercury oxidation rate can reach 79.43%. The saturation adsorption quantity of absorbent 5%-NaBr is 1 700 ng/g and the service life is about 480 hours. Flue gas temperature played an important role in mercury oxidation and the best temperature ranged from 100 to 200 ℃.  相似文献